WO2010113688A1 - Composition pour cavité buccale - Google Patents

Composition pour cavité buccale Download PDF

Info

Publication number
WO2010113688A1
WO2010113688A1 PCT/JP2010/054910 JP2010054910W WO2010113688A1 WO 2010113688 A1 WO2010113688 A1 WO 2010113688A1 JP 2010054910 W JP2010054910 W JP 2010054910W WO 2010113688 A1 WO2010113688 A1 WO 2010113688A1
Authority
WO
WIPO (PCT)
Prior art keywords
copper
composition
betaine
oral
effect
Prior art date
Application number
PCT/JP2010/054910
Other languages
English (en)
Japanese (ja)
Inventor
康太 堤
真達 丸山
Original Assignee
ライオン株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ライオン株式会社 filed Critical ライオン株式会社
Priority to JP2011507099A priority Critical patent/JP5930713B2/ja
Priority to CN201080015684.2A priority patent/CN102365077B/zh
Publication of WO2010113688A1 publication Critical patent/WO2010113688A1/fr
Priority to HK12104008.8A priority patent/HK1163509A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/34—Copper; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention has a sufficient astringent feeling imparting effect to the gums which is an effective feeling of periodontal disease improving effect, and exhibits an unpleasant bitterness improving effect peculiar to copper compounds and an inhibitory effect on oral mucosal irritation. It is related with the composition for oral cavity containing the copper compound excellent in the feeling.
  • Patent Documents 1 to 5 JP-A-2-212413, JP-A-8-310928, JP-A-2882017, (See Tables 10-505831 and 2003-231621).
  • dentifrices and periodontal treatment drugs are effective in the astringent feeling of gums as an effective feeling of periodontal disease improving effect, and a copper compound is preferably used as a component having an astringent action.
  • the copper compound has an unpleasant taste such as a bitter taste and a metallic taste and has an oral mucosal irritation
  • the copper compound can be added to the oral composition in an amount sufficient to sufficiently exhibit its effect.
  • blends there exists a problem that a usability
  • Many solutions have been proposed so far, and the applicant has disclosed that the metal taste can be improved by blending a metal ion releasing compound such as copper with a menthol derivative or the like (Japanese Patent Laid-Open No. 2003-137755). Proposal).
  • JP-A-2-212413 JP-A-8-310928 Japanese Patent No. 2882017 Japanese National Patent Publication No. 10-505831 JP 2003-231621 A JP 2003-137755 A JP 2000-297022 A JP 2008-150335 A JP 2007-320894 A
  • the present invention has an effect of imparting sufficient astringency to the gums, which is an effective feeling of periodontal disease improvement effect, and exhibits an unpleasant bitterness improvement effect unique to copper compounds and an effect of suppressing oral mucosal irritation.
  • An object of the present invention is to provide a composition for oral cavity containing a copper compound which is excellent in feeling.
  • the bitterness, oral mucosal irritation and astringent feeling derived from the copper compound are produced as a result of the interaction of the copper compound with the oral mucosa. That is, as described above, in the oral composition containing a copper compound, when an unpleasant taste such as a bitter taste derived from the copper compound and oral mucosal irritation are suppressed, the effect of imparting a convergence feeling is also impaired at the same time. This is thought to be due to the change in the interaction between the skin and the mucous membrane in the oral cavity.
  • betaine amphoteric surfactant and sugar alcohol act cooperatively on copper gluconate, copper sulfate or hydrate thereof, and the mutual interaction between the copper compound and the oral mucosa.
  • sugar alcohol is well-known as a compounding component to an oral composition, and is normally mix
  • Patent Document 7 JP 2000-297022 A
  • Patent document 8 Unexamined-Japanese-Patent No. 2008-150335 which improved storage stability with time by mix
  • Patent Document 4 Patent Document 4 and the like have been proposed.
  • Patent Document 9 Japanese Patent Application Laid-Open No. 2007-320894 and the like that improve retention in the oral cavity, feeling of use, and the like have been proposed.
  • Patent Document 1 a technique in which a sugar alcohol having a reducing sugar content of 0.2% by mass or less as a moisturizing agent is added to an oral composition containing a copper compound, and an amphoteric surfactant.
  • blends was proposed. These technologies enable the prevention of discoloration over time and the retention of bad breath removal effects derived from copper compounds, which are different from the present invention in solving problems. And the effect is not shown.
  • various proposals have been made for oral compositions containing copper compounds, and sugar alcohols and amphoteric surfactants are known as ingredients of oral compositions.
  • the present invention (A) one or more copper compounds selected from copper gluconate, copper sulfate and hydrates thereof; (B) a betaine-type amphoteric surfactant; (C) An oral composition comprising one or more sugar alcohols selected from erythritol, xylitol, and mannitol.
  • composition for oral cavity containing a copper compound of the present invention has a sufficient astringent feeling imparting effect to gums which is an effective feeling of periodontal disease improving effect, and has an unpleasant bitterness improving effect peculiar to a copper compound and oral mucosa Suppressive effect of irritation is demonstrated, and the feeling of use is excellent.
  • composition for oral cavity of the present invention comprises (A) a copper compound selected from copper gluconate, copper sulfate and hydrates thereof, (B) a betaine amphoteric surfactant, (C) erythritol, xylitol and mannitol. It contains 1 or more types of sugar alcohol chosen from these, It is characterized by the above-mentioned.
  • copper gluconate and copper sulfate are used, and 1 type may be used individually or 2 types may be used together. Copper gluconate and copper sulfate may each be an anhydride or a hydrate.
  • a hydrate containing crystal water such as copper sulfate pentahydrate, trihydrate, monohydrate and the like can be used.
  • the compounding amount of the copper compound is 0.0026 to 0.51% (mass%, the same applies hereinafter) of the entire composition as copper in the compound, particularly 0.013 to 0.26%, especially 0.026 to 0.26. % Is preferred.
  • the blending amount is less than 0.0026%, the astringent feeling imparting effect derived from the copper compound may not be sufficiently exhibited, and if it exceeds 0.51%, it becomes difficult to sufficiently exhibit the bitterness improving effect, and the feeling of use is satisfied. May not be improved.
  • Component betaine-type amphoteric surfactants include lauryl betaine, stearyl betaine, lauryldimethylaminoacetic acid betaine, stearyldimethylaminoacetic acid betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-lauroyl-N′-carboxymethyl-N′-hydroxyethylethylenediamine sodium, lauric acid amidopropyl betaine, coconut oil fatty acid amidopropyl betaine, lauryl hydroxysulfobetaine and the like.
  • lauryldimethylaminoacetic acid betaine coconut oil fatty acid amidopropyl betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-lauroyl-N′-carboxymethyl-N′-hydroxyethylethylenediamine sodium Those selected from are preferred.
  • betaine-type amphoteric surfactants can be used alone or in combination of two or more.
  • betaine type amphoteric surfactant commercially available products can be used.
  • 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine (trade name: Levon 105), N-lauroyl-N manufactured by Sanyo Chemical Industries, Ltd. '-Carboxymethyl-N'-hydroxyethylethylenediamine sodium (trade name: Levon 101-H), palm oil fatty acid amidopropyl betaine solution (trade name: Levon 2000), lauryldimethylaminoacetic acid betaine aqueous solution (trade name: NIKKOL) manufactured by Nikko Chemicals AM-301).
  • 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine 2-coconut oil alkyl-N-carboxymethyl-N-hydroxy sold by Lion Corporation under the trade name Enacol C-40H Ethyl imidazolinium betaine sodium aqueous solution can also be used.
  • the blending amount of the betaine amphoteric surfactant is preferably 0.01 to 5%, particularly 0.05 to 2%, particularly 0.1 to 1% of the entire composition. If the blending amount is less than 0.01%, the inhibitory effect on oral mucosal irritation may not be sufficiently exerted, and if it exceeds 5%, problems of oral mucosal irritation caused by surfactants occur, and the bitterness improving effect is not sufficiently exhibited. There is a case.
  • the component (C) is a sugar alcohol selected from erythritol, xylitol, and mannitol. These sugar alcohols may be used alone or in combination of two or three. When using 2 types together, the combined use of erythritol and xylitol is preferable.
  • the amount of the sugar alcohol as the component (C) is preferably 2 to 50%, particularly 5 to 30%, and most preferably 10 to 30% of the whole composition. If the blending amount is less than 2%, the bitterness improving effect may not be sufficiently exhibited, and if it exceeds 50%, the astringent feeling imparting effect by the copper compound may be inhibited, and the oral mucosal irritation suppressing effect may not be sufficiently exhibited. .
  • the composition for oral cavity of the present invention is a dentifrice such as toothpaste, toothpaste, liquid toothpaste, mouthwash, gel, ointment, mouth freshener, gargle tablet, oral paste, gum and other various agents.
  • a dentifrice such as toothpaste, toothpaste, liquid toothpaste, mouthwash, gel, ointment, mouth freshener, gargle tablet, oral paste, gum and other various agents.
  • it can be prepared into a mold, it is particularly suitable for dentifrices and gels, especially gels.
  • these preparations can be blended with other components according to the dosage form, if necessary, within a range not impairing the effects of the present invention, and can be prepared by ordinary methods.
  • various abrasives wetting agents, binders, surfactants, and sweeteners, fragrances, coloring agents, preservatives, pH adjusters, etc. as necessary Active ingredients and the like.
  • wetting agents, binders, surfactants, and sweeteners fragrances, colorants, preservatives, pH adjusters, alcohols, oily ingredients, and other active ingredients as needed it can.
  • abrasives precipitated silica, silica gel, aluminosilicate, zeolite, zirconosilicate, dicalcium phosphate dihydrate and anhydride, calcium pyrophosphate, calcium carbonate, aluminum hydroxide, alumina, magnesium carbonate, tertiary phosphorus
  • examples thereof include magnesium oxide, insoluble sodium metaphosphate, insoluble potassium metaphosphate, titanium oxide, hydroxyapatite, and synthetic resin-based abrasive (blending amount: usually 5 to 50% based on the entire composition).
  • wetting agent examples include those other than the sugar alcohol of component (C), for example, polyhydric alcohols such as sorbitol, glycerin, propylene glycol, polyethylene glycol, and 1,3-butylene glycol.
  • polyhydric alcohols such as sorbitol, glycerin, propylene glycol, polyethylene glycol, and 1,3-butylene glycol.
  • binder examples include cellulose derivatives such as sodium carboxymethyl cellulose and hydroxyethyl cellulose, alginic acid derivatives such as sodium alginate and propylene glycol alginate, gums such as guar gum, xanthan gum and gum arabic, carrageenan, gelatin, polyvinyl alcohol, and polyacrylic acid.
  • Synthetic binders such as sodium, carboxyvinyl polymer, polyvinylpyrrolidone and the like are included (the amount is usually 0.5 to 10%).
  • Nonionic surfactants include sugar alcohol fatty acid esters such as sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyethylene glycol Ether type or ester type surfactants such as fatty acid ester polyhydric alcohol fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene alkylphenyl ether, polyoxyethylene hydrogenated castor oil, etc. And fatty acid alkanolamides such as lauric acid diethanolamide.
  • Anionic surfactants include alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, sodium N-acyl sarcosine such as sodium N-lauroyl sarcosine, sodium N-myristoyl sarcosine, sodium dodecylbenzenesulfonate, hydrogenated coconut fatty acid Sodium monoglyceride monosulfate, sodium lauryl sulfoacetate, N-acyl glutamate such as sodium N-palmitoyl glutamate, sodium N-methyl-N-acyl taurate, sodium N-methyl-N-acylalanine, sodium ⁇ -olefin sulfonate, etc. Is mentioned.
  • Examples of the cationic surfactant include alkyl ammonium and alkyl benzyl ammonium salts. When these surfactants are blended as optional components, the blending amount is usually 0.01 to 2%.
  • an anionic surfactant particularly an alkyl sulfate such as sodium lauryl sulfate, is preferably not blended because it tends to reduce the feeling of use.
  • the blending amount is 0.5% or less, particularly preferably 0 to 0.1%, but may be 0%. It is particularly preferable that it is not blended.
  • Examples of the sweetener include saccharin sodium, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl hydrochalcone, and perilartin.
  • Examples of the colorant include blue No. 1 (FD & C Blue No. 1 (42090)), yellow No. 4 (FD & C Yellow No. 5 (19140)), titanium dioxide and the like.
  • Examples of the preservative include benzoic acid such as paraoxybenzoic acid ester and sodium benzoate, or a salt thereof.
  • Examples of the fragrances include terpenes such as l-menthol, carvone, anethole and limonene or derivatives thereof, peppermint oil and the like.
  • Examples of the pH adjuster include citric acid, fumaric acid, malic acid, tartaric acid, and lactic acid.
  • the alcohol examples include lower alcohols having 3 or less carbon atoms such as ethanol.
  • the blending amount is usually 1 to 20%.
  • Oil components include liquid paraffin, light liquid paraffin, paraffin wax, ceresin, microcrystalline wax, squalane, squalene and other hydrocarbon oils, lauric acid, myristic acid, palmitic acid, stearic acid, lauroleic acid, oleic acid, arachidonic acid , Linoleic acid, linolenic acid, ricinoleic acid and other fatty acids, linseed oil, sesame oil, safflower oil, soybean oil, corn oil, rapeseed oil, cottonseed oil, olive oil, coconut oil, castor oil, cocoa butter, palm oil, coconut oil, etc.
  • Animal oils such as beef tallow, pork tallow, horse tallow and sheep tallow.
  • hydrocarbon oils are preferable from the viewpoint of retention of the preparation in the oral cavity, and liquid paraffin and light liquid paraffin are more preferable.
  • the blending amount is usually 0.1 to 10%.
  • Active ingredients other than the copper compound of component (A) for example vitamins such as ascorbate and tocopherol ester, enzymes such as dextranase, mutanase and lysozyme, herbal medicines such as buckwheat extract, buckwheat extract, and clove extract Ingredients, cetylpyridinium chloride, benzethonium chloride, benzalkonium chloride, decalinium chloride, chlorhexidine hydrochloride, chlorhexidine gluconate, triclosan, isopropylmethylphenol, hinokitiol and other fungicides, sodium chloride, sodium polyphosphate, sodium metaphosphate, sodium orthophosphate Inorganic salts such as sodium tripolyphosphate, aluminum lactate, chitosan, and organic salts.
  • the compounding quantity of these active ingredients can be made into an effective quantity in the range which does not prevent the effect of this invention.
  • the present invention will be specifically described with reference to examples and comparative examples, but the present invention is not limited to the following examples.
  • the blending amount is mass%.
  • the component whose form is aqueous solution all showed the compounding quantity of pure conversion also including the table
  • Examples and comparative examples An oral composition (gel agent) having the composition shown in Tables 1 to 4 was prepared, and about 0.5 g of the oral composition was applied to the gingiva of five specialist panels with a finger.
  • the sensory evaluation of the effect of imparting astringency on the gums immediately afterwards, the effect of suppressing oral mucosal irritation, and the effect of improving bitterness were performed according to the following four criteria, and then evaluated according to the following criteria.
  • the results are shown in Tables 1-5.
  • the details of the ingredients are shown in Table 6.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Inorganic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention concerne une composition pour cavité buccale comprenant (A) au moins un type de composé à base de cuivre choisi parmi le gluconate de cuivre, le sulfate de cuivre et les hydrates associés ; (B) un tensioactif amphotère du type bétaïne ; et (C) au moins un type d'alcool de sucre choisi parmi l'érythritol, le xylitol et le mannitol. Cette composition pour cavité buccale produit une réelle sensation d'amélioration des parodontopathies en exerçant un effet de resserrement gingival suffisant ; par ailleurs, cette composition atténue l'amertume caractéristique des composés à base de cuivre et réduit l'irritation de la muqueuse buccale, ce qui procure une sensation extrêmement agréable.
PCT/JP2010/054910 2009-03-30 2010-03-23 Composition pour cavité buccale WO2010113688A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2011507099A JP5930713B2 (ja) 2009-03-30 2010-03-23 口腔用組成物
CN201080015684.2A CN102365077B (zh) 2009-03-30 2010-03-23 口腔用组合物
HK12104008.8A HK1163509A1 (en) 2009-03-30 2012-04-23 Composition for oral cavity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009-081716 2009-03-30
JP2009081716 2009-03-30

Publications (1)

Publication Number Publication Date
WO2010113688A1 true WO2010113688A1 (fr) 2010-10-07

Family

ID=42827983

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2010/054910 WO2010113688A1 (fr) 2009-03-30 2010-03-23 Composition pour cavité buccale

Country Status (5)

Country Link
JP (1) JP5930713B2 (fr)
KR (1) KR101649003B1 (fr)
CN (1) CN102365077B (fr)
HK (1) HK1163509A1 (fr)
WO (1) WO2010113688A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170094133A (ko) 2014-12-12 2017-08-17 라이온 가부시키가이샤 구강용 조성물
CN112041030A (zh) * 2018-07-17 2020-12-04 日本泽托克株式会社 非水性口腔护理组合物
KR20210013686A (ko) 2018-05-29 2021-02-05 라이온 가부시키가이샤 구강용 조성물

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3603626A1 (fr) * 2018-07-31 2020-02-05 Mucosa Innovations, S.L. Composés destinés à une utilisation dans la prévention et/ou le traitement de la muqueuse génito-urinaire

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57171909A (en) * 1981-04-15 1982-10-22 Lion Corp Composition for oral cavity
JPH02212413A (ja) * 1989-02-10 1990-08-23 Lion Corp 口腔用組成物
JPH04128217A (ja) * 1990-09-19 1992-04-28 Lion Corp 口腔用組成物
JPH08310928A (ja) * 1995-05-15 1996-11-26 Lion Corp 歯磨組成物
JPH10505831A (ja) * 1994-09-15 1998-06-09 ザ、プロクター、エンド、ギャンブル、カンパニー オーラル組成物
JP2005510538A (ja) * 2001-11-28 2005-04-21 ザ プロクター アンド ギャンブル カンパニー ポリリン酸塩及びイオン性活性成分を含む安定な低水相を含む歯磨剤組成物
JP2007008824A (ja) * 2005-06-28 2007-01-18 Lion Corp 口腔用組成物
JP2009007292A (ja) * 2007-06-28 2009-01-15 Lion Corp 口腔用組成物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2132033B1 (es) * 1997-11-06 2000-03-01 Dentaid Sa Composicion oral para el tratamiento de la halitosis.
JP2000297022A (ja) 1999-04-12 2000-10-24 Lion Corp 口腔用組成物
JP2003137755A (ja) 2001-11-02 2003-05-14 Lion Corp 口腔用組成物
JP2003231621A (ja) 2002-02-06 2003-08-19 Lion Corp 口臭予防用口腔用組成物
US7601002B2 (en) * 2004-03-29 2009-10-13 Colgate-Palmolive Co Dental whitening method
US20050271601A1 (en) * 2004-06-02 2005-12-08 Nebojsa Milanovich Anti-staining antibacterial dentifrice
JP2007320894A (ja) 2006-05-31 2007-12-13 Lion Corp 歯磨組成物
JP4825122B2 (ja) 2006-12-19 2011-11-30 ライオン株式会社 歯磨剤組成物

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57171909A (en) * 1981-04-15 1982-10-22 Lion Corp Composition for oral cavity
JPH02212413A (ja) * 1989-02-10 1990-08-23 Lion Corp 口腔用組成物
JPH04128217A (ja) * 1990-09-19 1992-04-28 Lion Corp 口腔用組成物
JPH10505831A (ja) * 1994-09-15 1998-06-09 ザ、プロクター、エンド、ギャンブル、カンパニー オーラル組成物
JPH08310928A (ja) * 1995-05-15 1996-11-26 Lion Corp 歯磨組成物
JP2005510538A (ja) * 2001-11-28 2005-04-21 ザ プロクター アンド ギャンブル カンパニー ポリリン酸塩及びイオン性活性成分を含む安定な低水相を含む歯磨剤組成物
JP2007008824A (ja) * 2005-06-28 2007-01-18 Lion Corp 口腔用組成物
JP2009007292A (ja) * 2007-06-28 2009-01-15 Lion Corp 口腔用組成物

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20170094133A (ko) 2014-12-12 2017-08-17 라이온 가부시키가이샤 구강용 조성물
KR20210013686A (ko) 2018-05-29 2021-02-05 라이온 가부시키가이샤 구강용 조성물
CN112041030A (zh) * 2018-07-17 2020-12-04 日本泽托克株式会社 非水性口腔护理组合物
CN112041030B (zh) * 2018-07-17 2023-08-15 日本泽托克株式会社 非水性口腔护理组合物

Also Published As

Publication number Publication date
JP5930713B2 (ja) 2016-06-08
JPWO2010113688A1 (ja) 2012-10-11
HK1163509A1 (en) 2012-09-14
KR20110133573A (ko) 2011-12-13
CN102365077B (zh) 2013-10-16
CN102365077A (zh) 2012-02-29
KR101649003B1 (ko) 2016-08-17

Similar Documents

Publication Publication Date Title
JP5251350B2 (ja) 歯磨組成物
JP6201851B2 (ja) 歯磨組成物
JP5672651B2 (ja) 洗口剤組成物
KR20120086685A (ko) 치마제 조성물
WO2015099152A1 (fr) Composition orale
WO2016093279A1 (fr) Composition destinée à être utilisés dans la cavité buccale
JP5930713B2 (ja) 口腔用組成物
JP5397204B2 (ja) 口腔用組成物
JP2020011951A (ja) 口腔用組成物
WO2018066341A1 (fr) Composition pour cavité buccale, et procédé d'inhibition de variation de couleur de préparation et de séparation de liquide associés
JP5509631B2 (ja) 口腔用塗布ゲル剤組成物
JP7124403B2 (ja) 歯磨剤組成物
JP6825339B2 (ja) 口腔用組成物
CA3008367C (fr) Produit de soin oral et procedes de fabrication et d'utilisation associes
CN111902125B (zh) 口腔用组合物及α-烯烃磺酸盐的苦味改进剂
JP7347916B2 (ja) 歯磨剤組成物
JP2010143842A (ja) 歯磨剤組成物
JP6734090B2 (ja) 口腔用組成物
JP6435852B2 (ja) 口腔用組成物及び口腔用組成物の変色防止方法
JP2004244404A (ja) 練歯磨組成物
WO2023063268A1 (fr) Composition non aqueuse pour cavité buccale
JP2006069987A (ja) 歯磨用組成物
KR20190076829A (ko) 구강용 조성물 및 그 변색 억제 방법
JP2024509602A (ja) ホップ及び甘味料を含む口腔ケア組成物
JP2024092119A (ja) 口腔用組成物

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 201080015684.2

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10758462

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2011507099

Country of ref document: JP

ENP Entry into the national phase

Ref document number: 20117022572

Country of ref document: KR

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 10758462

Country of ref document: EP

Kind code of ref document: A1