WO2003082840A1 - κ-OPIOID RECEPTOR AGONIST COMPRISING 2-PHENYLBENZOTHIAZOLINE DERIVATIVE - Google Patents

κ-OPIOID RECEPTOR AGONIST COMPRISING 2-PHENYLBENZOTHIAZOLINE DERIVATIVE Download PDF

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Publication number
WO2003082840A1
WO2003082840A1 PCT/JP2003/003928 JP0303928W WO03082840A1 WO 2003082840 A1 WO2003082840 A1 WO 2003082840A1 JP 0303928 W JP0303928 W JP 0303928W WO 03082840 A1 WO03082840 A1 WO 03082840A1
Authority
WO
WIPO (PCT)
Prior art keywords
phenylbenzothiazoline
opioid receptor
receptor agonist
derivative
compound
Prior art date
Application number
PCT/JP2003/003928
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
Maki Tokai
Takahiro Honda
Masashi Niwa
Yaeko Osumi
Ken-Ichi Fujimura
Shin-Ichi Kohno
Original Assignee
Santen Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santen Pharmaceutical Co., Ltd. filed Critical Santen Pharmaceutical Co., Ltd.
Priority to EP03715569A priority Critical patent/EP1496053B1/en
Priority to CA2480560A priority patent/CA2480560C/en
Priority to CN038072750A priority patent/CN1642929B/zh
Priority to AU2003220894A priority patent/AU2003220894B8/en
Priority to KR1020047015318A priority patent/KR101035931B1/ko
Priority to ES03715569T priority patent/ES2390052T3/es
Priority to NZ535987A priority patent/NZ535987A/en
Priority to US10/509,549 priority patent/US7112598B2/en
Publication of WO2003082840A1 publication Critical patent/WO2003082840A1/ja
Priority to US11/434,028 priority patent/US7410987B2/en
Priority to AU2009201233A priority patent/AU2009201233B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C07D277/66—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 with aromatic rings or ring systems directly attached in position 2
PCT/JP2003/003928 2002-03-29 2003-03-28 κ-OPIOID RECEPTOR AGONIST COMPRISING 2-PHENYLBENZOTHIAZOLINE DERIVATIVE WO2003082840A1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
EP03715569A EP1496053B1 (en) 2002-03-29 2003-03-28 Kappa-opioid receptor agonist comprising a 2-phenylbenzothiazoline derivative
CA2480560A CA2480560C (en) 2002-03-29 2003-03-28 .kappa.-opioid receptor agonist comprising 2-phenylbenzothiazoline derivative
CN038072750A CN1642929B (zh) 2002-03-29 2003-03-28 含有2-苯基苯并噻唑啉衍生物的κ-阿片样物质受体激动剂
AU2003220894A AU2003220894B8 (en) 2002-03-29 2003-03-28 Kappa-opioid receptor agonist comprising 2-phenylbenzothiazoline derivative
KR1020047015318A KR101035931B1 (ko) 2002-03-29 2003-03-28 2-페닐벤조티아졸린 유도체로 이루어진 κ 오피오이드 수용체 작용약
ES03715569T ES2390052T3 (es) 2002-03-29 2003-03-28 Agonistas del receptor opioide kappa que comprende un derivado de 2-fenilbenzotiazolina
NZ535987A NZ535987A (en) 2002-03-29 2003-03-28 k-opioid receptor agonist comprising 2-henylbenzothiazoline derivative
US10/509,549 US7112598B2 (en) 2002-03-29 2003-03-28 κ opioid receptor agonist comprising 2-phenylbenzothiazoline derivative
US11/434,028 US7410987B2 (en) 2002-03-29 2006-05-15 Method for treating pain or pruritis by administering κ-opioid receptor agonist comprising 2-phenylbenzothiazoline derivative
AU2009201233A AU2009201233B2 (en) 2002-03-29 2009-03-30 Kappa-opioid receptor agonist comprising 2-phenylbenzothiazoline derivative

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2002-097500 2002-03-29
JP2002097500 2002-03-29

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10509549 A-371-Of-International 2003-03-28
US11/434,028 Continuation US7410987B2 (en) 2002-03-29 2006-05-15 Method for treating pain or pruritis by administering κ-opioid receptor agonist comprising 2-phenylbenzothiazoline derivative

Publications (1)

Publication Number Publication Date
WO2003082840A1 true WO2003082840A1 (en) 2003-10-09

Family

ID=28671920

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2003/003928 WO2003082840A1 (en) 2002-03-29 2003-03-28 κ-OPIOID RECEPTOR AGONIST COMPRISING 2-PHENYLBENZOTHIAZOLINE DERIVATIVE

Country Status (10)

Country Link
US (2) US7112598B2 (US20060205796A1-20060914-C00073.png)
EP (2) EP1496053B1 (US20060205796A1-20060914-C00073.png)
JP (1) JP5061134B2 (US20060205796A1-20060914-C00073.png)
KR (1) KR101035931B1 (US20060205796A1-20060914-C00073.png)
CN (2) CN100522954C (US20060205796A1-20060914-C00073.png)
AU (2) AU2003220894B8 (US20060205796A1-20060914-C00073.png)
CA (1) CA2480560C (US20060205796A1-20060914-C00073.png)
ES (1) ES2390052T3 (US20060205796A1-20060914-C00073.png)
NZ (1) NZ535987A (US20060205796A1-20060914-C00073.png)
WO (1) WO2003082840A1 (US20060205796A1-20060914-C00073.png)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1642590A4 (en) * 2003-07-04 2009-05-13 Santen Pharmaceutical Co Ltd MEANS TO INHIBIT THE DEGRADATION OF THE PAIN LIMIT
US7642274B2 (en) 2004-07-02 2010-01-05 Santen Pharmaceutical Co., Ltd. Inhibitor of pain threshold decrease
EP1849465A4 (en) * 2005-02-18 2008-12-24 Takeda Pharmaceutical AGENT FOR CONTROLLING THE FUNCTION OF THE GPR34 RECEPTOR
US9303027B2 (en) 2010-07-19 2016-04-05 Dr. Reddy's Laboratories Ltd. Kappa opioid receptor agonists
CN104271552B (zh) 2012-03-05 2017-08-08 雷迪博士实验室有限公司 作为kappa阿片样物质受体(kor)激动剂的取代的杂环乙酰胺
JP6275517B2 (ja) 2013-03-22 2018-02-07 あゆみ製薬株式会社 Ｉｌ−２産生抑制
WO2015093567A1 (ja) 2013-12-18 2015-06-25 国立大学法人京都大学 疼痛に関する化合物及び医薬組成物
WO2018230711A1 (ja) 2017-06-16 2018-12-20 学校法人同志社 ｍＴＯＲインヒビターを含む、眼の症状、障害または疾患を治療または予防するための医薬およびその応用
US20200121652A1 (en) 2017-06-16 2020-04-23 The Doshisha Compounds having caspase inhibitory activity, pharmaceutical agent containing said compounds and for treating or preventing corneal endothelial symptoms, disorders, or diseases, and application of said pharmaceutical agent

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5846079A (ja) 1981-09-12 1983-03-17 Santen Pharmaceut Co Ltd ベンゾチアゾリン環を有するエ−テル類
JPS5967276A (ja) 1982-09-01 1984-04-16 Santen Pharmaceut Co Ltd ベンゾチアゾリン誘導体
JPS60139679A (ja) 1983-12-27 1985-07-24 Santen Pharmaceut Co Ltd ２−アリ−ルベンゾチアゾリン誘導体
JPS6183175A (ja) * 1984-09-06 1986-04-26 Santen Pharmaceut Co Ltd ベンゾチアゾリン誘導体およびそれを主成分とする循環器官用薬剤
JPS62221679A (ja) 1986-03-19 1987-09-29 Santen Pharmaceut Co Ltd ベンゾチアゾリン誘導体
JPS62221680A (ja) * 1986-03-19 1987-09-29 Santen Pharmaceut Co Ltd フエノキシアルキルアミン側鎖を有するベンゾチアゾリン誘導体
JPH08231399A (ja) * 1995-02-23 1996-09-10 Shionogi & Co Ltd モルヒネ禁断抑制作用剤
WO1998023290A1 (fr) 1996-11-25 1998-06-04 Toray Industries, Inc. Agent antiprurigineux

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US547513A (en) * 1895-10-08 Chell
JPS4994667A (US20060205796A1-20060914-C00073.png) * 1973-01-23 1974-09-09
JP2000344821A (ja) 1999-06-01 2000-12-12 Toagosei Co Ltd オレフィン重合用触媒

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5846079A (ja) 1981-09-12 1983-03-17 Santen Pharmaceut Co Ltd ベンゾチアゾリン環を有するエ−テル類
US4479949A (en) * 1981-09-12 1984-10-30 Santen Pharmaceutical Co., Ltd. Benzothiazoline compounds
JPS5967276A (ja) 1982-09-01 1984-04-16 Santen Pharmaceut Co Ltd ベンゾチアゾリン誘導体
JPS60139679A (ja) 1983-12-27 1985-07-24 Santen Pharmaceut Co Ltd ２−アリ−ルベンゾチアゾリン誘導体
US4547513A (en) * 1983-12-27 1985-10-15 Santen Pharmaceutical Co., Ltd. 2-Arylbenzothiazoline derivatives and their use in treating angina cordis
JPS6183175A (ja) * 1984-09-06 1986-04-26 Santen Pharmaceut Co Ltd ベンゾチアゾリン誘導体およびそれを主成分とする循環器官用薬剤
JPS62221679A (ja) 1986-03-19 1987-09-29 Santen Pharmaceut Co Ltd ベンゾチアゾリン誘導体
JPS62221680A (ja) * 1986-03-19 1987-09-29 Santen Pharmaceut Co Ltd フエノキシアルキルアミン側鎖を有するベンゾチアゾリン誘導体
JPH08231399A (ja) * 1995-02-23 1996-09-10 Shionogi & Co Ltd モルヒネ禁断抑制作用剤
WO1998023290A1 (fr) 1996-11-25 1998-06-04 Toray Industries, Inc. Agent antiprurigineux

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FUJITA M.: "Synthesis and calcium antagonistic activity of (+)-(R)-and(-)-(S)-3-acetyl-2-(5-methoxy-2-(4-(N-methyl-N-(3,4,5-trimethoxyphenethyl)amino)butoxy)phenyl)benzothiazoline hydrochloride", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 38, no. 4, 1990, pages 936 - 941, XP002962151 *
WAY E.L.: "Review of revues", ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, vol. 32, 1992, pages 9 - 23, XP002962152 *
YAMAMOTO K.: "Novel calcium antagonists. Synthesis and structure-activity relationship studies of benzothiazoline derivatives", JOURNAL OF MEDICINAL CHEMISTRY, vol. 31, no. 5, 1988, pages 919 - 930, XP001091266 *

Also Published As

Publication number Publication date
US7410987B2 (en) 2008-08-12
CN1642929A (zh) 2005-07-20
JP5061134B2 (ja) 2012-10-31
US20050113430A1 (en) 2005-05-26
CN100522954C (zh) 2009-08-05
EP1496053A1 (en) 2005-01-12
EP2042173A2 (en) 2009-04-01
ES2390052T3 (es) 2012-11-06
CN1911918A (zh) 2007-02-14
CN1642929B (zh) 2010-05-12
KR20040095329A (ko) 2004-11-12
NZ535987A (en) 2006-08-31
US7112598B2 (en) 2006-09-26
EP1496053B1 (en) 2012-06-20
AU2009201233B2 (en) 2012-07-05
CA2480560C (en) 2011-02-15
JP2009143940A (ja) 2009-07-02
AU2003220894B2 (en) 2009-02-05
EP2042173A3 (en) 2010-02-24
AU2003220894B8 (en) 2009-02-19
US20060205796A1 (en) 2006-09-14
CA2480560A1 (en) 2003-10-09
AU2009201233A1 (en) 2009-04-23
AU2003220894A1 (en) 2003-10-13
KR101035931B1 (ko) 2011-05-23
EP1496053A4 (en) 2008-01-16

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