WO2003043988A1 - Composes derives de piperidine-2-one et medicaments contenant lesdits composes comme principes actifs - Google Patents

Composes derives de piperidine-2-one et medicaments contenant lesdits composes comme principes actifs Download PDF

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Publication number
WO2003043988A1
WO2003043988A1 PCT/JP2002/012174 JP0212174W WO03043988A1 WO 2003043988 A1 WO2003043988 A1 WO 2003043988A1 JP 0212174 W JP0212174 W JP 0212174W WO 03043988 A1 WO03043988 A1 WO 03043988A1
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WIPO (PCT)
Prior art keywords
disease
compounds
arthritis
piperidin
general formula
Prior art date
Application number
PCT/JP2002/012174
Other languages
English (en)
French (fr)
Inventor
Kanji Takahashi
Shingo Yamamoto
Masao Naka
Original Assignee
Ono Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ono Pharmaceutical Co., Ltd. filed Critical Ono Pharmaceutical Co., Ltd.
Priority to IL16194002A priority Critical patent/IL161940A0/xx
Priority to HU0500027A priority patent/HUP0500027A2/hu
Priority to JP2003545625A priority patent/JPWO2003043988A1/ja
Priority to CA002467752A priority patent/CA2467752A1/en
Priority to AU2002349432A priority patent/AU2002349432A1/en
Priority to EP02783591A priority patent/EP1447401A1/en
Priority to MXPA04004830A priority patent/MXPA04004830A/es
Priority to US10/495,465 priority patent/US20050085509A1/en
Priority to BR0214345-3A priority patent/BR0214345A/pt
Publication of WO2003043988A1 publication Critical patent/WO2003043988A1/ja
Priority to NO20042153A priority patent/NO20042153L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/10—Oxygen or sulfur atoms
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/06—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings
    • C07D265/08—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D265/10—1,3-Oxazines; Hydrogenated 1,3-oxazines not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen atoms directly attached to ring carbon atoms
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PCT/JP2002/012174 2001-11-22 2002-11-21 Composes derives de piperidine-2-one et medicaments contenant lesdits composes comme principes actifs WO2003043988A1 (fr)

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IL16194002A IL161940A0 (en) 2001-11-22 2002-11-21 Piperidin-2-one derivative compounds and drugs containing these compounds as the active ingredient
HU0500027A HUP0500027A2 (hu) 2001-11-22 2002-11-21 Piperidin-2-on-származékok és hatóanyagként ezeket tartalmazó gyógyászati készítmények
JP2003545625A JPWO2003043988A1 (ja) 2001-11-22 2002-11-21 ピペリジン−２−オン誘導体化合物およびその化合物を有効成分として含有する薬剤
CA002467752A CA2467752A1 (en) 2001-11-22 2002-11-21 Piperidin-2-one derivative compounds and pharmaceutical composition comprising the same as active ingredient
AU2002349432A AU2002349432A1 (en) 2001-11-22 2002-11-21 Piperidin-2-one derivative compounds and drugs containing these compounds as the active ingredient
EP02783591A EP1447401A1 (en) 2001-11-22 2002-11-21 Piperidin-2-one derivative compounds and drugs containing these compounds as the active ingredient
MXPA04004830A MXPA04004830A (es) 2001-11-22 2002-11-21 Compuestos derivados de piperidin-2-ona, y composiciones farmaceuticas que los contienen como ingredientes activos.
US10/495,465 US20050085509A1 (en) 2001-11-22 2002-11-21 Piperidin-2-one derivative compounds and drugs containing these compounds as the active ingredient
BR0214345-3A BR0214345A (pt) 2001-11-22 2002-11-21 Compostos derivados de piperidin-2-ona e composições farmacêuticas contendo estes compostos como ingrediente ativo
NO20042153A NO20042153L (no) 2001-11-22 2004-05-25 Piperidin-2-on-derivatforbindelser og farmasoytisk sammensetning omfattende samme som aktiv ingrediens

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US8883778B2 (en) 2009-07-01 2014-11-11 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1
US8927539B2 (en) 2009-06-11 2015-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure
US8933072B2 (en) 2010-06-16 2015-01-13 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
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US7338947B2 (en) 2003-02-12 2008-03-04 Bristol-Myers Squibb Co. Cyclic derivatives as modulators of chemokine receptor activity
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US7902367B2 (en) 2004-08-11 2011-03-08 Kyorin Pharmaceutical Co., Ltd. Cyclic amino benzoic acid derivative
WO2006104280A1 (ja) * 2005-03-31 2006-10-05 Takeda Pharmaceutical Company Limited 糖尿病の予防・治療剤
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WO2007139150A1 (ja) * 2006-05-30 2007-12-06 The University Of Tokushima ＴＮＦα阻害物質を含有してなる抗インフルエンザウイルス剤
US8835426B2 (en) 2007-02-26 2014-09-16 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11β-hydroxysteroid dehydrogenase 1
US8329897B2 (en) 2007-07-26 2012-12-11 Vitae Pharmaceuticals, Inc. Synthesis of inhibitors of 11β-hydroxysteroid dehydrogenase type 1
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US8748444B2 (en) 2007-12-11 2014-06-10 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
US8440658B2 (en) 2007-12-11 2013-05-14 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
US8680281B2 (en) 2008-01-07 2014-03-25 Vitae Pharmaceuticals, Inc. Lactam inhibitors of 11-β-hydroxysteroid dehydrogenase 1
US8592409B2 (en) 2008-01-24 2013-11-26 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11β-hydroxysteroid dehydrogenase 1
US8202857B2 (en) 2008-02-11 2012-06-19 Vitae Pharmaceuticals, Inc. 1,3-oxazepan-2-one and 1,3-diazepan-2-one inhibitors of 11β-hydroxysteroid dehydrogenase 1
US8598160B2 (en) 2008-02-15 2013-12-03 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
US8242111B2 (en) 2008-05-01 2012-08-14 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
US8569292B2 (en) 2008-05-01 2013-10-29 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
US8138178B2 (en) 2008-05-01 2012-03-20 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8592410B2 (en) 2008-05-01 2013-11-26 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11BETA-hydroxysteroid dehydrogenase 1
US8114868B2 (en) 2008-07-25 2012-02-14 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1
US8846668B2 (en) 2008-07-25 2014-09-30 Vitae Pharmaceuticals, Inc. Inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8754076B2 (en) 2008-07-25 2014-06-17 Vitae Pharmaceuticals, Inc./Boehringer-Ingelheim Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP2012511008A (ja) * 2008-12-05 2012-05-17 持田製薬株式会社 ＩＸａ因子阻害薬としてのモルホリノン化合物
US8637505B2 (en) 2009-02-04 2014-01-28 Boehringer Ingelheim International Gmbh Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8680093B2 (en) 2009-04-30 2014-03-25 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8927539B2 (en) 2009-06-11 2015-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure
US8883778B2 (en) 2009-07-01 2014-11-11 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11 beta-hydroxysteroid dehydrogenase 1
US8933072B2 (en) 2010-06-16 2015-01-13 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
US9090605B2 (en) 2010-06-16 2015-07-28 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
US8765744B2 (en) 2010-06-25 2014-07-01 Boehringer Ingelheim International Gmbh Azaspirohexanones
WO2012002502A1 (ja) * 2010-06-30 2012-01-05 大日本住友製薬株式会社 ジヒドロピリミジノン誘導体およびその医薬用途
US8846613B2 (en) 2010-11-02 2014-09-30 Boehringer Ingelheim International Gmbh Pharmaceutical combinations for the treatment of metabolic disorders
US9908853B2 (en) 2012-08-01 2018-03-06 The Hospital For Sick Children Inhibitors of peptidyl arginine deiminase (PAD) enzymes and uses thereof
US11452713B2 (en) 2016-02-29 2022-09-27 University Of Florida Research Foundation, Incorporated Chemotherapeutic methods for treating low-proliferative disseminated tumor cells

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PL370636A1 (en) 2005-05-30
AU2002349432A1 (en) 2003-06-10
RU2004118719A (ru) 2005-03-27
CA2467752A1 (en) 2003-05-30
EP1447401A1 (en) 2004-08-18
IL161940A0 (en) 2005-11-20
MXPA04004830A (es) 2004-07-30
BR0214345A (pt) 2004-09-14
CN1578767A (zh) 2005-02-09
KR20050044581A (ko) 2005-05-12
JPWO2003043988A1 (ja) 2005-03-10
HUP0500027A2 (hu) 2005-04-28
TW200300687A (en) 2003-06-16

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