WO2009078481A1 - 二環性へテロ環誘導体 - Google Patents

二環性へテロ環誘導体 Download PDF

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Publication number
WO2009078481A1
WO2009078481A1 PCT/JP2008/073184 JP2008073184W WO2009078481A1 WO 2009078481 A1 WO2009078481 A1 WO 2009078481A1 JP 2008073184 W JP2008073184 W JP 2008073184W WO 2009078481 A1 WO2009078481 A1 WO 2009078481A1
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Prior art keywords
hydrogen atom
bicyclic heterocyclic
heterocyclic derivative
optionally substituted
formula
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Ceased
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PCT/JP2008/073184
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English (en)
French (fr)
Inventor
Hiroyuki Nakahira
Yohei Ikuma
Nobuhisa Fukuda
Kozo Yoshida
Hidenori Kimura
Satoshi Suetsugu
Akira Fusano
Kiyoto Sawamura
Junya Ikeda
Yoshio Nakai
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Sumitomo Pharma Co Ltd
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Sumitomo Dainippon Pharma Co Ltd
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Publication date
Application filed by Sumitomo Dainippon Pharma Co Ltd filed Critical Sumitomo Dainippon Pharma Co Ltd
Priority to CA2708866A priority Critical patent/CA2708866A1/en
Priority to CN200880127476.4A priority patent/CN101952280B/zh
Priority to US12/809,489 priority patent/US8389511B2/en
Priority to AU2008339351A priority patent/AU2008339351B2/en
Priority to EP20080863079 priority patent/EP2243779A4/en
Priority to JP2009546300A priority patent/JP5484069B2/ja
Priority to BRPI0821142A priority patent/BRPI0821142A2/pt
Publication of WO2009078481A1 publication Critical patent/WO2009078481A1/ja
Priority to IL206402A priority patent/IL206402A0/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

　本発明は、レニン阻害剤として有効な、下記式(Ｉ)の化合物、またはその薬学上許容される塩を提供する。 [式中、Ｒ１ａは、ハロゲン原子等であり;Ｒ１ｍは、水素原子等であり;Ｇ１は、-Ｎ(Ｒ１ｂ)-等であり;Ｇ２は、-ＣＯ-等であり;Ｇ３は、-Ｃ(Ｒ１ｃ)(Ｒ１ｄ)-等であり;Ｇ４は、酸素原子等であり;Ｒ１ｂは、置換されてもよいＣ１-６アルキル基等であり;Ｒ１ｃおよびＲ１ｄは、各々独立して、同一または異なって、水素原子等であり;Ｒ２は、水素原子、置換されてもよいＣ１-６アルキル基等であり;Ｒ３ａ、Ｒ３ｂ、Ｒ３ｃ、およびＲ３ｄは、各々独立して、同一または異なって、基:-Ａ-Ｂ(該Ａは、単結合等であり、該Ｂは、水素原子等である。)等であり;ｎは１、等である。]
PCT/JP2008/073184 2007-12-19 2008-12-19 二環性へテロ環誘導体 Ceased WO2009078481A1 (ja)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA2708866A CA2708866A1 (en) 2007-12-19 2008-12-19 Bicyclic heterocyclic derivative
CN200880127476.4A CN101952280B (zh) 2007-12-19 2008-12-19 双环杂环衍生物
US12/809,489 US8389511B2 (en) 2007-12-19 2008-12-19 Bicyclic heterocyclic derivative
AU2008339351A AU2008339351B2 (en) 2007-12-19 2008-12-19 Bicyclic heterocyclic derivative
EP20080863079 EP2243779A4 (en) 2007-12-19 2008-12-19 BICYCLIC HETEROCYCLIC DERIVATIVE
JP2009546300A JP5484069B2 (ja) 2007-12-19 2008-12-19 二環性へテロ環誘導体
BRPI0821142A BRPI0821142A2 (pt) 2007-12-19 2008-12-19 derivados heterocíclicos bicíclicos
IL206402A IL206402A0 (en) 2007-12-19 2010-06-16 Bicyclic heterocyclic derivative

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-328087 2007-12-19
JP2007328087 2007-12-19
JP2008202960 2008-08-06
JP2008-202960 2008-08-06

Publications (1)

Publication Number Publication Date
WO2009078481A1 true WO2009078481A1 (ja) 2009-06-25

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PCT/JP2008/073184 Ceased WO2009078481A1 (ja) 2007-12-19 2008-12-19 二環性へテロ環誘導体

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US (1) US8389511B2 (ja)
EP (1) EP2243779A4 (ja)
JP (1) JP5484069B2 (ja)
KR (1) KR20100095605A (ja)
CN (1) CN101952280B (ja)
AU (1) AU2008339351B2 (ja)
BR (1) BRPI0821142A2 (ja)
CA (1) CA2708866A1 (ja)
IL (1) IL206402A0 (ja)
RU (1) RU2010129690A (ja)
TW (1) TWI434690B (ja)
WO (1) WO2009078481A1 (ja)

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Cited By (18)

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US8389511B2 (en) 2007-12-19 2013-03-05 Dainippon Sumitomo Pharma Co., Ltd. Bicyclic heterocyclic derivative
US9221836B2 (en) 2008-06-19 2015-12-29 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
JP2011157391A (ja) * 2008-06-19 2011-08-18 Takeda Chem Ind Ltd 複素環化合物およびその用途
US8466282B2 (en) 2008-06-19 2013-06-18 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
US8664380B2 (en) 2008-06-19 2014-03-04 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
JP2014094950A (ja) * 2008-06-19 2014-05-22 Takeda Chem Ind Ltd 複素環化合物およびその用途
US9045436B2 (en) 2008-06-19 2015-06-02 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
USRE49686E1 (en) 2008-09-19 2023-10-10 Takeda Pharmaceutical Company Limited Nitrogen-containing heterocyclic compound and use of same
EP2336105A4 (en) * 2008-09-19 2012-03-28 Takeda Pharmaceutical NITROGENIC HETEROCYCLIC COMPOUND AND ITS USE
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JP5484069B2 (ja) 2014-05-07
TW200940066A (en) 2009-10-01
CN101952280B (zh) 2014-04-23
EP2243779A4 (en) 2011-04-20
US20110190278A1 (en) 2011-08-04
BRPI0821142A2 (pt) 2015-09-15
CN101952280A (zh) 2011-01-19
US8389511B2 (en) 2013-03-05
RU2010129690A (ru) 2012-01-27
JPWO2009078481A1 (ja) 2011-05-06
KR20100095605A (ko) 2010-08-31
TWI434690B (zh) 2014-04-21
AU2008339351B2 (en) 2013-02-28
EP2243779A1 (en) 2010-10-27

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