WO2004089992A1 - 改質アラビアガムおよびその用途 - Google Patents
改質アラビアガムおよびその用途 Download PDFInfo
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- WO2004089992A1 WO2004089992A1 PCT/JP2004/005146 JP2004005146W WO2004089992A1 WO 2004089992 A1 WO2004089992 A1 WO 2004089992A1 JP 2004005146 W JP2004005146 W JP 2004005146W WO 2004089992 A1 WO2004089992 A1 WO 2004089992A1
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- gum arabic
- modified
- dietary fiber
- food
- drink
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0087—Glucomannans or galactomannans; Tara or tara gum, i.e. D-mannose and D-galactose units, e.g. from Cesalpinia spinosa; Tamarind gum, i.e. D-galactose, D-glucose and D-xylose units, e.g. from Tamarindus indica; Gum Arabic, i.e. L-arabinose, L-rhamnose, D-galactose and D-glucuronic acid units, e.g. from Acacia Senegal or Acacia Seyal; Derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
- A23L33/22—Comminuted fibrous parts of plants, e.g. bagasse or pulp
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/736—Glucomannans or galactomannans, e.g. locust bean gum, guar gum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Definitions
- the present invention relates to modified gum arabic. More specifically, the present invention relates to gum arabic modified to have a high total dietary fiber content.
- Gum arabic is a natural resin prepared by drying a rubbery exudate obtained from the stems and branches of a plant belonging to the genus Acacia (Acacia: especially Acacia Senegal IT Acacia seyal). Gum arabic dissolves in water at high concentrations, and its aqueous solution, at relatively low concentrations, has strong emulsion stability, protective colloid properties, and film-forming properties. For this reason, gum arabic has been widely used as an emulsifier, a thickener, a stabilizer and a filming agent ((INDUSTRIAL GUMS-POLYSACCHAR IDES AND THEIR DERIVATIVES-), SECOND EDITION, ACADEMIC PRESS, New York and London, 1973, pp.
- a filming agent (INDUSTRIAL GUMS-POLYSACCHAR IDES AND THEIR DERIVATIVES-), SECOND EDITION, ACADEMIC PRESS, New York and London, 1973, pp.
- gum arabic contains dietary fiber that is not eliminated by human digestive enzymes. Its content is 80-90% according to the enzyme-HPLC method (Monthly Food Chemical 2002-6, P85-89), 85% according to the AO AC method and 70% or more according to the ENGLYST method. Aru (Monthly Food Chemical 1997-7, pi 02-104) is known.
- gum Arabia has the characteristics that it has extremely low viscosity, can be used at a high concentration, and is excellent in safety, compared to high molecular weight polysaccharides, which are other dietary fibers. For this reason, it is a useful material for ingesting a large amount of dietary fiber without impairing the original texture even when added to foods such as beverages. Therefore, the development of foods using gum arabic as a dietary fiber is required. DISCLOSURE OF THE INVENTION.
- the present invention aims at the development of foods and drinks and medicines using gum arabic as a dietary fiber, and is a gum arabic obtained by modifying a gum arabic so as to contain a greater amount of dietary fiber, especially total dietary fiber (modified Arabic gum). Gum).
- a further object of the present invention is to provide a food or drink using the modified arabia gum as a dietary fiber material.
- gum arabic as a raw material used for the reforming is simply referred to as "gum arabic” or “natural gum arabic” or “unmodified gum” to distinguish it from the modified gum arabic of the present invention.
- Arabic gum ”.
- the inventors of the present invention have conducted intensive studies to solve the above-mentioned problems, and found that a natural treatment is performed on gum arabic (Arabia gum belonging to the species Acacia Senegal or Acacia seyal) obtained under natural conditions. Found that the total dietary fiber content could be increased.
- Item 1 A water-soluble modified gum arabic having a total dietary fiber content (AO AC method) of 90% or more.
- Item 2 The modified gum arabia according to Item 1, having a weight average molecular weight of 1,000,000 or more.
- Item 3 The modified gum arabic according to Item 1 or 2, which is used as a raw material for dietary fiber of foods and drinks or pharmaceuticals.
- Item 4 The modified gum arabic according to Item 1 or 2, which is used as an additive for dietary fiber reinforcement of food or drink or pharmaceutical products.
- Item 5 The modified gum arabic according to any one of Items 1 to 4, which is obtained by heating arabia gum.
- Item 6 The modified arabia gum according to Item 5, which is obtained by heating gum arabic at 110 ° C. for 24 hours or more, or by treating it under the same effect as described above.
- Item 7 The modified gum arabic according to any one of Items 1 to 6, which is derived from Acacia senega! Item 8.
- Item 9 Foods for foods or drinks or pharmaceuticals (preferably oral pharmaceuticals) comprising or containing the modified gum arabic described in any of Items 1 to 7 above.
- Item 10 A method for using the modified gum arabic according to any one of Items 1 to 7 as a dietary fiber raw material for foods and drinks or pharmaceuticals (preferably oral pharmaceuticals).
- Item 11 An additive for enhancing dietary fiber for food or drink or a pharmaceutical product (preferably an oral pharmaceutical product), comprising the modified gum arabic described in any one of Items 1 to 7 or containing the modified gum arabic.
- Item 1 A method of using the modified gum arabic described in any one of Items 1 to 7 as an additive for reinforcing a dietary fiber of a food or drink or a drug (preferably an oral drug).
- Item 13 A food or drink (preferably an oral drug) containing the modified arapia gum according to any one of Items 1 to 7 as a dietary fiber material.
- Item 1 A food or drink comprising the modified gum arabic according to any one of Items 1 to 7 as a dietary fiber raw material, wherein the dietary fiber content is enhanced.
- Item 15 Items 13 or 14 aimed at improving stool convenience, intestinal control, improving intestinal environment, preventing obesity, regulating blood lipid levels, lowering blood cholesterol, regulating blood sugar levels or suppressing carcinogenesis.
- Item 16 A method for enhancing a dietary fiber content of a food or drink, comprising producing a food or beverage using the modified gum arabic according to any one of Items 1 to 7 as a dietary fiber raw material.
- Item 17. Use of the modified gum arabic described in any one of Items 1 to 7 as a dietary fiber material.
- Item 18 Use of the modified gum arabic described in any one of Items 1 to 7 as an additive for reinforcing dietary fiber.
- Item 19 Use of the modified gum arabic according to any one of Items 1 to 7 for the manufacture of a food or drink or a pharmaceutical (preferably an oral pharmaceutical).
- Item 20 If food or medicine is used to improve stool, intestine, intestinal environment, obesity, blood Item 20.
- Fig. 2 shows a mouth matogram obtained by subjecting the prepared modified gum arabic to GPC-MALLS (gel filtration mouth mouth chromatography).
- the modified gum arabic of the present invention is characterized by containing 90% or more of total dietary fiber (AOAC method) in 100% by weight of the modified gum arabic.
- total dietary fiber means indigestible polysaccharides and lignin that are not hydrolyzed by human digestive enzymes when ingested into the body.
- the amount of total dietary fiber contained in the modified Arabic gum of the present invention is determined by the Prosky method (AOAC official method: CEREAL FOODS CHAPER 32 (2000),. It can be obtained in accordance with "AOAC OFFICIAL METHODS OF ANALYSIS", AOAC official method 991.43).
- the Prosky method is a method for quantifying the total dietary fiber SUP content (including water-soluble dietary fiber and insoluble dietary fiber) contained in a target sample.
- the method for determining the total dietary fiber content in the sample is specifically as follows. 1 g (solid) of sample is treated stepwise with heat-resistant ⁇ -amylase, protease, and amyloglucosidase to hydrolyze starch and protein. The fiber and insoluble dietary fiber are comprehensively precipitated, and the residue is recovered by filtration. The collected residue is washed with ethanol and acetone, and then dried to determine the weight (dry residue weight). The total dietary fiber content in the sample is determined by subtracting the amount of indigestible protein and the amount of ash from the dried residue weight.
- the total dietary fiber content in the sample (in the present invention, the modified gum arabic) was easily determined. Can be measured using, for example, “Total Dietary Fiber Measurement Kit” sold by Japan Biocon Corporation.
- the modified arapia gum of the present invention is characterized in that the total dietary fiber content thus obtained is at least 90%, preferably at least 91% by weight, more preferably at least 93% by weight.
- the upper limit is not particularly limited as long as the modified gum arabic is water-soluble as a whole, up to 100% by weight.
- the ratio of insoluble dietary fiber in the total dietary fiber content is not particularly limited as long as the modified gum arabic is water-soluble as a whole.
- water-soluble means that the modified gum arabic contains an excessive amount of water (regardless of the type of water containing ion-exchanged water.
- the temperature of the water may be the temperature at which it is dissolved. It does not matter.) It means that it is almost completely soluble in water.
- the gum arabic once in a hydrogel state does not dissolve in water even if the amount is increased to 7 or heated. Therefore, the term “water-soluble” used in the present invention is used to distinguish it from a hydrogel-like arabia gum that does not dissolve in water.
- the modified gum arabic of the present invention does not substantially contain a polymerized modified arabia gum that does not dissolve in water, such as a hydrogel.
- the modified gum arabic of the present invention contains the total dietary fiber in the above ratio. It is water-soluble as a whole, and is equivalent or similar in immunological reactivity to the raw arabia gum material before the modification. Is preferred.
- "equivalent or similar in the immunological reactivity to the gum arabic material” means "indirect competitive ELISA method using an antibody capable of quantifying gum arabic (for example, SYCC7) [Thurston, M. I, et al., Detection of gum from Acacia seyal and species of combretum in mixtures with A. Senegal using monoclonalantibodies, Food & Agric. Immunol., 10: 237-241 (1998), Thurston, M. I, et. al., Effect of heat and pH on carbohydrate epitopes from Acacia Senegal by specific monoclonal antibodies, Food & Agric. Immunol., 11: 145-153 (1999)]. It means within 10%.
- the modified gum arabic of the present invention is not particularly limited in its shape, and may have any shape of a lump, a ball, a coarse powder, a granule, a granule, and a powder. Can be.
- the modified gum arabic of the present invention is prepared by treating arabic gum belonging to Acacia a / species or gum arabic belonging to caca / species as a raw material for 24 hours at 110 ° C. using a thermostat or a heater such as an oven. It can be prepared by heating as described above.
- the gum arabic used as a raw material here (hereinafter referred to as “Arabic gum raw material ⁇ A. Senegal or“ rabic gum raw material (n jra / seed) ”. Also collectively referred to as“ arabia gum raw material ”) is Acacia senegal (Aca'a senegaJ) belonging to the genus Acacia, a legume plant, Acacia cereal C4cac / 'a /), or rubber-like exudates obtained from trunks and branches of these homologous plants are dried. It is a natural resin (polysaccharide) prepared. Alternatively, these may be further subjected to processing such as purification treatment, dehydration or pulverization, or dry spraying.
- Gum arabic ingredients are typically found in the North African power from Ethiopia to Senegal, countries in West Africa (Ethiopia, Sudan, Senegal, Nigeria, Niger, Ghana), East African countries such as Kenya and Kenya, the Saharan region in Africa, and the Nile. It is also produced in the basin of a river tributary, but in the present invention, it does not matter from where it originated.
- gum arabic raw materials do not particularly limit the water content.
- commercially available arabia gum raw materials have a water content (loss on drying) reduced by heating and drying at 105 ° C for 6 hours at 40% by weight or less, preferably 30% by weight or less. It is particularly preferably at most 20% by weight.
- a gum arabic raw material having such a water content (drying loss) can be optionally used.
- gum arabic raw materials can be obtained in the form of lumps, beads, coarse powder, granules, $ standing, or powder (including spray-dried powder and mouth-to-mouth dry powder).
- any of these shapes can be used as a raw material to be reformed, regardless of their shape.
- it may be a powder having an average particle diameter of about several tens to several hundreds // m (including spray-dried powder and roller-dried powder).
- the upper limit of the average particle size is not particularly limited, but is preferably 100% or less from the viewpoint of reforming efficiency. Is desirable.
- the average particle size is in the range of 1 to: L00, more preferably in the range of 2 to 50 thighs.
- a method of heating at 110 for 24 hours or more using an oven can be exemplified.
- the heat treatment is performed at 110 ° C. for 48 hours or more.
- the upper limit of time is 72 hours.
- the above-mentioned heating temperature and heating time are merely examples of the method (conditions) for preparing the modified arabia gum of the present invention. Although it serves as a guide for obtaining gum arabic, it does not limit the modified arabia gum of the present invention.
- the heating temperature, heating time, heating means and heating environmental conditions can be arbitrarily selected and used, and is not particularly limited to the above heating conditions.
- the effect of the present invention obtained by the heat treatment under the above conditions is a method of performing a heat treatment at a temperature lower than 110 ° C. for a longer time than 24 hours, The same can be obtained depending on the processing method.
- the former there can be mentioned a method of heating at 80 for 3 days to 2 weeks or more.
- modified gum arabic of the present invention desirably has a weight average molecular weight of 100,000 or more, especially when a gum arabic material “Senegal mi” is used.
- the weight-average molecular weight is determined by gel filtration chromatography (MALLS: Multi Angle Laser Light Scattering), a refractive index (RI) detector, and a UV detector connected online. In the description, this can be obtained simply by the method of “GPC-MALLSJ.”
- MALLS Multi Angle Laser Light Scattering
- RI refractive index
- UV detector connected online
- the molecular weight can be detected by a light scattering detector (MALLS)
- the weight (composition ratio) of each component can be detected by a refractive index (RI) detector
- the protein can be detected by a UV detector.
- GPC-MALLS The measurement conditions of GPC-MALLS employed in the present invention are as follows:
- Detector 1 MALLS (multi angle laser light scattering) Detector: DAWN DSP (manufactured by Wyatt Technology, USA), 2 RI (refractive index) detector, 3 UV detector (absorption at 214 nm).
- the data obtained under the above conditions were processed by ASTRA Version 4.5 (Wyatt Technology) software to obtain the weight average molecular weight, recovery (% Mass), divergence value (P), radius of inertia (Rg ), And various parameters of gum arabic ingredients can be obtained.
- the entire peak on the chromatogram obtained by the RI detector (“When the rising part from the baseline of the RI chromatogram chart is the“ start point ”and the part that descends and intersects the baseline is the“ end point, Means the chart part from the “starting point” to the “ending point”.)), And when processed as one peak (processed as one peak), the obtained molecular weight is referred to as “weight average molecular weight” in the present invention. (More specifically, it is "weight average molecular weight (M wt processed as one peak) J).
- (ml) '' indicates the accumulated amount of eluate that passed through the column, and ⁇ AUX, 90 ° Detectorj '' on the vertical axis indicates the relative intensity (relatable intensity) of each detector (MALLS detector, RI detector, UV detector).
- MALLS detector shows the light scattering intensity at 90 ° and correlates with the molecular weight distribution
- RI detector shows the refractive index
- UV detector shows the UV absorption detected at 214 nm, indicating the intensity of the protein.
- the entire peak on the chromatogram obtained by the RI detector (the rising portion of the RI chromatogram from the baseline is referred to as the “starting point” (corresponding to the “A” point in Figure 1)).
- the part that descends and descends and intersects the baseline is called the “end point” ( When the equivalent)) in the “B” point in 1, means the region from the "starting point” to "end point”. ") If the data processing as one peak (Processed the as molecular weight obtained in one peak) is, in the present onset bright" weight average molecular weight (M wt) "beam" weight average good amounts in detail (M wt Processed as one peak) ”).
- the weight average molecular weight of the modified gum arabic of the present invention is preferably not less than 100,000, and is not particularly limited, but is preferably not less than 120,000, more preferably not less than 150,000, and still more preferably It is more than 200,000.
- the upper limit of the weight average molecular weight is not particularly limited as long as the modified arapia gum contains 90% by weight or more of total dietary fiber and is water-soluble, but it is usually preferably 250,000 or less. .
- the present invention provides the use of the above-mentioned modified gum arabic containing 90% by weight or more of total dietary fiber as a raw material for food or drink or a pharmaceutical based on the official measurement method of AOAC. is there.
- the modified gum arabic is used to enhance dietary fiber (to increase the dietary fiber content) in foods and drinks or pharmaceutical products.
- the present invention relates to an orally ingestible edible additive used to enhance dietary fiber (to increase the content of dietary fiber) in foods and drinks and pharmaceuticals for oral use. Offer things.
- such an edible additive is a dietary fiber raw material, and is an additive for reinforcing dietary fiber.
- the dietary fiber raw material or the dietary fiber-enriching additive of the present invention may consist solely of the modified arabia gum of the present invention, or may contain the modified Arabic gum of the present invention as an active ingredient. May further contain water-soluble dietary fiber or insoluble dietary fiber, or a food or pharmaceutically acceptable carrier or additive. In the latter case, it is preferable that the modified gum arabic of the present invention is contained in a proportion of at least 30% by weight or more.
- the water-soluble dietary fiber other than the modified gum arabic includes pectin, guar gum, psyllium, galactomannan, xyloglucan, lipo-castin gam, dalcomannan, sodium alginate, chondroitin sulfate, and low-molecular-weight algin. Acids, low molecular weight guar gum, indigestible dextrin, polydextrose, pullulan, and phipalone.
- insoluble dietary fiber examples include cellulose, wheat bran, azukare fiber, sweet potato fiber 1, corn fiber 1, and chitin.
- insoluble dietary fiber examples include cellulose, wheat bran, azukare fiber, sweet potato fiber 1, corn fiber 1, and chitin.
- saccharides such as dextrin, lactose, maltose, torehaulose, and darcose; and solpitol mannitol and the like.
- Sugar alcohols; glycerin and polyhydric alcohols such as propylene dalicol.
- the dietary fiber raw materials or dietary fiber fortifying additives are added together with other raw materials as a component of foods and drinks and oral pharmaceuticals in order to enhance the dietary fiber content It is used as a constituent of foods and drinks and oral drugs.
- the present invention relates to a food and drink and a pharmaceutical product in which the content of dietary fiber is enhanced by blending the above modified arabia gum containing 90% by weight or more of total dietary fiber based on the measurement by AOAC official method. provide.
- the foods and drinks and the pharmaceuticals may be replaced with the above-mentioned modified gum arabic, and the dietary fiber raw material or the dietary fiber reinforcing additive of the present invention described above. It can also be prepared using additives.
- the foods and beverages targeted by the present invention if the total dietary fiber is enhanced based on the content of the modified arabia gum of the present invention, the type, the content of the modified arabic gum, and The amount of total dietary fiber is not particularly questioned.
- the content of the modified gum arabic of the present invention is preferably 1% by weight or more, more preferably 5% by weight or more, and further preferably 10% or more.
- the upper limit is not particularly limited, it is 100% by weight in view of the fact that the modified gum arabic of the present invention can be used (eat) as a health food (functional food) as it is.
- the type of food and drink is not limited, but soft drinks, fruit drinks, milk drinks, lactic acid bacteria drinks, carbonated drinks, vegetable drinks, sports drinks, tea drinks, green tea drinks, powdered drinks, cocoa drinks, cocoa Beverages such as drinks, soups, and shirako; desserts such as pudding, jelly, and shodart; frozen desserts such as ice cream and popsicles; confectionery such as chewing gum, chocolate, soft candy, biscuits, and cookies Seasonings such as dressings, sauces, and ketchup; and other processed foods such as jams, varieties, fish paste products, syrups, breads, and various prepared dishes. It can also be provided as a supplement (health food. Functional food) in the form of tablets, capsules, pills, granules, powders, powders, or solutions (drinks).
- the food or drink of the present invention is in the form of the above-mentioned supplement, together with an effective amount (dietary fiber-enhancing amount) of the modified gum arabic of the present invention, which is an active ingredient, a carrier or other additives acceptable for food hygiene. Can be included.
- the amount of the modified gum arabic or its intake in the above food and drink is not particularly limited, and the kind of food and drink, the kind of the intended effect, the degree of the improvement effect, and other various conditions It is appropriately selected from a wide range according to the conditions.
- the amount of intake varies depending on the type of food and drink, but for a human weighing 60 kg, the range of about 1 to 100 g / day is calculated as the amount of modified gum arabic per day consumed. Can be selected as appropriate.
- the food and drink according to the present invention contains a large amount of dietary fiber, thereby providing blood cholesterol.
- Physiological functions or diseases such as lowering blood pressure, regulating blood lipid levels, improving stool (including constipation), improving intestinal environment, intestinal action, preventing obesity, regulating blood sugar levels, or suppressing carcinogenesis has a preventive effect.
- the food and drink of the present invention have the effect that, due to the low viscosity of the modified gum arabic, they do not impair the texture even when ingested in large amounts and do not show any side effects such as diarrhea. I have.
- Pharmaceutical products targeted by the present invention have a lowering of blood cholesterol, regulation of blood lipid level, improvement of stool (including improvement of constipation) or intestinal tract. It has a physiological function such as intestinal action for improving the environment, prevention of obesity, regulation of blood sugar level or suppression of carcinogenesis, or a disease prevention effect.
- the content of the modified gum arabic and the total amount of dietary fiber are not particularly limited as long as the function or the disease prevention effect is exhibited.
- the pharmaceuticals targeted by the present invention are orally used pharmaceuticals (oral pharmaceuticals).
- Such pharmaceuticals can be used in the usual manner in tablets, pills, powders, powders, solid dosage forms such as granules, capsules, and dry syrups, or liquid dosage forms such as solutions, suspensions, emulsions, and syrups. It can be prepared and molded.
- the medicament of the present invention may contain a pharmaceutically acceptable carrier or other additives together with the modified gum arabic.
- Carriers used in the preparation of these drugs include excipients, diluents, binders, humectants, disintegrants, disintegration inhibitors, P and accelerating agents that are commonly used depending on the dosage form of the preparation.
- Additives include stabilizers, preservatives, buffers, tonicity agents, chelating agents, pH adjusters, surfactants, coloring agents, flavors, Flavoring agents and sweetening agents can be exemplified.
- the amount of the modified gum arabic contained in the medicament of the present invention varies depending on the pharmaceutical form or administration route of the medicament and cannot be specified unconditionally, but is preferably 5% by weight or more in the final preparation. Preferably, the ratio is 10% by weight or more.
- the upper limit is not particularly limited, but is 100% by weight in view of the fact that the modified gum arabic of the present invention can be used as a pharmaceutical as it is.
- the dose of the medicament of the present invention is not particularly limited, and is appropriately selected from a wide range according to the desired effect, administration method, treatment period, patient age, sex, and other conditions. Dose Although it depends on the administration route, it can be appropriately selected from the range of about 1 to 100 g / day in terms of the amount of the active ingredient per day administered to a human weighing 60 kg.
- part J means “parts by weight” and “” means “% by weight” unless otherwise specified.
- Coarse-grained gum ae / 1 ⁇ 2 belonging to ae / ⁇ / species (U. Senegal gum arabic): Sample 1) 1 kg (bulb size 5 mm) is placed in a stainless steel container at 24 ° C at 110 ° C. The mixture was heated open for 48 hours and for 48 hours (24 hours heat-treated gum arabic was called rsample 1/24 "and 48 hours heat-treated arabia gum was called rsample 1/48 J).
- the total dietary fiber content of the arabia gum samples (Sample 1, Sample 1/24, Sample 1/48) obtained above was measured according to the Prosky (AOA C) method.
- one residue is removed together with celite, the nitrogen content of the residue is quantified by the semi-microgel method, and the protein content is determined by multiplying by a conversion factor of 6.25.
- the other residue is incinerated at 525 for 5 hours, allowed to cool in a desiccator, weighed to the nearest 0.1 mg, and the ash content in the residue is determined.
- the total dietary fiber content% is calculated based on the following formula. Sembakai White Min%
- Blank Planck separation mg— i X Blank mgf
- the arabia gum samples (SampleK Sample 1/24, Sample 1/48) obtained above were subjected to gel filtration chromatography according to the GPC-MALLS (Multi Angle Laser Light Scattering) method under the following conditions. A chromatogram was obtained.
- GPC-MALLS Multi Angle Laser Light Scattering
- Sample preparation Dissolve analysis sample in elution solvent (0.2M NaCl)
- MALLS multi angle laser light scattering detector: DAWNDSP (Wyatt Technology), (2) RI (refractive index) detector, (3) UV detector (absorption at 2 nm).
- the weight average molecular weight was determined by processing the data obtained under the above conditions using ASTRA Version 4.5 (Wyatt Technology) software. Specifically, the entire peak of the chart in the chromatogram obtained by the RI detector (specifically, the “starting point” is the rising part of the baseline of the chart, and the “end point” is the part that descends and intersects the baseline.
- the obtained molecular weight is referred to as "weight average molecular weight" in the present invention.
- Table 1 shows the total dietary fiber content and the weight average molecular weight (M wt processed as one peak) of the gum arabic samples (Sample 1 Sample 1/24 Sample 1/48).
- a monoclonal antibody was first prepared that showed quantitative cross-reactivity without specificity to the seeds of Arapia gum. Specifically, adjuvant was mixed with saline containing lmgm1 of A. Senegal sp. Gum arabic and immunized intraperitoneally three times at two-week intervals in Ba1bZc mice. Spleen cells from mice with increased antibody titers were collected and fused with myeoma cells using polyethylene glycol. After culturing for 10 days in a culture plate, the fused cells were selected based on the specificity of the antibody produced in the supernatant of the grown fused cells. Next, the fused cells are cultured again on a culture plate for 10 days, and the fused cells are selected in the same manner. Finally, fused cells that produce only the antibody having the above specificity (designated as SYCC 7) are obtained. Selected.
- the inhibition rate of the sample at each concentration was expressed as the inhibition rate of 100% based on the degree of color development of the raw material of gum arabic belonging to A./ ⁇ 3/ species (untreated gum arabic: Sample 1).
- the modified gum arabic (Sa Immediately 1/24, Sample 1/48) of the present invention showed a difference of ⁇ 1 between the gum arabic material (Sample 1) and the immunological inhibition rate at any of the concentrations tested. It was within 0%, and there was almost no difference, indicating that the immunological reaction with the gum arabic material (Sample 1) was substantially the same or similar.
- aqueous solutions of various concentrations were prepared and the viscosities were compared. Specifically, 10 g of a gum arabic sample (sample 1, sample 1/24, sample 1/48) was dissolved in 90 g of water to prepare a 10 wt% gum arabic aqueous solution. Similarly, 20% by weight and 30% by weight aqueous gum arabic solutions were prepared. Put this into a lOOmL screw tube and use a B-type rotary viscometer (BM type, manufactured by Tokyo Keiki Seisakusho) at 20. (m Pa ⁇ S) was measured. Table 2 shows the results.
- BM type manufactured by Tokyo Keiki Seisakusho
- the viscosity of 300 (mPa ⁇ S) is a relatively low viscosity, similar to that of soup, depending on the material. From these results, it was found that the modified gum arabic of the present invention, Sa immediate lel / 24 and Sa immediate lel / 48, had a higher viscosity than the untreated gum arabic raw material (Samplel). This increase in viscosity is related to the transfer of food from the stomach to the small intestine, and when adjusting the absorption of various nutrients and food components, for example, slows the rate of absorption of glucose from the small intestine and increases the blood glucose level. It is thought to delay the rise and bring about an insulin-saving effect. In addition, the increased viscosity may affect the villi of the small intestine and promote its metabolism. In addition, it may protect the stomach wall and show a preventive effect on gastric ulcer.
- Example 1 Preparation of arabia gum powder
- the modified gum arabic obtained in Experimental Example 1 can be prepared as a gum arabic powder by the following method, and further used to prepare various foods and drinks as shown in Examples 2 to 4. can do.
- Total (after preparation) 100.0 ) Mix sugar, starch syrup and water, heat to 155 ° C and dissolve. Cool to 125, add the modified arabic powder, cuenic acid, L-ascorbic acid, and pineapple fragrance in order and mix to form a hard candy.
- the following components are mixed with powder, and a tableting machine (tableting pressure of 1 dong) is used to prepare a fine powder.
- the modified gum arabic of the present invention has been modified so as to have a total dietary fiber content of 90% by weight or more and a high dietary fiber content.
- many researchers have pointed out the relationship between a lack of dietary fiber and an increase in lifestyle-related diseases such as diabetes, obesity, and arteriosclerosis. Attention has been paid to the physiological function of dietary fiber, and the necessity of ingesting dietary fiber has been advocated.
- ADVANTAGE OF THE INVENTION According to the modified gum arabic of the present invention, the dietary fiber content of the food and drink can be increased by being added to the food and drink as a dietary fiber raw material or a dietary fiber reinforcing additive.
- the modified gum arabic of the present invention has these physiological functions (blood cholesterol lowering function, convenience improving function, intestinal environment improving machine, intestinal regulation action, blood lipid level regulating action, blood glucose level regulating action). Action) or based on its carcinogenesis-suppressing action, it can also be used as a pharmaceutical raw material having such a function.
- the modified gum arabic of the present invention has a feature that the viscosity is low even at a high concentration. For this reason, it is possible to ingest a large amount of dietary fiber without impairing the original texture even when added to beverages and other foods.
- the present invention also provides a food or drink having an enhanced dietary fiber content by containing such modified arabia gum.
- the food or drink contains a large amount of dietary fiber, so that various physiological functions caused by dietary fiber (for example, blood cholesterol lowering function, stool improvement function, intestinal environment improving machine, intestinal action) It can be provided as a health food or a functional food having a blood lipid level regulating action, a blood sugar level regulating action) or a carcinogenesis suppressing action.
- various physiological functions caused by dietary fiber for example, blood cholesterol lowering function, stool improvement function, intestinal environment improving machine, intestinal regulation action, blood lipid level regulating action, blood glucose Value-adjusting action
- a drug having such a function based on the action of suppressing the generation of cancer.
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005505332A JPWO2004089992A1 (ja) | 2003-04-09 | 2004-04-09 | 改質アラビアガムおよびその用途 |
EP04726810A EP1612225A4 (en) | 2003-04-09 | 2004-04-09 | MODIFIED ACACIA GUM AND USE THEREOF |
CA002521692A CA2521692A1 (en) | 2003-04-09 | 2004-04-09 | Modified acacia and use thereof |
US10/552,480 US20060240166A1 (en) | 2003-04-09 | 2004-04-09 | Modified acacia and use thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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JP2003105903 | 2003-04-09 | ||
JP2003-105903 | 2003-04-09 |
Publications (2)
Publication Number | Publication Date |
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WO2004089992A1 true WO2004089992A1 (ja) | 2004-10-21 |
WO2004089992A8 WO2004089992A8 (ja) | 2005-01-20 |
Family
ID=33156894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/JP2004/005146 WO2004089992A1 (ja) | 2003-04-09 | 2004-04-09 | 改質アラビアガムおよびその用途 |
Country Status (6)
Country | Link |
---|---|
US (1) | US20060240166A1 (ja) |
EP (1) | EP1612225A4 (ja) |
JP (1) | JPWO2004089992A1 (ja) |
CN (1) | CN100447160C (ja) |
CA (1) | CA2521692A1 (ja) |
WO (1) | WO2004089992A1 (ja) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006132288A1 (ja) * | 2005-06-07 | 2006-12-14 | San-Ei Gen F.F.I., Inc. | ペクチンの改質方法及びその応用 |
JPWO2007037347A1 (ja) * | 2005-09-28 | 2009-04-09 | 三栄源エフ・エフ・アイ株式会社 | 乳化組成物及びその調製方法 |
JPWO2018181998A1 (ja) * | 2017-03-31 | 2020-03-12 | 三栄源エフ・エフ・アイ株式会社 | 乳化組成物 |
WO2021059344A1 (ja) * | 2019-09-24 | 2021-04-01 | 日油株式会社 | 植物性プロテオグリカン及びその用途 |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2349602C2 (ru) | 2003-09-10 | 2009-03-20 | Сан-Еи Ген Ф.Ф.И., Инк. | Способ получения модифицированного гуммиарабика |
JPWO2006009259A1 (ja) * | 2004-07-23 | 2008-07-31 | 三栄源エフ・エフ・アイ株式会社 | アラビアガム由来のハイドロゲル成分含有組成物 |
MA28714B1 (fr) | 2005-12-15 | 2007-07-02 | Green Technlology Sarl | Une arabinogalactane proteine ayant la propriete d'absorber les graisses et le procede d'obtention de cette arabinogalactane proteine |
US20080038432A1 (en) * | 2006-08-14 | 2008-02-14 | Hoffman Andrew J | Food Additive Comprising at Least One Fiber Source and at Least One Monosaccharide or Sugar Alcohol |
FR2917948B1 (fr) * | 2007-06-29 | 2010-10-29 | Gervais Danone Sa | Preparation de fruits stable a forte concentration de gomme d'acacia |
EP3100189A1 (fr) * | 2014-01-28 | 2016-12-07 | Debiotech S.A. | Dispositif de commande avec recommandation |
CA3038782A1 (en) | 2016-09-30 | 2018-04-05 | San-Ei Gen F.F.I., Inc. | Low molecular gum ghatti |
CN114599682A (zh) * | 2019-08-26 | 2022-06-07 | 玉米产品开发公司 | 阿拉伯树胶 |
CN113278090B (zh) * | 2021-06-28 | 2022-07-29 | 华侨大学 | 一种合欢花多糖、制备方法及应用 |
CN115606617B (zh) * | 2022-09-27 | 2023-08-22 | 四川旅游学院 | 一种控制亚硝胺含量并提高货架期的川味香肠制备方法 |
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JPH0249001A (ja) * | 1988-08-11 | 1990-02-19 | Kamisu Kagaku Kogyosho:Kk | 高粘度化されたアラビアガムの製造法 |
JP2000166489A (ja) * | 1998-12-02 | 2000-06-20 | Nisshin Oil Mills Ltd:The | 変性アラビアガムおよびその製造方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6610810B2 (en) * | 2001-03-13 | 2003-08-26 | Glyn Owen Phillips | Biopolymers obtained by solid state irradiation in an unsaturated gaseous atmosphere |
-
2004
- 2004-04-09 US US10/552,480 patent/US20060240166A1/en not_active Abandoned
- 2004-04-09 EP EP04726810A patent/EP1612225A4/en not_active Withdrawn
- 2004-04-09 CA CA002521692A patent/CA2521692A1/en not_active Abandoned
- 2004-04-09 JP JP2005505332A patent/JPWO2004089992A1/ja not_active Withdrawn
- 2004-04-09 CN CNB2004800095307A patent/CN100447160C/zh not_active Expired - Fee Related
- 2004-04-09 WO PCT/JP2004/005146 patent/WO2004089992A1/ja active Application Filing
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JPH0249001A (ja) * | 1988-08-11 | 1990-02-19 | Kamisu Kagaku Kogyosho:Kk | 高粘度化されたアラビアガムの製造法 |
JP2000166489A (ja) * | 1998-12-02 | 2000-06-20 | Nisshin Oil Mills Ltd:The | 変性アラビアガムおよびその製造方法 |
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Title |
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See also references of EP1612225A4 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006132288A1 (ja) * | 2005-06-07 | 2006-12-14 | San-Ei Gen F.F.I., Inc. | ペクチンの改質方法及びその応用 |
JP5057972B2 (ja) * | 2005-06-07 | 2012-10-24 | 三栄源エフ・エフ・アイ株式会社 | ペクチンの改質方法及びその応用 |
JPWO2007037347A1 (ja) * | 2005-09-28 | 2009-04-09 | 三栄源エフ・エフ・アイ株式会社 | 乳化組成物及びその調製方法 |
JPWO2018181998A1 (ja) * | 2017-03-31 | 2020-03-12 | 三栄源エフ・エフ・アイ株式会社 | 乳化組成物 |
WO2021059344A1 (ja) * | 2019-09-24 | 2021-04-01 | 日油株式会社 | 植物性プロテオグリカン及びその用途 |
CN114341198A (zh) * | 2019-09-24 | 2022-04-12 | 日油株式会社 | 植物性蛋白聚糖及其用途 |
CN114341198B (zh) * | 2019-09-24 | 2023-05-16 | 日油株式会社 | 植物性蛋白聚糖及其用途 |
Also Published As
Publication number | Publication date |
---|---|
EP1612225A1 (en) | 2006-01-04 |
US20060240166A1 (en) | 2006-10-26 |
CN1771263A (zh) | 2006-05-10 |
EP1612225A4 (en) | 2008-01-02 |
CN100447160C (zh) | 2008-12-31 |
WO2004089992A8 (ja) | 2005-01-20 |
CA2521692A1 (en) | 2004-10-21 |
JPWO2004089992A1 (ja) | 2006-07-06 |
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