WO2006030805A1 - トリアゾール誘導体またはその塩 - Google Patents
トリアゾール誘導体またはその塩 Download PDFInfo
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- WO2006030805A1 WO2006030805A1 PCT/JP2005/016896 JP2005016896W WO2006030805A1 WO 2006030805 A1 WO2006030805 A1 WO 2006030805A1 JP 2005016896 W JP2005016896 W JP 2005016896W WO 2006030805 A1 WO2006030805 A1 WO 2006030805A1
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- methyl
- substituted
- triazole
- lower alkyl
- triazol
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- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
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- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D487/04—Ortho-condensed systems
Definitions
- the present invention relates to a novel triazole derivative useful as a medicament, particularly as a therapeutic or prophylactic agent for a disease involving 11 ⁇ -hydroxysteroid dehydrogenase type 1, such as diabetes, insulin resistance, etc. Relates to a salt that is pharmaceutically acceptable.
- Darcocorticoids are hormones that cause metabolic abnormalities such as hyperglycemia, insulin resistance, obesity, hyperlipidemia, and hypertension, and are not only produced by the adrenal gland but also inactive at the tissue level. It is converted to the active form and acts through its receptor.
- 11 ⁇ -hydroxysteroid dehydrogenase (11 ⁇ -HSD) is an enzyme that catalyzes this conversion, and it is known that there are two subtypes.
- 11 j8 -Hydroxysteroid dehydrogenase type 1 (11 -HSDl) is an enzyme that converts an inactive form into an active form and is highly expressed in the liver
- 11 ⁇ -hydroxysteroid dehydrogenase type 2 (11 beta -HSD2) is an active form It is an enzyme that converts to an inactive form and is highly expressed in the kidney.
- 11 iS -HSDl and metabolic disorders are known to be 11 ⁇ -HSD1 hyperactivity in adipose tissue of obese (Non-Patent Document 1), and 11 j8-HSD1 activity is an indicator of obesity.
- HOMA-IR which is an index of insulin resistance, has been reported to be highly correlated with fasting blood glucose level (Non-patent Document 2).
- Non-patent Documents 3 and 4 Transgenic mice overexpressed with 11 iS-HSDl selectively in adipose tissue show elevated darcocorticoids in adipose tissue, insulin resistance, visceral fat obesity, hyperlipidemia, and hypertension
- 8 -HSD1 knockout mice have been reported to exhibit improved glucose tolerance, decreased blood triglycerides, and increased HDL-cholesterol (Non-patent Document 5).
- 11-HSD1-selective inhibitors suppress the conversion of darcocorticoids into tissues by inhibiting the conversion to active darcocorticoids, resulting in hyperglycemia and insulin resistance induced by darcocorticoids. It is expected to correct metabolic abnormalities such as sex, obesity, hyperlipidemia, and hypertension.
- non-selective 11 ⁇ -HSD inhibitor carbenoxolone has been reported to improve insulin secretion decrease by inactive glucocorticoid supplementation in mouse spleen ⁇ -cells (Non-patent document 6).
- 11 -HSD1 inhibitors may correct hyperglycemia by promoting insulin secretion as well as improving insulin resistance.
- HSD1 osteoporosis
- glaucoma Non-patent document 8
- cognitive decline Non-patent document 9
- Patent Documents 1 to 8 are known as compounds having 11 ⁇ -HSD1 inhibitory activity.
- Patent Document 1 reports a triazole derivative represented by the formula ( ⁇ ). However, it differs from the compound of the present invention in that there is no part corresponding to ⁇ and ⁇ of the compound of the present invention.
- R 1 represents an optionally substituted adamantyl
- X represents CH or a single bond
- Z represents S.
- Patent Document 2 reports a triazole derivative represented by the formula (B). However, it differs from the compound of the present invention in that the ring bonded to the triazole ring is bicyclo [2.2.2] octane.
- Patent Documents 3 and 4 report triazole derivatives represented by the formula (C). Shi However, it is substituted !, but is different from the compound of the present invention in that the phenyl ring is bonded to the triazo ring via one carbon atom.
- each R 3 is optionally substituted C alkyl.
- A is a C, optionally substituted C alkyl, OC alkyl or phenyl
- B is H, C, respectively.
- Patent Document 5 reports a triazole derivative represented by the formula (D).
- compounds having substituents in the portions corresponding to A and B of the compounds of the present invention are not disclosed as examples.
- R 3 10 1 6 is heteroaryl C-C alkyl, etc.
- R 3 is optionally substituted C-C
- R 8 C-C alkyl
- Other symbols are the gazette
- R is C-C cycloalkyl, C-C heterocycloalkyl, aryl, hetero
- Patent Document 7 published after the priority date of the present application, a triazole derivative represented by the formula (F) is reported.
- Y corresponding to A and B of the compound of the present invention is limited to the ring structure.
- Patent Document 8 published after the priority date of the present application, compounds represented by the formula (G) including a wide range of compounds are reported. However, in the compounds having substituents corresponding to A and B of the compound of the present invention, only the compounds in which the portion corresponding to R 1 of the compound of the present invention is aryl are disclosed as examples.
- R 1 represents a hydrogen atom or an optionally substituted cyclic group
- R 2 represents an optionally substituted cyclic group
- Ar represents an optionally substituted 5- or 6-membered aromatic heterocyclic ring
- L 1 and L 2 are The same or different (1) bond (2) substituted! May be a divalent hydrocarbon group or the like.
- Non-Patent Document 1 Rask E. et al., “The Journal of Clinical Endocrinology & Metabolism” (USA), 2001, 86th, p.1418-1421
- Non-Patent Document 2 Lindsay RS et al., “The Journal of Clinical Endocrinology & Metabolism” J, 2003, 88th, p.2738-2744
- Non-Patent Document 3 Masuzaki H. et al., “Science” (USA), 2000, 294, pp.2166-2170
- Non-Patent Document 4 Masaki H. et al., “The Journal of Clinical Investigation” (USA), 2003, 112th ⁇ , p.83-90
- Non-Patent Document 5 Morton NM et al., "The Journal of Biological Chemistry” (USA), 2001, 27th , P.41293- 41300
- Non-Patent Document 6 Davani B. et al., “The Journal of Biological Chemistry” (USA), 2000, 275th p. 3484 1-34844
- Non-Patent Document 7 Cooper M.S., et al., “Bone” (USA), 2000, No. 27, p.375-381
- Non-Patent Document 8 Rauz S. et al., “Investigative Opthalmology & Visual Science” (USA), 2001, 42nd , P.2037-2042
- Non-Patent Document 9 Sandeep TC, et al., “Proceedings of the National Academy of Sciences” (USA) 2004, No. 101, p.6734-6739
- Patent Document 1 International Publication No. 03/65983 Pamphlet Patent Document 2: US Patent Application Publication No. 2004/133011
- Patent Document 3 International Publication No. 03/104207 Pamphlet
- Patent Document 4 International Publication No. 03/104208 Pamphlet
- Patent Document 5 Pamphlet of International Publication No. 04/089367
- Patent Document 6 International Publication No. 04/089380 Pamphlet
- Patent Document 7 International Publication No. 05/044192 Pamphlet
- Patent Document 8 JP-A-2005-170939
- the present inventors have conducted extensive research on a compound having an 11 jS-HSD1 inhibitory action that can be expected to improve diabetes and insulin resistance.
- the novel triazole derivative of the present invention or its The present inventors have found that a salt has an excellent selective inhibitory action on 11 ⁇ -HSD1 and completed the present invention.
- the present invention relates to a triazole derivative represented by the following formula (I) or a pharmaceutically acceptable salt thereof that is useful as an 11 18 -HSD1 inhibitor.
- a cycloalkyl group or a heterocyclic group each of which may be substituted.
- R 4 each substituted or unsubstituted aryl, cycloalkyl or heterocyclic group.
- X -0-, -N (R 5 )-, -C (O)-, -S-, -S (O)-, -S (O)-, -C (0) N (R.)- ,-N (R °) C (0)-, -N (R °)
- C (0)-, -N (R 5 ) -lower alkylene, lower alkylene-N (R 5 )-, or each substituted! May be lower alkylene, lower alkenylene or lower alkynylene.
- R 5 -H, lower alkyl, lower alkylene-CO R °, lower alkylene-OR °, -C (0) R °, -C (
- R 6 —H, lower alkyl, —C (0) R. Or-C (O) -Areel.
- R ° same or different, -H or lower alkyl
- R 3 - R 7, -OR 7, - NHR 7, - N (R 7) - C (0) R °, - N (R 7) S (0) - lower alkyl, - N (R 7) or -S
- R 2 and R 3 may be substituted with a nitrogen atom and a carbon atom to which R 2 and R 3 are bonded to form a nitrogen-containing heterocycle.
- the ring formed by the condensation of the nitrogen-containing heterocycle and the triazole ring formed by combining R 2 and R 3 together with a nitrogen atom and a carbon atom is a pyrazo mouth [ 5, 1-c
- R 7 A lower alkyl, lower alkyl, lower alkyl, cycloalkyl, aryl or heterocyclic group which may be the same or different from each other and may be substituted.
- a and B same or different, halogen, -R 7 , -OH, -OR 7 , -NH, -NHR 7 , -N
- the present invention also relates to a pharmaceutical composition
- a pharmaceutical composition comprising a triazole derivative represented by the above general formula (I) or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier, particularly 11 18-
- a pharmaceutical composition that is a droxysteroid dehydrogenase inhibitor, an insulin sensitizer, or a prophylactic or therapeutic agent for diabetes.
- composition comprising a compound according to formula (I) or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier;
- composition according to (1) which is an 11 18 -hydroxysteroid dehydrogenase inhibitor
- composition according to (1) which is a preventive or therapeutic agent for diabetes
- It relates to a method for preventing or treating diabetes comprising administering to a patient a therapeutically effective amount of a compound according to formula (I) or a salt thereof.
- the procedure for measuring 11 18 -HSD1 inhibitory activity is as follows. The enzyme reaction and measurement were performed using a 384 well plate. Reaction is 10 mM phosphate buffer (pH 6.6), 200 nM Add various concentrations of test compound to a reaction solution consisting of cortisone, 40 M reduced nicotinamide adenine dinucleotide phosphate (NADPH), and human recombinant 11 jS -HSDl, and then incubate at room temperature for 1 hour. (10 1 / well). The test compound was dissolved in dimethyl sulfoxide (DMSO) to prepare a DMSO concentration of 1% in the reaction solution.
- DMSO dimethyl sulfoxide
- the conoretizole was time-resolved: 3 ⁇ 4: The enzyme inhibitory activity was measured by detecting using photometric method (Homogeneous time-resolved fluorescence (HTRF)).
- HTRF Homogeneous time-resolved fluorescence
- XL-665 labeled cortisol containing 400 ⁇ carbenoxolone and Cryptate labeled cortisol antibody (Ci'i'S'Bio 'International) 5 1 / ulka After incubation for 2 hours at room temperature, the fluorescence intensity was measured using a fluorimeter (trade name: Discovery, PerkinElmer), and the fluorescence intensity ratio of two wavelengths (665 nm / 620 n) m) Force The enzyme inhibitory activity was calculated.
- the 11-HSD2 inhibitory activity was measured in the same manner as the 11-HSD1 inhibitory activity, except for the enzyme reaction conditions. Enzymatic reactions can be performed in various reaction solutions consisting of 40 mM Tris-HCl buffer (Tris-HC1) (pH 8.0), 200 nM cortisol, 200 nicotinamide adenine dinucleotide (NAD), and human recombinant 11 i8 -HSD2. After incubating the test substance at a concentration of 37 ° C, incubation was performed at 37 ° C for 2 hours (10 1 / well).
- Tris-HC1 pH 8.0
- NAD nicotinamide adenine dinucleotide
- the measurement results were calculated by averaging the values of 3 wells under the same conditions.
- the ratio when DMSO is added instead of the test compound is 0%, the ratio when 11 ⁇ -HSD1 or 11 ⁇ -HSD2 is not added is 100%, and the concentration at which the test compound is inhibited by 50%.
- IC for compound inhibitory activity is a ratio when DMSO is added instead of the test compound.
- Example 68 having strong 11 jS-HSDl inhibitory activity showed a 32% blood glucose lowering action, and it was confirmed that the compound of the present invention has an excellent blood glucose lowering action.
- alkyl means a carbon chain having 1 to 6 carbon atoms unless otherwise specified.
- alkyl means a carbon chain having 1 to 6 carbon atoms unless otherwise specified.
- alkyl means a carbon chain having 1 to 6 carbon atoms unless otherwise specified.
- alkyl means a carbon chain having 1 to 6 carbon atoms unless otherwise specified.
- alkyl means a carbon chain having 1 to 6 carbon atoms unless otherwise specified.
- alkyl alkyl”, “alkyl”, “alkyl”, “alkylene”, “alkylene” and “alkylene” may each be linear or branched.
- lower alkyl means alkyl of C, specifically, for example, methyl
- “Lower alkenyl” means a C alkenyl having a plurality of double bonds.
- “Lower alkynyl” means C alkynyl having a plurality of triple bonds.
- ethynyl ethynyl, probule, butur, pentynyl, hexyl, etc., preferably C alkell, more preferably ethul, 1-prol.
- Alkylene means a divalent group formed by removing one hydrogen from any position of alkyl.
- Lower alkylene means C alkylene. Specifically, methylene,
- Tylene methylmethylene, dimethylmethylene, propylene, butylene, pentylene, hexylene and the like.
- Preferred is C alkylene, and more preferred is methylene, ethylene,
- Tilmethylene dimethylmethylene, 1-propylene, 2-propylene.
- “Lower alkene” refers to the removal of one hydrogen atom at any position of a C alkellene.
- “Lower alkylene” is a compound obtained by removing one hydrogen atom at any position of C alkyl.
- Means a divalent group include ethylene, propylene, petitylene, pentylene, hexylene and the like.
- it is C alkylene, more preferably
- Cycloalkyl means a non-aromatic hydrocarbon ring of C, and a bridged ring spiro ring.
- the benzene ring which may have a partially unsaturated bond may be condensed.
- the bond is on the non-aromatic ring.
- Specific examples include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclooctyl, cyclohexenyl, cyclooctane genyl, adamantyl, norbornyl, and indanyl having a bond at the 1 to 3 position. Is Cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl.
- Halogen means a halogen atom, and specific examples include fluoro, black mouth, bromine, iodine, etc., preferably fluoro and black mouth.
- halogeno lower alkyl means one or more arbitrary hydrogen atom forces of the “lower alkyl” that are the same or different from each other and substituted with the “halogen”. Specific examples include trifluoromethyl, pentafluoroethyl and the like. Preferred is trifluoromethyl.
- Aryl means a monocyclic to tricyclic C aromatic hydrocarbon ring, specifically
- phenyl for example, phenyl, naphthyl and the like can be mentioned, and preferred is phenyl. Also, C
- the chloroalkyl ring may be condensed. However, when the cycloalkyl ring is condensed, the bond is on the aromatic ring. For example, indanyl having a bond at positions 4 to 7 and tetrahydronaphthyl having a bond at positions 5 to 8 may be formed.
- Aromatic heterocycle refers to a monocyclic aromatic heterocycle that is a monocyclic 3- to 8-membered unsaturated ring containing 1 to 4 heteroatoms selected from 0, S and N forces.
- the ring atom S or N may be oxidized to form a dioxide.
- Heterocycle is a general term obtained by adding "non-aromatic heterocycle” to "aromatic heterocycle", and "non-aromatic heterocycle” means 0, S and N force Monocyclic ring containing 1 to 4 selected heteroatoms 3-12 membered saturated or partially unsaturated monocyclic non-aromatic heterocycles, and non-aromatic heterocycles Or the non-aromatic heterocycle is a cycloalkyl ring, benzene Or a bicyclic or tricyclic heterocycle condensed with an aromatic or aromatic heterocycle.
- the ring atom S or N may be oxidized to form an oxide or a dioxide, or a bridged ring or a spin ring may be formed.
- Non-aromatic heterocycles include, for example, oxetanyl, dihydropyridyl, dihydropyrrolyl, dihydrooxazolyl, dihydrothiazolyl, dihydroimidazolyl, piperidyl, morpholinyl, thiomorpholinyl, piperazil, virazolidyl, imidazolidinyl, Examples include pyrrolidinyl, oxazolidinyl, thiazolidinyl, azepanyl, homopiperazinyl, tetrahydrofuranyl, tetrahydrobiranyl, tetrahydropyrimidinyl, chromanyl, dioxoral, homomorpholinyl and the like. Preferred are pyrrolidyl, piperidyl, morpholinyl, thiomorpholinyl, piperazinyl, azepanyl, and homopiperazinyl.
- the "nitrogen-containing heterocycle" formed by combining R 2 and R 3 together with a nitrogen atom and a carbon atom is the above-mentioned "heterocycle”
- a heterocycle having one or more nitrogens for example, pyridyl, pyridazyl, pyrimidyl, pyrajur, pyrrolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, thiadiazolyl, imidazolyl, triazolyl, tetrazolyl, benzoxazolyl Heteroaryl, dihydropyridyl, dihydropyrrolyl, dihydroxazolyl, dihydrothiazolyl, dihydroimidazolyl, piperidyl, monoreforinole, thiomonoreforinore, thiomonorephoryl Pipette Examples include radizyl, virazolidyl, imidazo
- R respectively may be substituted "cycloalkyl” and "heterocyclic group" of 1, each substituted in R 4, be O, "Ariru”, “cycloalkyl” and “heterocycloalkyl ring group", A and B or A a and B a , together with the carbon atom to which they are bonded, are each substituted !, but may be a “cycloalkyl ring” and “non-flavored” Group heterocycle ", R 2 and R 3 together with the nitrogen and carbon atoms to which they are bonded, are each substituted! , And R 7 , each of which may be substituted !, may! /, A substituent allowed in “aryl”, “cycloalkyl” and “heterocyclic group”, preferably from the following G 1 group: The groups to be selected are listed.
- G 1 group lower alkyl, lower alkenyl, halogeno lower alkyl, halogen, -CN, -NO, oxo, -OR 0 , -0-halogeno lower alkyl, -OC (0) R °, -OC (O) -Ariel,-OC (O)
- the two substituents are combined into 0-lower alkylene-0-.
- the aryl and hetero ring groups in the G 1 group may each be substituted with a group selected from the G 2 group.
- G 2 group Nono androgenic, lower alkyl, halogeno-lower alkyl, -OR 0, -0- halogeno-lower al Kill - N (R °), Okiso, and, two substituents together form - 0- lower alkylene -0-.
- the substituent that is permissible in comparison with the permissible substituent in “—S-lower alkylene- (substituted, may be aryl)” in R 3 is preferably selected from Group G 2 above. Group to be mentioned.
- R 7 may be each substituted, “lower alkyl”, “lower alkenyl” and “lower alkyl”, and each optionally substituted “lower alkylene”, “lower alkyl” in X 7
- Substituents acceptable for “-len” and “lower alkylene” Preferably to include groups selected from the following Group G 3.
- G 3 groups neurogen, -CN, -OR °, -O-halogeno lower alkyl, -0-lower alkylene-OR °, oxo, -SR °, -S (0) R °, -S (O) R °, -N (R °), -CO R °, -C (0) N (R °), -N (R °) C (0) R °, -N (
- the alkyl, aryl and hetero ring groups may each be substituted with a group selected from the G 2 group power.
- R 1 is preferably -N (R °)-(lower alkyl which may be substituted), an optionally substituted heterocyclic group, or a group represented by -X-R 4 , particularly Preferably, -N (lower alkyl), each of which is optionally substituted with halogen, lower alkyl, or -0-R °.
- Ophene pyridine, benzothiophene or furan, or a group represented by -X-R 4 .
- X is preferably -0-, -N (R °)-, -C (0) N (R °)-, -N (R °) C (0)-, -N (R °) S (0 -Or
- R 4 is preferably an aryl or heterocyclic group that may be substituted, and particularly preferably a halogen, lower alkyl, or phenyl that may be substituted with ⁇ 0-R °.
- a and B are preferably lower alkyl and lower alkenyl which may be the same or different and may be substituted, more preferably lower alkyl, and particularly preferably methyl.
- the ring formed by combining A and B together with the carbon atom to which they are bonded is preferably a cycloalkyl ring, particularly preferably a cyclobutyl ring or a cyclopentyl ring.
- R 2 is preferably lower alkyl or cycloalkyl, more preferably methyl or cyclopropyl.
- R 3 is preferably an optionally substituted aryl, more preferably an optionally substituted phenyl, and particularly preferably a halogen, lower alkyl or -0- substituted. It ’s a fuel.
- the nitrogen-containing heterocycle formed by combining R 2 and R 3 together with the nitrogen atom and carbon atom to which R 2 and R 3 are bonded is preferable.
- Another preferred embodiment is C
- a a and B a the same or different from each other, halogen, -R 7 , -OH, -OR 7 , -NH, -NHR 7 ,-
- OR 1 is not an aromatic heterocyclic group
- R 1 may be substituted aromatic heterocyclic group, -N (lower alkyl), -NH- (substituted
- a a and B a become isomers, which are combined and substituted with the carbon atom!
- the compound according to (3) which forms a cycloalkyl ring.
- R 1 is —C (0) NH- (substituted !, may! /, Phenol) or —C (0) N (lower alkyl)-(substituted, may be (Finyl).
- the compound according to (6) is —C (0) NH- (substituted !, may! /, Phenol) or —C (0) N (lower alkyl)-(substituted, may be (Finyl).
- R 2 and R 3 are combined to form a nitrogen atom and a carbon atom, and are bonded to each other to form a nitrogen-containing heterocycle (1) The described compound.
- R 2 and R 3 are substituted as a isomer !, may! /, Form C alkylene, these are
- the triazole derivative represented by the formula (I) may form a salt, and is included in the compound of the present invention as long as the salt is a pharmaceutically acceptable salt.
- inorganic salts such as hydrochloric acid, hydrobromic acid, hydroiodic acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, propionic acid, oxalic acid, malonic acid, succinic acid, fumaric acid, Acid addition salts with organic acids such as maleic acid, lactic acid, malic acid, tartaric acid, citrate, methanesulfonic acid, ethanesulfonic acid, p-toluenesulfonic acid, aspartic acid, glutamic acid, sodium, potassium, calcium, Ma Examples thereof include inorganic bases containing metals such as gnesium, addition salts with organic bases such as methylamine, ethylamine, ethanolamine, lysine, and orthotin, and ammonium salts.
- the compound of the present invention may contain an asymmetric carbon atom depending on the type of substituent, and optical isomers based on this may exist.
- the present invention encompasses all of these optical isomer mixtures and isolated ones.
- the compounds of the present invention may have tautomers, but the present invention includes a mixture of these isomers or a mixture thereof.
- a label that is, a compound obtained by substituting one or more atoms of the compound of the present invention with a radioactive isotope or a non-radioactive isotope is also included in the present invention.
- the present invention includes various hydrates and solvates of the compounds of the present invention and substances having crystal polymorphs.
- the compounds of the present invention include all of the derivatives represented by the formula (I) and pharmaceutically acceptable salts thereof, which are not limited to the compounds described in the Examples below. Is.
- the compound of the present invention includes all compounds that are metabolized in vivo and converted into the compound of the present invention, so-called prodrugs.
- the group that forms a prodrug of the compound of the present invention is described in “Progress in Medicine”, Life Science, Medica, 1985, 5 ⁇ , P.2157-2161. And the groups described in Yodogawa Shoten 1999 “Pharmaceutical Development”, 7th Molecular Design, pages 163-198.
- the compound of the present invention and a pharmaceutically acceptable salt thereof can be produced by applying various known synthetic methods using characteristics based on the basic skeleton or the type of substituent.
- a typical production method is illustrated below.
- it is effective in terms of production technology to replace the functional group with a suitable protecting group at the raw material or intermediate stage, that is, a group that can be easily converted to the functional group. There is a case. Thereafter, the protecting group can be removed as necessary to obtain the desired compound.
- functional groups include a hydroxyl group, a carboxyl group, and an amino group.
- protective groups for these functional groups include “Protective”, “Groups”, “In” and “Organic” by Greene and Wuts. 'Protective Groups in Organic Svnthesis' (USA), 3rd
- the protecting groups described in the edition of John Wiley & Sons, 1999, can be mentioned, and these may be used as appropriate according to the reaction conditions.
- L 1 represents a leaving group
- This production method is a method for producing the compound (I) of the present invention by a cyclization reaction between the compound (II) and the compound (III).
- the leaving group for L 1 include black mouth, promo, methoxy, methylsulfur and the like.
- Reactions include ethers such as tetrahydrofuran (THF), 1,4-dioxane, diglyme, alcohols such as methanol, ethanol, propanol, butanol, or ⁇ , ⁇ -dimethylformamide (DMF), dimethylimidazolidinone, dimethylacetate.
- the reaction can be performed in a solvent such as an aprotic polar solvent such as amide or DMSO at room temperature or under heating conditions.
- an acid such as acetic acid, organic acids such as ⁇ -toluenesulfonic acid, and mineral acids such as sulfuric acid and hydrochloric acid.
- This production method is a method for producing the compound (I) of the present invention by a compound (IV) force alkylation reaction.
- a compound (IV) force alkylation reaction In the alkylation reaction in this step, sodium hydride, potassium hydride, butyllithium, lithium diisopropylamide or the like can be used as the base, and the corresponding alkyl halide, dihalogen-alkane or the like can be used as the electrophilic reagent.
- the reaction may be carried out in a solvent such as ethers or aprotic polar solvents under cooling, at room temperature or under heating conditions. it can.
- phase transfer catalyst such as tetra-n-butylammodium.
- This production method is a method for producing the compound (I) of the present invention by cyclization reaction between the activated carboxylic acid derivative compound (V) and the compound (VI).
- the leaving group for L 2 include black mouth, bromo, fluoro, and acyloxy.
- the reaction can be carried out in a solvent such as ethers, alcohols or aprotic polar solvents at room temperature or under heating conditions.
- an acid such as an organic acid such as acetic acid or P-toluenesulfonic acid, or a mineral acid such as sulfuric acid or hydrochloric acid.
- This production method is a method for producing the compound (1-1) of the present invention in which R 3 is —S-lower alkylene- (which may be substituted or aryl).
- This step is a step of producing compound (VIII) by addition reaction of compound (II) and compound (VII).
- the reaction can be carried out in a solvent such as alcohols or ethers at room temperature or under heating conditions.
- This step is a step for producing compound (IX) by cyclization reaction of compound (VIII).
- the reaction can be carried out under heating conditions in an aqueous solution of sodium hydroxide, potassium hydroxide or the like.
- This step is a step for producing the present compound (1-1) by a substitution reaction of the compound (IX).
- the leaving group for L 3 include black mouth, bromo, iodine, methanesulfoloxy, p-toluenesulfonyloxy, and the like.
- the reaction is carried out in the presence of a base such as sodium methoxide, sodium ethoxide, sodium carbonate, potassium carbonate, cesium carbonate, sodium hydride or potassium hydride in ethers or solvents such as aprotic polar solvents and alcohols.
- the raw material used for the production of the compound of the present invention can be produced, for example, by applying a method described in Reference Examples described later, a known method, a method obvious to those skilled in the art, or a modification thereof.
- the compound of the present invention produced as described above is isolated or purified as a salt by leaving it free or subjecting it to a salt formation treatment by a conventional method. Isolation 'purification, extraction, concentration, evaporation, crystallization
- racemic mixtures are diastereoisomeric with common optically active acids such as tartaric acid.
- a general racemic resolution method such as a method of leading to a mercer salt and optical resolution, it can be converted into an optically pure foreign substance.
- the diastereomeric mixture can be separated by, for example, fractional crystallization or various types of chromatography.
- An optically active compound can also be produced by using an appropriate optically active raw material.
- a pharmaceutical composition containing the compound of the present invention or one or more of pharmaceutically acceptable salts thereof as an active ingredient comprises a carrier carrier, excipient, and other additives for commonly used formulations. It is prepared into tablets, powders, fine granules, granules, capsules, pills, solutions, injections, suppositories, ointments, patches, etc. and administered orally or parenterally.
- the clinical dose of the compound of the present invention for humans is appropriately determined in consideration of the symptoms, body weight, age, sex, etc. of the patient to which it is applied.
- the daily dose is usually about 0.0001 per body weight. ⁇ 50 mg / kg, preferably about 0.001 to 10 mg / kg, more preferably 0.01 to 1 mg / kg, which is administered once or divided into 2 to 4 times.
- the daily dose is about 0.0001 to 1 mg / kg per body weight, preferably about 0.0001 to 0.1 mg / kg, and is administered once to several times a day. Since the dosage varies depending on various conditions, it may be less than the above dosage range!
- Tablets, powders, granules and the like are used as the solid composition for oral administration according to the present invention.
- one or more active substances are present in at least one inert diluent such as lactose, mannitol, glucose, hydroxypropyl cellulose, microcrystalline cellulose, starch, poly Mixed with bull pyrrolidone, magnesium metasilicate aluminate, etc.
- the composition contains additives other than inert diluents, for example, lubricants such as magnesium stearate, disintegrating agents such as calcium calcium glycolate, stabilizers, solubilizing agents and the like according to conventional methods. It may be. If necessary, tablets or pills may be coated with sugar coating such as sucrose, gelatin, hydroxypropylcellulose, hydroxypropylmethylcellulose phthalate, or a gastric or enteric film.
- Liquid compositions for oral administration include pharmaceutically acceptable emulsions, solutions, suspensions, syrups, elixirs and the like, commonly used inert diluents, For example, purified water and ethanol (EtOH) are included.
- This composition contains a wetting agent, a suspension, as well as an inert diluent.
- Adjuvants such as turbidity agents, sweetening agents, flavoring agents, fragrances, and preservatives may be contained.
- Injections for parenteral administration include sterile aqueous or non-aqueous solutions, suspensions, and emulsions. Examples of aqueous solutions and suspensions include distilled water for injection and physiological saline.
- non-aqueous solutions and suspensions examples include propylene glycol, polyethylene glycol, vegetable oils such as olive oil, alcohols such as EtOH, and polysorbate 80.
- a composition may further contain auxiliary agents such as preservatives, wetting agents, emulsifiers, dispersants, stabilizers, and solubilizing agents. These are sterilized, for example, by filtration through a bacteria-retaining filter, blending with a bactericide, or irradiation. These can also be used by producing a sterile solid composition and dissolving it in sterile water or a sterile solvent for injection before use.
- the raw material compound used in the examples includes a new substance, and a method for producing such raw material compound force will be described as a reference example.
- the number in front of the substituent indicates the position of substitution, and for example, 2-Me-3-C ⁇ Ph represents 2-methyl-3-chlorophenol.
- Syn made Production method (numbers indicate production using corresponding raw materials in the same manner as the example compound having the number as an example number), RSyn: production method (having the number as a reference example number) It shows that it was manufactured using the corresponding raw material in the same manner as the Reference Example Compound.)
- 1,3-Dibu-Mole 2-propanol, dimethoxymethane, and boron trifluoride jetyl ether complex were reacted in methylene chloride at room temperature to obtain 1,3-dibromo-2- (methoxymethoxy) pronone.
- Ethyl 2-propyl-2- (2-chenyl) pentanoate was obtained by reacting ethyl 2-phenylacetate with 1-propyl iodide in the presence of sodium hydride in DMF at room temperature.
- Acetyl 2-amino-lino-2-methylpropanoate was obtained by reacting a phosphorus, ethyl bromoisobutyrate, and potassium carbonate in DMF at 90 ° C.
- Ethyl 1 pyridine-4-ylcyclopentanecarboxylate and benzyl bromide were reacted in acetonitrile with superheating.
- Ethyl 1 (1-benzylpiperidine mono-4-yl) cyclopentanecarboxylate was obtained by reacting the residue obtained by distilling off the reaction solution under reduced pressure with triethylamine and acid-platinum in ethanol under a hydrogen atmosphere. Obtained.
- 1-aminocyclopentanecarbonitryl was obtained by reacting a phosphorus, cyclopentanone and trimethylsilaneacetonitrile in acetic acid.
- N- (1-Cyanocyclopentyl) N-phenylformamide was obtained by heating 1 aminocyclopentane-powered L-po-tolyl to a solution obtained by heating and stirring acetic anhydride and formic acid.
- N-methyl-2- (trifluoromethyl) benzamide was obtained by reacting 2- (trifluoromethyl) benzoyl chloride and methylamine (2M, THF solution) in chloroform at room temperature.
- N-cyclopropyl-4-hydroxybenzamide was obtained by stirring 4-hydroxybenzenecarboxylic acid, WSC 'hydrochloride, HOBt' hydrate and cyclopropylamine in DMF at room temperature.
- Reference Example 33 4-Methoxy-1- (phenylsulfonyl) -1,2,3 by dissolving 4- (phenylsulfol) -2-piperazinone in dichloromethane, adding tetramethyloxy-tetrafluoroborate and stirring. , 6-Tetrahydrovirazine was obtained.
- N, 2-dimethylbenzamide, thiol chloride, and a catalytic amount of DMF were reacted in methylene chloride under caloric heat.
- the residue obtained by evaporating the reaction solution under reduced pressure and tert butyl (2-hydra) Dino 1, 1 dimethyl-2-oxoethyl) carbamate is reacted in toluene under heating to produce tert butyl ⁇ 1 -methyl 1— [4 methyl 5— (2 methylphenol) —1, 2, 4 triazole Ill] Ye Chil ⁇ carbamates.
- the organic layer was washed successively with a saturated aqueous sodium hydrogen carbonate solution and a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered, and the solvent was removed under reduced pressure.
- the organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered, and then the solvent was distilled off under reduced pressure.
- Xylene (15 ml) and p-toluenesulfonic acid monohydrate (118 mg) were added to the obtained residue, and the mixture was stirred at 130 ° C. for 14 hours. After adding the reaction solution and black mouth form to a saturated aqueous solution of sodium hydrogen carbonate, the organic layer was separated.
- Benzyltriphenylphosphorobromide (1.15 g) was suspended in THF (30 ml), and n-butyllithium (1.60 M hexane solution, 1.50 ml) was added under ice-cooling and stirred at room temperature for 30 minutes. .
- To the reaction solution add 2- (5- (2 black mouth)) — 4-methyl-1,2,4 triazol-3-yl] 2 methylpropanal (633 mg) in THF (20 ml) dropwise. The mixture was stirred for 20 hours while heating under reflux.
- the reaction solution was entented with water (50 ml) and extracted with ethyl acetate (50 ml ⁇ 2).
- Example 40 1-(1 benzylpiperidine mono 4-yl) cyclopentane mono carbohydrazide (1.04 g) and 8-methoxy mono 2, 3, 4, 5, 6, 7 hexahydroazocine (1.46 g) in toluene ( In 10 ml) under heating to produce 3- [1 (1 benzil 4-piberidyl) cyclopentyl] —5, 6,7,8,9, 10 hexahydro [1,2,4] triazolo [4 , 3-a] azosin (0.686 g) was obtained.
- Methyl 4- [5- (1-Alino-1-methylethyl) -4-methyl-4H-1,2,4-triazol-3-yl] benzoate 300 mg was suspended in methanol (1 ml) Methylamine (30% methanol solution, 886.3 mg) was added, and the mixture was stirred at room temperature overnight. The resulting precipitate was collected by filtration to give 4- [5- (1-anilino-1-methylethyl) -4-methyl-4H-1,2,4-triazol-3-yl] -N-methylbenzamide ( 349 mg of white crystals were obtained.
- Example 48 N- (1- ⁇ 5- [4- (Benzyloxy) -3-chlorophine]-4-methyl-4H- 1,2,4-triazole-3-yl 1-methylethyl) aryl (925 mg) in methanol (10 ml) was added with palladium hydroxide, and the mixture was vigorously stirred under an atmospheric hydrogen atmosphere for 2 hours. The mixture was filtered through Celite using dioxane (150 ml), methanol (150 ml), and black mouth form (150 ml), and the solvent was evaporated to give a white solid.
- Cyclobutyl benzoate (487mg) was dissolved in 1-propanol (40ml), and [1,1,1bis (diphenylphosphino) pheucene] dichloropalladium ( ⁇ ) dichloromethane complex (82mg), potassium butyltrifluorovo The rate (402 mg) and triethylamine (0.14 ml) were added, and the mixture was heated to reflux for 15 hours under a nitrogen stream.
- the residue was dissolved in acetic acid (8 ml), N-chlorosuccinimide (150 mg) was added, and the mixture was stirred at 80 ° C. for 5 hours.
- the reaction solution was diluted with chloroform (40 ml) and washed with water (10 ml), 1M aqueous sodium hydroxide solution (10 ml) and saturated brine (10 ml).
- Cis-3— (5, 6, 7, 8, 9, 10 hexahydro [1, 2, 4] triazolo [4,3 a] azosin 3 yl) 3— (5 bi-ru 2 chalc) cyclobutanol (112 mg) was dissolved in methanol (10 ml), 10% palladium-carbon powder (20 mg) was added, Stir at temperature for 1 hour. The catalyst was filtered off through celite filtration, washed with methanol, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (methanol: chloroform 2: 98), and the resulting solid was washed with jetyl ether to give cis-3- (5-ethinole-2-phenol. ) 3— (5, 6, 7, 8, 9, 10 Hexahydro [1,2,4] triazolo [4,3-a] azosin-3-yl) cyclobutanol (white solid) was obtained in an amount of 90 mg.
- reaction solution was diluted with water (15 ml) and extracted with ethyl acetate (15 ml). The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, filtered, and the solvent was evaporated under reduced pressure.
- Tables 47 to 54 below show structures of other compounds of the present invention. These can be easily produced by using the production methods described above, the methods described in the examples, methods obvious to those skilled in the art, or variations thereof.
- the compound of the present invention has an excellent 11 j8-HSD1 inhibitory action, hyperglycemia, insulin resistance, obesity, hyperlipidemia, hypertension, osteoporosis, glaucoma, and cognitive function related to 11-HSD1 are involved. It is useful as a prophylactic / therapeutic agent for diseases such as lowering, especially diabetes and insulin resistance.
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Abstract
Description
Claims
Priority Applications (6)
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EP05783391A EP1790641A4 (en) | 2004-09-16 | 2005-09-14 | DERIVATIVE OF TRIAZOLE OR SALT OF SAID DERIVATIVE |
MX2007003161A MX2007003161A (es) | 2004-09-16 | 2005-09-14 | Derivado de triazol o una sal del mismo. |
JP2006535163A JP4882748B2 (ja) | 2004-09-16 | 2005-09-14 | トリアゾール誘導体またはその塩 |
CN2005800304576A CN101014578B (zh) | 2004-09-16 | 2005-09-14 | 三唑衍生物或其盐 |
CA2580409A CA2580409C (en) | 2004-09-16 | 2005-09-14 | Triazole derivative or salt thereof |
US11/663,089 US7776897B2 (en) | 2004-09-16 | 2005-09-14 | Triazole derivative or salt thereof |
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WO2007105753A1 (ja) | 2006-03-16 | 2007-09-20 | Astellas Pharma Inc. | トリアゾール誘導体またはその塩 |
WO2007128761A2 (de) | 2006-05-04 | 2007-11-15 | Boehringer Ingelheim International Gmbh | Verwendungen von dpp iv inhibitoren |
WO2008078725A1 (ja) * | 2006-12-26 | 2008-07-03 | Daiichi Sankyo Company, Limited | チアゼピン誘導体 |
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US7579360B2 (en) | 2005-06-09 | 2009-08-25 | Bristol-Myers Squibb Company | Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
WO2010001946A1 (ja) * | 2008-07-03 | 2010-01-07 | アステラス製薬株式会社 | トリアゾール誘導体またはその塩 |
JP2011520884A (ja) * | 2008-05-13 | 2011-07-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Cb2受容体を変調するスルホン化合物 |
US8119658B2 (en) | 2007-10-01 | 2012-02-21 | Bristol-Myers Squibb Company | Triazolopyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
WO2012033070A1 (ja) | 2010-09-07 | 2012-03-15 | アステラス製薬株式会社 | 疼痛治療剤 |
WO2012144478A1 (ja) | 2011-04-19 | 2012-10-26 | 第一三共株式会社 | テトラヒドロチアゼピン誘導体 |
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Publication number | Priority date | Publication date | Assignee | Title |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3907821A (en) | 1974-11-20 | 1975-09-23 | Upjohn Co | 2-{8 3-{8 1-(DIMETHYLAMINO)CYCLOPROPYL{8 -4H-1,2,4-triazol-4-yl{8 {0 benzophenone |
WO2003065983A2 (en) * | 2002-02-01 | 2003-08-14 | Merck & Co., Inc. | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia |
WO2003104207A2 (en) * | 2002-06-10 | 2003-12-18 | Merck & Co., Inc. | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia |
WO2005044192A2 (en) * | 2003-10-28 | 2005-05-19 | Amgen Inc. | Triazole compounds and uses related thereto |
EP1798226A1 (en) | 2004-08-04 | 2007-06-20 | Taisho Pharmaceutical Co., Ltd | Triazole derivative |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4577020A (en) * | 1983-01-25 | 1986-03-18 | The Upjohn Company | Aminoalkyl and aminoalkenyl triazoles as anti-psychotic agents |
US4481360A (en) * | 1983-08-26 | 1984-11-06 | The Upjohn Company | 4H-1,2,4-Triazol-3-yl compounds |
IL84093A (en) * | 1986-10-09 | 1992-09-06 | Ciba Geigy Ag | Aralkyl-4h-1,2,4-triazole derivatives,their preparation and pharmaceutical compositions containing them |
IL109770A0 (en) | 1993-05-29 | 1994-11-28 | Smithkline Beecham Corp | Thermal infusion process for preparing controlled release solid dosage forms of medicaments for oral administration and controlled release solid dosage forms of medicaments prepared thereby |
JP2001089758A (ja) * | 1999-09-21 | 2001-04-03 | Konica Corp | 露光量表示材料及び温度積算表示材料 |
JP4373033B2 (ja) * | 2000-07-06 | 2009-11-25 | 富士フイルム株式会社 | ピラゾロ[3,2−c]−1,2,4−トリアゾール化合物、1,2,4−トリアゾロ[3,4−b]チアジアジン化合物、及びその合成法 |
US7173040B2 (en) * | 2000-09-25 | 2007-02-06 | Janssen Pharmaceutica N.V. | Farnesyl transferase inhibiting 6-[(substituted phenyl)methyl]-quinoline and quinazoline derinazoline derivatives |
CN1894241A (zh) | 2002-08-09 | 2007-01-10 | 阿斯利康(瑞典)有限公司 | 作为代谢型谷氨酸受体-5调节剂的“1,2,4” 噁二唑 |
JO2397B1 (en) | 2002-12-20 | 2007-06-17 | ميرك شارب اند دوم كوربوريشن | Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors |
DK1615647T3 (da) | 2003-04-11 | 2010-04-06 | High Point Pharmaceuticals Llc | Farmaceutisk anvendelse af kondenserede 1,2,4-triazoler |
WO2004089367A1 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | Pharmaceutical use of substituted 1,2,4-triazoles |
ATE482747T1 (de) | 2003-04-11 | 2010-10-15 | High Point Pharmaceuticals Llc | Neue amide derivate und deren pharmazeutische verwendungen |
EP1638947B1 (en) * | 2003-05-29 | 2010-08-04 | Merck Sharp & Dohme Corp. | Triazole derivatives as inhibitors of 11-beta hydroxysteroid dehydrogenase-1 |
JP2005170939A (ja) | 2003-11-20 | 2005-06-30 | Takeda Chem Ind Ltd | 糖尿病の予防・治療剤 |
US7507832B2 (en) | 2003-12-22 | 2009-03-24 | Eli Lilly And Company | Triazole PPAR modulators |
RU2008140940A (ru) * | 2006-03-16 | 2010-04-27 | Астеллас Фарма Инк. (Jp) | Производное триазола или его соль |
-
2005
- 2005-09-14 CN CN2005800304576A patent/CN101014578B/zh not_active Expired - Fee Related
- 2005-09-14 WO PCT/JP2005/016896 patent/WO2006030805A1/ja active Application Filing
- 2005-09-14 CA CA2580409A patent/CA2580409C/en not_active Expired - Fee Related
- 2005-09-14 MX MX2007003161A patent/MX2007003161A/es active IP Right Grant
- 2005-09-14 US US11/663,089 patent/US7776897B2/en not_active Expired - Fee Related
- 2005-09-14 EP EP05783391A patent/EP1790641A4/en not_active Withdrawn
- 2005-09-14 KR KR1020077008448A patent/KR101214665B1/ko not_active IP Right Cessation
- 2005-09-14 JP JP2006535163A patent/JP4882748B2/ja not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3907821A (en) | 1974-11-20 | 1975-09-23 | Upjohn Co | 2-{8 3-{8 1-(DIMETHYLAMINO)CYCLOPROPYL{8 -4H-1,2,4-triazol-4-yl{8 {0 benzophenone |
WO2003065983A2 (en) * | 2002-02-01 | 2003-08-14 | Merck & Co., Inc. | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia |
WO2003104207A2 (en) * | 2002-06-10 | 2003-12-18 | Merck & Co., Inc. | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia |
WO2003104208A1 (en) * | 2002-06-10 | 2003-12-18 | Merck & Co., Inc. | 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia |
WO2005044192A2 (en) * | 2003-10-28 | 2005-05-19 | Amgen Inc. | Triazole compounds and uses related thereto |
EP1798226A1 (en) | 2004-08-04 | 2007-06-20 | Taisho Pharmaceutical Co., Ltd | Triazole derivative |
Non-Patent Citations (4)
Title |
---|
LINDSAY R S. ET AL., THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 88, 2003, pages 2738 - 2744 |
MASUZAKI H. ET AL., SCIENCE, vol. 294, 2001, pages 2166 - 2170 |
RASK E. ET AL., THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 86, 2001, pages 1418 - 1421 |
See also references of EP1790641A4 * |
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Also Published As
Publication number | Publication date |
---|---|
EP1790641A1 (en) | 2007-05-30 |
JP4882748B2 (ja) | 2012-02-22 |
MX2007003161A (es) | 2007-05-16 |
EP1790641A4 (en) | 2009-08-26 |
US7776897B2 (en) | 2010-08-17 |
CN101014578A (zh) | 2007-08-08 |
KR101214665B1 (ko) | 2012-12-21 |
KR20070058613A (ko) | 2007-06-08 |
JPWO2006030805A1 (ja) | 2008-05-15 |
CA2580409A1 (en) | 2006-03-23 |
US20070259854A1 (en) | 2007-11-08 |
CN101014578B (zh) | 2011-01-19 |
CA2580409C (en) | 2013-08-13 |
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