RU2009135260A - Композиции и способы изменения экспрессии генов - Google Patents
Композиции и способы изменения экспрессии генов Download PDFInfo
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- 239000000203 mixture Substances 0.000 title claims abstract 31
- 238000000034 method Methods 0.000 title claims abstract 20
- 230000014509 gene expression Effects 0.000 title claims abstract 4
- 108090000623 proteins and genes Proteins 0.000 claims abstract 6
- 230000035935 pregnancy Effects 0.000 claims abstract 5
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 claims abstract 4
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract 4
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims abstract 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000004472 Lysine Substances 0.000 claims abstract 4
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims abstract 4
- 229960004203 carnitine Drugs 0.000 claims abstract 4
- 229910052748 manganese Inorganic materials 0.000 claims abstract 4
- 239000011572 manganese Substances 0.000 claims abstract 4
- 229930182817 methionine Natural products 0.000 claims abstract 4
- 102000004169 proteins and genes Human genes 0.000 claims abstract 4
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims abstract 4
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract 2
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims abstract 2
- 229930003268 Vitamin C Natural products 0.000 claims abstract 2
- 229930003427 Vitamin E Natural products 0.000 claims abstract 2
- 235000014633 carbohydrates Nutrition 0.000 claims abstract 2
- 150000001720 carbohydrates Chemical class 0.000 claims abstract 2
- 229960001231 choline Drugs 0.000 claims abstract 2
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims abstract 2
- 235000013325 dietary fiber Nutrition 0.000 claims abstract 2
- 235000019197 fats Nutrition 0.000 claims abstract 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract 2
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract 2
- 235000020778 linoleic acid Nutrition 0.000 claims abstract 2
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims abstract 2
- 239000011707 mineral Substances 0.000 claims abstract 2
- 235000015097 nutrients Nutrition 0.000 claims abstract 2
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims abstract 2
- 230000001105 regulatory effect Effects 0.000 claims abstract 2
- 229960003080 taurine Drugs 0.000 claims abstract 2
- 229930003231 vitamin Natural products 0.000 claims abstract 2
- 235000013343 vitamin Nutrition 0.000 claims abstract 2
- 239000011782 vitamin Substances 0.000 claims abstract 2
- 229940088594 vitamin Drugs 0.000 claims abstract 2
- 235000019154 vitamin C Nutrition 0.000 claims abstract 2
- 239000011718 vitamin C Substances 0.000 claims abstract 2
- 235000019165 vitamin E Nutrition 0.000 claims abstract 2
- 229940046009 vitamin E Drugs 0.000 claims abstract 2
- 239000011709 vitamin E Substances 0.000 claims abstract 2
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000002349 favourable effect Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 235000013305 food Nutrition 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61P31/12—Antivirals
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Abstract
1. Композиция кормового продукта для домашнего животного, включающая: ! от около 5 до около 70% белка; ! от около 0,5 до около 1,6% метионина; ! от около 50 до около 200 частей на миллион марганца; ! от около 0,1 до около 0,5% ДГК; ! от около 0,1 до около 0,7% ЭПК; ! от около 1200 до около 7500 частей на миллион холина; ! от около от около 1000 до около 2000 частей на миллион таурина; ! от около 2,5 до около 6% линолевой кислоты; ! от около 1 до около 3% общих n-3 жирных кислот; ! от около 50 до около 1200 MEs/кг витамина Е; ! от около 50 до около 500 частей на миллион витамина С; ! от около 50 до около 500 частей на миллион карнитина; ! от около 2,5 до около 7 г лизина/1000 ккал. ! 2. Композиция по п.1, включающая: ! от около 0 до около 90 мас.% углеводов; ! от около 20 до около 60 мас.% белка; ! от около 2 до около 50 мас.% жира; ! от около 0,1 до около 20 мас.% общих пищевых волокон; ! от около 0 до около 15 мас.% витаминов, минеральных веществ и других нутриентов. ! 3. Композиция по п.1, включающая от около 0,1 до около 0,4% ДГК. ! 4. Композиция по п.1, включающая от около 100 до около 500 частей на миллион карнитина. ! 5. Композиция по п.1, включающая от около 2,5 до около 7 г/1000 ккал лизина. ! 6. Композиция по п.1, включающая от около 0,1 до около 0,6% ЭПК. ! 7. Композиция по п.1, включающая от около 50 до около 150 частей на миллион марганца. ! 8. Композиция по п.1, включающая от около 0,8 до около 1,6% метионина. ! 9. Способ регуляции экспрессии генов у собаки, включающий введение собаке или матери собаки, если собака находится в утробе, композиции по п.1. ! 10. Способ по п.9, где собака является щенком. ! 11. Способ по п.9, где щенок рожден от собаки, потребляющей во время беременности композицию по любому из пп.1-8. ! 12. Способ по п.10, где щенок находи
Claims (23)
1. Композиция кормового продукта для домашнего животного, включающая:
от около 5 до около 70% белка;
от около 0,5 до около 1,6% метионина;
от около 50 до около 200 частей на миллион марганца;
от около 0,1 до около 0,5% ДГК;
от около 0,1 до около 0,7% ЭПК;
от около 1200 до около 7500 частей на миллион холина;
от около от около 1000 до около 2000 частей на миллион таурина;
от около 2,5 до около 6% линолевой кислоты;
от около 1 до около 3% общих n-3 жирных кислот;
от около 50 до около 1200 MEs/кг витамина Е;
от около 50 до около 500 частей на миллион витамина С;
от около 50 до около 500 частей на миллион карнитина;
от около 2,5 до около 7 г лизина/1000 ккал.
2. Композиция по п.1, включающая:
от около 0 до около 90 мас.% углеводов;
от около 20 до около 60 мас.% белка;
от около 2 до около 50 мас.% жира;
от около 0,1 до около 20 мас.% общих пищевых волокон;
от около 0 до около 15 мас.% витаминов, минеральных веществ и других нутриентов.
3. Композиция по п.1, включающая от около 0,1 до около 0,4% ДГК.
4. Композиция по п.1, включающая от около 100 до около 500 частей на миллион карнитина.
5. Композиция по п.1, включающая от около 2,5 до около 7 г/1000 ккал лизина.
6. Композиция по п.1, включающая от около 0,1 до около 0,6% ЭПК.
7. Композиция по п.1, включающая от около 50 до около 150 частей на миллион марганца.
8. Композиция по п.1, включающая от около 0,8 до около 1,6% метионина.
9. Способ регуляции экспрессии генов у собаки, включающий введение собаке или матери собаки, если собака находится в утробе, композиции по п.1.
10. Способ по п.9, где собака является щенком.
11. Способ по п.9, где щенок рожден от собаки, потребляющей во время беременности композицию по любому из пп.1-8.
12. Способ по п.10, где щенок находится в утробе.
13. Способ по п.11, где самка потребляет композицию перед наступлением беременности.
14. Способ по п.11, где самка потребляет композицию в течение большей части беременности.
15. Способ по п.11, где самка потребляет композицию перед и во время беременности.
16. Способ по п.10, где щенок потребляет композицию перед отъемом.
17. Способ по п.10, где щенок потребляет композицию после отъема.
18. Способ по п.17, где щенок потребляет, по существу, исключительно композицию.
19. Способ по п.9, где собаке вводят эффективное количество композиции.
20. Способ по п.9, где собаке вводят композицию в течение периода времени, необходимого для эффективного воздействия.
21. Способ по п.20, где собаке вводят композицию по меньшей мере в течение одного года после рождения или одного года после отъема.
22. Способ по п.9, где ген выбирают из приведенных в Таблицах 2-15.
23. Способ получения благоприятной модификации экспрессии одного или более гена у животного, приведенного в Таблицах 2-15 для одного или более биологического состояния, направления или заболевания, приведенного в Таблицах 2-15, включающий введение животному эффективного количества композиции по п.1 или непосредственно животному, или самке, в утробе которой находится животное.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89117107P | 2007-02-22 | 2007-02-22 | |
| US60/891,171 | 2007-02-22 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2009135260A true RU2009135260A (ru) | 2011-03-27 |
| RU2441394C2 RU2441394C2 (ru) | 2012-02-10 |
Family
ID=39563552
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009135263/13A RU2435435C2 (ru) | 2007-02-22 | 2008-02-22 | Композиция и способ улучшения развития растущих животных |
| RU2009135260/15A RU2441394C2 (ru) | 2007-02-22 | 2008-02-22 | Композиции и способы изменения экспрессии генов |
| RU2009135261/13A RU2427278C2 (ru) | 2007-02-22 | 2008-02-22 | Композиции и способы улучшения развития костей |
| RU2009135245/13A RU2412611C1 (ru) | 2007-02-22 | 2008-02-22 | Композиция и способ усиления неврологического развития |
| RU2009135231/13A RU2436410C2 (ru) | 2007-02-22 | 2008-02-22 | Композиция и способ для усиления иммунного ответа кошачьих |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009135263/13A RU2435435C2 (ru) | 2007-02-22 | 2008-02-22 | Композиция и способ улучшения развития растущих животных |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2009135261/13A RU2427278C2 (ru) | 2007-02-22 | 2008-02-22 | Композиции и способы улучшения развития костей |
| RU2009135245/13A RU2412611C1 (ru) | 2007-02-22 | 2008-02-22 | Композиция и способ усиления неврологического развития |
| RU2009135231/13A RU2436410C2 (ru) | 2007-02-22 | 2008-02-22 | Композиция и способ для усиления иммунного ответа кошачьих |
Country Status (12)
| Country | Link |
|---|---|
| US (6) | US20100137404A1 (ru) |
| EP (5) | EP2129237B1 (ru) |
| JP (5) | JP5285625B2 (ru) |
| CN (6) | CN101686712B (ru) |
| AU (5) | AU2008218195C1 (ru) |
| BR (5) | BRPI0807373A2 (ru) |
| CA (5) | CA2678938C (ru) |
| DK (1) | DK2129237T3 (ru) |
| ES (1) | ES2546284T3 (ru) |
| RU (5) | RU2435435C2 (ru) |
| WO (5) | WO2008103956A1 (ru) |
| ZA (5) | ZA200906390B (ru) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL1937721T3 (pl) * | 2005-08-25 | 2010-12-31 | Lilly Co Eli | Przeciwciała anty-IL23 |
| WO2008103956A1 (en) * | 2007-02-22 | 2008-08-28 | Hill's Pet Nutrition, Inc. | Compositions and methods for promoting bone development |
| CN102316865B (zh) * | 2008-12-12 | 2017-04-19 | 科耐特有限公司 | 用于改善正常的认知功能的l‑赖氨酸 |
| DK2493491T3 (da) | 2009-12-29 | 2014-06-30 | Hills Pet Nutrition Inc | Sammensætninger, indeholdende ingefær til lindringen eller forebyggelsen af inflammatoriske tilstande hos katte og hunde |
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