WO2007118368A1 - Thé pharmaceutique destiné à réduire la glycémie et procédé associé - Google Patents

Thé pharmaceutique destiné à réduire la glycémie et procédé associé Download PDF

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Publication number
WO2007118368A1
WO2007118368A1 PCT/CN2006/001356 CN2006001356W WO2007118368A1 WO 2007118368 A1 WO2007118368 A1 WO 2007118368A1 CN 2006001356 W CN2006001356 W CN 2006001356W WO 2007118368 A1 WO2007118368 A1 WO 2007118368A1
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WO
WIPO (PCT)
Prior art keywords
tea
parts
hypoglycemic
blood sugar
insulin
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Application number
PCT/CN2006/001356
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English (en)
Chinese (zh)
Inventor
Fasheng Wang
Original Assignee
Fasheng Wang
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Publication of WO2007118368A1 publication Critical patent/WO2007118368A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Definitions

  • the invention relates to a composition for assisting in the treatment of diabetes, capable of effectively lowering blood sugar, restoring the function of the body's own islets, and simultaneously enhancing the body's resistance.
  • the invention relates to a method for preventing and treating high blood sugar and diagnosed diabetes by using pure Chinese medicine as raw material.
  • Medicinal tea composition and preparation method thereof Background technique
  • the pathogenesis and pathogenesis of diabetes is very complicated. It has not yet been fully elucidated.
  • the Western medicine concept is mainly related to genetic factors, obesity, neurological factors, viral infection, autoimmunity and other factors.
  • the cause of type I diabetes is relatively clear, mainly related to genetic factors, but the cause of type 2 diabetes is very complicated, and Western medicine and Chinese medicine have different views.
  • the treatment methods and techniques of diabetes are mainly based on Western medicine.
  • the treatment of Western medicine mainly relies on long-term oral hypoglycemic drugs and insulin supplementation in vitro to maintain the blood sugar balance of the human body. These two methods are treatments for treating the symptoms and not treating the symptoms, and will damage them in the long run. The body's own islet function. Oral hypoglycemic drugs treatment methods and limitations
  • oral hypoglycemic drugs mainly include: 1. Sulfonylureas such as glibenclamide. It mainly exerts hypoglycemic effect by stimulating islet ⁇ -cell secretion of insulin; 2. Insulin sensitizer drugs such as metformin, etc., mainly to increase blood glucose by increasing the uptake and utilization of glucose by peripheral tissues; , ⁇ -glucose inhibitors such as the sugar equal; this category is mainly to slow down the blood sugar by delaying the absorption of sugar in the small intestine.
  • Sulfonylureas such as glibenclamide. It mainly exerts hypoglycemic effect by stimulating islet ⁇ -cell secretion of insulin
  • Insulin sensitizer drugs such as metformin, etc., mainly to increase blood glucose by increasing the uptake and utilization of glucose by peripheral tissues
  • ⁇ -glucose inhibitors such as the sugar equal
  • this category is mainly to slow down the blood sugar by delaying the absorption of sugar in the small intestin
  • the above oral hypoglycemic drugs mainly reduce glucose by inhibiting glucosidase, reducing the decomposition of polysaccharides and sucrose, and delaying and reducing absorption, thereby lowering blood sugar and stimulating insulin secretion to lower blood sugar.
  • this method temporarily gains blood sugar balance, it does not improve and repair the body's own islet function, and the side effects caused by long-term drinking can cause harm to the human body, such as the risk of hypoglycemia, obesity, and liver and kidney. Damage.
  • the patient's blood glucose can be satisfactorily controlled at the beginning of the medication (months to years). As time goes on, the curative effect is getting worse and worse.
  • the oral administration of the maximum allowable dose of blood glucose is still not ideally controlled (fasting blood glucose > It is called "secondary failure", which is mainly due to the progress of the disease, the secretion function of the islet ⁇ -cells gradually declines, and the efficacy of the drug that promotes insulin secretion also decreases, and it is completely ineffective. According to statistics, the incidence of secondary failure is 5% to 10% per year. After treatment with sulfonylurea for 5 years, about 30% to 40% of patients will have secondary failure.
  • in vitro insulin supplementation is used as a treatment for various long-acting, intermediate-effect, short-acting insulins; the injection of synthetic or animal insulin is used to replace blood sugar in the body to balance blood sugar.
  • In vitro insulin supplementation can restore blood sugar balance, and damage to liver and kidney is small. Because the human body relies on supplementing exogenous insulin, the patient's own islets do not continue to work. In vitro injection of insulin does not restore the body's own islet function. In the long run, the human body itself Islet function gradually shrinks and degenerates, resulting in a greater injection of insulin, which is why insulin injections are increasing.
  • Diabetes is a metabolic disease, mainly due to people's diet, living habits, Sudden changes in lifestyle and mental state cause disorders in the endocrine system, leading to metabolic disorders in the body, especially with the improvement of living standards, long-term intake of high-fat, high-protein, high-nutrient, high-calorie foods, resulting in excess nutrients in the body, in order to maintain
  • the body's sugar metabolism balances the islets have to secrete a large amount of insulin, and the excess sugar into the human body is converted into fat for storage, so that the human islets are in an overloaded state for a long time, coupled with lifestyle changes, reduced exercise, and mental stress.
  • Treatment also different from general nutrition and health foods, only supplements and strengthens the deficiency of a certain aspect of nutrients, but adjusts the balance of human body function in two ways, mobilizes the internal vitality of the body, regulates the metabolism of the human body, improves the immunity of the body, and promotes all
  • the visceral or organ function is normalized; it is necessary to strengthen the spleen, strengthen the body's resistance, regulate and balance the metabolic function, activate the body's own islet vitality, thereby restoring the islet function, promoting the normal secretion of insulin, and achieving the goal of treating the symptoms and treating the disease.
  • the object of the present invention is to provide a hypoglycemic tea which can effectively reduce and stabilize blood sugar, better restore islet function, promote insulin secretion, restore glucose metabolism balance, reduce patient's drug and injection of exogenous insulin to control blood sugar.
  • Dependence at the same time, enhances body immunity and can be used to prevent and treat high blood sugar and diagnosed diabetes.
  • Another object of the present invention is to provide a method for preparing a hypoglycemic tea which is simple and easy to prepare.
  • hypoglycemic tea of the present invention contains the following components in parts by weight:
  • hypoglycemic tea contains 5-20 parts of almonds, preferably 5-10 parts.
  • the cockroach has a function of digesting and lowering blood sugar
  • the hypoglycemic tea contains 5 to 20 parts, preferably 5 to 10 parts.
  • the tea leaves of the invention can be selected from black tea, belonging to the whole fermented tea, and the fresh leaves are formed by four processes: withering, simmering, fermenting and drying.
  • Red tea has cholesterol-lowering, vitamin C-rich, and has antioxidant effects. It has a warm stomach, refreshing and refreshing effects.
  • the ganoderma lucidum according to the present invention can treat the ganoderma lucidum by breaking the wall, and can also directly adopt the ganoderma spore powder, which is easily absorbed by the human body.
  • raw materials used in the present invention are products that meet food quality requirements.
  • the preparation method of the hypoglycemic tea according to the present invention comprises the following steps:
  • the raw materials are mixed according to the ratio, pulverized to 80 to 120 mesh, and sterilized.
  • the sterilization is an ultraviolet irradiation method.
  • the invention combines the principle of yin and yang balance of Chinese medicine human body, utilizes edible Chinese medicine material without any toxic and side effects, and combines the traditional processing technology of traditional Chinese medicine with the modern high-tech special processing method to refine one kind of boilable water for brewing, and has certain medicinal use.
  • Effective tea The hypoglycemic tea of the invention can effectively reduce and stabilize blood sugar, better restore islet function, promote insulin secretion, enhance body resistance, reduce patient dependence on blood sugar control, and can be used for preventing and treating high blood sugar. And diagnosed diabetes.
  • Ganoderma lucidum helps the body to strengthen the body, has the enormous effect of enhancing the body's immune function and improving the body's resistance. It is different from general medicines in treating diseases. It is different from general nutrition and health foods, which only supplements and strengthens the deficiency of certain aspects of nutrients. Instead, it regulates the balance of human body function in both directions and adjusts the internal vitality of the body. Regulates the body's metabolic function, improves autoimmunity, and promotes the normalization of all internal organs or organs.
  • Yam meaty white, sweet, a big quality.
  • Yam is the root of the potato yam of the yam family, which has the effect of nourishing the spleen and nourishing the stomach, supplementing the lung and tonifying the kidney. It can be used to treat spleen deficiency and chronic diarrhea, chronic enteritis, lung deficiency and cough, chronic gastritis, diabetes, nocturnal emission, enuresis, and embolism.
  • Mucin is a mixture of polysaccharide proteins that have a special health care effect on the human body. It prevents fat deposits on the cardiovascular system, maintains blood vessel elasticity, prevents premature atherosclerosis, reduces subcutaneous fat accumulation, and prevents connective tissue. Atrophy, prevention of rheumatoid arthritis, scleroderma and other collagen diseases. Black tea: lowers cholesterol, is rich in vitamin C, and has antioxidant effects. It has a warm stomach, refreshing and refreshing effects.
  • Buckwheat This product is rich in protein, B vitamins, rutin (PMP), strengthening vascular substances, mineral nutrients and abundant plant cellulose. It inhibits obesity, inhibits blood lipid rise, and improves lipid metabolism. Activates the pancreas. Function, promote islet secretion, lower blood sugar, strengthen capillary elasticity. It has a significant effect on preventing and treating diabetes and improving hypertension.
  • the dietary fiber in buckwheat is mostly composed of pectin and mucilage. This dietary fiber has a positive effect on the prevention and treatment of diabetes and hyperlipidemia.
  • the hypoglycemic tea according to the present invention has remarkable effects on prevention and adjuvant treatment of diabetes, and has the functions of improving functional immunity, enhancing disease resistance, lowering blood pressure, blood lipids, and softening blood vessels.
  • the invention has less medicinal taste, simple manufacturing process and low cost.
  • the method of administration is as follows:
  • Drinking this product for 1 month is a course of treatment.
  • drinking 1 to 3 courses of this product will restore blood sugar to normal level (fasting ⁇ 6.1mmol/L; 2 hours after the meal ⁇ 7.8 mmol / L), continue to drink 1 ⁇ 3 courses, gradually repair the function of the islet of the body, after the blood sugar continues to normal for a period of time (15 days or more), under the guidance of a doctor, gradually reduce the drug or injection The amount of insulin used.
  • the invention utilizes the principle of traditional Chinese medicine and food homology, adopts edible Chinese herbal medicines, uses high-tech means and combines traditional techniques to carry out fine and deep processing, so that various useful elements are fully absorbed by the human body.
  • the hypoglycemic tea of the present invention has ten advantages compared with the current oral medication and insulin injection: 1. No side effects, no complications. 2, with tea as a medicine. 3, reduce the pain of patient injection. 4. It does not cause a risk of hypoglycemia and is safe. 5. Reduce medical expenses. 6, improve and repair islet function, treat the symptoms and cure the disease. 7, improve the body's immunity. 8, maintain a comprehensive balance of metabolism; 9, the effect is stable, does not rebound; 10, easy to carry, easy to take, easy to drink.
  • the treated raw material is pulverized through a 100 mesh sieve to form an ultrafine powder, uniformly stirred, and packaged in a standard and clean soakable tea bag paper to make a 15 gram bag of herbal tea.
  • the treated raw material is pulverized through an 80 mesh sieve to form an ultrafine powder, uniformly stirred, and packaged in a standard and clean soakable tea bag paper to prepare a 10 gram bag of medicated tea.
  • hypoglycemic tea consists of the following components:
  • hypoglycemic tea consists of the following components: Ganoderma lucidum 10 Kg, yam 30 Kg, green tea 10 Kg, buckwheat 60 Kg, almond 20 Kg.
  • hypoglycemic tea consists of the following components:
  • hypoglycemic tea consists of the following components:
  • hypoglycemic tea consists of the following components:
  • the present invention has observed clinical medications in 28 diabetic patients during the diagnosis and treatment.
  • the 18 cases of diabetes patients observed by clinical medication came from different units.
  • the hypoglycemic tea of Example 1 of the present invention was administered.
  • the blood glucose levels were as follows: fasting sputum, 7.5 or less after meal, and fasting blood glucose fluctuation range 1 ⁇ 2.
  • the injection volume was 18 ⁇ 30 units / day, divided into 2 times, early and before dinner.
  • the blood sugar is controlled at about 8 on an empty stomach and around 9 to 10 after a meal.
  • the blood glucose levels were as follows: fasting 8 or less, 9 or less after meals. Two of them took hypoglycemic tea after 1 month, and the blood glucose level returned to normal.
  • the insulin dosage was 28 units/day from the beginning of each injection day, gradually reduced to zero, and the blood glucose level returned to normal: fasting 6.1 or less, 7.8 after meal the following.
  • the first group took oral hypoglycemic drugs while eating hypoglycemic tea. Although some of the hypoglycemic agents were reduced, the hypoglycemic effect was not good. One was slow hypoglycemic and the other was poor hypoglycemic effect.
  • the second group had a fast hypoglycemic effect at the beginning, but the later effect gradually weakened, indicating that there is drug dependence. And the late dose is getting bigger and bigger, and there are side effects.
  • the initial hypoglycemic effect was in the middle, but the blood glucose index was always in a state of decline, the hypoglycemic effect was stable, and the dose was gradually reduced. It shows that the tea can restore the function of the body's own islets, regulate metabolism, restore the function of human islets, and cure the symptoms.
  • the hypoglycemic tea according to the present invention adopts edible Chinese medicine, regulates human metabolism, enhances body immunity, reduces islet burden, and restores islet function, thereby finally restoring islet secretion of insulin and establishing human body.
  • Self-insulin secretion function to achieve the goal of cure.
  • the tea not only has obvious hypoglycemic effect, but also restores islet function, promotes insulin secretion, and has the effect of strengthening the spleen and qi and strengthening the body's resistance. It can reduce and stabilize blood sugar, reduce the dependence of patients on blood sugar control, and reduce the damage of liver and kidney function. It is suitable for long-term drinking of people with diabetes and high blood sugar.

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention concerne un thé pharmaceutique pour la prévention et le traitement du diabète. Ledit thé est préparé à l'aide de 5 à 30 parties en poids de Ganoderma, de 10 à 40 parties en poids de Rhizoma Dioscoreae, de 5 à 30 parties en poids de Folium Camelliae sinensis et de 30 à 80 parties en poids de Semen Fagopyri Esculenti. Ledit thé peut réduire et stabiliser la glycémie, restaurer la fonction insulaire, promouvoir la sécrétion d'insuline, améliorer l'immunité et la résistance du corps humain, réduire la dépendance à l'insuline.
PCT/CN2006/001356 2006-04-18 2006-06-16 Thé pharmaceutique destiné à réduire la glycémie et procédé associé WO2007118368A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN200610072276 2006-04-18
CN200610072276.6 2006-04-18

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WO2007118368A1 true WO2007118368A1 (fr) 2007-10-25

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101264331B (zh) * 2008-01-24 2010-06-02 上海大学 中药杏仁的新用途
CN102308895A (zh) * 2011-06-17 2012-01-11 朱世宗 灵芝苦荞茶
CN109568471A (zh) * 2019-01-25 2019-04-05 大连海洋大学 具有降血糖作用的笼目海带褐藻聚糖硫酸酯复方制剂

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1097272A (zh) * 1993-12-03 1995-01-18 王若浩 灵芝茶

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1097272A (zh) * 1993-12-03 1995-01-18 王若浩 灵芝茶

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101264331B (zh) * 2008-01-24 2010-06-02 上海大学 中药杏仁的新用途
CN102308895A (zh) * 2011-06-17 2012-01-11 朱世宗 灵芝苦荞茶
CN109568471A (zh) * 2019-01-25 2019-04-05 大连海洋大学 具有降血糖作用的笼目海带褐藻聚糖硫酸酯复方制剂
CN109568471B (zh) * 2019-01-25 2021-12-21 大连海洋大学 具有降血糖作用的笼目海带褐藻聚糖硫酸酯复方制剂

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