WO2009066763A1 - 体表適用製剤、並びに、体表適用製剤保持シート - Google Patents

体表適用製剤、並びに、体表適用製剤保持シート Download PDF

Info

Publication number
WO2009066763A1
WO2009066763A1 PCT/JP2008/071224 JP2008071224W WO2009066763A1 WO 2009066763 A1 WO2009066763 A1 WO 2009066763A1 JP 2008071224 W JP2008071224 W JP 2008071224W WO 2009066763 A1 WO2009066763 A1 WO 2009066763A1
Authority
WO
WIPO (PCT)
Prior art keywords
body surface
application
preparation
end portion
target substance
Prior art date
Application number
PCT/JP2008/071224
Other languages
English (en)
French (fr)
Inventor
Kanji Takada
Original Assignee
Bioserentach Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40667585&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009066763(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bioserentach Co., Ltd. filed Critical Bioserentach Co., Ltd.
Priority to CN200880117328A priority Critical patent/CN101868229A/zh
Priority to CA2706404A priority patent/CA2706404C/en
Priority to JP2009542602A priority patent/JP5538897B2/ja
Priority to US12/734,755 priority patent/US8491534B2/en
Priority to EP08851780.0A priority patent/EP2213284B1/en
Priority to AU2008327083A priority patent/AU2008327083B2/en
Publication of WO2009066763A1 publication Critical patent/WO2009066763A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

　より高い吸収率と薬理学的効果を実現することができる、自己溶解性の基剤からなるマイクロニードルとマイクロニードルアレイを提供することを目的とする。 　体表適用製剤１は挿入方向に分けられた２つの区分、すなわち先端部５と後端部６とを有している。先端部５は体表挿入端２を含む区分であり、基剤溶解性の目的物質を保持している。後端部６は押圧端３を含む区分であり、主として基剤のみから構成され、目的物質を保持していない。体表適用製剤１を皮膚等の体表に挿入した際に、その後端側の一部が体表内に挿入されずに残った場合でも、目的物質が先端部５に含まれているので、目的物質の実際の投与量が所望量より少なくなることがなく、高い吸収率と薬理学的効果を実現することができる。
PCT/JP2008/071224 2007-11-21 2008-11-21 体表適用製剤、並びに、体表適用製剤保持シート WO2009066763A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN200880117328A CN101868229A (zh) 2007-11-21 2008-11-21 体表适用制剂和体表适用制剂保持片
CA2706404A CA2706404C (en) 2007-11-21 2008-11-21 Preparation for body surface application and preparation for body surface application-holding sheet
JP2009542602A JP5538897B2 (ja) 2007-11-21 2008-11-21 体表適用製剤、並びに、体表適用製剤保持シート
US12/734,755 US8491534B2 (en) 2007-11-21 2008-11-21 Preparation for body surface application and preparation for body surface application-holding sheet
EP08851780.0A EP2213284B1 (en) 2007-11-21 2008-11-21 Preparation for application to body surface and preparation holding sheet for application to body surface
AU2008327083A AU2008327083B2 (en) 2007-11-21 2008-11-21 Preparation for application to body surface and preparation holding sheet for application to body surface

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2007-302185 2007-11-21
JP2007302185 2007-11-21
JP2008039814 2008-02-21
JP2008-039814 2008-02-21
JP2008-182525 2008-07-14
JP2008182525 2008-07-14

Publications (1)

Publication Number Publication Date
WO2009066763A1 true WO2009066763A1 (ja) 2009-05-28

Family

ID=40667585

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/071224 WO2009066763A1 (ja) 2007-11-21 2008-11-21 体表適用製剤、並びに、体表適用製剤保持シート

Country Status (8)

Country Link
US (1) US8491534B2 (ja)
EP (1) EP2213284B1 (ja)
JP (1) JP5538897B2 (ja)
KR (1) KR101555391B1 (ja)
CN (1) CN101868229A (ja)
AU (1) AU2008327083B2 (ja)
CA (1) CA2706404C (ja)
WO (1) WO2009066763A1 (ja)

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010140401A1 (ja) * 2009-06-03 2010-12-09 株式会社バイオセレンタック 多孔性基盤を用いたマイクロニードル・アレイとその製造方法
JP2011206178A (ja) * 2010-03-29 2011-10-20 Toray Eng Co Ltd マイクロニードルシート及びその製造方法
EP2379160A1 (en) * 2008-12-22 2011-10-26 The University Of Queensland Patch production
JP2012090767A (ja) * 2010-10-27 2012-05-17 Bioserentack Co Ltd ワクチン抗原表皮デリバリー用溶解性３層マイクロニードル・アレイ・パッチ
JP2012254952A (ja) * 2011-06-08 2012-12-27 Bioserentack Co Ltd 経皮吸収製剤
WO2013002331A1 (ja) 2011-06-28 2013-01-03 株式会社バイオセレンタック 皮膚治療用微細針集積型製剤
EP2548608A1 (en) * 2010-03-19 2013-01-23 Otsuka Pharmaceutical Co., Ltd. Proteoglycan-containing microneedle array
WO2014142135A1 (ja) 2013-03-12 2014-09-18 武田薬品工業株式会社 マイクロニードルパッチ
US8883015B2 (en) 2008-02-07 2014-11-11 The University Of Queensland Patch production
WO2015093452A1 (ja) 2013-12-16 2015-06-25 武田薬品工業株式会社 マイクロニードル
US9220678B2 (en) 2007-12-24 2015-12-29 The University Of Queensland Coating method
US9387000B2 (en) 2008-05-23 2016-07-12 The University Of Queensland Analyte detection using a needle projection patch
JP5980347B2 (ja) * 2012-11-13 2016-08-31 富士フイルム株式会社 経皮吸収シートの製造方法
KR20160125420A (ko) 2014-03-12 2016-10-31 가부시키가이샤 바이오세렌택 진피 내 목적 물질 유치용 마이크로니들 제제 투여 부재 및 마이크로니들 제제 신속 투여 기구
US9572969B2 (en) 2004-01-30 2017-02-21 The University Of Queensland Delivery device
JPWO2014196522A1 (ja) * 2013-06-03 2017-02-23 凸版印刷株式会社 針状体の製造方法及び製造装置
JP2017061447A (ja) * 2015-09-21 2017-03-30 ビーアンドエル バイオテック インコーポレイティッド 歯茎の屈曲に合うように柔軟な、歯科用物質伝達のためのマイクロニードルおよびその製作方法
US9943673B2 (en) 2010-07-14 2018-04-17 Vaxxas Pty Limited Patch applying apparatus
US9993423B2 (en) 2011-10-20 2018-06-12 Cosmed Pharmaceutical Co., Ltd. Microneedle deposition method
JP2018535236A (ja) * 2015-11-25 2018-11-29 パイアン エステティクス インコーポレイテッド 水溶性微細ニードル粉末とこれを含有する非水系化粧剤組成物
WO2019021954A1 (ja) * 2017-07-24 2019-01-31 株式会社バイオセレンタック ワクチンアジュバント及びマイクロニードル製剤
JP2020507422A (ja) * 2017-02-17 2020-03-12 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 活性成分を含むマイクロニードルアレイ
US11103259B2 (en) 2015-09-18 2021-08-31 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
US11147954B2 (en) 2015-02-02 2021-10-19 Vaxxas Pty Limited Microprojection array applicator and method
US11175128B2 (en) 2017-06-13 2021-11-16 Vaxxas Pty Limited Quality control of substrate coatings
US11179553B2 (en) 2011-10-12 2021-11-23 Vaxxas Pty Limited Delivery device
US11254126B2 (en) 2017-03-31 2022-02-22 Vaxxas Pty Limited Device and method for coating surfaces
US11464957B2 (en) 2017-08-04 2022-10-11 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2820335T3 (es) 2007-04-16 2021-04-20 Corium Inc Matrices de microagujas coladas con disolvente que contienen agente activo
WO2010124255A2 (en) * 2009-04-24 2010-10-28 Corium International, Inc. Methods for manufacturing microprojection arrays
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
EP2566501B1 (en) 2010-05-04 2019-03-13 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
JP5770055B2 (ja) * 2010-09-29 2015-08-26 富士フイルム株式会社 針状アレイ経皮吸収シートの製造方法
GB201107642D0 (en) * 2011-05-09 2011-06-22 Univ Cork Method
KR101314091B1 (ko) * 2011-07-26 2013-10-04 연세대학교 산학협력단 치료 부위내 경피 유전자 전달을 위한 일렉트로 마이크로니들 집적체 및 이의 제조방법
EP4112112A1 (en) 2012-05-01 2023-01-04 University of Pittsburgh - Of the Commonwealth System of Higher Education Tip-loaded microneedle arrays for transdermal insertion
US20140200509A1 (en) * 2012-06-29 2014-07-17 Issac David Cohen Dissolvable Microneedles Comprising One Or More Encapsulated Cosmetic Ingredients
WO2014093934A1 (en) 2012-12-14 2014-06-19 Mindera Corporation Methods and devices for detection and acquisition of biomarkers
JP6865524B2 (ja) 2012-12-21 2021-04-28 コリウム， インコーポレイテッド 治療剤を送達するためのマイクロアレイおよび使用方法
KR101491075B1 (ko) * 2013-02-12 2015-02-11 안동대학교 산학협력단 마이크로니들 디바이스
WO2014126837A2 (en) 2013-02-12 2014-08-21 Eipi Systems, Inc. Continuous liquid interphase printing
KR101460499B1 (ko) * 2013-02-12 2014-11-12 안동대학교 산학협력단 마이크로니들 디바이스의 제조방법
CN104027324B (zh) * 2013-03-06 2017-12-15 中国科学院理化技术研究所 一种可溶性微针疫苗贴片及其制备方法
MX2015012155A (es) 2013-03-12 2015-11-30 Corium Int Inc Aplicadores de microproyeccion.
EP2968751B1 (en) 2013-03-15 2022-11-30 Corium, Inc. Multiple impact microprojection applicators
AU2014233695A1 (en) 2013-03-15 2015-10-01 Corium International, Inc. Microarray for delivery of therapeutic agent and methods of use
WO2014150293A1 (en) 2013-03-15 2014-09-25 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
WO2014176325A2 (en) * 2013-04-23 2014-10-30 University Of Maryland, Baltimore Extending and maintaining micropore viability of microneedle treated skin with lipid biosynthesis inhibitors for sustained drug delivery
CN105492064B (zh) * 2013-06-17 2019-08-02 诸必克株式会社 无痛及无膜片的注射微型结构体
TWI528975B (zh) * 2013-07-12 2016-04-11 國立成功大學 微針經皮傳輸裝置及應用其之微針經皮傳輸方法
US10869832B2 (en) 2013-07-12 2020-12-22 National Cheng Kung University Substance delivery device and substance delivery method using the same
JP6369026B2 (ja) * 2014-01-21 2018-08-08 凸版印刷株式会社 マイクロニードル、および、マイクロニードルの製造方法
WO2015122838A1 (en) * 2014-02-14 2015-08-20 Chee Yen Lim Rapidly dissolvable microneedles with drug-impregnated tips
US20160279401A1 (en) 2015-03-27 2016-09-29 Allergan, Inc. Dissolvable microneedles for skin treatment
WO2015183179A1 (en) * 2014-05-28 2015-12-03 Chee Yen Lim A flexible dissolvable patch
JP6611801B2 (ja) 2014-06-20 2019-11-27 カーボン，インコーポレイテッド 重合性液体の往復運動供給による三次元印刷
KR101950693B1 (ko) * 2014-07-24 2019-02-21 주식회사 엘지생활건강 레티놀 또는 레티놀 유도체를 함유하는 마이크로니들
US10624843B2 (en) 2014-09-04 2020-04-21 Corium, Inc. Microstructure array, methods of making, and methods of use
CN104382884B (zh) * 2014-10-28 2017-03-01 中国科学院理化技术研究所 一种青蒿素衍生物的皮内给药微针制剂的制备方法
JP6906885B2 (ja) * 2014-11-14 2021-07-21 ロレアル しわを減少させるためのマイクロニードルシート
WO2016149152A1 (en) * 2015-03-13 2016-09-22 The University Of North Carolina At Chapel Hill Polymeric microneedles and rapid additive manufacturing of the same
WO2016149673A1 (en) 2015-03-18 2016-09-22 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Bioactive components conjugated to substrates of microneedle arrays
CN114515269A (zh) * 2015-04-06 2022-05-20 株式会社Lg生活健康 微针及其制造方法
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
CN105078880A (zh) * 2015-09-12 2015-11-25 北京化工大学 一种用于多肽和蛋白质类药物透皮给药的高分子可溶微针及其制备方法
US11684763B2 (en) 2015-10-16 2023-06-27 University of Pittsburgh—of the Commonwealth System of Higher Education Multi-component bio-active drug delivery and controlled release to the skin by microneedle array devices
US20180344998A1 (en) * 2015-11-27 2018-12-06 Labo Juversa Co., Ltd. Microneedle and method for producing same
CN105411997A (zh) * 2015-12-30 2016-03-23 李媚 一种可降解微结构体及其制备方法
US11744889B2 (en) 2016-01-05 2023-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
EP3434314B1 (en) * 2016-03-25 2022-11-09 Toppan Printing Co., Ltd. Transdermal delivery device
JP6736337B2 (ja) * 2016-04-15 2020-08-05 富士フイルム株式会社 マイクロニードルアレイ
JP6434193B2 (ja) 2016-05-31 2018-12-05 Ｎｉｓｓｈａ株式会社 マイクロニードルアレイ及びその製造方法
US11241563B2 (en) * 2016-12-22 2022-02-08 Johnson & Johnson Consumer Inc. Microneedle arrays and methods for making and using
WO2018170132A1 (en) 2017-03-14 2018-09-20 University Of Connecticut Biodegradable pressure sensor
CN110475581A (zh) * 2017-05-10 2019-11-19 林治远 具有增强药物装载能力的棱锥形微针和制造方法
SG10201800072YA (en) * 2018-01-03 2019-08-27 Micropoint Tech Pte Ltd Microneedle Patches Comprising Corticosteroid
CN118320289A (zh) * 2018-03-05 2024-07-12 康涅狄格大学 用于经皮和脉冲药物/疫苗递送的核壳微针平台及其制造方法
CN108653192A (zh) * 2018-04-23 2018-10-16 中山大学 一种用于控制释放生长激素治疗侏儒症的复合式微针贴片装置及其制作方法
CA3101595A1 (en) 2018-06-29 2020-01-02 Johnson & Johnson Consumer Inc. Three-dimensional microfluidics devices for the delivery of actives
CN109528695B (zh) * 2019-01-12 2022-04-19 蚌埠医学院 一种治疗类风湿性关节炎的微针透皮给药贴片及其制备方法
US11826495B2 (en) 2019-03-01 2023-11-28 University Of Connecticut Biodegradable piezoelectric ultrasonic transducer system
US11678989B2 (en) 2019-03-01 2023-06-20 University Of Connecticut Biodegradable piezoelectric nanofiber scaffold for bone or tissue regeneration
TW202220713A (zh) * 2019-04-02 2022-06-01 寶齡富錦生技股份有限公司 微針裝置
WO2021183626A1 (en) 2020-03-10 2021-09-16 University Of Connecticut Therapeutic bandage
JP2023029328A (ja) 2021-08-20 2023-03-03 コスメディ製薬株式会社 高性能マイクロニードルアレイ２

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003238347A (ja) 2002-02-18 2003-08-27 Nano Device & System Research Inc 機能性マイクロパイル及びその製造方法
WO2004000389A2 (en) 2002-06-25 2003-12-31 Sung-Yun Kwon Rapidly dissolving micro-perforator for drug delivery and other applications
JP2005154321A (ja) 2003-11-25 2005-06-16 Nano Device & System Research Inc アスコルビン酸投与用マイクロニードル
JP2005152180A (ja) 2003-11-25 2005-06-16 Nano Device & System Research Inc インスリン投与用マイクロニードル
WO2006080508A1 (ja) 2005-01-31 2006-08-03 Bioserentach Co., Ltd. 経皮吸収製剤、経皮吸収製剤保持シート、及び経皮吸収製剤保持用具
WO2007030477A2 (en) 2005-09-06 2007-03-15 Theraject, Inc. Solid solution perforator containing drug particle and/or drug-adsorbed particles

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0017999D0 (en) * 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
MXPA03003815A (es) * 2000-10-26 2004-08-12 Johnson & Johnson Dispositivos de suministro transdermico de farmaco que tienen microrresaltos recubiertos.
US9302903B2 (en) * 2000-12-14 2016-04-05 Georgia Tech Research Corporation Microneedle devices and production thereof
CN101102809B (zh) * 2004-11-18 2010-05-26 3M创新有限公司 涂敷微针阵列的遮蔽方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003238347A (ja) 2002-02-18 2003-08-27 Nano Device & System Research Inc 機能性マイクロパイル及びその製造方法
WO2004000389A2 (en) 2002-06-25 2003-12-31 Sung-Yun Kwon Rapidly dissolving micro-perforator for drug delivery and other applications
JP2005154321A (ja) 2003-11-25 2005-06-16 Nano Device & System Research Inc アスコルビン酸投与用マイクロニードル
JP2005152180A (ja) 2003-11-25 2005-06-16 Nano Device & System Research Inc インスリン投与用マイクロニードル
WO2006080508A1 (ja) 2005-01-31 2006-08-03 Bioserentach Co., Ltd. 経皮吸収製剤、経皮吸収製剤保持シート、及び経皮吸収製剤保持用具
WO2007030477A2 (en) 2005-09-06 2007-03-15 Theraject, Inc. Solid solution perforator containing drug particle and/or drug-adsorbed particles

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
D. K. ARMINI; C. LUI: "Microfabrication technology for polycaprolactone, a biodegradable polymer", JOURNAL OF MICROMECHANICS AND MICROENGINEERING, vol. 10, 2000, pages 80 - 84
J. JIANG: "Coated Microneedles for Drug Delivery to the Eye", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 48, 2007, pages 4038 - 4043
KOLLI ET AL., PHARMACEUTICAL RESEARCH, vol. 25, 2007, pages 104 - 113
M. R. PRAUSNITZ: "Microneedles for transdermal drug delivery", ADVANCED DRUG DELIVERY REVIEWS, vol. 56, 2004, pages 581 - 587, XP009077380, DOI: doi:10.1016/j.addr.2003.10.023
See also references of EP2213284A4

Cited By (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9572969B2 (en) 2004-01-30 2017-02-21 The University Of Queensland Delivery device
US9888932B2 (en) 2004-01-30 2018-02-13 Vaxxas Pty Limited Method of delivering material or stimulus to a biological subject
US11207086B2 (en) 2004-01-30 2021-12-28 Vaxxas Pty Limited Method of delivering material or stimulus to a biological subject
US10751072B2 (en) 2004-01-30 2020-08-25 Vaxxas Pty Limited Delivery device
US10022322B2 (en) 2007-12-24 2018-07-17 Vaxxas Pty Limited Coating method
US9220678B2 (en) 2007-12-24 2015-12-29 The University Of Queensland Coating method
US9283365B2 (en) 2008-02-07 2016-03-15 The University Of Queensland Patch production
US8883015B2 (en) 2008-02-07 2014-11-11 The University Of Queensland Patch production
US9387000B2 (en) 2008-05-23 2016-07-12 The University Of Queensland Analyte detection using a needle projection patch
EP2379160A4 (en) * 2008-12-22 2012-08-22 Univ Queensland PIECE PRODUCTION
US8734697B2 (en) 2008-12-22 2014-05-27 The University Of Queensland Patch production
EP2379160A1 (en) * 2008-12-22 2011-10-26 The University Of Queensland Patch production
WO2010140401A1 (ja) * 2009-06-03 2010-12-09 株式会社バイオセレンタック 多孔性基盤を用いたマイクロニードル・アレイとその製造方法
EP2548608A1 (en) * 2010-03-19 2013-01-23 Otsuka Pharmaceutical Co., Ltd. Proteoglycan-containing microneedle array
CN105107083A (zh) * 2010-03-19 2015-12-02 考思美德制药株式会社 含有蛋白聚糖的微针阵列
EP2548608A4 (en) * 2010-03-19 2013-10-09 Otsuka Pharma Co Ltd PROTEOGLYCAN CONTAINING MICRONADELARRAY
US9539418B2 (en) 2010-03-19 2017-01-10 Cosmed Pharmaceutical Co., Ltd. Proteoglycan-containing microneedle array
JP2011206178A (ja) * 2010-03-29 2011-10-20 Toray Eng Co Ltd マイクロニードルシート及びその製造方法
US9943673B2 (en) 2010-07-14 2018-04-17 Vaxxas Pty Limited Patch applying apparatus
JP2012090767A (ja) * 2010-10-27 2012-05-17 Bioserentack Co Ltd ワクチン抗原表皮デリバリー用溶解性３層マイクロニードル・アレイ・パッチ
JP2012254952A (ja) * 2011-06-08 2012-12-27 Bioserentack Co Ltd 経皮吸収製剤
KR20140048024A (ko) 2011-06-28 2014-04-23 가부시키가이샤 바이오세렌택 피부 치료용 미세침 집적형 제제
WO2013002331A1 (ja) 2011-06-28 2013-01-03 株式会社バイオセレンタック 皮膚治療用微細針集積型製剤
AU2012247089B2 (en) * 2011-06-28 2015-04-09 Bioserentach Co., Ltd. Microneedle assembly formulation for skin treatment
JPWO2013002331A1 (ja) * 2011-06-28 2015-02-23 株式会社バイオセレンタック 皮膚治療用微細針集積型製剤
US9795774B2 (en) 2011-06-28 2017-10-24 Bioserentach Co., Ltd. Microneedle assembly formulation for skin treatment
US11179553B2 (en) 2011-10-12 2021-11-23 Vaxxas Pty Limited Delivery device
US9993423B2 (en) 2011-10-20 2018-06-12 Cosmed Pharmaceutical Co., Ltd. Microneedle deposition method
JP2016195847A (ja) * 2012-11-13 2016-11-24 富士フイルム株式会社 経皮吸収シート
JPWO2014077244A1 (ja) * 2012-11-13 2017-01-05 富士フイルム株式会社 経皮吸収シートの製造方法
JP5980347B2 (ja) * 2012-11-13 2016-08-31 富士フイルム株式会社 経皮吸収シートの製造方法
US10668260B2 (en) 2013-03-12 2020-06-02 Takeda Pharmaceutical Company Limited Microneedle patch
WO2014142135A1 (ja) 2013-03-12 2014-09-18 武田薬品工業株式会社 マイクロニードルパッチ
JPWO2014196522A1 (ja) * 2013-06-03 2017-02-23 凸版印刷株式会社 針状体の製造方法及び製造装置
JPWO2015093452A1 (ja) * 2013-12-16 2017-03-16 武田薬品工業株式会社 マイクロニードル
WO2015093452A1 (ja) 2013-12-16 2015-06-25 武田薬品工業株式会社 マイクロニードル
US10342964B2 (en) 2014-03-12 2019-07-09 Labo Juversa Co., Ltd. Microneedle preparation administration member for placement of objective substance in dermis, and apparatus for quick administration of microneedle preparation
KR20160125420A (ko) 2014-03-12 2016-10-31 가부시키가이샤 바이오세렌택 진피 내 목적 물질 유치용 마이크로니들 제제 투여 부재 및 마이크로니들 제제 신속 투여 기구
US11147954B2 (en) 2015-02-02 2021-10-19 Vaxxas Pty Limited Microprojection array applicator and method
US11653939B2 (en) 2015-09-18 2023-05-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
US11103259B2 (en) 2015-09-18 2021-08-31 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
JP2017061447A (ja) * 2015-09-21 2017-03-30 ビーアンドエル バイオテック インコーポレイティッド 歯茎の屈曲に合うように柔軟な、歯科用物質伝達のためのマイクロニードルおよびその製作方法
JP2018535236A (ja) * 2015-11-25 2018-11-29 パイアン エステティクス インコーポレイテッド 水溶性微細ニードル粉末とこれを含有する非水系化粧剤組成物
JP2020507422A (ja) * 2017-02-17 2020-03-12 アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ 活性成分を含むマイクロニードルアレイ
US11065428B2 (en) 2017-02-17 2021-07-20 Allergan, Inc. Microneedle array with active ingredient
JP2022050472A (ja) * 2017-02-17 2022-03-30 アラーガン、インコーポレイテッド 活性成分を含むマイクロニードルアレイ
US11254126B2 (en) 2017-03-31 2022-02-22 Vaxxas Pty Limited Device and method for coating surfaces
US11175128B2 (en) 2017-06-13 2021-11-16 Vaxxas Pty Limited Quality control of substrate coatings
US11828584B2 (en) 2017-06-13 2023-11-28 Vaxxas Pty Limited Quality control of substrate coatings
JPWO2019021954A1 (ja) * 2017-07-24 2020-05-28 株式会社バイオセレンタック ワクチンアジュバント及びマイクロニードル製剤
WO2019021954A1 (ja) * 2017-07-24 2019-01-31 株式会社バイオセレンタック ワクチンアジュバント及びマイクロニードル製剤
JP7313683B2 (ja) 2017-07-24 2023-07-25 株式会社バイオセレンタック ワクチンアジュバント及びマイクロニードル製剤
US11464957B2 (en) 2017-08-04 2022-10-11 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (MAP)

Also Published As

Publication number Publication date
EP2213284B1 (en) 2017-11-15
EP2213284A4 (en) 2012-03-21
AU2008327083B2 (en) 2014-01-16
JP5538897B2 (ja) 2014-07-02
CN101868229A (zh) 2010-10-20
JPWO2009066763A1 (ja) 2011-04-07
US8491534B2 (en) 2013-07-23
CA2706404C (en) 2017-04-11
US20110028905A1 (en) 2011-02-03
AU2008327083A1 (en) 2009-05-28
KR20100098406A (ko) 2010-09-06
KR101555391B1 (ko) 2015-09-23
EP2213284A1 (en) 2010-08-04
CA2706404A1 (en) 2009-05-28

Similar Documents

Publication Publication Date Title
WO2009066763A1 (ja) 体表適用製剤、並びに、体表適用製剤保持シート
USD567944S1 (en) Lancet
USD612939S1 (en) Microdermabrasion treatment tip mount
USD613848S1 (en) Inhalation device
USD663893S1 (en) Applicator of skin formulations
WO2008045960A3 (en) Lancet device, removal system for lancet device, and method
WO2009064762A3 (en) Metered gel dispenser
EP1892009A4 (en) ENDOSCOPE TREATMENT INSTRUMENT AND ENDOSCOPE TREATMENT INSTRUMENT DEVICE
CA131449S (en) Electrical connector
USD636087S1 (en) Hand-held applicator with disposable tissue interface for applying energy to body tissue
HK1101536A1 (en) Cap with revolving body for dermal tissue lancing device
CA127132S (en) Measuring instrument, in particular for measuring muscle performance
WO2008117755A1 (ja) 吸収性物品
EP2106769A3 (en) Urinary incontinence device applicator
WO2007094004A3 (en) A device and method for the prolonged delivery of an active agent to a body cavity
WO2009131949A8 (en) Temporary tattoo applicators
IL210789A (en) Susanimidyl 4-acetylsulfanyl butyrate, para-nitrophenyl 4-acetylsulfanyl butyrate, a method for synthesized oligosaccharide-bearing synthesis, an oligosaccharide-containing preparation, and an oligosaccharide-bore oligosaccharide pair
CA125922S (en) Animal shelter
CA128128S (en) Valve cap for a fuel cell
WO2008117763A1 (ja) 吸収性物品
TW200624089A (en) Absorptive article
CA128265S (en) Metering valve for a fuel cell
WO2008117768A1 (ja) レンズホルダ
PL2289352T3 (pl) Środek do stosowania w leczeniu nietolerancji fruktozy
CA130258S (en) Disposable endotracheal tube insertion device

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200880117328.4

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08851780

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2009542602

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2008327083

Country of ref document: AU

REEP Request for entry into the european phase

Ref document number: 2008851780

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2706404

Country of ref document: CA

Ref document number: 2008851780

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2008327083

Country of ref document: AU

Date of ref document: 20081121

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 12734755

Country of ref document: US

ENP Entry into the national phase

Ref document number: 20107013551

Country of ref document: KR

Kind code of ref document: A