Classifications

• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
  • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
  • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
  • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
  • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
  • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
  • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
  • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
  • C07D213/62—Oxygen or sulfur atoms
  • C07D213/63—One oxygen atom
  • C07D213/64—One oxygen atom attached in position 2 or 6
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07D—HETEROCYCLIC COMPOUNDS
  • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
  • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
  • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
  • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
  • C07D213/62—Oxygen or sulfur atoms
  • C07D213/70—Sulfur atoms
  • C07D213/71—Sulfur atoms to which a second hetero atom is attached
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
  • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
  • C07F9/02—Phosphorus compounds
  • C07F9/28—Phosphorus compounds with one or more P—C bonds
  • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
  • C07F9/40—Esters thereof
• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
  • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
  • C07F9/02—Phosphorus compounds
  • C07F9/28—Phosphorus compounds with one or more P—C bonds
  • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
  • C07F9/40—Esters thereof
  • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
  • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl

Definitions

• Substituted pyridines are valuable building blocks in organic systems such as pharmaceutical or agrochemical synthesis, e.g. herbicide, fungicide or insecticide synthesis.
• Electron withdrawing substituent shall mean herein a substituent having a -M and/or a - 1 - effect; preferably such substituents are
• halogens are chlorine or fluorine, most preferably fluorine.
• C 1-6 -afkyls or C 6 . 10 -aryls such as trifluormethyl, pentafluorethyl, heptafluorpropyl, heptafluorisopropyl, pentafluorphenyl, most preferably trifluormethyl;
• halogen atoms are chlorine or fluorine.
• Very preferable are fully fluorinated C ⁇ -6 -alkoxy or C 6-10 -aryloxy, such as trifluormethoxy, pentafluorphenoxy;
• a further demand is for pyridine derivatives which bear in the 3-position a sulfur containing group (eg a thiolate group) which sulfur is bond directly to the pyridine ring.
• a sulfur containing group eg a thiolate group
• a further demand is for pyridine derivatives which bear in the 4-position an electron withdrawing group and in the 3-position a sulfur containing group which sulfur is directly bound to the pyridine ring.
• pyridine derivatives which bear in the 2-position a hydroxy, amino or alkoxy substituent and preferably additionally in the 4-position an electron withdrawing group.
• pyridine derivatives which bear in the 2-position a hydroxy, amino or alkoxy substituent and preferably additionally in the 4-position an electron withdrawing group and in the 3-position a sulfur containing group which sulfur is directly bound to the pyridine ring.
• the object of the present invention is to provide a versatile process for the preparation of substituted pyridines, in particular substituted pyridines which have an electron withdrawing substituent in the 4-position or pyridines which bear in the 4-position an electron withdrawing group and in the 3-position a sulfur containing group which sulfur is directly bound to the pyridine ring.
• the further object the present invention is to provide phosphorus compounds and/or other intermediates which are useful in the preparation of above mentioned pyridine synthesis process.
• the further object the present invention is to provide the use of phosphorus compounds, ⁇ - ⁇ -unsaturated carbonyl compound and/or other intermediates in the preparation of substituted pyridine synthesis.
• the phosphorus reagents (III) are prepared by reaction of a phosphorus compound P(Ar) 3 - in which Ar is a substituted or preferably unsubstituted C 6 . 2 o aryl, such as phenyl, tolyl, naphtyl.- or P(OR') 3 - in which R' is equal or different and independently means C 1-20 alkyl, branched or straight or cycic, such as methyl, ethyl, n-propyl, i-propyl, n-butyl or C 6-2 o aryl, such as phenyl, tolyl, benzyl, with a suitable organic halide of formula a III.
• Ar is a substituted or preferably unsubstituted C 6 . 2 o aryl, such as phenyl, tolyl, naphtyl.- or P(OR') 3 - in which R' is equal or different and independently means C 1-20
• R 6 is defined as R 1 , except H.
• R 6 is methyl, ethyl, propyl, isopropyl, benzyl or phenyl.
• the Wittig Reagent (Illa1) or Homer Reagent (Illa2) is than reacted, as generally known in an organic solvent, such as alcohols (preferably for Horner Reagent), halogenated hydrocarbons or polar aprotic solvents (preferably for Wittig Reagents) like THF, DMF or NMP usually at a temperature in the range of from -15 °C, to 120 °C, preferably 0 °C to 70 °C, with the ⁇ - ⁇ - unsaturated carbonyl compound of formula (lla)
• an organic solvent such as alcohols (preferably for Horner Reagent), halogenated hydrocarbons or polar aprotic solvents (preferably for Wittig Reagents) like THF, DMF or NMP usually at a temperature in the range of from -15 °C, to 120 °C, preferably 0 °C to 70 °C, with the ⁇ - ⁇ - unsaturated carbonyl compound of formula (ll
• R 1 , R 2 independently the same or different are H; C ⁇ -2 o-alkyl (branched or straight chain or cyclic); C 6-2 o-aryl - which each of those may be substituted with one or more of the following groups: F, Cl, Br, I, C 1-20 -alkoxy, C 6-2 o-aryloxy, non substituted or preferably substituted amino -; F, Cl, Br, I, preferably R 1 , R 2 , are H, methyl, in particular H.
• R 3 is the same as R 1 or R 2 (except H and halogens) and additionally R 3 shall mean - CN, - NO 2l .
• R 3 is an electron withdrawing group (as defined above) more preferably a fully fluorinated C-
• the molar ratio of (Illa1) or (Illa2) to (lla) is in general 1 : 1 to 1 : 3, preferably 1 : 1,2.
• the molar ratio of (lllal) or (Illa2) to (lla) is in general 1 : 1 to 1 : 3, preferably 1 : 1,2.
• variables including their preferred meanings, are defined as above (e.g. under A1 -2, A1-1).
• variables including their preferred meanings, are as defined above (e.g. under A1 -2).
• Reagent lllbl or Illb2 can be then reacted analogous to A1 2.) above with the ⁇ - ⁇ -unsaturated carbonyl compound of formula Mb
• Suitable leaving groups G are -OR 1 , -NHR 1 , -N(R 1 ) 2 , halogen (F, Cl, Br, I) in which R 1 has the same meaning, including its preferred meaning, as specified for formula (II a) above, except H.
• R 1 independently the same or different, is a C ⁇ -6 alkyl such as methyl, ethyl, n-propyl, i-propyl, n-butyl, sec-butyl, tert.-butyl, cyclohexyl; i-butyl; a C 6 . ⁇ oaryl such as phenyl, tolyl, benzyl.
• Reaction path B1 and B2 usually lead to the following intermediates IV or their related stereo isomers:
• intermediates IV are present in a mixture. From this mixture intermediates can be isolated e.g. by destination or chromatography and characterized.
• Compounds and mixtures of formula IV-1 to IV-4 can be reacted with Bronsted-acids with or without an organic solvent. Temperatures between -30 °C and 150 C C can be used. The acid can be used between catalytic amounts and large excesses.
• B 4-3 base eg ammonium catalysed cyclization
• products can be isolated by extractive workup after hydrolysis with water. They can be purified by crystallization or, in certain cases, by distillation.
• B 4-1 and B 4-3 lead usually to a) compounds I a-1 and I a-2 if the mixture containing IV-1 a, IV-2a, IV-3a or IV-4a is used as starting material and b) compounds I a-3 and I a-4 if the mixture containing IV-1 b, IV-2b, IV-3b or IV-4b is used as starting material.
• B4-3a is a variation of B4-3. This base induced cyclization can be conducted in ammonia, preferably liquid ammonia, as solvent under usual conditions.
• B 4-3a leads usually to compounds I a-1 or I a-2 if the mixture containing IV 1-c,a, IV-2c,a, IV 3-c,a, IV-4c,a is used as starting material and B 4-3a leads usually to the compounds I a-3 or I a-4 if the mixture containing IV-1 b,d, IV-2b,d, IV-3b,d or IV-4b,d is used as starting material.
• a suitable procedure to conduct the process of the instant invention is the following:
• the Wittig Reagent or Homer Reagent is synthesized and - normally after isolation and purification is reacted with the ⁇ - ⁇ -unsaturated carbonyl compound (cf. path A2 or B2).
• the phosphorus organic compounds of type III are isolated and than further reacted with the ⁇ - ⁇ unsaturated carbonyl compound. This leads depending on the substitution of the ⁇ - ⁇ unsaturated carbonyl compound directly to the pyridine derivative (in case of 4-amino substituted ⁇ - ⁇ unsaturated carbonyl compound) or to the intermediates of formula IV (in case of 4-leaving group substituted ⁇ - ⁇ unsaturated carbonyl compound) which intermediates may than be cyclicized.
• Those intermediates preferably may be isolated and cyclisized by the above-mentioned reactions, or may be without isolation cyclisized by the above mentioned cyclication reactions.
• the process of the instant invention can be used in the synthesis of agrochemicals or pharmaceuticals e.g. agrochemicals as described in WO 02/36595 A2 (DOW AgrSciences LLC) or US 5,571 ,775 (DOW Elanco) or Research Disclosure July 2002, 1230-1231 which are expressly incorporated by reference herein.
• agrochemicals as described in WO 02/36595 A2 (DOW AgrSciences LLC) or US 5,571 ,775 (DOW Elanco) or Research Disclosure July 2002, 1230-1231 which are expressly incorporated by reference herein.
• the process of the instant invention leads regioselectively to valuable pyridine derivatives which may be used as valuable compounds for the preparation of pharmaceuticals, agrochemicals, in particular sulfonamide type herbicides, or other chemicals.

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• Chemical & Material Sciences (AREA)
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• Life Sciences & Earth Sciences (AREA)
• Biochemistry (AREA)
• General Health & Medical Sciences (AREA)
• Molecular Biology (AREA)
• Pyridine Compounds (AREA)
• Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
• Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
• Indole Compounds (AREA)

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