WO2005120358A1 - 弾性画像表示方法及び超音波診断装置 - Google Patents
弾性画像表示方法及び超音波診断装置 Download PDFInfo
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- WO2005120358A1 WO2005120358A1 PCT/JP2005/010567 JP2005010567W WO2005120358A1 WO 2005120358 A1 WO2005120358 A1 WO 2005120358A1 JP 2005010567 W JP2005010567 W JP 2005010567W WO 2005120358 A1 WO2005120358 A1 WO 2005120358A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0048—Detecting, measuring or recording by applying mechanical forces or stimuli
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- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
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- A61B8/42—Details of probe positioning or probe attachment to the patient
- A61B8/4272—Details of probe positioning or probe attachment to the patient involving the acoustic interface between the transducer and the tissue
- A61B8/4281—Details of probe positioning or probe attachment to the patient involving the acoustic interface between the transducer and the tissue characterised by sound-transmitting media or devices for coupling the transducer to the tissue
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- A61B8/461—Displaying means of special interest
- A61B8/463—Displaying means of special interest characterised by displaying multiple images or images and diagnostic data on one display
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- A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
- A61B8/5238—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for combining image data of patient, e.g. merging several images from different acquisition modes into one image
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
- G01S15/00—Systems using the reflection or reradiation of acoustic waves, e.g. sonar systems
- G01S15/88—Sonar systems specially adapted for specific applications
- G01S15/89—Sonar systems specially adapted for specific applications for mapping or imaging
- G01S15/8906—Short-range imaging systems; Acoustic microscope systems using pulse-echo techniques
- G01S15/8909—Short-range imaging systems; Acoustic microscope systems using pulse-echo techniques using a static transducer configuration
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
- G01S15/00—Systems using the reflection or reradiation of acoustic waves, e.g. sonar systems
- G01S15/88—Sonar systems specially adapted for specific applications
- G01S15/89—Sonar systems specially adapted for specific applications for mapping or imaging
- G01S15/8906—Short-range imaging systems; Acoustic microscope systems using pulse-echo techniques
- G01S15/899—Combination of imaging systems with ancillary equipment
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- G—PHYSICS
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- G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
- G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
- G01S7/52—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00
- G01S7/52017—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00 particularly adapted to short-range imaging
- G01S7/52023—Details of receivers
- G01S7/52036—Details of receivers using analysis of echo signal for target characterisation
- G01S7/52042—Details of receivers using analysis of echo signal for target characterisation determining elastic properties of the propagation medium or of the reflective target
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- G01—MEASURING; TESTING
- G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
- G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
- G01S7/52—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00
- G01S7/52017—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00 particularly adapted to short-range imaging
- G01S7/52053—Display arrangements
- G01S7/52057—Cathode ray tube displays
- G01S7/52074—Composite displays, e.g. split-screen displays; Combination of multiple images or of images and alphanumeric tabular information
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- A61B90/36—Image-producing devices or illumination devices not otherwise provided for
- A61B90/37—Surgical systems with images on a monitor during operation
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- A61B8/42—Details of probe positioning or probe attachment to the patient
- A61B8/4272—Details of probe positioning or probe attachment to the patient involving the acoustic interface between the transducer and the tissue
- A61B8/429—Details of probe positioning or probe attachment to the patient involving the acoustic interface between the transducer and the tissue characterised by determining or monitoring the contact between the transducer and the tissue
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- A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
- A61B8/445—Details of catheter construction
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- A61B8/5223—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for extracting a diagnostic or physiological parameter from medical diagnostic data
Definitions
- the present invention relates to an elastic image display method and an ultrasonic diagnostic apparatus that indicate the hardness or softness of a living tissue at a diagnostic site in ultrasonic diagnosis.
- An ultrasonic diagnostic apparatus transmits an ultrasonic wave into an object using an ultrasonic probe, receives a reflected echo signal of an ultrasonic wave corresponding to the structure of a living tissue from inside the object, and performs, for example, a B-mode operation.
- a tomographic image such as an image is constructed and displayed for diagnosis.
- ultrasonic image data is measured by applying a compressive force to a subject by a manual technique or a mechanical method, and is generated by compression based on two ultrasonic image data having different measurement times. It has been proposed to determine the displacement of each part of the living body and generate an elastic image representing the hardness or softness of the living tissue based on the displacement data of each part of the living body.
- a pressure sensor is provided behind the transducer element portion of the ultrasonic probe, the pressure applied to the ultrasonic probe by pressing the subject is obtained, the Young's modulus is obtained, and the elasticity image is obtained. Display. When the pressure exceeds a certain pressure threshold, the light emitting diode provided in the probe emits light.
- Such a measurement method is described in the patent document ⁇ JP2003_225239A.
- FIGS. Fig. 1 (A) shows an example of an image when compression is appropriate, in which hard tissue areas are displayed as black circles and other soft tissue areas are displayed in white.
- Fig. 1 (B) shows an example of an image in the case of excessive compression.Distortion also occurs in the black circle, which is a hard tissue area, and the boundary with the surrounding soft tissue area becomes unclear. Also, the contrast of the image is reduced.
- Figure 1 (C) shows an example of the image when the compression is insufficient. Since sufficient stress does not act on the living tissue, a point with zero strain (which is recognized as hard) even in a soft tissue region that is uniformly soft. Parts) are scattered, resulting in an inhomogeneous image.
- the present invention has been made in view of the above points, and has as its object to enable an objective or definitive diagnosis based on an elasticity image, regardless of experience or skill.
- the elastic image display method measures ultrasonic tomographic data of a tomographic part of the subject by applying pressure to the subject, A physical quantity correlated with the elasticity of the tissue at the tomographic site is determined based on the cross-sectional data, an elasticity image at the tomographic site is generated based on the physical quantity and displayed on a display device, and the pressure applied to the subject is measured. Compression state information relating to the compression state of the tomographic region is obtained based on the compression state information, and the compression state information is displayed on the display device together with the elasticity image.
- the physical quantity correlated with elasticity is one of tissue strain and elastic modulus
- the elastic image can be any one of strain image and elastic modulus image.
- the pressure applied to the subject can be applied by a compression member provided on the ultrasonic probe used in contact with the subject. In this case, the pressure can be measured by either the pressure sensor provided on the compression member or the pressure detecting means of the reference deformable body. it can.
- the displacement of the tissue at the tomographic site can be determined based on two ultrasonic tomographic data measured at different times, and the pressure applied to the subject can be determined based on the displacement data.
- the elasticity image display method of the first aspect of the present invention it is possible to simultaneously provide the examiner with the elasticity image and the compression state.
- the compression state information correlated with the pressure applied to the subject is displayed together with the elasticity image, so the examiner can determine the compression conditions (appropriate compression, insufficient compression, excessive compression) based on the displayed compression state information.
- the diagnosis can be made based on the elasticity image measured under appropriate compression. As a result, an objective or definitive diagnosis can be made regardless of experience or skill.
- the compression state information displayed on the display device changes according to the temporal change of the pressure applied to the subject.
- the pressure applied to the subject can be applied via an ultrasonic probe used in contact with the subject.
- it is determined whether or not the pressure applied to the subject is within the set range based on the compression state information, and when the pressure is out of the set range, an alarm to that effect is given by sound and image display.
- It is preferable to output by at least one. This allows the examiner to adjust the amount of compression applied via the ultrasonic probe to the proper range according to the method used.
- This image may be displayed using graphics such as a downward arrow or an upward arrow, blue in the case of appropriate compression, red in the case of excessive compression, yellow in the case of insufficient compression, or as audio. You can use "press less” or "increase more".
- the compression state information is pressure distribution data obtained in association with a long axis direction which is an arrangement direction of a plurality of transducers constituting the ultrasonic probe, and this pressure distribution data is
- the elasticity image can be displayed on the display device by a bar graph or a diagram in accordance with the coordinate direction corresponding to the major axis direction of the ultrasonic probe.
- a deviation of the pressure distribution data from the reference pressure can be obtained, and the deviation can be displayed on a display device in a diagram in accordance with the coordinate direction corresponding to the longitudinal direction of the ultrasonic probe in the elasticity image.
- the examiner has a bias in the amount of compression that can be obtained through the ultrasonic probe by the use method. Since it is possible to recognize that, the amount of compression can be adjusted uniformly.
- the pressure data includes a numerical value, a bar graph having a length corresponding to the numerical value, a graphic with luminance or hue corresponding to the numerical value, a luminance having a length corresponding to the numerical value and corresponding to the numerical value.
- a bar graph with a hue a simulated meter that represents the numerical value by the rotation angle of the needle, a circular figure having the diameter of the numerical value, and a figure that simulates the state of the compressive deformation of the tomographic part by displaying the numerical value.
- a bar graph, simulation meter, or circular figure it is easier to objectively recognize the amount of compression by displaying the numerical scale of the pressure data together.
- the logarithmic scale can be adopted as a numerical scale because the change in the compression state may be large depending on the examination site.
- the numerical scale of the pressure data can be displayed in association with the luminance or hue.
- the elasticity image display method measures ultrasonic tomographic data of a tomographic portion of the subject while repeatedly applying pressure to the subject, and based on the ultrasonic tomographic data.
- a physical quantity correlated with the elasticity of the tissue at the tomographic part is obtained, an elasticity image at the tomographic part is generated and displayed on a display device based on the physical quantity, and a time change of the pressure applied to the tomographic part is obtained.
- the change diagram may be displayed on the display device together with the elasticity image.
- the pressure change diagram in this case is the average, variance, median, and maximum values of the pressure distribution obtained in association with the long axis direction, which is the arrangement direction of the multiple transducers that make up the ultrasonic probe. , At least one of the minimum values.
- a reference diagram which serves as a model of the time change of the pressure applied to the fault site, on the display device so as to overlap the pressure change diagram.
- the examiner can adjust the compression operation applied via the ultrasonic probe to a proper state by the use method.
- the pressure change diagram and the elasticity image are stored in the cine memory, and when displaying the pressure change diagram and the elasticity image read from the cine memory, a mark is placed on the time axis of the pressure change diagram. When the mark is displayed and the mark is moved along the time axis, an elastic image corresponding to the time of the mark can be displayed.
- the pressure change diagram and the elasticity image are frozen, the start point and the end point of one cycle of the pressure change are set in the pressure change diagram, and the pressure change diagram and the elasticity for one set cycle are set.
- the start point and end point of one cycle of pressure change can be set automatically.
- the ultrasonic diagnostic apparatus that implements the elasticity image display method of the present invention generates a tomographic image and an elasticity image by processing a signal detected by an ultrasonic probe abutting on a subject.
- Signal processing means pressure detection means for obtaining pressure applied to the subject, compression state evaluation means for evaluating the compression state of the subject based on pressure data obtained by the pressure detection means,
- a display means for displaying the compression state information evaluated by the compression state evaluation means in association with the elasticity image can be provided.
- the cine memory includes a cine memory for storing the pressure change diagram and the elasticity image, and control means for controlling the cine memory.
- the control unit includes the pressure change diagram read from the cine memory and the cine memory.
- a mark is displayed on the time axis of the pressure change diagram, and when the mark is moved along the time axis, an elastic image corresponding to the time of the mark is displayed.
- the information can be read out from the cine memory and displayed.
- control means freezes the pressure change diagram and the elasticity image, sets a start point and an end point of one cycle of the pressure change in the pressure change diagram, and sets the pressure for the set one cycle.
- the change diagram and the elasticity image can be stored in a recording medium. This makes it possible to select the appropriate compression operation elasticity image from among the elasticity images stored in the cine memory while checking the information reflecting the time-dependent change in the magnitude of the pressure data, making it optimal for diagnosis. It is possible to artificially select and save a range of various compression states.
- the control means can automatically set a start point and an end point of one cycle of pressure change. According to this, it is necessary to automatically detect and select the beginning and end of an appropriate compression period, that is, one cycle of an appropriate compression operation, save the elastic image group for this one cycle, and check it later. Power s can.
- FIG. 1 is a diagram illustrating that an elasticity image depends on the degree of compression.
- FIG. 2 is a block diagram showing an embodiment of an ultrasonic diagnostic apparatus according to the present invention.
- FIG. 3 is a view showing an embodiment of an ultrasonic probe equipped with a compression plate.
- FIG. 4 is a view showing an embodiment of an ultrasonic probe provided with a pressure detecting means.
- FIG. 5 is a block diagram showing an embodiment of a compression state evaluation unit according to a feature of the present invention.
- FIG. 6 is a diagram showing a pressure sensor group in which a number of pressure sensors are arranged on a compression board.
- FIG. 7 is a diagram showing compression state information imaged as a bar graph.
- FIG. 8 is a diagram showing that the length of a bar graph indicating compression state information at the current time changes according to the compression strength.
- FIG. 9 is a diagram showing an example of a display image in which compression state information and an elasticity image of a bar graph image are simultaneously displayed.
- FIG. 10 is a diagram showing an example in which a longitudinal axis pressure distribution of an ultrasonic probe is displayed in association with an elasticity image.
- FIG. 11 is a diagram showing an example in which compression state information is displayed as a figure simulating the state of compression deformation of a subject.
- FIG. 12 is a diagram showing examples of various display methods of pressure data of compression state information.
- FIG. 13 is a view showing a modification of the display image of the compression state information.
- FIG. 14 is a diagram showing a modification in the case where pressure data of compression state information is displayed using a bar graph.
- FIG. 15 is a diagram showing an example in which a time change of the compression state from the past to the present is displayed by a pressure change diagram.
- FIG. 16 A diagram showing an example of displaying an example of a compression operation on the pressure change diagram of the compression state in FIG. It is.
- Garden 17 is a diagram showing an example in which inappropriate compression is detected and fed back to the examiner.
- FIG. 18 is a diagram showing another display example when the pressure range is in an appropriate compression range.
- FIG. 22 is a diagram showing an example of a case where an appropriate compression state period is set in a pressure range and an elastic image group in that range is set as a storage range.
- Garden 23 is a diagram showing an example of a detection method when automatically detecting one cycle of an appropriate compression state.
- FIG. 24 is a diagram showing another display example when the pressure range is appropriate, insufficient, or excessive.
- FIG. 26 A diagram showing an example in which the absolute pressure distribution in the major axis direction of the ultrasonic probe and the pressure change distribution corresponding to the change in the magnitude of the pressure are displayed in a bar graph in association with the elasticity image.
- FIG. 27 A diagram showing an example in which a stress distribution and a pressure change distribution in the major axis direction of the ultrasonic probe at a stress line of interest set on the image are displayed in a bar graph in correspondence with the elasticity image.
- FIG. 29 (a) is a sectional view of a cMUT vibrator.
- Garden 29 (b)] is a plan view of a vibrator in which a plurality of cMUT vibrators are arranged.
- FIG. 30 An example of an in-body ultrasonic probe to which the pressure measurement means of a cMUT transducer is applied FIG.
- FIG. 31 (a) is a diagram showing another example of the in-vivo ultrasonic probe to which the pressure measuring means of the cMUT vibrator is applied.
- FIG. 31 (b) is a view for explaining the operation of the in-vivo ultrasonic probe of FIG. 31 (a).
- FIG. 32 is a view for explaining a fixing tool and a fixing method of the reference deformable body.
- FIG. 33 is a view showing another example of a method for fixing a reference deformable body.
- FIG. 34 is a view showing an example of a concave reference deformed body.
- FIG. 35 is an external view of an example in which a reference deformable body and a fixture thereof are integrally formed.
- FIG. 2 is a block diagram showing an embodiment of the ultrasonic diagnostic apparatus of the present invention.
- the ultrasonic diagnostic apparatus obtains a tomographic image of a diagnostic site of the subject 10 using ultrasonic waves, and displays an elastic image representing the hardness or softness of the living tissue of the subject 10.
- the ultrasonic diagnostic apparatus includes a probe 100, an ultrasonic transmission / reception control circuit 101, a transmission circuit 102, a reception circuit 103, a phasing addition circuit 104, a signal processing unit 105, It has a black-and-white scan computer 106, an image display 107, and a device control interface unit 116, and further includes an RF signal frame data selection unit 108, a displacement measurement unit 109, a pressure measurement unit 110, a distortion and elastic modulus. It includes an operation unit 111, an elasticity data processing unit 112, a color scan converter 113, a switching adder 114, a compression state evaluation unit 115, and a cine memory unit 117.
- the probe 100 transmits and receives ultrasonic waves to and from the subject 10 by performing beam scanning mechanically or electronically.
- a group of transducer elements that are a source of ultrasonic waves and receive reflected echoes are arranged in a line.
- the compression operation of the subject in elasticity imaging using ultrasonic waves is performed by an ultrasonic probe having a shape as shown in FIGS. 3 (A) and 3 (B).
- the compression plate 21 is brought into contact with the ultrasonic transmitting / receiving surface 1001 of the ultrasonic probe 100. Is used.
- the compression surface constituted by both the ultrasonic transmission / reception surface 1001 of the ultrasonic probe 100 and the compression plate 21 is brought into contact with the body surface of the subject 10, and the compression surface is manually moved up and down to receive the object.
- Compress sample 10 The method of doing it.
- the ultrasonic transmission / reception control circuit 101 controls the transmission and reception timing of ultrasonic waves.
- the transmission circuit 102 generates a transmission pulse for driving the probe 100 to generate an ultrasonic wave.
- the convergence point of the ultrasonic wave to be transmitted is set to a certain depth by a built-in transmission delay circuit.
- the receiving circuit 103 amplifies the signal of the reflected echo received by the probe 100 with a predetermined gain.
- the phasing addition circuit 104 inputs the reception signal amplified by the reception circuit 103, controls the phase, and phasing and adds the reception signals from one point or a plurality of convergence points.
- the signal processing unit 105 receives the received signal from the phasing addition circuit 104 and performs signal processing such as gain correction, log compression, detection, contour emphasis, and filter processing.
- the probe 100, the transmission circuit 102, the reception circuit 103, the phasing addition circuit 104, and the signal processing unit 105 constitute an ultrasonic transmission / reception means as a whole.
- a single tomographic image is obtained by scanning the tomographic region in the body of the subject 10 in a fixed direction with the beam.
- the signal processing unit 105 constitutes signal processing means for generating a tomographic image.
- the black-and-white scan converter 106 includes an A / D converter that converts a reflected echo signal, which is ultrasonic tomographic image data output from the signal processing unit 105, into a digital signal, and a digital signal generated by the A / D converter. It is composed of a plurality of frame memories that store the converted tomographic image data in time series, and a controller that controls these operations. That is, the reflected echo signal output from the signal processing unit 105 is fetched, and the RF signal frame data of the tomographic region is obtained at an ultrasonic cycle.
- the apparatus further includes tomographic scanning means for reading out the RF signal frame data in synchronization with the television and means for controlling the system.
- the image display 107 is a means for displaying time-series tomographic image data obtained by the monochrome scan converter 106. That is, a D / A converter that captures image data from the black-and-white scan converter 106 via the switching adder 114 and converts the captured image data into an analog signal, and an analog video signal from the DZA converter are input. And a color television monitor for displaying as an image.
- the RF signal frame data selection unit 108 and the displacement measurement unit 109 are provided branching from the output side of the phasing addition circuit 104.
- the pressure measurement unit 110 selects the RF signal frame data It is provided in parallel with the selection unit 108 and the displacement measurement unit 109.
- the strain and elastic modulus calculation unit 111 is provided at the subsequent stage of the pressure measurement unit 110 and the displacement measurement unit 109.
- the output of the distortion and elastic modulus calculation unit 111 is input to the elasticity data processing unit 112 so that elasticity image data is generated.
- the distortion and elastic modulus calculation unit 111 and the elasticity data processing unit 112 constitute a signal processing means for generating an elasticity image.
- the compression state evaluation unit 115 is provided by branching from the output side of the pressure measurement unit 110.
- the elasticity data processing unit 112 is provided at the subsequent stage of the strain and elastic modulus calculating unit 111.
- the color scan converter 113 is provided downstream of the elasticity data processing unit 112.
- a switching adder 114 is provided on the output side of the compression state evaluation unit 115, the color scan converter 113, and the black-and-white scan converter 106.
- the RF signal frame data selection unit 108 is provided with the RF signal frame data that is sequentially output from the phasing addition circuit 104 at the frame rate of the ultrasonic diagnostic apparatus over time, in the RF signal frame data selection unit 108. Allocate sequentially in the frame memory.
- the RF signal frame data currently secured in the RF signal frame data selection unit 108 is defined as the RF signal frame data N, and the past RF signal frame data N-1, N-2, N-3, — ⁇ And
- the RF signal frame data selection unit 108 outputs one of the temporally past RF signal frame data ⁇ —1, ⁇ —2, ⁇ —3, ⁇ — ⁇ in accordance with the control command of the ultrasonic diagnostic apparatus.
- the RF signal frame data is selected, and this is output as RF signal frame data X to the displacement measurement unit 109 together with the RF signal frame data ⁇ . That is, RF signal frame data selection section 108 outputs one set of RF signal frame data ( ⁇ , X).
- the power of describing the output signal from the phasing and adding circuit 104 as RF signal frame data may be, for example, a signal in the form of I and Q signals obtained by complex demodulation of an RF signal.
- the displacement measuring unit 109 performs a one-dimensional or two-dimensional correlation process on the set of RF signal frame data selected by the RF signal frame data selecting unit 108 to perform displacement or movement vector ( Displacement direction and magnitude) and generate displacement frame data.
- a method for detecting the moving stickiness there are, for example, a block matching method and a gradient method described in JP 5-31713 ⁇ .
- the block matching method divides an image into blocks consisting of, for example, NX pixels and focuses on the current frame. In this case, the block closest to the current block is searched from the previous frame, and predictive coding is performed with reference to this.
- the pressure measuring unit 110 is mounted on a pressure sensor 31-36 mounted on a compression plate 21 or the like as shown in Fig. 4 (A) or mounted on a compression plate 21 or the like as shown in Fig. 4 (B).
- the pressure applied to the body surface or the like of the subject 10 is measured using the reference deformable body 37 or the like.
- the measurement result is sent as pressure data to the strain and elastic modulus calculation unit 111 and the compression state evaluation unit 115.
- the method of obtaining the pressure data is described in detail in Japanese Patent Application No. 2003-178685 FP2005-13283A) and Japanese Patent Application No. 2003-300325 FP2005-66041 filed earlier by the present applicant.
- the strain and elasticity calculating unit 111 Calculate the distortion and elastic modulus of the data, generate numerical data of elasticity or strain (elastic frame data), and output it to the elastic data processing unit 112 as elastic frame data. Strain calculations can be calculated, for example, by spatially differentiating the displacement, and do not require pressure data.
- the calculation of one of the elastic moduli, for example, the Young's modulus Ym, is performed by dividing the stress (pressure) at each calculation point by the strain amount at each calculation point as shown in the following equation. Required by
- the indices i and j represent the coordinates of the frame data.
- the elasticity data processing unit 112 performs smoothing processing in the coordinate plane, contrast optimization processing, smoothing processing in the time axis direction between frames, and the like on the elasticity frame data input from the strain and elasticity modulus calculation unit 111. Then, the elastic frame data after the processing is sent to the color scan converter 113.
- the elasticity data processing unit 112 is described in Japanese Patent Application No. 2003-006932 filed by the applicant of the present invention, CFP2004-261198A).
- the color scan converter 113 constitutes hue information conversion means, and receives elasticity frame data output from the elasticity data processing unit 112 and commands from the ultrasonic diagnostic apparatus control unit. Input the upper limit value and the lower limit value as the gradation selection range in the elasticity frame data from the elasticity data processing unit 112. Then, hue information such as red, green, and blue is added as elastic image data from the elastic frame data. For example, in the elasticity frame data output from the elasticity data processing unit 112, an area where a large distortion is measured is converted into a red code in the elasticity image data, and an area where a small distortion is measured is an elasticity image. It is converted into a blue code in the data.
- the color scan converter 113 is constituted by a black-and-white scan converter, an area where large distortion is measured is displayed in the elasticity image data with a brighter brightness, and an area where distortion is measured small.
- the luminance may be displayed dark in the elastic image data.
- the switch adder 114 inputs the black-and-white tomographic image data from the black-and-white scan converter 106 and the color elastic image data from the color scan converter 113, and adds or switches both images to the image display 107. Output. In this case, switching can be made so as to output only black-and-white tomographic image data or only color elastic image data, or to combine and output both image data. In this case, for example, as shown in Patent Document S ⁇ JP2000-60853A, a black-and-white tomographic image and a black-and-white elastic image by the color or black-and-white scan converter 106 may be simultaneously displayed in a two-screen display.
- a color elastic image may be translucently superimposed on a monochrome tomographic image and displayed.
- the switching adder 114 outputs display image data to the cine memory unit 117 and the image display 107.
- the compression state evaluation unit 115 uses the pressure data output from the pressure measurement unit 110 to evaluate the compression state of the site of interest at the current time and reflect the compression state.
- the generated compression state information is generated.
- the generated compression state information is converted into an image by the color scan converter 113 and output to the image display 107 via the switching adder 114.
- the compression state information of the region of interest at the current time is displayed as an image on the image display 107, and can be fed back to the examiner.
- the method of displaying an elasticity image uses the ultrasonic probe 100
- the RF signal frame data which is the ultrasonic tomographic data of the tomographic part of the subject, is measured while applying pressure to 10, and based on the RF signal frame data, distortion or distortion, which is a physical quantity correlated with the elasticity of the tissue at the tomographic part, is measured.
- the elasticity is obtained, an elasticity image at the tomographic site is generated based on the distortion or the elasticity, and displayed on the image display 107.
- the compression state evaluation unit 115 obtains compression state information on the compression state of the cross-sectional area, and displays the compression state information on the image display 107 together with the elasticity image. It has become.
- FIG. 5 is a block diagram illustrating a flow of a series of processes performed by the compression state evaluating unit 115 according to the embodiment.
- the compression state evaluation unit 115 includes a memory circuit 1151, a compression state evaluation circuit 1152, and an image construction circuit 1153.
- the memory circuit 1151 secures the pressure data of the measurement result output from the pressure measurement unit 110 and outputs it to the compression state evaluation circuit 1152.
- the compression state evaluation circuit 1152 receives the pressure data output from the memory circuit 1151 and performs overflow processing, average value calculation, etc. on the pressure data so that an optimal image is displayed when displaying the compression state. , And outputs the resulting numerical data to the next-stage image construction circuit 1153 as compression state evaluation data.
- the image construction circuit 1153 receives the compression state evaluation data output from the compression state evaluation circuit 1152, constructs an image reflecting the compression state evaluation data as compression state image data, and outputs the image to the switching adder 114. .
- FIG. 6 is a diagram showing a modified example of the probe when measuring pressure using a plurality of sensors.
- FIG. 4 (A) shows a case where pressure sensors 3 :! to 36 are attached along the periphery of the circular compression plate 21.
- the probe in FIG. 6 shows a pressure sensor group in the pressure measurement unit.
- These pressure sensors 5 pressure data from! ⁇ 5f, 61 ⁇ 6f
- a case in which compression state information is created using one group will be described.
- the index i indicates the coordinates in the long axis direction of the ultrasonic transmitting and receiving surface of the probe
- the index j indicates the coordinates in the short axis direction
- all pressure data groups are referred to by the index.
- These pressure data groups Pi, j (t) are the measurement result data groups.
- the compression state evaluation circuit 1152 performs, for example, statistical processing using the measurement result data group Ri, j (t) as a population, and as its statistical feature amount, its average value ⁇ Ri, j (t) Is calculated by the following formula.
- Ri, j (t)> ⁇ (measurement result data Ri, j (t)) ⁇ / (NXM)
- This average value Ri , j ( t )> is set as compression state evaluation data.
- the image construction circuit 1153 displays the value of the average value ⁇ Ri, j (t)> of the measurement result data group as a bar graph 201 having a length corresponding to the compression state. Construct image data. Further, compression state image data for displaying an image of the gauge 202 with the numerical value of the average value and the unit is constructed.
- the compression state image data changes every moment depending on the compression state at the current time. For example, as shown schematically in FIG.
- the length of the bar graph 203 showing the compression state image data at the moment changes every moment.
- FIG. 9 is a diagram showing an operation example of the switching adder 114 according to this embodiment.
- the compression state image data is constructed and output to the switching adder 114
- the compression state image 205 output from the compression state evaluation unit 115 and the elastic image output from the color scan converter 113 are output.
- 206 and the tomographic image 207 output from the black-and-white scan converter 106 are combined to form, for example, one display image data as shown in FIG.
- This display image data is sent to the image display 107 so that the examiner can observe it.
- the pressure measuring unit 110 particularly used a pressure sensor as shown in FIG. 4 (A).
- the present invention is not limited to this.
- a similar operation may be realized by using a reference deformable body 37 as shown in B) as a substitute for the pressure sensor. That is, the reference deformable body 37 is provided so as to cover the ultrasonic transmission / reception surface 1001 of the ultrasonic probe 10, and the signal processing is performed so that the pressure applied to the body surface when the diagnosis site is pressed is measured. I do.
- the pressure distribution displayed on the image display 107 shows the boundary between the reference deformable body 37 and the subject.
- the boundary detection circuit detects the boundary between the skin of the subject 10 and the reference deformable body 37 using the RF signal frame data, and detects the boundary in the detected RF signal frame data.
- the coordinates are output as boundary coordinate data to a pressure calculation circuit (not shown).
- the pressure calculation circuit extracts the RF signal from the reference deformation body 37 in the RF signal frame data using the boundary coordinate data detected by the boundary detection circuit, and gives the RF signal to the boundary between the skin of the subject 1 and the reference deformation body 37.
- the calculated pressure is obtained by calculation. Since the elastic modulus of the reference deformable body 37 is known, if this is Ym (for example, Young's modulus),
- the pressure distribution inside the data area dl, d2, d3 '' 'dn can be obtained as the pressure distribution pi, ⁇ 2, ⁇ 3 ⁇ ⁇ , respectively.
- the pressures at the boundary between the skin of the subject 10 and the reference deformable body 37 are defined as pressures pi, p2, 3,
- the pressure below the oscillator vl, ⁇ 2, ⁇ 3 ⁇ ⁇ ⁇ ⁇ can be obtained.
- the reference deformable body 37 has excellent acoustic coupling characteristics with a living body, such as a small acoustic attenuation of an acoustic coupling material or an acoustic lens material, and a sound velocity and an acoustic impedance close to those in a living body. It is preferable to use a material composed of a material having excellent shape restoring properties and shape retention properties.
- acoustic coupling materials are common in ultrasound imaging This is the material that constitutes the acoustic medium used for This acoustic medium is intended to prevent the generation of a gap when the ultrasonic transmission / reception surface 1001 of the ultrasonic probe 10 is brought into contact with an uneven portion such as a living body surface. That is, when a gap is generated between the ultrasonic transmitting / receiving surface 1001 and the living body surface, the ultrasonic waves emitted from the ultrasonic probe 10 are rebounded at the boundary between the air in the gap and the ultrasonic probe 10. As a result, the displayed image is disturbed. Therefore, such a problem is solved by interposing an acoustic medium that propagates ultrasonic waves on a contact surface between the head of the ultrasonic probe 10 and a living body.
- the reference deformable body may be an oil-based gel material, a water-based gel material such as acrylamide, or a material generated based on silicon. If it is made of a material such as acrylamide with low viscosity, it is suitable for pressure measurement because it responds quickly to compression operations.
- the pressure immediately below the vibrator can be measured, and the pressure corresponding to the image can be measured. Also, pressure information can be obtained without using a pressure sensor or a signal processing system.
- a reference deformable body fixing tool for attaching the reference deformable body to the probe is used.
- One pressure measurement unit is constructed by the reference deformation body 37 and the fixture, and this pressure measurement unit is attached to and detached from the probe with one touch.
- FIG. 32 shows details of the fixture 500.
- the reference deformable body 37 is fixed to the inner frame of the fixture 500 by a method such as adhesion or welding. Also, the reference deformable body 37 can be attached or detached by fitting the reference deformable body 37 into the inner frame of the fixture 500.
- the fixing tool 500 is provided with a projection (not shown) so as to be sandwiched between grooves on the side of the probe 100, and can be fitted with a one touch.
- a recess (not shown) is provided in the fixture 500 so that a projection provided on the conventional probe for recognizing the ultrasonic scanning direction can be grasped.
- the fixture 500 is provided with a non-slip grip (not shown) for grasping by hand, and the examiner grasps the non-slip grip and presses the subject 10.
- a non-slip grip (not shown) for grasping by hand, and the examiner grasps the non-slip grip and presses the subject 10.
- Anti-slip grip To make it easier to hold the grip, the anti-slip grip is shaped for the fingers.
- FIG. 33 shows an example in which the reference deformable body 37 is fixed to the fixture 500 with a thin belt 501, for example. In this manner, both ends of the reference deformable body 37 are turned to the fixing device 500 with the two belts 501 to be fixed. I have decided.
- the belt 501 is removable with an adhesive tape or the like.
- a bag (not shown) through which the ultrasonic wave is transmitted may be provided in the fixing tool 500, and the reference deformable body 37 may be put in and out of the bag. Further, the bag may be provided with a window through which the ultrasonic wave passes, so that the transmission / reception signal of the ultrasonic wave is not blocked by the bag.
- the reference deformable body 37 for example, a mechanism for inserting and removing a needle into and from the groove wall of the fixture 500 is provided.
- the deformed body 37 is now stabbed and fixed.
- the pressure measurement unit can be selected from reference deformation bodies having various shapes, hardnesses, and acoustic characteristics that are suitable for the measurement of the target tissue, and can be combined with the fixture 500. It has become. For example, when the entire target tissue is relatively hard or the lesion of interest is deep, the use of a rigid reference deformable body can effectively reduce the pressure on the target tissue. A high-quality elastic image can be easily obtained.
- the present invention is not limited to this, and as shown in FIG.
- the deformed body and the reference deformed body fixing device may be configured as an integrated type (for example, the whole is made of silicon). Now you can put it on.
- the pressure measurement unit 110 particularly uses a plurality of pressure sensors.
- the present invention is not limited to this. Only one pressure sensor is attached to the compression plate provided in the measurement unit 110, and the compression state evaluation unit 115 determines the compression state image data according to the size of the pressure data output from the single pressure sensor. Let's build a.
- the compression state evaluation unit 115 particularly uses a plurality of pressure sensors.
- the case where the average value is calculated as statistical processing using the output pressure data group and the compression state image is presented has been described.However, the present invention is not limited thereto.
- Compression status information indicating the statistical characteristics of the pressure data group may be presented using values, median values, maximum values, minimum values, and the like. In addition to presenting only one statistical feature, a plurality of statistical information may be presented simultaneously.
- the compression state image data may be constructed using each pressure data of each pressure sensor, and may be displayed independently. That is, when a plurality of pressure sensors are arranged along the long axis direction of the ultrasonic transmitting and receiving surface as shown in FIG. 6, for example, as shown in FIG. And the compression state image data 10A in which the respective pressure data are constructed independently in correspondence with the corresponding portions of the elasticity image and the tomographic image.
- FIG. 6 the compression state image data 10A in which the respective pressure data are constructed independently in correspondence with the corresponding portions of the elasticity image and the tomographic image.
- each bar graph of the compression state image data 10A corresponds to each of the pressure sensor groups 51 to 5f and 61 to 6f in FIG. Since two pressure sensor groups 51 to 5f and 61 to 6f in Fig. 6 are arranged in the short axis direction, the average value of the two pressure sensors in the short axis direction and the compression state image data in Fig. 10 are used.
- the height of the graph at 10A corresponds to the height. Therefore, by visually checking the compression state image data 10A in FIG. 10, the examiner can accurately grasp the state of the compression in the longitudinal direction of the probe.
- the pressure distribution obtained in association with the long axis direction which is the arrangement direction of the plurality of transducers forming the ultrasonic probe, is used as the length of the ultrasonic probe.
- a bar graph is displayed according to the coordinate direction of the elastic image corresponding to the axial direction. Also, instead of the bar graph of the compression state image data 10A, it can be displayed by a diagram.
- Fig. 11 replaces the bar graph part in the display image of Fig. 9 with a figure 208 that simulates the state of compressive deformation of the fault site compressed by the probe shown in the upper part of Fig. 8. It is a figure showing an example of the case. As described above, the state in which the probe is compressing the target tissue is indicated, so that the examiner can intuitively recognize the compression state.
- a pressure data value 209 is displayed below the schematic diagram of the probe and the target tissue.
- the compression state evaluation unit 115 constructs the compression state image data so as to present the compression state information, particularly, as a bar graph.
- the present invention is not limited to this, and any method may be used as long as information reflecting the size of the pressure data is presented.
- pressure data may be directly displayed as numerical data in the pressure dimension.
- the pressure data may be converted into hue information and displayed in hue.
- the pressure data may be converted into luminance information and displayed as luminance.
- the size of the pressure data can be determined by the respective displays.
- the pressure data as the compression state information can be displayed by a meter type in which a semicircular scale is indicated by a rotary needle.
- pressure data as compression state information can be displayed in a circle size.
- any other display method may be used as long as the compression state is displayed in a form that can be grasped instantaneously.
- the unit of the displayed pressure is not limited to [kPa], but may be any unit such as [mbar], [Ton:], [arm], [kgf / cm 2 ], [psi], and the like. These settings can be switched on the ultrasound diagnostic apparatus side. The setting may be switched so that the numerical value and the unit are not displayed.
- the pressure data is displayed in hue or luminance, the visibility is improved as compared with the case where the data is displayed in a numerical value.
- a scale corresponding to the pressure data is provided, and the size of the pressure data is displayed on the scale.
- FIG. 14 is a diagram showing a modification in which a bar graph is used as a compression state image indicating compression state information.
- the force of the gauge is set to a linear shape.
- the scale of the gauge 202 is displayed in logarithmic scale. Note that a scale other than that shown may be used for the logarithmic display. (Example 6)
- FIG. 15 is a diagram illustrating an example of a display method in which a temporal change in pressure, which is compression state information, is reduced.
- the compression state evaluation unit 115 constructs the pressure change diagram 210 so that the information on the compression state at the current time is presented.
- the present invention is not limited to this.
- the compression state image data is constructed so that the time change of the compression state from the past to the present can be observed, and finally the examiner displays the image on the image display 107. May be displayed so that can be observed.
- the graph may be scrolled and displayed in time, as if an oscilloscope observes the change in voltage over time.
- image data indicating the time change of the compression state for example, as shown in FIG. 16, a curve (dotted line curve in the figure) serving as an example of the compression operation is displayed, and the examiner displays the curve. You can also act as a guide so that you can press according to the curve.
- FIG. 17 is a diagram illustrating an example of a case in which feedback (warning) is given that the compression state is inappropriate.
- the compression state evaluation unit 115 constructs compression state image data so as to present compression state information in a graph, particularly using pressure data output from the pressure sensor 1.
- the present invention is not limited to this.
- an inappropriate compression state such as an excessive compression or insufficient compression is detected based on the pressure data based on the pressure data.
- the compression state evaluation unit 115 can have a function of performing the compression. In this case, for example, as shown in Fig. 17 (B), if the compression is too strong, the compression should be reduced, and as shown in Fig.
- the pressure range of 10 to 20 kPa is set as an appropriate compression range, and if it is higher than it, the compression is excessive.
- This appropriate compression range is an example and is not intended to be limiting.
- This compression range can be set and changed as appropriate. In particular, it is not limited to the method of feeding back to the examiner with images, As shown in the figure, a similar purpose may be achieved by voice pronunciation such as "please reduce compression” or "please increase compression”. The purpose of this is to lead to an appropriate compression method for high image quality, not only in an excessively dangerous state.
- the compression force it is determined whether or not the compression force is within the set range, and when the compression force is out of the set range, an alarm to that effect is provided by at least one of sound and image display. Output.
- FIG. 18 is a diagram showing a modification of the display when the pressure range is in an appropriate compression range.
- the downward arrow 131 or the upward arrow 132 is displayed as a pressure range of about 10 to 20 kPa as an appropriate compression range, and if the pressure is higher than the pressure range, the compression is excessive, and if it is lower than that, the compression is insufficient.
- the color of the bar itself in the bar graph is blue (Fig. 18 (A)) for appropriate compression, red (Fig. 18 (B)) for excessive compression, and yellow (Fig. 18) for insufficient compression. 18 (C)), and so on. Further, when displaying in color, the color may be changed stepwise.
- the color of the figure simulating the state of compressive deformation of the fault site compressed by the probe as shown in the upper part of Fig. 8 is blue for appropriate compression, red for excessive compression, and insufficient compression. May be displayed as yellow. Thereby, the pressure state can be intuitively recognized.
- the compression state evaluation unit 115 evaluates the compression state of, for example, a site of interest at the current time, and generates image information reflecting the compression state. Then, the image can be displayed on the image display 107 in association with the elasticity image. As a result, the compression state can be fed back to the examiner, and at any time, the examiner can objectively evaluate the compression state of the displayed elasticity image. At the same time, the desired compression state can be uniquely generated or reproduced. As a result, a certain compression state determined to be applied to the diagnosis can be realized, and the elasticity image acquired under the predetermined compression condition can be selected and the image diagnosis can be definitely performed. At the same time, image diagnosis under compression conditions depending on the examiner's subjectivity can avoid an event in which different diagnostic results are obtained between examiners, and an objective and universal diagnosis can be established. An ultrasonic diagnostic apparatus useful on the floor can be provided.
- the cine memory unit 117 secures display image data in a memory, calls up past display image data according to a control signal from the device control interface unit 116, and displays the image data on the image display 107, or displays the selected image data. It plays the role of transferring the displayed image data to a recording medium such as an MO for recording.
- the cine memory unit 117 according to the present embodiment uses the information of the compression state image data portion in the display image data secured in a time-series manner in the memory provided therein, and performs elasticity control. It has functions to refer to and extract image data.
- details of the cine memory unit 117 according to this embodiment will be described.
- FIG. 19 is a diagram illustrating an example of the operation of the cine memory unit according to this embodiment.
- the examiner refers to the compression state image data of the image construction circuit 1153 in the compression state evaluation section 115 and causes the image display 107 to display the display image data at the same time.
- the ultrasonic diagnostic apparatus is frozen by a control signal from the apparatus control interface section 116, and the triangular shape of the image display 107 is selected from the display image data secured in the cine memory section 117.
- the elastic image data at the time designated by the button 141 is sequentially displayed on the image display 107.
- the slide control of the button 141 is performed by a mouse or the like via the device control interface unit 116.
- elastic image data corresponding to the time is selected from the cine memory unit 117 and sequentially displayed on the image display 107 as shown in FIG. Become like
- FIG. 20 is a diagram illustrating an example of a case where the examiner selects an optimal compression state based on a graph indicating the compression state and saves the compression state.
- the ultrasonic diagnostic apparatus is frozen by a control signal from the apparatus control interface section 116, and the display image data at a certain time secured in the cine memory section 117 is displayed on the image display 107.
- Selective display The compression state image data indicating the temporal change of the compression state included in the display image data is displayed, and as shown in FIG.
- the examiner slides the triangular buttons 151 and 152 to specify the frame at the time tl and the frame at the last time t2.
- a time-series display image data group (frame group) existing between the times tl and t2 is extracted from the cine memory unit 117 and stored.
- FIG. 21 is a diagram showing an example of a case in which one cycle of an appropriate compression state is automatically detected and set as a storage range.
- FIG. 20 illustrates a case where the examiner refers to the compression state image and extracts continuous display image data in a specified range, particularly in the cine memory unit 117. Automatically detect (extract) the beginning and end of the period. For example, as shown in FIG. 21, one cycle of an appropriate compression operation is automatically detected, and the display image data group for this one cycle is stored.
- FIG. 21 a case has been described in which the cine memory unit 117 uses the information in the compression state image data unit to extract display image data acquired in an appropriately compressed state, but is not limited to this. Instead, the same operation may be realized by using the compression state evaluation data output from the compression state evaluation circuit 1152 of the compression state evaluation unit 115.
- the display image data group whose range is determined and extracted in the cine memory unit 117 is applied to the force S displayed on the image display 107 in response to a control signal from the device control interface unit 116.
- the present invention is not limited to this, and it is possible to continuously play back and display the data in a loop, or transfer and record the data to a recording medium such as an MO.
- FIG. 22 is a diagram illustrating an example of a case where the range of the appropriate compression state is set by the size of the pressure axis, and the range is set as the storage range.
- Fig. 21 describes the case where the beginning and end of the period of appropriate compression are automatically detected (extracted) and stored as a display image data group for one cycle.
- the appropriate compression data P1 and P2 were set in order to extract pa-pg during the period of compression after passing through this range. This detection may be performed automatically or manually.
- FIG. 23 is a diagram illustrating an example of a detection method when an appropriate one cycle is automatically detected.
- each range range 1, range 2 ⁇ ⁇ ⁇
- each sampling point the difference between the actual compression state curve and the sample compression curve (indicated by a dotted line in the figure) is calculated.
- the difference at each sampling point is added, and the range in which the smallest sum is added can be extracted as the most optimal one cycle.
- range 3 is selected as the most optimal range.
- an elasticity image acquired under a predetermined compression condition is extracted based on an objective criterion using the compression state evaluation unit 115, the switching adder 114, and the cine memory unit 117. Deterministic image diagnosis which does not depend on the image can be efficiently performed.
- the compression state evaluation unit 115, the switching adder 114, and the cine memory unit 117 use the example of the absolute pressure value data output from the pressure sensor among various information indicating the compression state.
- the present invention is not limited to this.
- time change of pressure data pressure change between frames before and after compression
- pressure change at current time gradient of pressure value
- the compression state image data may be generated and displayed on the image display 107.
- the deviation of the pressure distribution with respect to the reference pressure is obtained, and the deviation is displayed in a diagram 212 in accordance with the coordinate direction of the elastic image corresponding to the longitudinal direction of the ultrasonic probe.
- the ability to do S. In this case, the bias of the compression force in the longitudinal direction of the ultrasonic probe can be immediately recognized by the image.
- a magnetic sensor is provided in the ultrasonic probe 100, and the position coordinate data output from the magnetic sensor is used to generate compression state image data. May be generated and displayed on the image display 107. Further, compression speed data and displacement (betatone) data derived from the position coordinate data may be displayed together.
- the displacement measurement unit 109 May be used as the measurement result data used by the compression state evaluation unit 115. That is, the compression state image data may be generated using the displacement frame data output from the displacement measurement section 109 as the measurement result data in the compression state evaluation section 115. At this time, the data displayed on the image display 107 is the average of the displacement data, the data subjected to statistical processing, or the compression speed data and displacement data calculated based on the displacement data over time. Accumulated displacement data may be used.
- a plurality of images of the compression state information may be simultaneously displayed on the image display.
- This ultrasonic diagnostic apparatus allows the examiner to freely select and set information for constructing compression state image data from among a plurality of pieces of information such as displacement indicating the compression state and compression speed via the apparatus control interface unit 116. You can do it.
- the information selected here is not limited to a single piece of information, and a plurality of pieces of information can be selected at the same time.
- the selected plurality of pieces of compression state image data are displayed. It is constructed as display image data and is simultaneously displayed on the image display 107.
- the examiner can freely control the selection of adoption / non-adoption of the display of the compression state image and the setting of the display range in the compression state image by using the device control interface unit 116. Te, ru.
- the compression state information is provided to the examiner in association with the elasticity image, thereby providing a highly objective elasticity image diagnosis. Make it possible.
- the transmission circuit 102 applies a high-voltage electric pulse to the probe 100 that has come into contact with the body surface of the subject, emits an ultrasonic wave, and searches for a reflected echo signal from the diagnostic site. Received by the probe 100. Next, the received signal is input to the receiving circuit 103, pre-amplified, and then input to the phasing addition circuit 104. The received signal whose phase has been adjusted by the phasing addition circuit 104 is subjected to signal processing such as compression and detection in the next signal processing unit 105, and then input to the monochrome scan converter 106.
- signal processing such as compression and detection in the next signal processing unit 105
- the black-and-white scan converter 106 performs AZD conversion of the received signal and stores the signal in a plurality of internal frame memories as a plurality of time-series continuous tomographic image data.
- the RF signal frame data is sequentially taken into the RF signal frame data selection unit 108. From the RF signal frame data stored in the RF signal frame data selection unit 108, a plurality of RF signal frame data that are continuous in time series are selected by the RF signal frame data selection unit 108 and captured by the displacement measurement unit 109. It is. In the first displacement measurement 109, a one-dimensional or two-dimensional displacement distribution (A Li, j) is obtained.
- the displacement distribution is calculated, for example, by the block matching method as a method for detecting the moving stickiness described above.
- the autocorrelation in the same area of two image data which is generally used without using this method is preferable. May be calculated to calculate the displacement.
- the pressure measuring unit 110 measures the pressure applied to the body surface by the pressure sensor, and the pressure data is transmitted from the pressure measuring unit 110 to the distortion / elastic modulus calculating unit 111 and the compression state evaluating unit 115. Sent out.
- Respective measurement signals of the displacement ( ⁇ Li, j) and the pressure ( ⁇ i, j) output from the displacement measuring unit 109 and the pressure measuring unit 110 are input to the strain and elastic modulus calculating unit 111, The strain distribution “i, j) is obtained.
- the strain distribution ( ⁇ i, j) is calculated by spatially differentiating ( ⁇ Li, j / ⁇ ⁇ ) the displacement distribution (A Li, j).
- the Young's modulus Ymi, j of the elastic modulus is calculated by the following equation.
- the modulus of elasticity at each measurement point is determined from the modulus of elasticity Ymi, j thus determined, and elastic frame data is generated.
- the elasticity data processing unit 112 to which the elasticity frame data is input is subjected to various image processing such as smoothing processing in a coordinate plane, contrast optimizing processing, and smoothing processing in the time axis direction between frames.
- the compression state evaluation unit 115 evaluates the compression state of the target tissue at the current time, constructs compression state image data using the compression state as information, and sends the compression state image data to the switching adder 114.
- the switching adder 114 displays a compression state image at the same time as a black-and-white tomographic image and a color elasticity image, so that the correspondence between the two can be simultaneously observed.
- the strain of the living tissue or the Young's modulus Ym is determined.
- the present invention is not limited to this, and the elasticity modulus is calculated by using other parameters such as a stiffness parameter, a piezoelasticity coefficient Ep, and an incremental elasticity coefficient Einc. IP5—317313A).
- the present invention is not limited to this.
- the present invention can be similarly applied to any ultrasonic probe such as an esophageal probe, an intraoperative probe, and an intravascular probe.
- the compression state information is displayed in association with the elasticity image, so that the elasticity image diagnosis with high objectivity can be performed.
- An ultrasonic diagnostic apparatus can be provided.
- the length of the bar graph showing the compression state image data at the current time is displayed according to the strength of the compression of the target tissue so that the length of the bar graph changes every moment, or the compression is performed by the probe.
- the case where the state of the target tissue to be displayed is schematically displayed is shown.
- the eyes and mouth are schematically displayed on the target tissue, and the expression changes depending on the appropriate compression state, under-compression, and over-compression. It may be.
- the mouth is opened when the compression is insufficient, indicating that the compression is insufficient.
- the compression is excessive, the mouth is closed and the eyes are closed.
- the color of the target tissue along with the change in facial expression is also matched, such as blue for appropriate compression, red for overcompression, and yellow for insufficient compression as shown in Fig. 18. It may be expressed.
- the method has been described in which the pressure data indicating the absolute compression strength at the current time is manifested as the compression state data.
- the present invention is not limited to this, and the distribution of the pressure change is described. Can be displayed.
- the displacement measurement unit 109 measures the displacement of each measurement point on the tomographic image from the set of RF signal frame data selected by the RF signal frame data selection unit 108, and generates displacement frame data. However, the displacement is generated by changing the magnitude of the pressure applied to the living body. If the living body is compressed, the pressure change is in the positive direction, and if it is relaxed, the pressure change is in the negative direction.
- a change in the magnitude of the pressure between one frame is defined as a pressure change distribution 10B. indicate.
- This pressure change distribution 10B is displayed in real time simultaneously with the absolute pressure distribution 1OA as shown in FIG. 26, for example. Since the change in the magnitude of the pressure during one frame is very small, the graph of the pressure change distribution 10B is displayed larger than the absolute pressure distribution 10A.
- the pressure distribution to be displayed can be switched between the absolute pressure distribution and the pressure change distribution, or the deviation can be switched.
- the hardness of a living tissue has non-linearity, and the hardness of the tissue changes depending on the compression condition.
- an arbitrary stress interest line 305 is provided on the image, and a stress distribution 300 and a stress change distribution 301 along the line 305 are displayed.
- the stress on the stress line of interest 305 to be displayed in the stress distribution 300 and the stress change distribution 301 is obtained by a finite element method based on information such as surface pressure, material properties, strain, and distance a from the surface.
- the finite element method is a known technique of a numerical calculation method.
- the structure to be calculated is deformed by the external force of the probe, the structure of the object worthy inside the subject is separated by mesh. Then, a system of linear equations in each small element is created.
- the stress on the line is set as an unknown value, and an equation is established based on information such as surface pressure, material properties, strain, and distance a from the surface. Then, the equations of each element are added to form a simultaneous linear equation, and the stress that is the solution is obtained.
- the specific method of obtaining the information is described in a non-patent literature, such as an introduction to the finite element method: Toshiro Miyoshi (author), and will not be described here.
- the stress on the stress line of interest 305 is obtained, and the stress distribution 300 is displayed. Also, the change in the magnitude of the stress between one frame is displayed as a stress change distribution 301.
- the stress change distribution 301 is displayed in real time simultaneously with the stress distribution 300 as shown in FIG. 27, for example.
- an arbitrary stress region of interest 306 is provided on the image, and the stress distribution and the stress distribution in the region of interest are determined.
- the change in stress may be measured.
- the magnitude of the stress inside the stress region of interest and the change in stress before and after the compression are measured by the finite element method described above, and are displayed as, for example, a bar graph 302.
- FIG. 28 shows a form in which the integrated value of distortion is displayed in real time.
- a region of interest for distortion is set in the lesion region, and an integrated value of distortion is integrated and measured from a state of zero pressure, and is displayed on, for example, a bar graph 304.
- the integrated value of distortion is the component value of how much compression was performed from zero compression. According to this, it is possible to grasp the relationship between the magnitude of the product of the strain in the lesion area and the elasticity measured under the condition.
- a linear region where the elastic modulus is maintained at a constant value and a nonlinear region where the elastic modulus fluctuates are divided around the integrated value of the strain force of about 3 ⁇ 4%.
- This non-linear region is caused by the phenomenon that the subject 10 is not distorted (hardened) when the subject 10 is pushed too much. In the nonlinear region, the elastic modulus is considered to be unreliable.
- the method of identifying the nonlinear response based on the integrated value of strain has been described.
- the method is not limited to the integrated value of strain but may be a method based on the magnitude of the stress or the like. , Based on the appropriate information indicating.
- the cMUT vibrator generally includes a silicon member 404 sandwiching a vacuum gap 403, and an electrode 405 for applying a bias voltage across the silicon member 404.
- the ultrasonic probe having the cMUT vibrator on the surface is brought into contact with the subject 10 and the pressure is increased, the vacuum gap 403 is compressed according to the pressure.
- the pressure is measured using this phenomenon.
- the relationship between the radius of the vacuum gap 403 and the voltage and the relationship between the voltage and the pressure are stored in advance. For example, if the deflection of the vacuum gap 403 is 10 ⁇ m, the voltage changes by 5V. If the pressure changes by 5V, the pressure is 10kPa. In this way, the surface pressure of the cMUT vibrator can be measured via the radius of the vacuum gap 403.
- FIG. 29 (b) is a diagram in which the cMUT vibrator 400 is arranged.
- the pressure can be calculated for each cMUT oscillator 400. Also, the pressure in the area where the cMUT vibrator 400 is arranged can be measured at the same time.
- FIG. 29 (c) shows a mode in which cMUT transducers are arranged on both sides of the ultrasonic transducer 401.
- the pressure can be measured in the same manner as in the example of FIG. Note that the touch panel may be fixed around the head of the ultrasonic probe 100.
- cMUT transducer may be arranged on the object contact surface.
- pressure can be measured at the same time as ordinary ultrasonic diagnosis.
- the cMUT vibrator / touch panel can be configured as a thin device, it is not only a normal linear probe / convex probe but also an ultrasonic probe of the type that enters the body such as the prostate as shown in Fig. 30. Even at 402, it is possible to detect the pressure distribution by a method with a small burden on the patient.
- the ultrasonic probe for body use 402 has a linear vibrator 403 and a curved vibrator 404 arranged at two positions.
- the cMUT vibrators 400 are arranged on both sides of each vibrator. In the vicinity of the linear vibrator 403, they are arranged in a straight line, and in the vicinity of the curved vibrator 404, they are arranged in a curved shape.
- the cMUT vibrator 400 scans ultrasonic signals It is positioned in the same direction as the direction.
- the pressure can be appropriately measured.
- the arrangement of the cMUT vibrators 400 is not limited to this mode, and may be attached so as to surround the vibrators. Then, the pressure is measured in the same manner as in Example 17. That is, the ultrasound probe 402 for a body can also display the compression state image of the bar graph 201 and the pressure change diagram 210 according to the pressure value.
- the pressure can be measured simultaneously with the normal ultrasonic diagnosis, in which only the cMUT vibrator 400 may be arranged on the compression surface.
- In-body ultrasonic probes can be used as pressure sensors by attaching sensors that detect “stretch” and “radius” to the handle. As shown in FIG. 31, a sensor 410 for detecting “elongation” or “radius” such as a touch panel technology, a MEMS technology (cMUT vibrator), and a strain gauge is attached to a portion of the probe handle. The mounting location may be far from the head.
- the strain gauges can be electrical or optical.
- the handle portion of the ultrasound probe 402 for a body is curved.
- the degree of bending is measured by a pressure sensor provided on the handle.
- the pressure sensor 410 is arranged so that the curved vibrator 404 covers all directions.
- the relationship between the expansion (radius) of the region of the handle or the displacement of the bias voltage due to the distortion of the cMUT transducer and the pressure at the tip of the ultrasonic probe for internal use is stored in advance, and the region is expanded. Measure the pressure corresponding to.
- the region 411 in the same direction as the compression direction expands in the long axis direction. This phenomenon is measured by the above-mentioned pressure sensor, the pressure and the compression direction are calculated, and the pressure and the compression direction are displayed on the screen.
- the pressure and the compression direction can be obtained. Moreover, even if a plurality of strain gauges are arranged in an arc shape, the force S can be realized.
- the sensor realizes a structure that can be easily attached and detached as a unit. It can be easily applied to intracorporeal probes such as transrectal, vaginal, transesophageal, and endoscopic probes, and according to the method for detecting this bending, it is necessary to introduce a sensor into the body. And can be measured safely without patient burden.
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Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
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EP05749015.3A EP1762180B1 (en) | 2004-06-09 | 2005-06-09 | Elastic image display method and ultrasonographic device |
JP2006514555A JP4465535B2 (ja) | 2004-06-09 | 2005-06-09 | 弾性画像表示方法及び超音波診断装置 |
US11/628,940 US8043216B2 (en) | 2004-06-09 | 2005-06-09 | Method of displaying elastic image and diagnostic ultrasound system |
US13/243,289 US8951197B2 (en) | 2004-06-09 | 2011-09-23 | Method of displaying elastic image and diagnostic ultrasound system |
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JP2004-170959 | 2004-06-09 | ||
JP2004170959 | 2004-06-09 |
Related Child Applications (2)
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US11/628,940 A-371-Of-International US8043216B2 (en) | 2004-06-09 | 2005-06-09 | Method of displaying elastic image and diagnostic ultrasound system |
US13/243,289 Continuation US8951197B2 (en) | 2004-06-09 | 2011-09-23 | Method of displaying elastic image and diagnostic ultrasound system |
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WO2005120358A1 true WO2005120358A1 (ja) | 2005-12-22 |
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US (2) | US8043216B2 (ja) |
EP (1) | EP1762180B1 (ja) |
JP (3) | JP4465535B2 (ja) |
CN (1) | CN100518662C (ja) |
WO (1) | WO2005120358A1 (ja) |
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EP1762180A1 (en) | 2007-03-14 |
US8043216B2 (en) | 2011-10-25 |
US20120016238A1 (en) | 2012-01-19 |
EP1762180A4 (en) | 2009-08-05 |
CN1980606A (zh) | 2007-06-13 |
US20080269606A1 (en) | 2008-10-30 |
CN100518662C (zh) | 2009-07-29 |
EP1762180B1 (en) | 2015-04-15 |
JP2012135679A (ja) | 2012-07-19 |
JP5400919B2 (ja) | 2014-01-29 |
JP2010017585A (ja) | 2010-01-28 |
JP4465535B2 (ja) | 2010-05-19 |
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US8951197B2 (en) | 2015-02-10 |
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