EP1364004A4 - Administration d'une sequence d'acides amines a un animal femelle - Google Patents

Administration d'une sequence d'acides amines a un animal femelle

Info

Publication number
EP1364004A4
EP1364004A4 EP01997073A EP01997073A EP1364004A4 EP 1364004 A4 EP1364004 A4 EP 1364004A4 EP 01997073 A EP01997073 A EP 01997073A EP 01997073 A EP01997073 A EP 01997073A EP 1364004 A4 EP1364004 A4 EP 1364004A4
Authority
EP
European Patent Office
Prior art keywords
administration
nucleic acid
acid sequence
female animal
ghrh
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP01997073A
Other languages
German (de)
English (en)
Other versions
EP1364004A2 (fr
Inventor
Robert J Schwartz
Robert H Carpenter
Ruxandra Draghia-Akli
Douglas R Kern
Roy G Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
Advisys Inc
Original Assignee
Baylor College of Medicine
Advisys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College of Medicine, Advisys Inc filed Critical Baylor College of Medicine
Publication of EP1364004A2 publication Critical patent/EP1364004A2/fr
Publication of EP1364004A4 publication Critical patent/EP1364004A4/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0271—Chimeric animals, e.g. comprising exogenous cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth-hormone releasing factors (GH-RF) (Somatoliberin)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Abstract

La croissance est améliorée au moyen d'une technique d'amélioration du potentiel de la croissance, laquelle technique consiste à administrer une séquence d'acides aminés, telle que GHRH ou un analogue, à un animal femelle, de préférence par administration par voie parentérale. Les porcelets nés de truies auxquelles on a injecté un ADN codant pour GHRH, sont plus gros. Ces effets sont démontrés lors de gestations ultérieures sans administration(s) supplémentaire(s) du vecteur.
EP01997073A 2000-12-12 2001-12-12 Administration d'une sequence d'acides amines a un animal femelle Ceased EP1364004A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25502100P 2000-12-12 2000-12-12
US255021P 2000-12-12
PCT/US2001/048726 WO2002061037A2 (fr) 2000-12-12 2001-12-12 Administration d'une sequence d'acides amines a un animal femelle

Publications (2)

Publication Number Publication Date
EP1364004A2 EP1364004A2 (fr) 2003-11-26
EP1364004A4 true EP1364004A4 (fr) 2005-11-09

Family

ID=22966509

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01997073A Ceased EP1364004A4 (fr) 2000-12-12 2001-12-12 Administration d'une sequence d'acides amines a un animal femelle

Country Status (10)

Country Link
EP (1) EP1364004A4 (fr)
KR (1) KR20040039187A (fr)
CN (1) CN1575301A (fr)
AR (1) AR035671A1 (fr)
AU (1) AU2002248194B2 (fr)
BR (1) BR0116472A (fr)
CA (1) CA2430921C (fr)
MX (1) MXPA03005236A (fr)
PL (1) PL366116A1 (fr)
WO (1) WO2002061037A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1450605B1 (fr) * 2001-10-26 2011-12-07 Baylor College Of Medicine Composition permettant de modifier les proprietes osseuses d'un sujet
WO2003066825A2 (fr) * 2002-02-07 2003-08-14 Baylor College Of Medicine Developpement modifie de l'hypophyse chez la progeniture de femelles animales portantes traitees par la therapie hormonale de liberation de l'hormone de croissance
DE60336736D1 (de) 2002-07-16 2011-05-26 VGX Pharmaceuticals LLC Codon-optimierte synthetische plasmide
DE10240418A1 (de) * 2002-09-02 2004-03-11 Avontec Gmbh Formulierung zur Einschleusung von Nukleinsäuren in eukaryotische Zellen
TWI290174B (en) * 2002-11-04 2007-11-21 Advisys Inc Synthetic muscle promoters with activities exceeding naturally occurring regulatory sequences in cardiac cells
CA2513743C (fr) * 2003-01-28 2013-06-25 Advisys, Inc. Reduction de reforme dans l'hormone de croissance (ghrh) d'animaux de troupeau
CN102127545A (zh) * 2010-11-24 2011-07-20 山东农业大学 一种骨骼肌特异性ckm启动子及其应用
CN104031930B (zh) * 2014-05-30 2017-09-22 华南农业大学 一种提高母猪乳中营养及免疫物质含量的方法
CN105219774B (zh) * 2015-10-10 2019-04-30 广西大学 猪胰岛素特异性表达启动子pip2及其应用
CN105617404A (zh) * 2016-01-27 2016-06-01 广州市科虎生物技术研究开发中心 Grf表达质粒在制备降低仔猪出生弱仔率的药物中的用途
DE202018105142U1 (de) * 2018-04-29 2018-10-08 Kalmarna Limited - CCS Trustees Limited Zusammensetzungen zur oralen Verabreichung zum Beeinflussen der Nachkommenschaft von Säugetieren

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0317387A1 (fr) * 1987-11-04 1989-05-24 Institut National De La Recherche Agronomique Procédé pour augmenter la production laitière chez les mammifères et/ou accroître le poids de leurs nouveaux-nés à la naissance et améliorer la croissance post-natale
WO1992000095A1 (fr) * 1990-06-29 1992-01-09 Hoffmann-La Roche Inc. Analogues du facteur de liberation d'hormone de croissance a substitution hystidine
WO1999005300A2 (fr) * 1997-07-24 1999-02-04 Valentis, Inc. Systeme d'expression de ghrh et procedes d'utilisation
WO2001006988A2 (fr) * 1999-07-26 2001-02-01 Baylor College Of Medicine Analogue superactif de la somatostatine porcine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6165755A (en) * 1997-01-23 2000-12-26 University Of Victoria Innovation And Development Corporation Chicken neuropeptide gene useful for improved poultry production

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0317387A1 (fr) * 1987-11-04 1989-05-24 Institut National De La Recherche Agronomique Procédé pour augmenter la production laitière chez les mammifères et/ou accroître le poids de leurs nouveaux-nés à la naissance et améliorer la croissance post-natale
WO1992000095A1 (fr) * 1990-06-29 1992-01-09 Hoffmann-La Roche Inc. Analogues du facteur de liberation d'hormone de croissance a substitution hystidine
WO1999005300A2 (fr) * 1997-07-24 1999-02-04 Valentis, Inc. Systeme d'expression de ghrh et procedes d'utilisation
WO2001006988A2 (fr) * 1999-07-26 2001-02-01 Baylor College Of Medicine Analogue superactif de la somatostatine porcine

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DRAGHIA-AKLI R ET AL: "ENHANCED GROWTH BY ECTOPIC EXPRESSION OF GROWTH HORMONE RELEASING HORMONE USING AN INJECTABLE MYOGENIC VECTOR", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 15, no. 12, November 1997 (1997-11-01), pages 1285 - 1289, XP002060954, ISSN: 1087-0156 *
DRAGHIA-AKLI RUXANDRA ET AL: "Myogenic expression of an injectable protease-resistant growth hormone-releasing hormone augments long-term growth in pigs", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 17, no. 12, December 1999 (1999-12-01), pages 1179 - 1183, XP002159711, ISSN: 1087-0156 *
KHAN A S ET AL: "GHRH GENE DELIVERY TO PREGNANT RATS INCREASES SOMATOTROPH POPULATION AND GROWTH OF PUPS.", SOCIETY FOR NEUROSCIENCE ABSTRACT VIEWER AND ITINERARY PLANNER, vol. 2002, 2002, & 32ND ANNUAL MEETING OF THE SOCIETY FOR NEUROSCIENCE; ORLANDO, FLORIDA, USA; NOVEMBER 02-07, 2002, pages Abstract No. 74.3 URL - http://sf, XP009053813 *

Also Published As

Publication number Publication date
KR20040039187A (ko) 2004-05-10
WO2002061037A3 (fr) 2003-10-02
EP1364004A2 (fr) 2003-11-26
MXPA03005236A (es) 2005-04-08
CA2430921A1 (fr) 2002-08-08
CA2430921C (fr) 2016-06-07
PL366116A1 (en) 2005-01-24
AR035671A1 (es) 2004-06-23
WO2002061037A2 (fr) 2002-08-08
BR0116472A (pt) 2005-04-05
CN1575301A (zh) 2005-02-02
AU2002248194B2 (en) 2007-04-05
WO2002061037B1 (fr) 2004-01-15

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