WO2003006339A1 - Contenant de petite taille pour inhibiteurs de degenerescence de substances, et contenant de solution de perfusion dans lequel est incorpore ce premier contenant - Google Patents

Contenant de petite taille pour inhibiteurs de degenerescence de substances, et contenant de solution de perfusion dans lequel est incorpore ce premier contenant Download PDF

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Publication number
WO2003006339A1
WO2003006339A1 PCT/JP2002/006919 JP0206919W WO03006339A1 WO 2003006339 A1 WO2003006339 A1 WO 2003006339A1 JP 0206919 W JP0206919 W JP 0206919W WO 03006339 A1 WO03006339 A1 WO 03006339A1
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WO
WIPO (PCT)
Prior art keywords
container
small
small container
storage chamber
drug
Prior art date
Application number
PCT/JP2002/006919
Other languages
English (en)
Japanese (ja)
Inventor
Seizo Sunago
Osamu Takahata
Original Assignee
Fujisawa Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co., Ltd. filed Critical Fujisawa Pharmaceutical Co., Ltd.
Priority to JP2003512121A priority Critical patent/JP4175255B2/ja
Publication of WO2003006339A1 publication Critical patent/WO2003006339A1/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
    • B65D81/266—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A61J1/1425—Snap-fit type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1462—Containers with provisions for hanging, e.g. integral adaptations of the container
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/18—Arrangements for indicating condition of container contents, e.g. sterile condition
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/24—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes
    • B65D51/28—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials
    • B65D51/30—Closures not otherwise provided for combined or co-operating with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials for desiccators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1468—Containers characterised by specific material properties

Definitions

  • the present invention relates to a small container for a substance altering agent and an infusion container incorporating the same, and more particularly to a small container for a substance altering agent, for example, a desiccant container containing a desiccant, and drying thereof.
  • the present invention relates to an infusion container in which a small container for medicine is built in a medicine storage room. Background art
  • a drug and its solution are stored in a single container in a separated state, and when used, the drug and the solution are aseptically mixed in the container to prepare an infusion solution for infusion.
  • a desiccant storage chamber may be provided in the drug storage chamber so that moisture or the like can pass therethrough. It has been proposed (see re-published patent WO96 / 25136).
  • the medicine storage chamber is provided with a cap member for sealing the mouth thereof, and a desiccant storage chamber for storing a desiccant (eg, silica gel) is provided on the cap member.
  • a desiccant storage chamber for storing a desiccant (eg, silica gel) is provided on the cap member.
  • a thin tube section with a hydrophobic filter inserted is provided so as to communicate with the interior of the storage room. Then, moisture coming into the medicine storage chamber from the outside is adsorbed by the desiccant through the thin tube section, so that the deterioration of the medicine can be prevented.
  • one of the main objects of the present invention is to provide a substance-altering agent (for example, a drug) that has a very simple structure and can be easily inserted into a substance storage chamber (for example, a drug storage chamber) by itself.
  • a substance-altering agent for example, a drug
  • Another main object of the present invention is to provide an infusion container containing a desiccant small container for a medicine having a very simple structure. Disclosure of the invention
  • the present invention relates to a small container which is formed of a synthetic resin into a three-dimensional container shape and has a space for accommodating an agent for preventing deterioration of a substance therein, wherein the constituent walls constituting the small container are entirely formed of a liquid.
  • a small container for a substance deterioration preventing agent comprising a gas permeable portion, which is permeable to gas and a portion of which is permeable to gas and made thinner than other portions. That is, the small container for the substance deterioration preventing agent according to the present invention has a small three-dimensional container shape, and at least a part of the constituent wall is a gas permeable portion which is permeable to gas and thinner than other parts.
  • the small container for a substance deterioration preventing agent according to the present invention is made of a synthetic resin that is impermeable to liquid and small in size. It is formed in a container shape. Specifically, this means that it can maintain the shape of a small three-dimensional container such as a small box, cylinder, pole, etc., and can prevent the permeation (permeation) of liquid from its constituent walls.
  • this small three-dimensional container-shaped container itself guarantees a space for storing the substance altering agent inside, and the substance altering agent stored in that space is This means that it is not affected by liquid (such as water) that permeates (penetrates) from the constituent walls of the small container.
  • liquid such as water
  • permeates penetrates
  • the small container of the present invention at least a part of the constituent wall is used as a gas permeable portion, and is sometimes referred to as water vapor (moisture, moisture, etc.) which affects the deterioration of substances (articles) such as drugs and foods. It has a portion that allows gas such as oxygen to permeate.
  • a gas permeable portion can be obtained by forming the synthetic resin to a specific thickness, that is, a thin wall.
  • the small container of the present invention is formed almost uniformly and thickly so that the entire configuration can be kept in a small three-dimensional container shape with a resin, and a part of the constituent wall has an entire structure. Provided that the shape is maintained, one concave step is formed, or a plurality of concave steps are dispersed and formed. This is preferable because the structure is simple and the molding can be easily performed only by the injection molding (molding) method.
  • a small container formed of a synthetic resin into a three-dimensional container shape and containing therein an agent for preventing alteration of a substance, wherein a constituent wall constituting the small container has an entirety.
  • a small container for a substance-altering agent comprising a gas-permeable portion, which is made impermeable to liquid and partially permeable to gas and made thinner than other portions, can be provided.
  • a solution storage chamber for storing a solution, and a drug, wherein the solution storage chamber is partitioned before use, and is communicatively connected when used. And a small container for preventing the alteration of the drug contained in the drug storage room.
  • the small container for the agent for preventing alteration of the drug is molded into a three-dimensional container with a synthetic resin, and contains the agent for preventing the alteration of the agent inside.
  • the constituent walls constituting the small container are entirely incompatible with the liquid. It is possible to provide an infusion container comprising a gas permeable portion which is permeable and a portion of which is permeable to gas and which is thinner than other portions.
  • FIG. 1 is a longitudinal sectional view showing Embodiment 1 of an infusion container according to the present invention.
  • C FIG. 2 is a longitudinal sectional view in a direction different from FIG. 1 by 90 °.
  • FIG. 3 is a sectional view taken along line AA of FIG.
  • FIG. 4 is a partially exploded perspective view mainly illustrating an open state of the communication hole.
  • Fig. 5 shows a small container for the anti-deterioration agent of the substance in Fig. 1,
  • A) is a plan view
  • B) is a partial longitudinal sectional view
  • C) is a bottom view
  • D is a small lid.
  • E) is an enlarged view of part X of the small lid of (B).
  • FIG. 6 is a perspective view showing the small container for the alteration preventing agent of the substance of FIG. 5 without the small lid.
  • FIG. 7 is a vertical cross-sectional view of a main part showing Embodiment 2 of the infusion container according to the present invention.
  • FIG. 8 is a vertical sectional view of a main part in a vertical section perpendicular to FIG.
  • FIG. 9 (A) is a plan view showing a small container for a chemical deterioration preventing agent used in Embodiment 2.
  • FIG. 9 (B) is a side view showing a small container for preventing deterioration of a drug used in the second embodiment.
  • FIG. 9 (C) is a back view showing the small container for preventing deterioration of the drug used in the second embodiment.
  • FIG. 9 (D) is a sectional view taken along line A-A of FIG. 9 (A).
  • FIG. 10 is an enlarged sectional view of a portion B in FIG. 9 (B).
  • FIG. 11 is a cross-sectional view showing the holder.
  • FIG. 12 is a bottom view of the holder of FIG. BEST MODE FOR CARRYING OUT THE INVENTION
  • the small container for the substance deterioration preventing agent according to the present invention is formed almost uniformly and thickly so as to be able to keep the entire structure in a small three-dimensional container shape with resin.
  • One of the concave steps is formed or a plurality of concave steps are formed separately, and the bottom of the concave steps is used as a thin gas permeable section.
  • the resin is polypropylene
  • the overall thickness is set to 0.5 to 1. It is preferable to set the thickness to 5 mm and the thickness of the bottom of the concave step to 50 to 300 m, respectively.
  • resins that can be suitably used as the resin include polychlorinated vinyl and cyclic polyolefin.
  • these concave steps are formed on the inner surface of the component wall of the small container.
  • the small container is composed of a small container main body having a mouth and a small lid sealed to the mouth, and at least a concave step is formed in the small lid.
  • the small container for a substance deterioration preventing agent according to the present invention can be positioned in a storage room for storing the substance. Specifically, it is preferable to be able to position, that is, hold the small container for preventing the deterioration of the drug in the drug storage chamber of the infusion container for storing the drug.
  • the holding means for holding the small container for preventing deterioration of the medicine in the medicine storage chamber is to provide a locking portion for locking a part of the small container in the medicine storage chamber.
  • a longitudinal groove and / or a concave groove on the bottom wall are formed on the side wall of the small container, respectively, and the container body of the medicine storage room is engaged with the longitudinal groove and / or the concave groove.
  • a projection specifically, a projection Z or a projection can be given.
  • a holder for holding the small container can be provided in the medicine storage chamber, for example, at the bottom of the cap member. .
  • examples of the substance alteration preventing agent include a desiccant for a drug and a deoxidizing agent.
  • the desiccant is intended for stabilization of a drug that changes due to moisture.
  • Preferable examples include those containing silica gel, zeolite, or the like as a component.
  • an oxygen scavenger such as activated iron oxide or amorphous copper can be used alone or in addition to a desiccant.
  • the solution storage chamber according to the present invention is formed into a bag shape by fusing a sheet of a relatively soft synthetic resin such as polyethylene, polypropylene, or polychlorinated vinyl.
  • the container is Specific examples of the drug stored in the drug storage chamber of the infusion container of the present invention include the following active ingredients.
  • Antibiotics include cefazolin sodium, ceftizoxime sodium, cefotiam hydrochloride, cefmenoxime hydrochloride, cefacetrile sodium, cepha mandone sodium, cephalorizine, cefataxime sodium, cefotetan sodium, cefoperazone sodium, Cefem antibiotics such as cefsulozin sodium, ceftesone / lenadium, cefpyramidonatrium, cefmetazonorenadium, cefuroxy sodium, cefocles sulfate, cefpirome sulfate, and ampicillin sodium, carpenicillin sodium, and sulbenicillin Penicillin antibiotics such as sodium and ticarcillin sodium; vancomycin hydrochloride, ticobranine; and antifungal agents such as micafungin is there.
  • Antitumor agents include mitomycin (:, fluorouracil, tegafur, cytarabine, etc.
  • Antiulcer agents include f
  • dissolving solution contained in the dissolving solution storage chamber of the infusion container of the present invention examples include physiological saline, pudose sugar solution, or amino acid solution to which cysteine, tributofan and the like are added, but are not particularly limited thereto. Not something.
  • the cap member specifically includes, for example, a pierceable plug, and a lid and a force optionally attached to the plug.
  • FIG. 1 is a longitudinal sectional view showing an infusion container incorporating a small container for a desiccant for a medicine as a first embodiment of a small container for a substance deterioration preventing agent according to the present invention
  • FIG. 2 is 90 ° different from FIG.
  • FIG. 3 is a longitudinal sectional view in different directions
  • FIG. 3 is an A-A sectional view of FIG. 2
  • FIG. 4 is a partially exploded perspective view mainly illustrating an open state of the communication hole.
  • Fig. 5 shows a small container for a desiccant for a drug inserted into the drug storage chamber of the infusion container in Fig. 1,
  • A) is a plan view
  • (B) is a partial longitudinal sectional view
  • (C) is a bottom view.
  • D) is a plan view without the small lid
  • (E) is an enlarged view of the X part of the small lid in (B).
  • FIG. 6 is a perspective view showing the small container for a desiccant of the drug of FIG. 5 without the small lid.
  • the infusion container 10 shown in FIGS. 1 and 2 is composed of a drug storage chamber 1 containing a powder-filled drug (not shown) and a solution storage chamber 2 containing a solution (not shown). It is mainly composed.
  • the medicine storage chamber 1 is a wide-mouthed container, the bottom of which is connected to the container body 8 connected to the solution storage chamber 2, the medicine stored in the container main body, and a small container for the desiccant of the medicine 15 (Details will be described later) and a cap member 3.
  • the container body 8 has, at its upper end, an opening 1 a for mounting the cap member 3, and has a communication hole 5, which will be described later, at its bottom 6.
  • the rigidity is increased compared to the storage room 2.
  • the solution storage chamber 2 is formed in a liquid-tight and flat bag shape (thickness: 0.2 to 0.5 mm) from transparent polypropylene, and has sufficient flexibility and elasticity.
  • a flange-shaped mouth 2 b connected to a port 1 b formed at the lower end of the medicine storage chamber 1 is formed.
  • a suspension hole 23 as a suspension support is formed.
  • the port 1b of the drug storage chamber 1 and the flange-shaped opening 2b of the solution storage chamber 2 are heat-welded to connect (connect) the drug storage chamber 1 to the solution storage chamber 2.
  • the medicine storage chamber 1 and the solution storage chamber 2 may be integrally molded.
  • a communication hole 5 (5a, 5b) for communicating between the drug storage chamber 1 and the solution storage chamber 2 is formed at the bottom 6 of the drug storage chamber 1 which is connected to the solution storage chamber 2 in a liquid-tight manner.
  • a pair of protrusions 7 c and 7 d are formed as protrusions 7 that protrude into the medicine storage chamber 1 and cover and seal the communication holes 5.
  • These projections 7c and 7d are a pair of side-by-side towers, especially provided with fin-like ribs 7 ⁇ 7g to provide strength against torsion, and their common bottom 7 e is formed with fan-shaped notches (or openings) 7a and 7b.
  • the fan-shaped communication holes 5a and 5b formed in the bottom portion 6 of the medicine storage chamber 1 are formed to face each other at the center of the bottom portion 6, and the center angles are all about 90 °.
  • the fan-shaped notches 7a and 7b are formed corresponding to the communication holes 5a and 5b. Therefore, by the rotation of the protrusions 7c and 7d, the notches 7a and 7b of the bottom portion 7e and the pair of fan-shaped communication holes 5a and 5b formed in the bottom 6 of the medicine storage chamber 1 When combined, the medicine storage chamber 1 and the melted liquid storage chamber 2 can communicate with each other.
  • 7h is a ridge as one of the protruding portions 7 formed on the bottom portion 7e.
  • the protruding portions 7c and 7d have their tips inserted (engaged) into engagement holes 20d and 20e formed in a rubber plug 20 described later of the cap member 3, respectively.
  • the cap member 3 and the rubber plug 20 are formed by combining the former Y-shaped socket 31 formed on the ceiling part with the Y-shaped recessed part 21 formed on the upper surface of the latter. The rotation of the cap member 3 can be reliably transmitted to the rubber plug 20 by locking the cap member 3.
  • the communication holes 5a and 5b are closed in a liquid-tight manner by the bottom part 7e, but as the cap member 3 is turned, the engagement holes are made as shown in Fig. 4. 20 d ⁇ 20 e and the bottom 7 e rotate through the projection 7 c. 7 d, and the communication holes 5 a ⁇ 5 b are notched 7 a ⁇ 7 b as shown in Fig. 4.
  • the medicine storage chamber 1 and the solution storage chamber 2 can be communicated.
  • the lower surface of the rubber stopper 20 (particularly, the stopper body 20a described later) is provided on the lower surface of the rubber stopper 20 to reduce the frictional resistance with respect to the mouth 1a in order to facilitate the rotation when dissolving the drug in the solution. (Laminating) the ultra high molecular weight polyethylene film. Further, an O-type ring packing 33 is interposed between the rubber stopper 20, the mouth la of the medicine storage chamber 1, and the cap member 3 to improve liquid tightness.
  • the protrusion 7 is a mixture of 5 to 20% of polypropylene and 95 to 80% of polyethylene, and the medicine storage chamber 1 is formed of 100% of polypropylene. Until these are mixed, they are resin-bonded (temporarily fixed), and the sealing properties of the communication holes 5a and 5b are secured.
  • convex portions 1 1 and 1 2 are formed at equal angular intervals on the outer periphery of the opening of the container body 8 of the drug storage chamber 1, while the inner surface of the cap member 3 has a range of 90 °.
  • Concave grooves 3 4-35 are formed to regulate the relative movement with the convex portions 1 1 and 1 2.
  • paragraphs 40 and 41 are formed at 180 ° intervals around the outer periphery of the container body 8 to facilitate holding the cap member 3 described later (when the cap member 3 is rotated). See Figure 2).
  • a rubber stopper (plug) 20 of a cap member 3 is rotatably inserted into the mouth 1 a of the medicine storage chamber 1 to make the medicine storage chamber 1 airtight.
  • the rubber stopper 20 is provided with a stopper body 20 a made of chlorinated butyl rubber selected to improve stability with the medicine stored in the medicine storage chamber 1, and is located substantially at the center of the upper surface of the stopper body.
  • the double structure of the small rubber stopper portion 20b for preventing liquid leakage after penetration of the puncture needle corresponding to the cutout hole 3b as the chemical solution outlet 4 of the lid portion 3a of the cap member 3 Become.
  • This small rubber stopper portion 20b is made of isoprene rubber with good resilience and is partially exposed at the notch hole 3, but the notch hole 3b is covered at the top to prevent contamination of the rubber stopper 20 surface.
  • Protected in part 9. The upper part 9 is attached to the cap member 3 by welding, and the upper lid part 9 is pulled through the tension piece 9a to break the weld and open, thereby forming the small rubber through the notch hole 3b. It is configured so that the plug portion 20b appears.
  • the upper lid 9 has a flat upper surface so that the infusion container 10 filled with the drug and the dissolving solution can stand on its own.
  • the lower surface of the rubber stopper 20 has a lower concave portion 20c for facilitating the penetration of the puncture needle, and an engaging hole 20d for engaging the tip of the protrusion 7c-7d. 0 e is formed.
  • the diameter of these engagement holes is 2-6 mm.
  • the small container 15 for a drug desiccant comprises a small container body 16 having a mouth, a desiccant (not shown), and a small lid 18.
  • the main body 16 is a small, substantially cylindrical container, and has vertical grooves 36-37 and a concave groove (lateral groove) 38 connected to its side wall and bottom wall, respectively. It is molded.
  • concave steps 19d, 19d- (diameter: 4mm) are dispersedly formed (average center distance: 6mm). .
  • the bottom of these concave steps 19 d, 19 d ... has a thickness of 100 / xm to allow gas (steam and oxygen) to pass through.
  • a large number of narrow ribs 17, 17, ... are formed vertically on the inner surface of the side wall of the small container body 16. The entire thickness except for the concave steps 19 d, 19 d,... Is 0.5 to 1.0 mm.
  • the small lid 18 has six concave steps (diameter: 3 mm) 18 b, 18 b,... dispersed on the back surface in particular in (A) and (B) of FIG. : 4.5 mm) and a lid 18a extending upward from the outer peripheral edge of the lid portion 18a, fitted into the inner peripheral edge of the mouth of the small container body 15, and the rib 17 of the small container body 15 , 17,.., And a ring-shaped edge portion 18 c as a fitting ring, which is welded to the inner peripheral edge of the mouth portion of the small container body 16 and the rib 1 by heat welding. It is connected to the upper end of 7, 1 7, ...
  • each of the many concave steps 18b and 18b [18d, especially see Fig. 5 (E)] has a thickness of 100 m so that gas (water vapor or oxygen) can pass therethrough.
  • the overall thickness except for the concave steps 18b, 18b, ... is 1. Omm.
  • silica gel as a desiccant is first put into the small container 15 from this mouth, and then the above-mentioned small lid 18 is sealed. As shown in FIGS. Positioned within 1.
  • the small container 15 is inserted through the mouth 1 a, and the vertical groove 36. 38 is positioned and fixed by engaging with the protrusions 7c and 7d and the protrusion 7h as protrusions, respectively.
  • the small container 15 reduces the moisture (humidity or water vapor) entering the medicine storage chamber 1 by the concave steps 18 b and 18 b formed in the small lid 18 and the small container body 15, respectively.
  • the concave steps 18 b and 18 b formed in the small lid 18 and the small container body 15 respectively.
  • ... And 19 d, 19 d,... are taken in through the thin bottom part and adsorbed to the desiccant to prevent deterioration of the drug.
  • the rubber stopper 20 When the infusion container 10 is used, when the cap member 3 is operated to rotate, the rubber stopper 20 is rotated accordingly, and the engagement hole 20 d .20 e of the rubber stopper 20 is further closed.
  • the protrusions 7c and 7d also rotate through the gap to break the resin bond (temporary fixation) with the bottom 6 of the drug storage chamber 1, and a large communication hole 5 between the drug storage chamber 1 and the solution storage chamber 2. (5a ⁇ 5b) can be easily formed (especially, see Fig. 4).
  • the solution is poured into the medicine storage chamber 1 through the communication hole 5.
  • the lysing solution quickly dissolves the drug stored in the drug storage chamber 1.
  • the small container 15 has a liquid permeation inhibiting ability, the dissolving solution does not enter inside.
  • the upper lid 9 is removed by the pulling piece 9a, the notch hole 3b as the chemical solution outlet 4 is opened, and the puncture needle integrally connected to a drip device (not shown, the same applies hereinafter). Pierce the small rubber stopper 20 b of the exposed rubber stopper 20, and then pierce the stopper main body 20 a, and then hang the hanging hole 23 of the solution storage chamber 3 on the stand.
  • the drug solution mixed with the dissolving solution can be taken out to the other end of the infusion device as an infusion.
  • the communication operation between the medicine storage chamber 1 and the solution storage chamber 2 is very easily achieved by the rotation of the cap member 3.
  • the infusion container 10 has a flat shape due to the flat shape of the solution storage chamber 2 itself and its elasticity, so that it does not allow invasion of outside air during drip (even without using an air needle). The solution can be drained and the drug solution does not come into contact with the outside air until the drip is completed. In addition, sterility in the container is guaranteed.
  • the container material other than the rubber stopper is an all-plastic container consisting of only polyethylene and polypropylene described in the Plastic Container Test for Infusion for Japan, the container for infusion (injection kit) is usually used. It is not necessary to separate and discard glass and metal at the end of the drip, which is performed in the above.
  • a moisture-permeable and waterproof thin film can also be used for the small container body 16 of the small container 15. That is, for example, a large number of through holes may be formed in the bottom portion (moisture-proof and waterproof portion) of the small container main body 16 and a moisture-permeable and waterproof thin film may be thermally welded to the entire bottom portion.
  • FIG. 5 is a vertical cross-sectional view of a main part of an infusion container according to a second embodiment of the present invention
  • FIG. 8 is a vertical cross-sectional view of a main part in a vertical cross section perpendicular to FIG.
  • FIG. 9 (A) is a plan view showing a small container for an agent for preventing deterioration of a drug used in Embodiment 2
  • FIG. 9 (B) is a side view
  • FIG. 9 (C) is a rear view
  • FIG. ) Is an A-A cross section.
  • FIG. 10 is an enlarged sectional view of a portion B in FIG. 9 (B).
  • FIG. 11 is a sectional view showing the holder, and FIG. 12 is a bottom view thereof.
  • the infusion container 60 contains a solution storage chamber 52 for storing a solution and a drug, and the solution storage chamber 52 is partitioned and used before use.
  • the medicine storage room 51 is provided so as to be able to communicate with the medicine storage room, and a small container 65 for preventing the deterioration of the medicine is built in the medicine storage room.
  • the solution and solution storage chamber 52 has the same configuration as the solution and solution storage chamber 2 of the first embodiment, and a description thereof will be omitted.
  • the medicine storage chamber 51 has a container body 58 having an opening 51 a and a bottom 56 connected to the solution storage chamber 52, and a cap member for sealing the opening 51 a of the container body.
  • the cap member is provided with a lid 53 a and a rubber stopper 70, and a central recess 70 c on the lower surface of the rubber stopper for facilitating insertion of a needle for taking out an infusion solution.
  • a pair of engagement holes 70d and 70e as engagement portions facing each other with the center recess as a center is formed.
  • a communication hole 5 5 for communicating between the drug storage chamber 51 and the solution storage chamber 52 is provided at the bottom of the drug storage chamber 51 that is in fluid communication with the solution storage chamber 52.
  • a ⁇ 55 b) are formed, and a pair of protrusions 57 c ⁇ 57 d are formed as protrusions 57 projecting into the medicine storage chamber 51 and covering and sealing the communication holes 55.
  • the tips of the projections 57 are fitted to the engagement portions (engagement holes 70d, 70e) formed in the rubber stopper 70 described above.
  • the projection 57 is moved by the rotation operation of the cap member 53 to open the communication holes 55 (55a, 55b), and the drug storage chamber 51 and the solution
  • the communication with the storage room 52 is established.
  • the configuration of the communication hole 55, the protruding portion 57, and the periphery thereof is the same as that of the communication hole 5, the protruding portion 7, and the periphery thereof of the first embodiment, and thus the description is omitted.
  • the small container 65 for the agent for preventing deterioration of the drug is held by the holder 101 at the bottom of the cap member 53 and is housed in the container body 58.
  • the small container 65 for the anti-deterioration agent of this chemical is sealed to the small container body 66 having the small opening 102 at one end and the small opening 102 in FIGS.
  • the small lid is made of a (container-shaped) silicon rubber small lid 103 having a concave stepped portion 68b, and the inner peripheral surface of this small lid is The outer peripheral surface of the small lid 103 is pressed against the inner peripheral surface of the small opening 102, thereby closing the small opening 102 in a liquid-tight manner. Pressing tool 104.
  • reference numeral 105 denotes a thin portion formed near the bottom of the small lid 103 as a gas permeable portion, which can prevent gas permeation while being gas permeable. Therefore, the moisture (such as water vapor) on the drug side can be absorbed through the thin portion 105, and the deterioration of the drug can be prevented.
  • the small container body 66 is made of polypropylene resin.
  • the holder 101 is provided with a mounting plate portion 108 on which the small container body 66 is mounted and a cap member 53 extending upward from the periphery of the mounting plate portion. take And an attachment plate 109 for holding the small container body 66 close to the bottom surface of the cap member 53.
  • the small container body 66 is partitioned from the small container body 66 itself, penetrates vertically, and passes through a needle for passing an infusion removal needle inserted into the cap member 53.
  • the center through hole for needle passage is opposed to the center, is separated from the small container body 66, and a pair of protrusions 5 7c It further has a pair of opposed through-holes 1 1 1 and 1 1 2 for passing 7d.
  • the holder 101 also passes through the mounting plate portion 108 through an infusion taking needle (not shown) and a pair of protrusions 57c and 57d as protrusions 57. It further has a large through hole 113 for allowing it to flow.
  • the protrusions 5 7 (5) are formed through the pair of engagement holes 1 1 1 and 1 1 2 of the rubber stopper 70. 7 c, 57 d), and the communication hole 55 between the solution storage chamber 52 and the drug storage chamber 51 can be opened in the same manner as in the first embodiment.
  • the drug in the storage chamber 51 can be dissolved in the solution in the solution storage chamber 52 to obtain an infusion.
  • the small container for the substance deterioration preventing agent of this invention is a small three-dimensional container, and at least one part of the component wall is made into a gas permeable part.
  • specific surrounding gas can be adsorbed by the alteration preventive agent through the gas permeable portion, thereby preventing the alteration of the surrounding materials and preventing the change with a very simple configuration. , And can be used easily by itself.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Food Science & Technology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Packages (AREA)

Abstract

L'invention concerne un contenant de petite taille pour inhibiteurs de dégénérescence de substances (par exemple, déshydratants pour produits chimiques), de conception très simple et d'insertion unitaire aisée dans une chambre de stockage de substances (par exemple, chambre de stockage de produits chimiques). L'invention concerne un contenant de ce type, moulé en résine synthétique dans une enceinte en trois dimensions à espace interne de stockage pour les inhibiteurs considérés. La paroi du contenant de petite taille est imperméable aux liquides, dans son intégralité, mais avec une partie perméable aux gaz qui présente une zone plus mince que le reste de la partie proprement dite.
PCT/JP2002/006919 2001-07-09 2002-07-08 Contenant de petite taille pour inhibiteurs de degenerescence de substances, et contenant de solution de perfusion dans lequel est incorpore ce premier contenant WO2003006339A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2003512121A JP4175255B2 (ja) 2001-07-09 2002-07-08 物質の変質防止剤用小容器およびそれを内蔵した輸液用容器

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-208314 2001-07-09
JP2001208314 2001-07-09

Publications (1)

Publication Number Publication Date
WO2003006339A1 true WO2003006339A1 (fr) 2003-01-23

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/006919 WO2003006339A1 (fr) 2001-07-09 2002-07-08 Contenant de petite taille pour inhibiteurs de degenerescence de substances, et contenant de solution de perfusion dans lequel est incorpore ce premier contenant

Country Status (2)

Country Link
JP (1) JP4175255B2 (fr)
WO (1) WO2003006339A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007252759A (ja) * 2006-03-24 2007-10-04 Shinko Chemical Co Ltd 点眼薬容器
WO2010004926A1 (fr) * 2008-07-09 2010-01-14 テルモ株式会社 Récipient contenant un médicament

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5744309B2 (fr) * 1978-07-21 1982-09-20
JPS60101456U (ja) * 1983-12-14 1985-07-10 株式会社資生堂 液体収納容器用蓋
JPS644693Y2 (fr) * 1983-12-28 1989-02-07
JPH0536845Y2 (fr) * 1986-03-31 1993-09-17
JPH0710172A (ja) * 1993-06-18 1995-01-13 Eisai Co Ltd 用時混合容器および用時混合方法
JPH09255047A (ja) * 1996-03-22 1997-09-30 Toppan Printing Co Ltd 容 器
JPH09328173A (ja) * 1996-06-07 1997-12-22 Seven Kagaku:Kk 錠剤混合容器
JP3028296B2 (ja) * 1996-11-22 2000-04-04 荒木工業株式会社 点滴注射用輸液容器
JP2001161791A (ja) * 1999-09-30 2001-06-19 Fujisawa Pharmaceut Co Ltd 輸液用容器及びその凍結乾燥薬剤収納方法

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5744309B2 (fr) * 1978-07-21 1982-09-20
JPS60101456U (ja) * 1983-12-14 1985-07-10 株式会社資生堂 液体収納容器用蓋
JPS644693Y2 (fr) * 1983-12-28 1989-02-07
JPH0536845Y2 (fr) * 1986-03-31 1993-09-17
JPH0710172A (ja) * 1993-06-18 1995-01-13 Eisai Co Ltd 用時混合容器および用時混合方法
JPH09255047A (ja) * 1996-03-22 1997-09-30 Toppan Printing Co Ltd 容 器
JPH09328173A (ja) * 1996-06-07 1997-12-22 Seven Kagaku:Kk 錠剤混合容器
JP3028296B2 (ja) * 1996-11-22 2000-04-04 荒木工業株式会社 点滴注射用輸液容器
JP2001161791A (ja) * 1999-09-30 2001-06-19 Fujisawa Pharmaceut Co Ltd 輸液用容器及びその凍結乾燥薬剤収納方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007252759A (ja) * 2006-03-24 2007-10-04 Shinko Chemical Co Ltd 点眼薬容器
WO2010004926A1 (fr) * 2008-07-09 2010-01-14 テルモ株式会社 Récipient contenant un médicament

Also Published As

Publication number Publication date
JP4175255B2 (ja) 2008-11-05
JPWO2003006339A1 (ja) 2004-10-28

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