WO2003082840A1 - κ-OPIOID RECEPTOR AGONIST COMPRISING 2-PHENYLBENZOTHIAZOLINE DERIVATIVE - Google Patents
κ-OPIOID RECEPTOR AGONIST COMPRISING 2-PHENYLBENZOTHIAZOLINE DERIVATIVE Download PDFInfo
- Publication number
- WO2003082840A1 WO2003082840A1 PCT/JP2003/003928 JP0303928W WO03082840A1 WO 2003082840 A1 WO2003082840 A1 WO 2003082840A1 JP 0303928 W JP0303928 W JP 0303928W WO 03082840 A1 WO03082840 A1 WO 03082840A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- phenylbenzothiazoline
- opioid receptor
- receptor agonist
- derivative
- compound
- Prior art date
Links
- XBHOUXSGHYZCNH-UHFFFAOYSA-N 2-phenyl-1,3-benzothiazole Chemical class C1=CC=CC=C1C1=NC2=CC=CC=C2S1 XBHOUXSGHYZCNH-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002632 kappa opiate receptor agonist Substances 0.000 title abstract 2
- 229940126470 kappa opioid receptor agonist Drugs 0.000 title abstract 2
- YKJUYTXCRIKRND-UHFFFAOYSA-N 2-phenyl-2,3-dihydro-1,3-benzothiazole Chemical compound S1C2=CC=CC=C2NC1C1=CC=CC=C1 YKJUYTXCRIKRND-UHFFFAOYSA-N 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000003277 amino group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000001270 agonistic effect Effects 0.000 abstract 1
- 102000048260 kappa Opioid Receptors Human genes 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 108020001588 κ-opioid receptors Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/509,549 US7112598B2 (en) | 2002-03-29 | 2003-03-28 | κ opioid receptor agonist comprising 2-phenylbenzothiazoline derivative |
NZ535987A NZ535987A (en) | 2002-03-29 | 2003-03-28 | k-opioid receptor agonist comprising 2-henylbenzothiazoline derivative |
ES03715569T ES2390052T3 (es) | 2002-03-29 | 2003-03-28 | Agonistas del receptor opioide kappa que comprende un derivado de 2-fenilbenzotiazolina |
KR1020047015318A KR101035931B1 (ko) | 2002-03-29 | 2003-03-28 | 2-페닐벤조티아졸린 유도체로 이루어진 κ 오피오이드 수용체 작용약 |
CA2480560A CA2480560C (en) | 2002-03-29 | 2003-03-28 | .kappa.-opioid receptor agonist comprising 2-phenylbenzothiazoline derivative |
AU2003220894A AU2003220894B8 (en) | 2002-03-29 | 2003-03-28 | Kappa-opioid receptor agonist comprising 2-phenylbenzothiazoline derivative |
CN038072750A CN1642929B (zh) | 2002-03-29 | 2003-03-28 | 含有2-苯基苯并噻唑啉衍生物的κ-阿片样物质受体激动剂 |
EP03715569A EP1496053B1 (en) | 2002-03-29 | 2003-03-28 | Kappa-opioid receptor agonist comprising a 2-phenylbenzothiazoline derivative |
US11/434,028 US7410987B2 (en) | 2002-03-29 | 2006-05-15 | Method for treating pain or pruritis by administering κ-opioid receptor agonist comprising 2-phenylbenzothiazoline derivative |
AU2009201233A AU2009201233B2 (en) | 2002-03-29 | 2009-03-30 | Kappa-opioid receptor agonist comprising 2-phenylbenzothiazoline derivative |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002097500 | 2002-03-29 | ||
JP2002-097500 | 2002-03-29 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10509549 A-371-Of-International | 2003-03-28 | ||
US11/434,028 Continuation US7410987B2 (en) | 2002-03-29 | 2006-05-15 | Method for treating pain or pruritis by administering κ-opioid receptor agonist comprising 2-phenylbenzothiazoline derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003082840A1 true WO2003082840A1 (en) | 2003-10-09 |
Family
ID=28671920
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2003/003928 WO2003082840A1 (en) | 2002-03-29 | 2003-03-28 | κ-OPIOID RECEPTOR AGONIST COMPRISING 2-PHENYLBENZOTHIAZOLINE DERIVATIVE |
Country Status (10)
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005002622A1 (ja) * | 2003-07-04 | 2005-01-13 | Santen Pharmaceutical Co., Ltd. | 疼痛閾値低下抑制剤 |
US7642274B2 (en) | 2004-07-02 | 2010-01-05 | Santen Pharmaceutical Co., Ltd. | Inhibitor of pain threshold decrease |
JPWO2006088246A1 (ja) * | 2005-02-18 | 2008-07-10 | 武田薬品工業株式会社 | Gpr34受容体機能調節剤 |
US9303027B2 (en) | 2010-07-19 | 2016-04-05 | Dr. Reddy's Laboratories Ltd. | Kappa opioid receptor agonists |
MX355142B (es) | 2012-03-05 | 2018-04-05 | Dr Reddys Laboratories Ltd | Acetamidas heterociclicas sustituidas como agonistas del receptor opioide kappa (kor). |
WO2014148574A1 (ja) | 2013-03-22 | 2014-09-25 | 参天製薬株式会社 | Il-2産生抑制 |
EP3085698B1 (en) | 2013-12-18 | 2019-11-13 | Kyoto University | Pain-related compound and medicinal composition |
US11433090B2 (en) | 2017-06-16 | 2022-09-06 | The Doshisha | mTOR-inhibitor-containing medicine for treating or preventing ophthalmic symptoms, disorders, or diseases, and application thereof |
JPWO2018230713A1 (ja) | 2017-06-16 | 2020-04-16 | 学校法人同志社 | カスパーゼ阻害活性を有する化合物、これらの化合物を含む、角膜内皮の症状、障害または疾患を治療または予防するための医薬およびその応用 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5846079A (ja) | 1981-09-12 | 1983-03-17 | Santen Pharmaceut Co Ltd | ベンゾチアゾリン環を有するエ−テル類 |
JPS5967276A (ja) | 1982-09-01 | 1984-04-16 | Santen Pharmaceut Co Ltd | ベンゾチアゾリン誘導体 |
JPS60139679A (ja) | 1983-12-27 | 1985-07-24 | Santen Pharmaceut Co Ltd | 2−アリ−ルベンゾチアゾリン誘導体 |
JPS6183175A (ja) * | 1984-09-06 | 1986-04-26 | Santen Pharmaceut Co Ltd | ベンゾチアゾリン誘導体およびそれを主成分とする循環器官用薬剤 |
JPS62221680A (ja) * | 1986-03-19 | 1987-09-29 | Santen Pharmaceut Co Ltd | フエノキシアルキルアミン側鎖を有するベンゾチアゾリン誘導体 |
JPS62221679A (ja) | 1986-03-19 | 1987-09-29 | Santen Pharmaceut Co Ltd | ベンゾチアゾリン誘導体 |
JPH08231399A (ja) * | 1995-02-23 | 1996-09-10 | Shionogi & Co Ltd | モルヒネ禁断抑制作用剤 |
WO1998023290A1 (fr) | 1996-11-25 | 1998-06-04 | Toray Industries, Inc. | Agent antiprurigineux |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US547513A (en) * | 1895-10-08 | Chell | ||
JPS4994667A (US20060205796A1-20060914-C00130.png) * | 1973-01-23 | 1974-09-09 | ||
JP2000344821A (ja) | 1999-06-01 | 2000-12-12 | Toagosei Co Ltd | オレフィン重合用触媒 |
-
2003
- 2003-03-28 EP EP09000611A patent/EP2042173A3/en not_active Withdrawn
- 2003-03-28 KR KR1020047015318A patent/KR101035931B1/ko not_active IP Right Cessation
- 2003-03-28 CN CN038072750A patent/CN1642929B/zh not_active Expired - Fee Related
- 2003-03-28 US US10/509,549 patent/US7112598B2/en not_active Expired - Fee Related
- 2003-03-28 AU AU2003220894A patent/AU2003220894B8/en not_active Ceased
- 2003-03-28 NZ NZ535987A patent/NZ535987A/en not_active IP Right Cessation
- 2003-03-28 CA CA2480560A patent/CA2480560C/en not_active Expired - Fee Related
- 2003-03-28 ES ES03715569T patent/ES2390052T3/es not_active Expired - Lifetime
- 2003-03-28 CN CNB2006101392068A patent/CN100522954C/zh not_active Expired - Fee Related
- 2003-03-28 WO PCT/JP2003/003928 patent/WO2003082840A1/ja active Application Filing
- 2003-03-28 EP EP03715569A patent/EP1496053B1/en not_active Expired - Lifetime
-
2006
- 2006-05-15 US US11/434,028 patent/US7410987B2/en not_active Expired - Fee Related
-
2009
- 2009-02-02 JP JP2009021413A patent/JP5061134B2/ja not_active Expired - Fee Related
- 2009-03-30 AU AU2009201233A patent/AU2009201233B2/en not_active Ceased
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5846079A (ja) | 1981-09-12 | 1983-03-17 | Santen Pharmaceut Co Ltd | ベンゾチアゾリン環を有するエ−テル類 |
US4479949A (en) * | 1981-09-12 | 1984-10-30 | Santen Pharmaceutical Co., Ltd. | Benzothiazoline compounds |
JPS5967276A (ja) | 1982-09-01 | 1984-04-16 | Santen Pharmaceut Co Ltd | ベンゾチアゾリン誘導体 |
JPS60139679A (ja) | 1983-12-27 | 1985-07-24 | Santen Pharmaceut Co Ltd | 2−アリ−ルベンゾチアゾリン誘導体 |
US4547513A (en) * | 1983-12-27 | 1985-10-15 | Santen Pharmaceutical Co., Ltd. | 2-Arylbenzothiazoline derivatives and their use in treating angina cordis |
JPS6183175A (ja) * | 1984-09-06 | 1986-04-26 | Santen Pharmaceut Co Ltd | ベンゾチアゾリン誘導体およびそれを主成分とする循環器官用薬剤 |
JPS62221680A (ja) * | 1986-03-19 | 1987-09-29 | Santen Pharmaceut Co Ltd | フエノキシアルキルアミン側鎖を有するベンゾチアゾリン誘導体 |
JPS62221679A (ja) | 1986-03-19 | 1987-09-29 | Santen Pharmaceut Co Ltd | ベンゾチアゾリン誘導体 |
JPH08231399A (ja) * | 1995-02-23 | 1996-09-10 | Shionogi & Co Ltd | モルヒネ禁断抑制作用剤 |
WO1998023290A1 (fr) | 1996-11-25 | 1998-06-04 | Toray Industries, Inc. | Agent antiprurigineux |
Non-Patent Citations (3)
Title |
---|
FUJITA M.: "Synthesis and calcium antagonistic activity of (+)-(R)-and(-)-(S)-3-acetyl-2-(5-methoxy-2-(4-(N-methyl-N-(3,4,5-trimethoxyphenethyl)amino)butoxy)phenyl)benzothiazoline hydrochloride", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 38, no. 4, 1990, pages 936 - 941, XP002962151 * |
WAY E.L.: "Review of revues", ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, vol. 32, 1992, pages 9 - 23, XP002962152 * |
YAMAMOTO K.: "Novel calcium antagonists. Synthesis and structure-activity relationship studies of benzothiazoline derivatives", JOURNAL OF MEDICINAL CHEMISTRY, vol. 31, no. 5, 1988, pages 919 - 930, XP001091266 * |
Also Published As
Publication number | Publication date |
---|---|
EP2042173A3 (en) | 2010-02-24 |
JP2009143940A (ja) | 2009-07-02 |
EP2042173A2 (en) | 2009-04-01 |
AU2003220894B2 (en) | 2009-02-05 |
NZ535987A (en) | 2006-08-31 |
EP1496053A4 (en) | 2008-01-16 |
AU2003220894B8 (en) | 2009-02-19 |
ES2390052T3 (es) | 2012-11-06 |
US20060205796A1 (en) | 2006-09-14 |
JP5061134B2 (ja) | 2012-10-31 |
KR20040095329A (ko) | 2004-11-12 |
CN100522954C (zh) | 2009-08-05 |
CN1642929B (zh) | 2010-05-12 |
EP1496053A1 (en) | 2005-01-12 |
AU2009201233A1 (en) | 2009-04-23 |
CA2480560A1 (en) | 2003-10-09 |
KR101035931B1 (ko) | 2011-05-23 |
AU2009201233B2 (en) | 2012-07-05 |
US7112598B2 (en) | 2006-09-26 |
US7410987B2 (en) | 2008-08-12 |
AU2003220894A1 (en) | 2003-10-13 |
CA2480560C (en) | 2011-02-15 |
US20050113430A1 (en) | 2005-05-26 |
CN1911918A (zh) | 2007-02-14 |
CN1642929A (zh) | 2005-07-20 |
EP1496053B1 (en) | 2012-06-20 |
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