CN104922068B - 一种Decoy核酸阳离子脂质体载体及其制备方法 - Google Patents
一种Decoy核酸阳离子脂质体载体及其制备方法 Download PDFInfo
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- CN104922068B CN104922068B CN201510268568.6A CN201510268568A CN104922068B CN 104922068 B CN104922068 B CN 104922068B CN 201510268568 A CN201510268568 A CN 201510268568A CN 104922068 B CN104922068 B CN 104922068B
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- CN
- China
- Prior art keywords
- nucleic acid
- decoy nucleic
- liposome
- cationics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (10)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510268568.6A CN104922068B (zh) | 2015-05-22 | 2015-05-22 | 一种Decoy核酸阳离子脂质体载体及其制备方法 |
PCT/CN2015/083577 WO2016187935A1 (zh) | 2015-05-22 | 2015-07-08 | 一种Decoy核酸阳离子脂质体载体及其制备方法 |
US15/572,845 US20180133154A1 (en) | 2015-05-22 | 2015-07-08 | Decoy nucleic acid cationic liposome carrier and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201510268568.6A CN104922068B (zh) | 2015-05-22 | 2015-05-22 | 一种Decoy核酸阳离子脂质体载体及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104922068A CN104922068A (zh) | 2015-09-23 |
CN104922068B true CN104922068B (zh) | 2017-10-13 |
Family
ID=54109732
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201510268568.6A Active CN104922068B (zh) | 2015-05-22 | 2015-05-22 | 一种Decoy核酸阳离子脂质体载体及其制备方法 |
Country Status (3)
Country | Link |
---|---|
US (1) | US20180133154A1 (zh) |
CN (1) | CN104922068B (zh) |
WO (1) | WO2016187935A1 (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104922068B (zh) * | 2015-05-22 | 2017-10-13 | 江苏凯基生物技术股份有限公司 | 一种Decoy核酸阳离子脂质体载体及其制备方法 |
CN108562737A (zh) * | 2018-01-12 | 2018-09-21 | 天津大学 | 用阳离子脂质体包裹负载钙黄绿素的介孔二氧化硅纳米颗粒的制备方法 |
CN109260157A (zh) * | 2018-11-19 | 2019-01-25 | 上海交通大学 | 一种正电荷多肽脂质体纳米制剂及其制备方法与应用 |
IT201900003639A1 (it) * | 2019-03-13 | 2020-09-13 | Evobiotech S R L | Composizioni di vescicole extracellulari (EV) derivate da piante e loro usi |
CN113577039A (zh) * | 2021-07-01 | 2021-11-02 | 温州医科大学附属第二医院(温州医科大学附属育英儿童医院) | 鱼精蛋白压缩dna后被红细胞膜包裹构成的纳米颗粒的应用及其制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1764089A1 (en) * | 2005-09-15 | 2007-03-21 | Novosom AG | Serum stable liposomes comprising amphoter II lipid mixtures |
CN102216462A (zh) * | 2008-11-17 | 2011-10-12 | 安龙制药公司 | 用于核酸递送系统的支化阳离子脂质 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1144012A1 (en) * | 1999-01-21 | 2001-10-17 | Georgetown University | Ligand-peg post-coating stabilized lipoplex and polyplex for targeted gene delivery |
WO2007107304A2 (en) * | 2006-03-17 | 2007-09-27 | Novosom Ag | An efficient method for loading amphoteric liposomes with nucleic acid active substances |
US20080145413A1 (en) * | 2006-12-19 | 2008-06-19 | Steffen Panzner | Lipids and lipid assemblies comprising transfection enhancer elements |
JP5191478B2 (ja) * | 2007-03-30 | 2013-05-08 | 洋文 竹内 | 薬物送達制御用経肺投与リポソーム |
CN103194489B (zh) * | 2013-03-26 | 2015-09-30 | 中国科学院过程工程研究所 | 新型阳离子脂质体核酸类药物制剂,及其制备方法和应用 |
CN104922068B (zh) * | 2015-05-22 | 2017-10-13 | 江苏凯基生物技术股份有限公司 | 一种Decoy核酸阳离子脂质体载体及其制备方法 |
-
2015
- 2015-05-22 CN CN201510268568.6A patent/CN104922068B/zh active Active
- 2015-07-08 US US15/572,845 patent/US20180133154A1/en not_active Abandoned
- 2015-07-08 WO PCT/CN2015/083577 patent/WO2016187935A1/zh active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1764089A1 (en) * | 2005-09-15 | 2007-03-21 | Novosom AG | Serum stable liposomes comprising amphoter II lipid mixtures |
CN102216462A (zh) * | 2008-11-17 | 2011-10-12 | 安龙制药公司 | 用于核酸递送系统的支化阳离子脂质 |
Also Published As
Publication number | Publication date |
---|---|
CN104922068A (zh) | 2015-09-23 |
US20180133154A1 (en) | 2018-05-17 |
WO2016187935A1 (zh) | 2016-12-01 |
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Address after: Jiangning Science Park Road, Jiangning District of Nanjing city and Jiangsu province 210008 No. 18 Applicant after: Jiangsu Kaiji biological technology Limited by Share Ltd Applicant after: Nanjing NMG-ADDS Co., Ltd. Address before: Garden Road Jiangning District Nanjing 211100 Jiangsu province No. 8 Zijin Fangshan venture special community building 6 Building 2-5 Applicant before: Kaiji Biotech Development Co., Ltd., Nanjing Applicant before: Nanjing NMG-ADDS Co., Ltd. |
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GR01 | Patent grant | ||
TR01 | Transfer of patent right |
Effective date of registration: 20180827 Address after: 211100 building 6, Zijin Park, 18 Zhi Lan Road, Jiangning District, Nanjing, Jiangsu. Co-patentee after: Nanjing New Industrial Investment Group Co., Ltd. Patentee after: Jiangsu Kaiji biological technology Limited by Share Ltd Address before: 210008 Jiangning Science Park, Jiangning District, Nanjing, Jiangsu 18 Co-patentee before: Nanjing NMG-ADDS Co., Ltd. Patentee before: Jiangsu Kaiji biological technology Limited by Share Ltd |
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TR01 | Transfer of patent right |