WO2010114245A3 - 5'-이노신산 생산성이 향상된 코리네박테리움 속 미생물 및 이를 이용한 핵산의 생산방법 - Google Patents

5'-이노신산 생산성이 향상된 코리네박테리움 속 미생물 및 이를 이용한 핵산의 생산방법 Download PDF

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WO2010114245A3
WO2010114245A3 PCT/KR2010/001760 KR2010001760W WO2010114245A3 WO 2010114245 A3 WO2010114245 A3 WO 2010114245A3 KR 2010001760 W KR2010001760 W KR 2010001760W WO 2010114245 A3 WO2010114245 A3 WO 2010114245A3
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corynebacterium
microorganisms
improved
nucleic acids
inosinic acid
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PCT/KR2010/001760
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English (en)
French (fr)
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WO2010114245A2 (ko
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김정환
권중근
안태민
황수연
백민지
권나라
윤난영
김주정
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씨제이 제일제당(주)
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Priority to CN201080019531.5A priority Critical patent/CN102549144B/zh
Priority to ES10758970.7T priority patent/ES2657837T3/es
Priority to PL10758970T priority patent/PL2415861T3/pl
Priority to DK10758970.7T priority patent/DK2415861T3/en
Priority to US13/262,202 priority patent/US8993272B2/en
Priority to MX2011010250A priority patent/MX2011010250A/es
Priority to BRPI1014056A priority patent/BRPI1014056B1/pt
Priority to JP2012503311A priority patent/JP2012522503A/ja
Priority to RU2011144024/10A priority patent/RU2482178C1/ru
Priority to EP10758970.7A priority patent/EP2415861B1/en
Publication of WO2010114245A2 publication Critical patent/WO2010114245A2/ko
Publication of WO2010114245A3 publication Critical patent/WO2010114245A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1235—Diphosphotransferases (2.7.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/32—Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/15—Corynebacterium

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

본 발명은 퓨린 생합성 효소를 코딩하는 유전자의 발현량이 내재적 발현량보다 증가된, 5'-이노신산 생산능을 갖는 코리네박테리움 속 미생물 및 향상된 5'-이노신산 생산능을 갖는 코리네박테리움 속 미생물을 배양하는 단계를 포함하는 5'-이노신산 생산방법에 관한 것이다.
PCT/KR2010/001760 2009-04-01 2010-03-23 5'-이노신산 생산성이 향상된 코리네박테리움 속 미생물 및 이를 이용한 핵산의 생산방법 WO2010114245A2 (ko)

Priority Applications (10)

Application Number Priority Date Filing Date Title
CN201080019531.5A CN102549144B (zh) 2009-04-01 2010-03-23 具有提高的5＇-肌苷酸生产力的棒状杆菌属微生物及使用该微生物产生核酸的方法
ES10758970.7T ES2657837T3 (es) 2009-04-01 2010-03-23 Microorganismos de Corynebacterium con productividad mejorada de ácido 5'-inosínico, y procedimiento de producción de ácidos nucleicos usando los mismos
PL10758970T PL2415861T3 (pl) 2009-04-01 2010-03-23 Mikroorganizmy corynebacterium o zwiększonej produktywności kwasu 5'-inozynowego oraz sposób produkcji kwasów nukleinowych z ich użyciem
DK10758970.7T DK2415861T3 (en) 2009-04-01 2010-03-23 Corynebacterium microorganisms with improved 5'-inosinic acid productivity and method of producing nucleic acids using them
US13/262,202 US8993272B2 (en) 2009-04-01 2010-03-23 Microorganisms of Corynebacterium with improved 5′-inosinic acid productivity, and method for producing nucleic acids using same
MX2011010250A MX2011010250A (es) 2009-04-01 2010-03-23 Microorganismo de corynebacterium con productividad mejorada de acido 5´-inosinico, y metodo para producir acidos nucleicos utilizando los mismos.
BRPI1014056A BRPI1014056B1 (pt) 2009-04-01 2010-03-23 micro-organismos de corynebacterium com maior produtividade de ácido 5'-inosínico e método para produzir ácidos nucleicos com eles.
JP2012503311A JP2012522503A (ja) 2009-04-01 2010-03-23 ５’−イノシン酸生産性が向上したコリネバクテリウム属微生物及びこれを用いた核酸の生産方法
RU2011144024/10A RU2482178C1 (ru) 2009-04-01 2010-03-23 МИКРООРГАНИЗМЫ Corynebacterium С ПОВЫШЕННОЙ ПРОДУКЦИЕЙ 5'- ИНОЗИНОВОЙ КИСЛОТЫ И СПОСОБ ПОЛУЧЕНИЯ НУКЛЕИНОВЫХ КИСЛОТ С ИХ ИСПОЛЬЗОВАНИЕМ
EP10758970.7A EP2415861B1 (en) 2009-04-01 2010-03-23 Microorganisms of corynebacterium with improved 5'-inosinic acid productivity, and method for producing nucleic acids using same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020090028145A KR101166027B1 (ko) 2009-04-01 2009-04-01 5'-이노신산 생산성이 향상된 코리네박테리움 속 미생물 및 이를 이용한 핵산의 생산방법
KR10-2009-0028145 2009-04-01

Publications (2)

Publication Number Publication Date
WO2010114245A2 WO2010114245A2 (ko) 2010-10-07
WO2010114245A3 true WO2010114245A3 (ko) 2011-06-23

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PCT/KR2010/001760 WO2010114245A2 (ko) 2009-04-01 2010-03-23 5'-이노신산 생산성이 향상된 코리네박테리움 속 미생물 및 이를 이용한 핵산의 생산방법

Country Status (12)

Country Link
US (1) US8993272B2 (ko)
EP (2) EP3219789A1 (ko)
JP (1) JP2012522503A (ko)
KR (1) KR101166027B1 (ko)
CN (1) CN102549144B (ko)
BR (1) BRPI1014056B1 (ko)
DK (1) DK2415861T3 (ko)
ES (1) ES2657837T3 (ko)
MX (1) MX2011010250A (ko)
PL (1) PL2415861T3 (ko)
RU (1) RU2482178C1 (ko)
WO (1) WO2010114245A2 (ko)

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KR101744958B1 (ko) 2014-12-24 2017-06-12 대상 주식회사 5’-이노신산의 고생성능 코리네박테리움 암모니아게네스 변이 균주 및 이를 이용한 5’-이노신산의 제조 방법
CN106282220B (zh) * 2015-05-29 2021-03-23 上海市农业科学院 一种提高枯草芽孢杆菌合成肌苷能力的方法
KR101916611B1 (ko) 2017-12-15 2018-11-07 씨제이제일제당 (주) 신규 폴리펩타이드 및 이를 이용한 imp 생산방법
US11180754B2 (en) 2017-12-15 2021-11-23 Cj Cheiljedang Corporation Polypeptide and method of producing IMP using the same
KR101904675B1 (ko) * 2017-12-15 2018-10-04 씨제이제일제당 (주) 5'-이노신산을 생산하는 미생물 및 이를 이용한 5'-이노신산의 생산 방법
KR101999454B1 (ko) * 2017-12-19 2019-07-11 씨제이제일제당 (주) L-아르기닌을 생산하는 코리네박테리움 속 미생물 및 이를 이용한 l-아르기닌 생산방법
KR101916622B1 (ko) * 2018-01-04 2018-11-07 씨제이제일제당 (주) 신규 폴리펩타이드 및 이를 이용한 imp 생산방법
KR102013873B1 (ko) 2018-01-25 2019-08-23 씨제이제일제당 주식회사 퓨린 뉴클레오티드를 생산하는 코리네박테리움 속 미생물 및 이를 이용한 퓨린 뉴클레오티드의 생산방법
KR101956510B1 (ko) * 2018-07-27 2019-03-08 씨제이제일제당 (주) 신규 5'-이노신산 디하이드로게나아제 및 이를 이용한 5'-이노신산 제조방법
KR101950141B1 (ko) * 2018-08-01 2019-02-19 씨제이제일제당 (주) 신규 아데닐로석시네이트 신세타아제 및 이를 이용한 퓨린 뉴클레오티드 생산방법
KR20210091255A (ko) * 2018-12-18 2021-07-21 데이진 가부시키가이샤 니코틴아미드 유도체를 제조하기 위한 재조합 미생물 및 방법, 그리고 그것에 사용되는 벡터
KR102006976B1 (ko) * 2019-02-26 2019-08-06 씨제이제일제당 주식회사 신규 프로모터 및 이를 이용한 퓨린 뉴클레오티드 제조방법
KR102006977B1 (ko) * 2019-03-28 2019-08-05 씨제이제일제당 주식회사 변이형 포스포리보실피로포스페이트 아미도트랜스퍼라아제 및 이를 이용한 퓨린 뉴클레오티드 제조방법
KR102185850B1 (ko) * 2020-02-21 2020-12-02 씨제이제일제당 주식회사 퓨린 뉴클레오티드를 생산하는 미생물 및 이를 이용한 퓨린 뉴클레오티드의 생산방법
KR102277409B1 (ko) * 2021-04-29 2021-07-14 씨제이제일제당 주식회사 신규한 2중기능성 포스포리보실아미노이미다졸카르복사미드 포밀트랜스퍼라아제/imp 사이클로하이드롤라아제 변이체 및 이를 이용한 imp 생산 방법
KR102614734B1 (ko) 2023-04-06 2023-12-19 대상 주식회사 5-데하이드로-2-데옥시글루코노키나아제 신규 변이체 및 이를 이용한 5’-이노신산 생산 방법
KR102614733B1 (ko) 2023-04-06 2023-12-19 대상 주식회사 포스포에놀피루베이트 카르복실라아제 신규 변이체 및 이를 이용한 5’-이노신산 생산 방법

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KR101166027B1 (ko) 2012-07-19
MX2011010250A (es) 2011-11-29
US20120021466A1 (en) 2012-01-26
JP2012522503A (ja) 2012-09-27
EP2415861B1 (en) 2017-11-29
DK2415861T3 (en) 2018-01-22
WO2010114245A2 (ko) 2010-10-07
US8993272B2 (en) 2015-03-31
CN102549144B (zh) 2014-06-18
ES2657837T3 (es) 2018-03-07
BRPI1014056A2 (pt) 2017-05-30
RU2482178C1 (ru) 2013-05-20
PL2415861T3 (pl) 2018-07-31
EP2415861A4 (en) 2012-09-12
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