WO2008103956A1 - Compositions and methods for promoting bone development - Google Patents

Compositions and methods for promoting bone development Download PDF

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Publication number
WO2008103956A1
WO2008103956A1 PCT/US2008/054796 US2008054796W WO2008103956A1 WO 2008103956 A1 WO2008103956 A1 WO 2008103956A1 US 2008054796 W US2008054796 W US 2008054796W WO 2008103956 A1 WO2008103956 A1 WO 2008103956A1
Authority
WO
WIPO (PCT)
Prior art keywords
composition
compositions
ppm
fed
animal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2008/054796
Other languages
English (en)
French (fr)
Inventor
Ryan Michael Yamka
Kim Gene Friesen
Steven Curtis Zicker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hills Pet Nutrition Inc
Original Assignee
Hills Pet Nutrition Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP08730572.8A priority Critical patent/EP2129237B1/en
Priority to AU2008218193A priority patent/AU2008218193B2/en
Priority to DK08730572.8T priority patent/DK2129237T3/en
Priority to ES08730572.8T priority patent/ES2546284T3/es
Priority to US12/528,158 priority patent/US20100143497A1/en
Priority to JP2009551047A priority patent/JP5286287B2/ja
Application filed by Hills Pet Nutrition Inc filed Critical Hills Pet Nutrition Inc
Priority to CA2679008A priority patent/CA2679008C/en
Priority to BRPI0807373-2A priority patent/BRPI0807373A2/pt
Publication of WO2008103956A1 publication Critical patent/WO2008103956A1/en
Anticipated expiration legal-status Critical
Priority to ZA2009/06390A priority patent/ZA200906390B/en
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/105—Aliphatic or alicyclic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/174—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/30—Oligoelements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • Bones are metabolically active, undergoing constant resorption and redeposition of calcium. This requires the sequential and coordinated actions of osteoclasts, to remove bone (resorption), and the osteblasts to replace it (deposition). This is commonly called “bone turnover.”
  • bone turnover In normal bone, following skeletal growth of an animal, the mineral deposition is in equilibrium with mineral resorption; however, in certain conditions, bone resorption exceeds bone deposition, resulting in loss of bone mineral content. High bone turnover with increased bone resorption can compromise bone strength, leading to a thinning of the bone structure. This may result in abnormal bone microarchitecture and reduced bone mineralization.
  • compositions comprising about 0.1 % to about 0.6 % EPA, e.g., about 0.2%, about 0.3%, about 0.4%, or about 0.5%;
  • compositions further comprising: 0 to about 90% by weight of carbohydrates; about 5% to about 70% by weight of protein; about 2% to about 50% by weight of fat; about 0.1% to about 20% by weight of total dietary fiber;
  • compositions comprising about 0.5% to about 6.0 % linoleic acid, e.g., about 2.5% to about 5%;
  • Type I collagen tissue is one of the most abundant collagen type in an animal, and is the only collagen type found in mineralized bone, where it accounts for more than 90% of the organic matrix.
  • type I collagen is found in connective tissues, such as joints, together with other collagen types.
  • Carboxyterminal cross-linked telopeptide of type I collagen (“ICTP") is the carboxyterminal tehopeptide region of type I collagen. The peptide is derived from bone resorption and degradation of connective tissues. It is believed that increased serum concentrations of ICTP is indicative of loss of bone or joint materials.
  • the invention relates to a method to promote the healthy bones and joints in an animal comprising administering to said animal a composition of the present invention.
  • the invention relates to a method to reduce the ICTP, e.g., serum levels, in an animal comprising administering to the animal a composition of the present invention.
  • compositions of the present invention comprise nutritionally complete and balanced animal feed compositions.
  • Such compositions include, among other nutrients and ingredients, recommended healthful amounts of protein, carbohydrate and fat.
  • "Nutritionally complete and balanced animal feed compositions" as well as nutrients and ingredients suitable for animal feed compositions, and recommended amounts thereof, are familiar to one of skill in the art (see, for example, National Research Council, 2006 Nutritional Requirements for Dogs and Cats, National Academy Press, Washington D. C. or the Official Publication of the Association of American Feed Control Officials, Inc. Nutrient Requirements for Dogs and Cats 2006).
  • Examples include, but are not limited to, beta-carotene, selenium, coenzyme QlO (ubiquinone), lutein, tocotrienols, soy isoflavones, S- adenosylmethionine, glutathione, taurine, N-acetylcysteine, vitamin E, vitamin D, vitamin C, flavanoids, anthocyanindins, and lipoic acid.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Biotechnology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PCT/US2008/054796 2007-02-22 2008-02-22 Compositions and methods for promoting bone development Ceased WO2008103956A1 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU2008218193A AU2008218193B2 (en) 2007-02-22 2008-02-22 Compositions and methods for promoting bone development
DK08730572.8T DK2129237T3 (en) 2007-02-22 2008-02-22 Compositions and methods for promoting bone development
ES08730572.8T ES2546284T3 (es) 2007-02-22 2008-02-22 Composiciones y métodos para fomentar el desarrollo óseo
US12/528,158 US20100143497A1 (en) 2007-02-22 2008-02-22 Compositions and Methods For Promoting Bone Development
JP2009551047A JP5286287B2 (ja) 2007-02-22 2008-02-22 骨発達を促進するための組成物及び方法
EP08730572.8A EP2129237B1 (en) 2007-02-22 2008-02-22 Compositions and methods for promoting bone development
CA2679008A CA2679008C (en) 2007-02-22 2008-02-22 Compositions and methods for promoting bone development
BRPI0807373-2A BRPI0807373A2 (pt) 2007-02-22 2008-02-22 Composição de ração de animal de estimação, e, método para promover formação óssea
ZA2009/06390A ZA200906390B (en) 2007-02-22 2009-09-14 Compositions and methods for promoting bone development

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89117107P 2007-02-22 2007-02-22
US60/891,171 2007-02-22

Publications (1)

Publication Number Publication Date
WO2008103956A1 true WO2008103956A1 (en) 2008-08-28

Family

ID=39563552

Family Applications (5)

Application Number Title Priority Date Filing Date
PCT/US2008/054796 Ceased WO2008103956A1 (en) 2007-02-22 2008-02-22 Compositions and methods for promoting bone development
PCT/US2008/054789 Ceased WO2008103950A1 (en) 2007-02-22 2008-02-22 Compositions and methods for enhancing immune system of felines
PCT/US2008/054800 Ceased WO2008103958A1 (en) 2007-02-22 2008-02-22 Compositions and methods for altering gene expression
PCT/US2008/054786 Ceased WO2008118586A1 (en) 2007-02-22 2008-02-22 Compositions and methods for enhancing neurologic development
PCT/US2008/054773 Ceased WO2008103939A1 (en) 2007-02-22 2008-02-22 Compositions and methods for enhancing the development of growing animals

Family Applications After (4)

Application Number Title Priority Date Filing Date
PCT/US2008/054789 Ceased WO2008103950A1 (en) 2007-02-22 2008-02-22 Compositions and methods for enhancing immune system of felines
PCT/US2008/054800 Ceased WO2008103958A1 (en) 2007-02-22 2008-02-22 Compositions and methods for altering gene expression
PCT/US2008/054786 Ceased WO2008118586A1 (en) 2007-02-22 2008-02-22 Compositions and methods for enhancing neurologic development
PCT/US2008/054773 Ceased WO2008103939A1 (en) 2007-02-22 2008-02-22 Compositions and methods for enhancing the development of growing animals

Country Status (12)

Country Link
US (6) US20100143497A1 (https=)
EP (5) EP2124612B1 (https=)
JP (5) JP5286286B2 (https=)
CN (6) CN101662949B (https=)
AU (5) AU2008218176B2 (https=)
BR (5) BRPI0807789A2 (https=)
CA (5) CA2679215C (https=)
DK (1) DK2129237T3 (https=)
ES (1) ES2546284T3 (https=)
RU (5) RU2427278C2 (https=)
WO (5) WO2008103956A1 (https=)
ZA (5) ZA200906390B (https=)

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CN110537630A (zh) * 2019-09-09 2019-12-06 天津农学院 1，2二硫戊环-3-戊酸的应用、幼犬鲜粮和延长幼犬鲜粮贮藏期的方法
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