WO2008120736A1 - 薬物送達制御用経肺投与リポソーム - Google Patents

薬物送達制御用経肺投与リポソーム Download PDF

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Publication number
WO2008120736A1
WO2008120736A1 PCT/JP2008/056156 JP2008056156W WO2008120736A1 WO 2008120736 A1 WO2008120736 A1 WO 2008120736A1 JP 2008056156 W JP2008056156 W JP 2008056156W WO 2008120736 A1 WO2008120736 A1 WO 2008120736A1
Authority
WO
WIPO (PCT)
Prior art keywords
liposome
controlling drug
arrival
transpulmonary
gene
Prior art date
Application number
PCT/JP2008/056156
Other languages
English (en)
French (fr)
Inventor
Hirofumi Takeuchi
Koji Nakano
Hidekazu Toyobuku
Original Assignee
Otsuka Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES08739274.2T priority Critical patent/ES2618457T3/es
Priority to JP2009507528A priority patent/JP5191478B2/ja
Application filed by Otsuka Pharmaceutical Co., Ltd. filed Critical Otsuka Pharmaceutical Co., Ltd.
Priority to BRPI0809852-2A priority patent/BRPI0809852A2/pt
Priority to RU2009140058/15A priority patent/RU2493874C2/ru
Priority to CA2682376A priority patent/CA2682376C/en
Priority to KR1020147029191A priority patent/KR20140136047A/ko
Priority to AU2008233656A priority patent/AU2008233656B2/en
Priority to NZ579881A priority patent/NZ579881A/xx
Priority to EP08739274.2A priority patent/EP2133097B1/en
Priority to MX2009010479A priority patent/MX2009010479A/es
Priority to US12/593,827 priority patent/US8658204B2/en
Publication of WO2008120736A1 publication Critical patent/WO2008120736A1/ja
Priority to IL201172A priority patent/IL201172A0/en
Priority to ZA2009/06742A priority patent/ZA200906742B/en
Priority to US14/108,826 priority patent/US9750694B2/en
Priority to PH12014502430A priority patent/PH12014502430A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/10—Vectors comprising a non-peptidic targeting moiety

Abstract

本発明の目的は、薬剤や遺伝子の肺内送達制御性に優れ、経肺投与に適したリポソームを提供することである。 　末端疎水化ポリビニルアルコール及び／又はキトサンを用いてリポソームの表面を修飾することによって、リポソーム内に封入された薬剤や遺伝子の肺組織表面での滞留性や肺組織内への移行性を適切に調節でき、その生体内挙動を制御することが可能になる。
PCT/JP2008/056156 2007-03-30 2008-03-28 薬物送達制御用経肺投与リポソーム WO2008120736A1 (ja)

Priority Applications (15)

Application Number Priority Date Filing Date Title
EP08739274.2A EP2133097B1 (en) 2007-03-30 2008-03-28 Transpulmonary liposome for controlling drug arrival
NZ579881A NZ579881A (en) 2007-03-30 2008-03-28 Transpulmonary liposome for controlling drug arrival
BRPI0809852-2A BRPI0809852A2 (pt) 2007-03-30 2008-03-28 Lipossoma transpulmonar para controlar a chegada de fármaco
JP2009507528A JP5191478B2 (ja) 2007-03-30 2008-03-28 薬物送達制御用経肺投与リポソーム
CA2682376A CA2682376C (en) 2007-03-30 2008-03-28 Transpulmonary liposome for controlling drug arrival
KR1020147029191A KR20140136047A (ko) 2007-03-30 2008-03-28 약물 송달 제어용 경폐 투여 리포좀
MX2009010479A MX2009010479A (es) 2007-03-30 2008-03-28 Liposoma transpulmonar para controlar la llegada del farmaco.
ES08739274.2T ES2618457T3 (es) 2007-03-30 2008-03-28 Liposoma transpulmonar para controlar la llegada del fármaco
RU2009140058/15A RU2493874C2 (ru) 2007-03-30 2008-03-28 Транслегочная липосома для регулирования доставки лекарственного средства
AU2008233656A AU2008233656B2 (en) 2007-03-30 2008-03-28 Transpulmonary liposome for controlling drug arrival
US12/593,827 US8658204B2 (en) 2007-03-30 2008-03-28 Transpulmonary liposome for controlling drug arrival
IL201172A IL201172A0 (en) 2007-03-30 2009-09-24 Transpulmonary liposome for controlling drug arrival
ZA2009/06742A ZA200906742B (en) 2007-03-30 2009-09-28 Transpulmonary liposome for controlling drug arrival
US14/108,826 US9750694B2 (en) 2007-03-30 2013-12-17 Transpulmonary liposome for controlling drug arrival
PH12014502430A PH12014502430A1 (en) 2007-03-30 2014-10-30 Transpulmonary liposome for controlling drug arrival

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-090874 2007-03-30
JP2007090874 2007-03-30

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/593,827 A-371-Of-International US8658204B2 (en) 2007-03-30 2008-03-28 Transpulmonary liposome for controlling drug arrival
US14/108,826 Continuation US9750694B2 (en) 2007-03-30 2013-12-17 Transpulmonary liposome for controlling drug arrival

Publications (1)

Publication Number Publication Date
WO2008120736A1 true WO2008120736A1 (ja) 2008-10-09

Family

ID=39808316

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/056156 WO2008120736A1 (ja) 2007-03-30 2008-03-28 薬物送達制御用経肺投与リポソーム

Country Status (20)

Country Link
US (2) US8658204B2 (ja)
EP (2) EP2133097B1 (ja)
JP (2) JP5191478B2 (ja)
KR (2) KR20140136047A (ja)
CN (2) CN101646462A (ja)
AR (1) AR065865A1 (ja)
AU (2) AU2008233656B2 (ja)
BR (1) BRPI0809852A2 (ja)
CA (2) CA2682376C (ja)
CO (1) CO6260108A2 (ja)
ES (2) ES2618457T3 (ja)
IL (1) IL201172A0 (ja)
MX (1) MX2009010479A (ja)
NZ (1) NZ579881A (ja)
PH (1) PH12014502430A1 (ja)
RU (1) RU2493874C2 (ja)
TW (1) TW200902085A (ja)
UA (1) UA100375C2 (ja)
WO (1) WO2008120736A1 (ja)
ZA (1) ZA200906742B (ja)

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JP2016511255A (ja) * 2013-02-28 2016-04-14 チョン クン ダン ファーマシューティカル コーポレーション キトサンおよび液晶形成物質を含む遺伝子伝達用組成物
WO2017046416A1 (en) 2015-09-18 2017-03-23 Technische Universität München LIGANDS FOR INTEGRIN AVß6, SYNTHESIS AND USES THEREOF
WO2018167295A1 (en) 2017-03-17 2018-09-20 Technische Universität München LIGANDS FOR INTEGRIN αvβ8, SYNTHESIS AND USES THEREOF

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TR201908550T4 (tr) 2014-06-04 2019-07-22 Exicure Inc Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi.
SG11201702656WA (en) 2014-10-06 2017-04-27 Exicure Inc Anti-tnf compounds
CN104922068B (zh) * 2015-05-22 2017-10-13 江苏凯基生物技术股份有限公司 一种Decoy核酸阳离子脂质体载体及其制备方法
US10154947B2 (en) 2016-01-06 2018-12-18 The Procter & Gamble Company Antiperspirant composition
US9730867B2 (en) 2016-01-06 2017-08-15 The Procter & Gamble Company Methods of forming a slurry with microcapsules formed from phosphate esters
US9732303B2 (en) 2016-01-06 2017-08-15 The Procter & Gamble Company Microcapsules formed from phosphate esters and compositions containing same
WO2017136467A1 (en) * 2016-02-01 2017-08-10 Exicure, Inc. Surface functionaliztion of liposomes and liposomal spherical nucleic acids (snas)
US11866700B2 (en) 2016-05-06 2024-01-09 Exicure Operating Company Liposomal spherical nucleic acid (SNA) constructs presenting antisense oligonucleotides (ASO) for specific knockdown of interleukin 17 receptor mRNA
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Cited By (6)

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Publication number Priority date Publication date Assignee Title
JP2012513460A (ja) * 2008-12-26 2012-06-14 サムヤン コーポレイション アニオン性薬物含有薬剤学的組成物及びその製造方法
JP2011246464A (ja) * 2010-04-28 2011-12-08 Wakamoto Pharmaceutical Co Ltd ジクロフェナクナトリウムを封入した後眼部到達用ポリマーコーティングリポソーム
JP2016511255A (ja) * 2013-02-28 2016-04-14 チョン クン ダン ファーマシューティカル コーポレーション キトサンおよび液晶形成物質を含む遺伝子伝達用組成物
US11318215B2 (en) 2013-02-28 2022-05-03 Chong Kun Dang Pharmaceutical Corp. Composition for gene delivery comprising chitosan and liquid crystal formation material
WO2017046416A1 (en) 2015-09-18 2017-03-23 Technische Universität München LIGANDS FOR INTEGRIN AVß6, SYNTHESIS AND USES THEREOF
WO2018167295A1 (en) 2017-03-17 2018-09-20 Technische Universität München LIGANDS FOR INTEGRIN αvβ8, SYNTHESIS AND USES THEREOF

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KR20090128491A (ko) 2009-12-15
KR20140136047A (ko) 2014-11-27
IL201172A0 (en) 2010-05-17
RU2009140058A (ru) 2011-05-10
US20140105968A1 (en) 2014-04-17
KR101476167B1 (ko) 2014-12-24
AU2008233656A1 (en) 2008-10-09
CA2682376C (en) 2015-10-06
UA100375C2 (ru) 2012-12-25
CA2885621C (en) 2016-01-05
CN103356482A (zh) 2013-10-23
NZ579881A (en) 2012-10-26
RU2493874C2 (ru) 2013-09-27
JP5191478B2 (ja) 2013-05-08
TW200902085A (en) 2009-01-16
EP2133097A1 (en) 2009-12-16
AU2014204483A1 (en) 2014-08-07
CN101646462A (zh) 2010-02-10
CA2682376A1 (en) 2008-10-09
ZA200906742B (en) 2010-12-29
CA2885621A1 (en) 2008-10-09
PH12014502430A1 (en) 2015-09-07
US8658204B2 (en) 2014-02-25
US20100112043A1 (en) 2010-05-06
CO6260108A2 (es) 2011-03-22
EP2133097A4 (en) 2013-01-16
JP5674831B2 (ja) 2015-02-25
ES2643938T3 (es) 2017-11-27
JPWO2008120736A1 (ja) 2010-07-15
AR065865A1 (es) 2009-07-08
EP2133097B1 (en) 2017-01-25
BRPI0809852A2 (pt) 2014-09-23
EP2656858A1 (en) 2013-10-30
ES2618457T3 (es) 2017-06-21
AU2008233656B2 (en) 2014-05-22
MX2009010479A (es) 2009-10-19
US9750694B2 (en) 2017-09-05
JP2013100332A (ja) 2013-05-23
EP2656858B1 (en) 2017-08-16

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