WO2010053306A3 - 메칠페니데이트의 방출 제어용 약제학적 조성물 - Google Patents

메칠페니데이트의 방출 제어용 약제학적 조성물 Download PDF

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Publication number
WO2010053306A3
WO2010053306A3 PCT/KR2009/006510 KR2009006510W WO2010053306A3 WO 2010053306 A3 WO2010053306 A3 WO 2010053306A3 KR 2009006510 W KR2009006510 W KR 2009006510W WO 2010053306 A3 WO2010053306 A3 WO 2010053306A3
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WO
WIPO (PCT)
Prior art keywords
controlled release
pharmaceutical composition
methylphenidate
core material
coating layer
Prior art date
Application number
PCT/KR2009/006510
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English (en)
French (fr)
Other versions
WO2010053306A2 (ko
Inventor
박상엽
정호진
배철민
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주식회사 삼양사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 주식회사 삼양사 filed Critical 주식회사 삼양사
Priority to AU2009311877A priority Critical patent/AU2009311877C1/en
Priority to NZ592665A priority patent/NZ592665A/xx
Priority to CN200980149142.1A priority patent/CN102238946B/zh
Priority to JP2011535511A priority patent/JP2012508228A/ja
Priority to EP09824989.9A priority patent/EP2368546A4/en
Priority to US13/126,855 priority patent/US8465768B2/en
Priority to CA2742680A priority patent/CA2742680C/en
Publication of WO2010053306A2 publication Critical patent/WO2010053306A2/ko
Publication of WO2010053306A3 publication Critical patent/WO2010053306A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Psychology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

메칠페니데이트를 함유하는 코어 물질; 및 상기 코어 물질 상에 형성된 방출 제어용 고분자 코팅층을 포함하는 복수 개의 방출 제어용 입자를 포함하되, 상기 복수개의 방출 제어용 입자는 상기 방출 제어용 고분자 코팅층의 평균 두께를 기준으로 두 가지 이상의 군으로 나누어지며, 각각의 입자군들은 고분자 코팅층의 고분자 조성이 동일하지만, 코팅된 평균 두께가 상이한 것을 특징으로 하는 방출 제어용 약제학적 조성물이 개시된다. 상기 방출 제어용 약제학적 조성물은, 코어 물질에 함유된 메칠페니데이트의 방출 패턴을 원하는 대로 제어할 수 있으며, 속붕해성 정제 등 다양한 형태의 경구용 제제로 활용이 가능하다.
PCT/KR2009/006510 2008-11-07 2009-11-06 메칠페니데이트의 방출 제어용 약제학적 조성물 WO2010053306A2 (ko)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU2009311877A AU2009311877C1 (en) 2008-11-07 2009-11-06 Pharmaceutical composition for release control of methylphenidate
NZ592665A NZ592665A (en) 2008-11-07 2009-11-06 Controlled release methylphenidate compostions comprising at least two groups of particles, each with a methylphenidate core coated with a controlled release polymer coating, each group distinguished by the coating thickness
CN200980149142.1A CN102238946B (zh) 2008-11-07 2009-11-06 用于哌醋甲酯的控制释放的药物组合物
JP2011535511A JP2012508228A (ja) 2008-11-07 2009-11-06 メチルフェニデートの放出制御用薬剤学的組成物
EP09824989.9A EP2368546A4 (en) 2008-11-07 2009-11-06 PHARMACEUTICAL COMPOSITION WITH PROGRESSIVE RELEASE OF METHYLPHENIDATE
US13/126,855 US8465768B2 (en) 2008-11-07 2009-11-06 Pharmaceutical compositions for release control of methylphenidate
CA2742680A CA2742680C (en) 2008-11-07 2009-11-06 Pharmaceutical compositions for release control of methylphenidate

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0110351 2008-11-07
KR20080110351 2008-11-07

Publications (2)

Publication Number Publication Date
WO2010053306A2 WO2010053306A2 (ko) 2010-05-14
WO2010053306A3 true WO2010053306A3 (ko) 2010-08-19

Family

ID=42153396

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/006510 WO2010053306A2 (ko) 2008-11-07 2009-11-06 메칠페니데이트의 방출 제어용 약제학적 조성물

Country Status (9)

Country Link
US (1) US8465768B2 (ko)
EP (1) EP2368546A4 (ko)
JP (2) JP2012508228A (ko)
KR (1) KR101264961B1 (ko)
CN (1) CN102238946B (ko)
AU (1) AU2009311877C1 (ko)
CA (1) CA2742680C (ko)
NZ (1) NZ592665A (ko)
WO (1) WO2010053306A2 (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20130076015A (ko) 2011-12-28 2013-07-08 주식회사 삼양바이오팜 높은 경도를 갖는 속붕정 및 이의 제조 방법
CN102429884A (zh) * 2011-12-29 2012-05-02 天津市嵩锐医药科技有限公司 盐酸哌甲酯口腔崩解药物组合物
BR112015003120B1 (pt) 2012-08-15 2022-08-09 Tris Pharma , Inc Tablete mastigável de liberação estendida de metilfenidato e seu uso
KR101340733B1 (ko) * 2012-12-31 2013-12-12 (주) 에프엔지리서치 신규한 마이크로그래뉼 제형
RU2015146324A (ru) * 2013-03-29 2017-05-15 Вокхардт Лимитед Фармацевтические композиции модифицированного высвобождения дексметилфенидата или его солей
PL2987484T3 (pl) 2013-04-18 2019-07-31 Shandong Luye Pharmaceutical Co., Ltd. Kompozycja farmaceutyczna mikrosfery o przedłużonym uwalnianiu gosereliny
EP2801349A1 (en) * 2013-05-06 2014-11-12 Siegfried AG Oral Pharmaceutical Formulation
JP6238401B2 (ja) * 2013-10-28 2017-11-29 日本化薬株式会社 生理活性ペプチド徐放性微粒子及びその製造方法
AU2016225052B2 (en) * 2015-02-27 2021-07-08 Cingulate Therapeutics LLC Tripulse release stimulant formulations
US10350822B1 (en) * 2018-01-09 2019-07-16 Triastek Inc. Dosage forms with desired release profiles and methods of designing and making thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100540035B1 (ko) * 2002-02-01 2005-12-29 주식회사 태평양 다단계 경구 약물 방출 제어 시스템
WO2007093642A2 (fr) * 2006-02-16 2007-08-23 Flamel Technologies Formes pharmaceutiques multimicroparticulaires qui resistent a la decharge immediate du principe actif en presence d'alcool
KR20080026754A (ko) * 2006-09-21 2008-03-26 주식회사 삼양사 생물학적 활성성분을 함유하는 방출 제어형 입자, 및 이의제조방법

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260068A (en) * 1992-05-04 1993-11-09 Anda Sr Pharmaceuticals Inc. Multiparticulate pulsatile drug delivery system
JP2665858B2 (ja) * 1992-05-30 1997-10-22 日本ヘキスト・マリオン・ルセル株式会社 持効性塩酸オキシブチニン製剤
US5260069A (en) * 1992-11-27 1993-11-09 Anda Sr Pharmaceuticals Inc. Pulsatile particles drug delivery system
US5837284A (en) * 1995-12-04 1998-11-17 Mehta; Atul M. Delivery of multiple doses of medications
ES2229783T3 (es) * 1998-06-03 2005-04-16 Alza Corporation Dispositivos para proporcionar una terapia faramaceutica prolongada.
PT1126826E (pt) 1998-11-02 2008-11-25 Elan Pharma Int Ltd Composição de metilfenidato de libertação modificada multiparticulada
US20060240105A1 (en) * 1998-11-02 2006-10-26 Elan Corporation, Plc Multiparticulate modified release composition
US6673367B1 (en) * 1998-12-17 2004-01-06 Euro-Celtique, S.A. Controlled/modified release oral methylphenidate formulations
US7083808B2 (en) * 1998-12-17 2006-08-01 Euro-Celtique S.A. Controlled/modified release oral methylphenidate formulations
US6475493B1 (en) * 1999-09-02 2002-11-05 Norstrum Pharmaceuticals, Inc. Controlled release pellet formulation
WO2001052813A1 (en) * 2000-01-19 2001-07-26 Pharmaceutical Discovery Corporation Multi-spike release formulation for drug delivery
US6627223B2 (en) * 2000-02-11 2003-09-30 Eurand Pharmaceuticals Ltd. Timed pulsatile drug delivery systems
US7674480B2 (en) * 2000-06-23 2010-03-09 Teva Pharmaceutical Industries Ltd. Rapidly expanding composition for gastric retention and controlled release of therapeutic agents, and dosage forms including the composition
AU2001268722B8 (en) * 2000-06-23 2005-09-29 Teva Pharmaceutical Industries Ltd. Rapidly expanding composition for gastric retention and controlled release of therapeutic agents, and dosage forms including the composition
US6344215B1 (en) * 2000-10-27 2002-02-05 Eurand America, Inc. Methylphenidate modified release formulations
US6960357B2 (en) * 2001-05-25 2005-11-01 Mistral Pharma Inc. Chemical delivery device
JP2003171277A (ja) * 2001-12-07 2003-06-17 Wyeth Lederle Japan Ltd 薬物放出時間制御型固形製剤
EP1519717B1 (en) * 2002-07-05 2010-09-29 Temrel Limited Controlled release composition
CA2491572C (en) * 2002-07-05 2010-03-23 Collegium Pharmaceutical, Inc. Abuse-deterrent pharmaceutical compositions of opiods and other drugs
JP2007520421A (ja) * 2003-06-26 2007-07-26 コリア リサーチ インスティテュート オブ ケミカル テクノロジー 経口投与用放出制御型薬物送達システム
ES2261006B1 (es) * 2004-06-10 2007-11-01 Laboratorios Rubio, S.A. Pellet multicapa de liberacion controlada de metilfenidato.
WO2007011707A2 (en) * 2005-07-15 2007-01-25 Micell Technologies, Inc. Polymer coatings containing drug powder of controlled morphology

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100540035B1 (ko) * 2002-02-01 2005-12-29 주식회사 태평양 다단계 경구 약물 방출 제어 시스템
WO2007093642A2 (fr) * 2006-02-16 2007-08-23 Flamel Technologies Formes pharmaceutiques multimicroparticulaires qui resistent a la decharge immediate du principe actif en presence d'alcool
KR20080026754A (ko) * 2006-09-21 2008-03-26 주식회사 삼양사 생물학적 활성성분을 함유하는 방출 제어형 입자, 및 이의제조방법

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ANAL, A. K.: "Time-controlled pulsatile delivery systems for bioactive compounds", RECENT PATENTS ON DRUG DELIVERY & FORMULATION, vol. 1, 2007, pages 73 - 79 *

Also Published As

Publication number Publication date
JP2015083599A (ja) 2015-04-30
KR101264961B1 (ko) 2013-05-16
CA2742680A1 (en) 2010-05-14
WO2010053306A2 (ko) 2010-05-14
CN102238946A (zh) 2011-11-09
AU2009311877B2 (en) 2013-03-21
US20110223247A1 (en) 2011-09-15
EP2368546A4 (en) 2013-11-20
JP2012508228A (ja) 2012-04-05
NZ592665A (en) 2012-12-21
AU2009311877C1 (en) 2013-08-15
EP2368546A2 (en) 2011-09-28
KR20100051561A (ko) 2010-05-17
AU2009311877A1 (en) 2010-05-14
CA2742680C (en) 2013-12-31
CN102238946B (zh) 2014-11-26
US8465768B2 (en) 2013-06-18

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