WO2009028631A1 - 角膜内皮細胞接着促進剤 - Google Patents
角膜内皮細胞接着促進剤 Download PDFInfo
- Publication number
- WO2009028631A1 WO2009028631A1 PCT/JP2008/065459 JP2008065459W WO2009028631A1 WO 2009028631 A1 WO2009028631 A1 WO 2009028631A1 JP 2008065459 W JP2008065459 W JP 2008065459W WO 2009028631 A1 WO2009028631 A1 WO 2009028631A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- corneal endothelial
- agent
- cell adhesion
- endothelial cell
- kinase inhibitor
- Prior art date
Links
- 210000000399 corneal endothelial cell Anatomy 0.000 title abstract 5
- 230000021164 cell adhesion Effects 0.000 title abstract 2
- 230000001737 promoting effect Effects 0.000 title abstract 2
- 239000003590 rho kinase inhibitor Substances 0.000 abstract 3
- 230000003511 endothelial effect Effects 0.000 abstract 2
- 239000001963 growth medium Substances 0.000 abstract 2
- 238000009630 liquid culture Methods 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Dermatology (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
Priority Applications (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2010111744/15A RU2474434C2 (ru) | 2007-08-29 | 2008-08-28 | Средство для содействия адгезии роговичных эндотелиальных клеток |
KR1020227037529A KR20220151013A (ko) | 2007-08-29 | 2008-08-28 | 각막 내피 세포 접착 촉진제 |
ES08828145.6T ES2659980T3 (es) | 2007-08-29 | 2008-08-28 | Agente para promover la adherencia de células endoteliales de la córnea |
KR1020247009980A KR20240045364A (ko) | 2007-08-29 | 2008-08-28 | 각막 내피 세포 접착 촉진제 |
EP08828145.6A EP2193806B1 (en) | 2007-08-29 | 2008-08-28 | Agent for promoting corneal endothelial cell adhesion |
MX2010002426A MX2010002426A (es) | 2007-08-29 | 2008-08-28 | Agente para promover la adhesion de las celulas del endotelio corneal. |
CN200880112897.XA CN101835491B (zh) | 2007-08-29 | 2008-08-28 | 促进角膜内皮细胞粘附的药剂 |
KR1020217017484A KR20210070407A (ko) | 2007-08-29 | 2008-08-28 | 각막 내피 세포 접착 촉진제 |
JP2009530186A JP5657252B2 (ja) | 2007-08-29 | 2008-08-28 | 角膜内皮細胞接着促進剤 |
KR1020187007476A KR20180031066A (ko) | 2007-08-29 | 2008-08-28 | 각막 내피 세포 접착 촉진제 |
CA2697895A CA2697895C (en) | 2007-08-29 | 2008-08-28 | Agent for promoting corneal endothelial cell adhesion |
KR1020197022179A KR20190091567A (ko) | 2007-08-29 | 2008-08-28 | 각막 내피 세포 접착 촉진제 |
US12/675,475 US9248125B2 (en) | 2007-08-29 | 2008-08-28 | Agent for promoting corneal endothelial cell adhesion |
BRPI0816182 BRPI0816182A2 (pt) | 2007-08-29 | 2008-08-28 | Agente para promoção de adesão celular endotelial corneana |
KR1020147033392A KR20150004899A (ko) | 2007-08-29 | 2008-08-28 | 각막 내피 세포 접착 촉진제 |
KR1020157018932A KR20150088907A (ko) | 2007-08-29 | 2008-08-28 | 각막 내피 세포 접착 촉진제 |
US14/879,857 US11839618B2 (en) | 2007-08-29 | 2015-10-09 | Agent for promoting corneal endothelial cell adhesion |
US14/879,658 US11633404B2 (en) | 2007-08-29 | 2015-10-09 | Agent for promoting corneal endothelial cell adhesion |
US18/182,873 US20230210864A1 (en) | 2007-08-29 | 2023-03-13 | Agent for promoting corneal endothelial cell adhesion |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007-223141 | 2007-08-29 | ||
JP2007223141 | 2007-08-29 | ||
JP2008016088 | 2008-01-28 | ||
JP2008-016088 | 2008-01-28 |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/675,475 A-371-Of-International US9248125B2 (en) | 2007-08-29 | 2008-08-28 | Agent for promoting corneal endothelial cell adhesion |
US14/879,857 Continuation US11839618B2 (en) | 2007-08-29 | 2015-10-09 | Agent for promoting corneal endothelial cell adhesion |
US14/879,658 Continuation US11633404B2 (en) | 2007-08-29 | 2015-10-09 | Agent for promoting corneal endothelial cell adhesion |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009028631A1 true WO2009028631A1 (ja) | 2009-03-05 |
Family
ID=40387345
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/065459 WO2009028631A1 (ja) | 2007-08-29 | 2008-08-28 | 角膜内皮細胞接着促進剤 |
Country Status (11)
Country | Link |
---|---|
US (4) | US9248125B2 (ja) |
EP (1) | EP2193806B1 (ja) |
JP (9) | JP5657252B2 (ja) |
KR (8) | KR20150088907A (ja) |
CN (3) | CN101835491B (ja) |
BR (1) | BRPI0816182A2 (ja) |
CA (1) | CA2697895C (ja) |
ES (1) | ES2659980T3 (ja) |
MX (1) | MX2010002426A (ja) |
RU (1) | RU2474434C2 (ja) |
WO (1) | WO2009028631A1 (ja) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011080984A1 (en) | 2009-12-29 | 2011-07-07 | Senju Pharmaceutical Co., Ltd. | Therapeutic agent (y - 39983 ) for corneal endothelial dysfunction |
JP2012521200A (ja) * | 2009-03-23 | 2012-09-13 | 中国海洋大学 | 組織工学によって作製されたヒト角膜内皮の再生方法 |
WO2013100208A1 (ja) | 2011-12-28 | 2013-07-04 | 京都府公立大学法人 | 角膜内皮細胞の培養正常化 |
WO2014007402A1 (ja) * | 2012-07-06 | 2014-01-09 | 京都府公立大学法人 | 眼細胞の分化マーカーおよび分化制御 |
WO2014038639A1 (ja) | 2012-09-07 | 2014-03-13 | 日本ケミカルリサーチ株式会社 | 間葉系幹細胞の馴化培地を含有する角膜内皮細胞培養用培地 |
WO2015097920A1 (ja) * | 2013-12-27 | 2015-07-02 | 京都府公立大学法人 | 角膜内皮細胞の細胞治療併用剤 |
WO2016047647A1 (ja) * | 2014-09-24 | 2016-03-31 | 興和株式会社 | 角膜厚調節剤 |
WO2020071438A1 (ja) * | 2018-10-02 | 2020-04-09 | 学校法人同志社 | 角膜内皮細胞を保存するための方法および容器 |
JP2020054330A (ja) * | 2018-10-02 | 2020-04-09 | 学校法人同志社 | 角膜内皮細胞を保存するための方法および容器 |
JPWO2022085680A1 (ja) * | 2020-10-22 | 2022-04-28 |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20150088907A (ko) | 2007-08-29 | 2015-08-03 | 센주 세이야꾸 가부시키가이샤 | 각막 내피 세포 접착 촉진제 |
PT2788472T (pt) | 2011-12-06 | 2019-04-01 | Astellas Inst For Regenerative Medicine | Método de diferenciação dirigida para a produção de células endoteliais corneanas |
CN103053511A (zh) * | 2012-12-10 | 2013-04-24 | 山东省眼科研究所 | 一种角膜中期保存液及其制备和使用方法 |
EP3069732B1 (en) * | 2013-11-14 | 2023-07-12 | The Doshisha | Drug for treating corneal endothelium by promoting cell proliferation or inhibiting cell damage |
CA2931280A1 (en) | 2013-11-27 | 2015-06-04 | Senju Pharmaceutical Co., Ltd. | Application of laminin to corneal endothelial cell culture |
US11633477B2 (en) * | 2014-10-31 | 2023-04-25 | Kyoto Prefectural Public University Corporation | Treatment of cornea using laminin |
WO2016067629A1 (ja) | 2014-10-31 | 2016-05-06 | 京都府公立大学法人 | ラミニンによる網膜および神経の新規治療 |
CA3008113A1 (en) | 2015-12-24 | 2017-06-29 | The Doshisha | Drug for treating or preventing disorder caused by tgf-.beta. signals, and application thereof |
JP7008337B2 (ja) * | 2016-02-15 | 2022-02-10 | 京都府公立大学法人 | ヒト機能性角膜内皮細胞およびその応用 |
WO2020045642A1 (ja) * | 2018-08-31 | 2020-03-05 | 学校法人同志社 | 眼細胞を保存または培養するための組成物および方法 |
WO2022235586A1 (en) | 2021-05-03 | 2022-11-10 | Astellas Institute For Regenerative Medicine | Methods of generating mature corneal endothelial cells |
CN115006593B (zh) * | 2022-06-26 | 2023-07-25 | 中国海洋大学 | 机械增强型组织工程角膜内皮的体外构建方法 |
Citations (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3421217A (en) | 1967-06-29 | 1969-01-14 | Schick Electric Inc | Hair receptacle for electric shaver |
US4678783A (en) | 1983-11-04 | 1987-07-07 | Asahi Kasei Kogyo Kabushiki Kaisha | Substituted isoquinolinesulfonyl compounds |
JPH10113187A (ja) * | 1995-11-20 | 1998-05-06 | Kirin Brewery Co Ltd | Rho標的タンパク質Rhoキナーゼ |
WO1999020620A1 (fr) | 1997-10-22 | 1999-04-29 | Nippon Shinyaku Co Ltd | Derive d'isoquinoleine et medicament |
WO1999061403A1 (fr) | 1998-05-25 | 1999-12-02 | Santen Pharmaceutical Co., Ltd. | Nouveaux derives vinylbenzene |
WO2001074393A1 (fr) * | 2000-04-04 | 2001-10-11 | Wakamoto Pharmaceutical Co., Ltd. | Agents de protection des tissus vitaux |
WO2002076976A2 (en) | 2001-03-23 | 2002-10-03 | Bayer Corporation | Rho-kinase inhibitors |
WO2002076977A2 (en) | 2001-03-23 | 2002-10-03 | Bayer Corporation | Rho-kinase inhibitors |
WO2002083175A1 (fr) | 2001-04-11 | 2002-10-24 | Senju Pharmaceutical Co., Ltd. | Agents ameliorant la fonction visuelle |
WO2002100833A1 (fr) | 2001-06-12 | 2002-12-19 | Sumitomo Pharmaceuticals Company, Limited | Inhibiteurs de rho kinase |
WO2003059913A1 (en) | 2002-01-10 | 2003-07-24 | Bayer Healthcare Ag | Roh-kinase inhibitors |
WO2003062227A1 (en) | 2002-01-23 | 2003-07-31 | Bayer Pharmaceuticals Corporation | Rho-kinase inhibitors |
JP2004024852A (ja) | 2002-04-30 | 2004-01-29 | Amniotec:Kk | 角膜内皮様シート、及びその作製方法 |
WO2004009555A1 (ja) | 2002-07-22 | 2004-01-29 | Asahi Kasei Pharma Corporation | 5−置換イソキノリン誘導体 |
WO2004022541A1 (en) | 2002-09-03 | 2004-03-18 | Universite De Montreal | 1,4-substituted cyclohexane derivatives |
WO2004108724A1 (ja) | 2003-06-06 | 2004-12-16 | Asahi Kasei Pharma Corporation | 3環系化合物 |
WO2005003101A2 (en) | 2003-07-02 | 2005-01-13 | Biofocus Discovery Limited | Pyrazine and pyridine derivatives as rho kinase inhibitors |
WO2005035506A1 (ja) | 2003-10-15 | 2005-04-21 | Ube Industries, Ltd. | 新規インダゾール誘導体 |
WO2005035503A1 (ja) | 2003-10-15 | 2005-04-21 | Ube Industries, Ltd. | 新規イソキノリン誘導体 |
WO2005035501A1 (ja) | 2003-10-15 | 2005-04-21 | Ube Industries, Ltd. | 新規オレフィン誘導体 |
WO2005034866A2 (en) | 2003-10-06 | 2005-04-21 | Glaxo Group Limited | Preparation of 1, 6, 7- trisubstituted azabenzimidazoles as kinase inhibitors |
WO2005037198A2 (en) | 2003-10-06 | 2005-04-28 | Glaxo Group Limited | Preparation of 1,7-disubstituted azabenzimidazoles as kinase inhibitors |
WO2005037197A2 (en) | 2003-10-06 | 2005-04-28 | Glaxo Group Limited | Preperation of 1,6-disubstituted azabenzimidazoles as kinase inhibitors |
WO2005039564A1 (en) | 2003-10-02 | 2005-05-06 | Vertex Pharmaceuticals Incorporated | Phthalimide compounds useful as protein kinase inhibitors |
WO2005078071A1 (ja) * | 2004-02-18 | 2005-08-25 | Satoru Yamagami | ヒト角膜内皮細胞の培養物層積層体及びその作製方法 |
WO2005080394A1 (en) | 2004-02-24 | 2005-09-01 | Bioaxone Therapeutique Inc. | 4-substituted piperidine derivatives |
WO2005103050A2 (en) | 2004-04-02 | 2005-11-03 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of rock and other protein kinases |
WO2005118582A1 (ja) | 2004-06-03 | 2005-12-15 | Senju Pharmaceutical Co., Ltd. | アミド化合物を含有する角膜知覚回復剤 |
WO2006057270A1 (ja) | 2004-11-26 | 2006-06-01 | Asahi Kasei Pharma Corporation | 含窒素3環化合物 |
WO2007018226A1 (ja) * | 2005-08-10 | 2007-02-15 | Mitsubishi Tanabe Pharma Corporation | 角膜障害の予防及び/又は治療剤 |
WO2007026664A1 (ja) | 2005-08-30 | 2007-03-08 | Asahi Kasei Pharma Corporation | スルホンアミド化合物 |
WO2007083685A1 (ja) * | 2006-01-19 | 2007-07-26 | Senju Pharmaceutical Co., Ltd. | 生体内で細胞増殖可能な角膜内皮製剤 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5906819A (en) * | 1995-11-20 | 1999-05-25 | Kirin Beer Kabushiki Kaisha | Rho target protein Rho-kinase |
ATE359822T1 (de) * | 1996-08-12 | 2007-05-15 | Mitsubishi Pharma Corp | Medikamente enthaltend rho-kinase inhibitoren |
RU2249591C2 (ru) | 1997-05-22 | 2005-04-10 | Дж.Д. Серл Энд Ко. | 3(5)-гетероарилзамещенные пиразолы в качестве ингибиторов киназы p38 |
ES2247822T3 (es) * | 1998-08-17 | 2006-03-01 | Senju Pharmaceutical Co., Ltd. | Medicamentos preventivos/curativos para glaucoma. |
WO2000064477A1 (fr) | 1999-04-22 | 2000-11-02 | Mitsubishi Pharma Corporation | Compositions preventives/ traitements contre l'angiostenose |
CA2325842C (en) * | 2000-11-02 | 2007-08-07 | Lisa Mckerracher | Methods for making and delivering rho-antagonist tissue adhesive formulations to the injured mammalian central and peripheral nervous systems and uses thereof |
CA2483659A1 (en) | 2002-04-30 | 2003-11-13 | Amniotec Inc. | Corneal endothelium-like sheet and method of constructing the same |
WO2004069181A2 (en) * | 2003-02-03 | 2004-08-19 | Pharmacia Corporation | Composition for the treatment of intraocular pressure |
JP4566130B2 (ja) | 2003-04-18 | 2010-10-20 | 千寿製薬株式会社 | 角膜知覚回復剤 |
WO2007043255A1 (ja) | 2005-09-13 | 2007-04-19 | Arblast Co., Ltd. | 培養角膜内皮シート及びその作製方法 |
US7867999B1 (en) * | 2005-12-22 | 2011-01-11 | Alcon Research, Ltd. | Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions |
KR20150088907A (ko) | 2007-08-29 | 2015-08-03 | 센주 세이야꾸 가부시키가이샤 | 각막 내피 세포 접착 촉진제 |
US8568234B2 (en) * | 2010-03-16 | 2013-10-29 | Harmonix Music Systems, Inc. | Simulating musical instruments |
KR20150111645A (ko) | 2014-03-26 | 2015-10-06 | 주식회사 인프라웨어 | 단일 통신인터페이스 전송방법 및 장치 |
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Patent Citations (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3421217A (en) | 1967-06-29 | 1969-01-14 | Schick Electric Inc | Hair receptacle for electric shaver |
US4678783A (en) | 1983-11-04 | 1987-07-07 | Asahi Kasei Kogyo Kabushiki Kaisha | Substituted isoquinolinesulfonyl compounds |
US4678783B1 (en) | 1983-11-04 | 1995-04-04 | Asahi Chemical Ind | Substituted isoquinolinesulfonyl compounds |
JPH10113187A (ja) * | 1995-11-20 | 1998-05-06 | Kirin Brewery Co Ltd | Rho標的タンパク質Rhoキナーゼ |
WO1999020620A1 (fr) | 1997-10-22 | 1999-04-29 | Nippon Shinyaku Co Ltd | Derive d'isoquinoleine et medicament |
WO1999061403A1 (fr) | 1998-05-25 | 1999-12-02 | Santen Pharmaceutical Co., Ltd. | Nouveaux derives vinylbenzene |
WO2001074393A1 (fr) * | 2000-04-04 | 2001-10-11 | Wakamoto Pharmaceutical Co., Ltd. | Agents de protection des tissus vitaux |
WO2002076976A2 (en) | 2001-03-23 | 2002-10-03 | Bayer Corporation | Rho-kinase inhibitors |
WO2002076977A2 (en) | 2001-03-23 | 2002-10-03 | Bayer Corporation | Rho-kinase inhibitors |
WO2002083175A1 (fr) | 2001-04-11 | 2002-10-24 | Senju Pharmaceutical Co., Ltd. | Agents ameliorant la fonction visuelle |
WO2002100833A1 (fr) | 2001-06-12 | 2002-12-19 | Sumitomo Pharmaceuticals Company, Limited | Inhibiteurs de rho kinase |
WO2003059913A1 (en) | 2002-01-10 | 2003-07-24 | Bayer Healthcare Ag | Roh-kinase inhibitors |
WO2003062227A1 (en) | 2002-01-23 | 2003-07-31 | Bayer Pharmaceuticals Corporation | Rho-kinase inhibitors |
JP2004024852A (ja) | 2002-04-30 | 2004-01-29 | Amniotec:Kk | 角膜内皮様シート、及びその作製方法 |
WO2004009555A1 (ja) | 2002-07-22 | 2004-01-29 | Asahi Kasei Pharma Corporation | 5−置換イソキノリン誘導体 |
WO2004022541A1 (en) | 2002-09-03 | 2004-03-18 | Universite De Montreal | 1,4-substituted cyclohexane derivatives |
WO2004108724A1 (ja) | 2003-06-06 | 2004-12-16 | Asahi Kasei Pharma Corporation | 3環系化合物 |
WO2005003101A2 (en) | 2003-07-02 | 2005-01-13 | Biofocus Discovery Limited | Pyrazine and pyridine derivatives as rho kinase inhibitors |
WO2005039564A1 (en) | 2003-10-02 | 2005-05-06 | Vertex Pharmaceuticals Incorporated | Phthalimide compounds useful as protein kinase inhibitors |
WO2005034866A2 (en) | 2003-10-06 | 2005-04-21 | Glaxo Group Limited | Preparation of 1, 6, 7- trisubstituted azabenzimidazoles as kinase inhibitors |
WO2005037198A2 (en) | 2003-10-06 | 2005-04-28 | Glaxo Group Limited | Preparation of 1,7-disubstituted azabenzimidazoles as kinase inhibitors |
WO2005037197A2 (en) | 2003-10-06 | 2005-04-28 | Glaxo Group Limited | Preperation of 1,6-disubstituted azabenzimidazoles as kinase inhibitors |
WO2005035506A1 (ja) | 2003-10-15 | 2005-04-21 | Ube Industries, Ltd. | 新規インダゾール誘導体 |
WO2005035503A1 (ja) | 2003-10-15 | 2005-04-21 | Ube Industries, Ltd. | 新規イソキノリン誘導体 |
WO2005035501A1 (ja) | 2003-10-15 | 2005-04-21 | Ube Industries, Ltd. | 新規オレフィン誘導体 |
WO2005078071A1 (ja) * | 2004-02-18 | 2005-08-25 | Satoru Yamagami | ヒト角膜内皮細胞の培養物層積層体及びその作製方法 |
JP2005229869A (ja) | 2004-02-18 | 2005-09-02 | Satoshi Yamagami | ヒト角膜内皮細胞の培養物層積層体及びその作製方法 |
WO2005080394A1 (en) | 2004-02-24 | 2005-09-01 | Bioaxone Therapeutique Inc. | 4-substituted piperidine derivatives |
WO2005103050A2 (en) | 2004-04-02 | 2005-11-03 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of rock and other protein kinases |
WO2005118582A1 (ja) | 2004-06-03 | 2005-12-15 | Senju Pharmaceutical Co., Ltd. | アミド化合物を含有する角膜知覚回復剤 |
WO2006057270A1 (ja) | 2004-11-26 | 2006-06-01 | Asahi Kasei Pharma Corporation | 含窒素3環化合物 |
WO2007018226A1 (ja) * | 2005-08-10 | 2007-02-15 | Mitsubishi Tanabe Pharma Corporation | 角膜障害の予防及び/又は治療剤 |
WO2007026664A1 (ja) | 2005-08-30 | 2007-03-08 | Asahi Kasei Pharma Corporation | スルホンアミド化合物 |
WO2007083685A1 (ja) * | 2006-01-19 | 2007-07-26 | Senju Pharmaceutical Co., Ltd. | 生体内で細胞増殖可能な角膜内皮製剤 |
Non-Patent Citations (6)
Title |
---|
ANDERSON,SC ET AL.: "Rho and Rho-kinase (ROCK) signaling in adherens and gap junction assembly in corneal epithelium", INVST.OPTHAL.VIS.SCI., vol. 43, no. 4, April 2002 (2002-04-01), pages 978 - 986, XP008131969 * |
ISHIZAKI, T. ET AL., THE EMBO J., vol. 15, no. 8, 1996, pages 1885 - 1893 |
LEE JG ET AL.: "FGF-2-induced wound healing in corneal endothelial cells requires Cdc42 activation and Rho inactivation through the phosphatidylinositol 3-kinase pathway", INV.OPTHALMOL.VIS.SCI., vol. 47, no. 4, 2006, pages 1376 - 1386, XP008131970 * |
LEUNG, T ET AL., J. BIOL. CHEM., vol. 270, 1995, pages 29051 - 29054 |
NAT BIOTECHNOL., vol. 25, 2007, pages 681 |
SATPATHY M. ET AL.: "Thrombin-induced phosphorylation of the regulatory light chain of myosin II in cultured bovine corneal endothelial cells", EXPERIMENT.EYE.RES., vol. 79, no. 4, October 2004 (2004-10-01), pages 477 - 486, XP004566449 * |
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