WO2002061037B1 - Administration d'une sequence d'acides amines a un animal femelle - Google Patents
Administration d'une sequence d'acides amines a un animal femelleInfo
- Publication number
- WO2002061037B1 WO2002061037B1 PCT/US2001/048726 US0148726W WO02061037B1 WO 2002061037 B1 WO2002061037 B1 WO 2002061037B1 US 0148726 W US0148726 W US 0148726W WO 02061037 B1 WO02061037 B1 WO 02061037B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- vector
- animal
- female
- cells
- offspring
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title claims abstract 100
- 108091028043 Nucleic acid sequence Proteins 0.000 title claims abstract 11
- 150000007523 nucleic acids Chemical group 0.000 title claims abstract 11
- 238000000034 method Methods 0.000 claims abstract 124
- 239000013598 vector Substances 0.000 claims abstract 63
- 101710142969 Somatoliberin Proteins 0.000 claims abstract 20
- 230000035935 pregnancy Effects 0.000 claims abstract 17
- 210000004027 cell Anatomy 0.000 claims 39
- 108091036066 Three prime untranslated region Proteins 0.000 claims 25
- 102000038461 Growth Hormone-Releasing Hormone Human genes 0.000 claims 18
- 239000000095 Growth Hormone-Releasing Hormone Substances 0.000 claims 18
- 241000282414 Homo sapiens Species 0.000 claims 18
- 239000002773 nucleotide Substances 0.000 claims 18
- 125000003729 nucleotide group Chemical group 0.000 claims 18
- 239000013603 viral vector Substances 0.000 claims 18
- 239000003446 ligand Substances 0.000 claims 16
- 230000001965 increasing effect Effects 0.000 claims 13
- 241000283690 Bos taurus Species 0.000 claims 9
- 241000283707 Capra Species 0.000 claims 9
- 241000287828 Gallus gallus Species 0.000 claims 9
- 241001494479 Pecora Species 0.000 claims 9
- 241000282898 Sus scrofa Species 0.000 claims 9
- -1 cationic lipid Chemical class 0.000 claims 9
- 210000001840 diploid cell Anatomy 0.000 claims 9
- 238000004520 electroporation Methods 0.000 claims 9
- 235000013305 food Nutrition 0.000 claims 9
- 239000003111 growth hormone derivative Substances 0.000 claims 9
- 239000002502 liposome Substances 0.000 claims 9
- 210000000663 muscle cell Anatomy 0.000 claims 9
- 230000001114 myogenic effect Effects 0.000 claims 9
- 239000013612 plasmid Substances 0.000 claims 9
- 102000000393 Ghrelin Receptors Human genes 0.000 claims 8
- 108010016122 Ghrelin Receptors Proteins 0.000 claims 8
- 239000005556 hormone Substances 0.000 claims 3
- 229940088597 hormone Drugs 0.000 claims 3
- 102000018997 Growth Hormone Human genes 0.000 claims 2
- 108010051696 Growth Hormone Proteins 0.000 claims 2
- 206010062767 Hypophysitis Diseases 0.000 claims 2
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims 2
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims 2
- 108091023045 Untranslated Region Proteins 0.000 claims 2
- 239000000122 growth hormone Substances 0.000 claims 2
- 239000008267 milk Substances 0.000 claims 2
- 210000004080 milk Anatomy 0.000 claims 2
- 235000013336 milk Nutrition 0.000 claims 2
- 210000003635 pituitary gland Anatomy 0.000 claims 2
- 210000001875 somatotroph Anatomy 0.000 claims 2
- 210000001257 corticotroph Anatomy 0.000 claims 1
- 230000003131 corticotrophic effect Effects 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 210000004368 gonadotroph Anatomy 0.000 claims 1
- 230000001456 gonadotroph Effects 0.000 claims 1
- 210000001756 lactotroph Anatomy 0.000 claims 1
- 230000001381 lactotroph Effects 0.000 claims 1
- 102100022831 Somatoliberin Human genes 0.000 abstract 2
- 108020004414 DNA Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Environmental Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Toxicology (AREA)
- Pregnancy & Childbirth (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Animal Husbandry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01997073A EP1364004A4 (fr) | 2000-12-12 | 2001-12-12 | Administration d'une sequence d'acides amines a un animal femelle |
AU2002248194A AU2002248194B2 (en) | 2000-12-12 | 2001-12-12 | Administration of nucleic acid sequence to female animal |
BR0116472-4A BR0116472A (pt) | 2000-12-12 | 2001-12-12 | Administração de sequência de ácido nucléico a animal fêmea para aumentar o crescimento de prole |
CA2430921A CA2430921C (fr) | 2000-12-12 | 2001-12-12 | Utilisation d'un vecteur codant pour un peptide de ghrh destine a ameliorer la croissance dans de multiples portees de la progeniture d'animaux femelles |
MXPA03005236A MXPA03005236A (es) | 2000-12-12 | 2001-12-12 | Administracion de secuencia de acido nucleico a un animal hembra para mejorar el crecimiento en la progenie. |
KR10-2003-7007872A KR20040039187A (ko) | 2000-12-12 | 2001-12-12 | 암컷 동물에 핵산 서열의 투여 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25502100P | 2000-12-12 | 2000-12-12 | |
US60/255,021 | 2000-12-12 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2002061037A2 WO2002061037A2 (fr) | 2002-08-08 |
WO2002061037A3 WO2002061037A3 (fr) | 2003-10-02 |
WO2002061037B1 true WO2002061037B1 (fr) | 2004-01-15 |
Family
ID=22966509
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/048726 WO2002061037A2 (fr) | 2000-12-12 | 2001-12-12 | Administration d'une sequence d'acides amines a un animal femelle |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1364004A4 (fr) |
KR (1) | KR20040039187A (fr) |
CN (1) | CN1575301A (fr) |
AR (1) | AR035671A1 (fr) |
AU (1) | AU2002248194B2 (fr) |
BR (1) | BR0116472A (fr) |
CA (1) | CA2430921C (fr) |
MX (1) | MXPA03005236A (fr) |
PL (1) | PL366116A1 (fr) |
WO (1) | WO2002061037A2 (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0213965A (pt) | 2001-10-26 | 2005-03-15 | Baylor College Medicine | Composição e método para alterar as propriedades de massa corporal magra e ósseas em um indivìduo |
EP1499731B1 (fr) * | 2002-02-07 | 2011-05-25 | Baylor College Of Medicine | Developpement modifie de l'hypophyse chez la progeniture de femelles animales portantes traitees par la therapie hormonale de liberation de l'hormone de croissance |
US7316925B2 (en) | 2002-07-16 | 2008-01-08 | Vgx Pharmaceuticals, Inc. | Codon optimized synthetic plasmids |
DE10240418A1 (de) * | 2002-09-02 | 2004-03-11 | Avontec Gmbh | Formulierung zur Einschleusung von Nukleinsäuren in eukaryotische Zellen |
US20040175727A1 (en) * | 2002-11-04 | 2004-09-09 | Advisys, Inc. | Synthetic muscle promoters with activities exceeding naturally occurring regulatory sequences in cardiac cells |
CA2513743C (fr) * | 2003-01-28 | 2013-06-25 | Advisys, Inc. | Reduction de reforme dans l'hormone de croissance (ghrh) d'animaux de troupeau |
CN102127545A (zh) * | 2010-11-24 | 2011-07-20 | 山东农业大学 | 一种骨骼肌特异性ckm启动子及其应用 |
CN104031930B (zh) * | 2014-05-30 | 2017-09-22 | 华南农业大学 | 一种提高母猪乳中营养及免疫物质含量的方法 |
CN105219774B (zh) * | 2015-10-10 | 2019-04-30 | 广西大学 | 猪胰岛素特异性表达启动子pip2及其应用 |
CN105617404A (zh) * | 2016-01-27 | 2016-06-01 | 广州市科虎生物技术研究开发中心 | Grf表达质粒在制备降低仔猪出生弱仔率的药物中的用途 |
DE202018105142U1 (de) * | 2018-04-29 | 2018-10-08 | Kalmarna Limited - CCS Trustees Limited | Zusammensetzungen zur oralen Verabreichung zum Beeinflussen der Nachkommenschaft von Säugetieren |
CN115044666B (zh) * | 2022-06-13 | 2024-06-25 | 天津市农业科学院 | 一种用于预测母猪二胎综合征的snp分子标记及其应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2622455B1 (fr) * | 1987-11-04 | 1991-07-12 | Agronomique Inst Nat Rech | Application du facteur de stimulation de la secretion de l'hormone de croissance humaine, de ses fragments actifs et des analogues correspondants, pour augmenter la production laitiere et le poids des nouveau-nes chez les mammiferes |
CA2085362A1 (fr) * | 1990-06-29 | 1991-12-30 | Arthur M. Felix | Analogues d'un facteur liberant de l'hormone de croissance substituee par l'histidine |
US6165755A (en) * | 1997-01-23 | 2000-12-26 | University Of Victoria Innovation And Development Corporation | Chicken neuropeptide gene useful for improved poultry production |
EP0988388A2 (fr) * | 1997-07-24 | 2000-03-29 | Valentis Inc. | Systeme d'expression de ghrh et procedes d'utilisation |
DE60023906T2 (de) * | 1999-07-26 | 2006-07-20 | Baylor College Of Medicine, Houston | Superaktive, wachstumshormone freisetzende hormonanaloge vom schwein |
-
2001
- 2001-12-11 AR ARP010105745A patent/AR035671A1/es not_active Application Discontinuation
- 2001-12-12 MX MXPA03005236A patent/MXPA03005236A/es not_active Application Discontinuation
- 2001-12-12 AU AU2002248194A patent/AU2002248194B2/en not_active Expired
- 2001-12-12 BR BR0116472-4A patent/BR0116472A/pt not_active IP Right Cessation
- 2001-12-12 CN CNA018220088A patent/CN1575301A/zh active Pending
- 2001-12-12 CA CA2430921A patent/CA2430921C/fr not_active Expired - Lifetime
- 2001-12-12 EP EP01997073A patent/EP1364004A4/fr not_active Ceased
- 2001-12-12 WO PCT/US2001/048726 patent/WO2002061037A2/fr active IP Right Grant
- 2001-12-12 KR KR10-2003-7007872A patent/KR20040039187A/ko not_active Application Discontinuation
- 2001-12-12 PL PL01366116A patent/PL366116A1/xx not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2002248194B2 (en) | 2007-04-05 |
CA2430921C (fr) | 2016-06-07 |
WO2002061037A3 (fr) | 2003-10-02 |
PL366116A1 (en) | 2005-01-24 |
KR20040039187A (ko) | 2004-05-10 |
CN1575301A (zh) | 2005-02-02 |
AR035671A1 (es) | 2004-06-23 |
CA2430921A1 (fr) | 2002-08-08 |
MXPA03005236A (es) | 2005-04-08 |
EP1364004A4 (fr) | 2005-11-09 |
BR0116472A (pt) | 2005-04-05 |
WO2002061037A2 (fr) | 2002-08-08 |
EP1364004A2 (fr) | 2003-11-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2002061037B1 (fr) | Administration d'une sequence d'acides amines a un animal femelle | |
US5037806A (en) | Biologically active method using somatotropins | |
CN102399283B (zh) | 水貂生长激素释放激素cDNA及其应用 | |
CA2378943A1 (fr) | Analogue superactif de la somatostatine porcine | |
CN102399284B (zh) | 狐狸生长激素释放激素cDNA及其应用 | |
CZ282867B6 (cs) | Expresní vektory pro zvýšenou produkci polypeptidů, plasmidy obsahující tyto vektory, hostitelé obsahující tyto plasmidy, získané produkty a související způsoby | |
CN107050434A (zh) | 包含重组hcg的药物制剂 | |
US20230357345A1 (en) | Glycoprotein Hormone Long-Acting Superagonists | |
Mao et al. | Ontogeny of growth hormone receptor gene expression in tissue of growth-selected strains of broiler chickens | |
CA2513743A1 (fr) | Reduction de reforme dans l'hormone de croissance (ghrh) d'animaux de troupeau | |
Khan et al. | Effects of maternal plasmid GHRH treatment on offspring growth | |
Wray-Cahen et al. | Redefining body composition: nutrients, hormones, and genes in meat production | |
Bai et al. | Effects of immunization against a DNA vaccine encoding somatostatin gene (pGM-CSF/SS) by attenuated Salmonella typhimurium on growth, reproduction and lactation in female mice | |
Guillaumot et al. | Prolactin receptors are expressed and hormonally regulated in rat Sertoli cells | |
EP1218508B1 (fr) | Séquences d'ADN pour accroître l'efficacité de l'alimentation et la vitesse de croissance des porcins | |
RU2034457C1 (ru) | Способ повышения продуктивности сельскохозяйственных животных и препарат для его осуществления | |
Dunaiski et al. | Effect of growth hormone administration on IGF binding protein-3 mRNA levels in porcine tissues | |
CN104789514B (zh) | 一种生长抑制素超表达dna疫苗及构建方法和应用 | |
Etherton | Emerging strategies for enhancing growth: is there a biotechnology better than somatotropin? | |
Duittoz et al. | The Horse: An Unexpected Animal Model for (Unexpected) Neuroendocrinology | |
Armstrong et al. | The application of biotechnology for future livestock production | |
SHORT | MRC Unit of Reproductive Biology, Edinburgh | |
Hansel | Prospective developments in animal agriculture | |
AU647374B2 (en) | Sheep growth hormone | |
CN118271466A (zh) | 一种重组鱼GtH融合蛋白及其制备方法与应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 01822008.8 Country of ref document: CN |
|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2430921 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1020037007872 Country of ref document: KR Ref document number: PA/a/2003/005236 Country of ref document: MX |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2002248194 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 526621 Country of ref document: NZ |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2001997073 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1-2003-500503 Country of ref document: PH |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: 2001997073 Country of ref document: EP |
|
B | Later publication of amended claims |
Effective date: 20031013 |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWP | Wipo information: published in national office |
Ref document number: 1020037007872 Country of ref document: KR |
|
NENP | Non-entry into the national phase |
Ref country code: JP |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: JP |
|
WWG | Wipo information: grant in national office |
Ref document number: 2002248194 Country of ref document: AU |