CA2430921C - Utilisation d'un vecteur codant pour un peptide de ghrh destine a ameliorer la croissance dans de multiples portees de la progeniture d'animaux femelles - Google Patents

Utilisation d'un vecteur codant pour un peptide de ghrh destine a ameliorer la croissance dans de multiples portees de la progeniture d'animaux femelles Download PDF

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Publication number
CA2430921C
CA2430921C CA2430921A CA2430921A CA2430921C CA 2430921 C CA2430921 C CA 2430921C CA 2430921 A CA2430921 A CA 2430921A CA 2430921 A CA2430921 A CA 2430921A CA 2430921 C CA2430921 C CA 2430921C
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CA
Canada
Prior art keywords
ghrh
vector
growth
specific embodiment
growth hormone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2430921A
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English (en)
Other versions
CA2430921A1 (fr
Inventor
Robert J. Schwartz
Robert H. Carpenter
Ruxandra Draghia-Akli
Douglas R. Kern
Roy G. Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baylor College of Medicine
Advisys Inc
Original Assignee
Baylor College of Medicine
Advisys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College of Medicine, Advisys Inc filed Critical Baylor College of Medicine
Publication of CA2430921A1 publication Critical patent/CA2430921A1/fr
Application granted granted Critical
Publication of CA2430921C publication Critical patent/CA2430921C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
    • A01K67/027—New breeds of vertebrates
    • A01K67/0271—Chimeric animals, e.g. comprising exogenous cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth-hormone releasing factors (GH-RF) (Somatoliberin)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Abstract

La croissance est améliorée au moyen d'une technique d'amélioration du potentiel de la croissance, laquelle technique consiste à administrer une séquence d'acides aminés, telle que GHRH ou un analogue, à un animal femelle, de préférence par administration par voie parentérale. Les porcelets nés de truies auxquelles on a injecté un ADN codant pour GHRH, sont plus gros. Ces effets sont démontrés lors de gestations ultérieures sans administration(s) supplémentaire(s) du vecteur.
CA2430921A 2000-12-12 2001-12-12 Utilisation d'un vecteur codant pour un peptide de ghrh destine a ameliorer la croissance dans de multiples portees de la progeniture d'animaux femelles Expired - Lifetime CA2430921C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25502100P 2000-12-12 2000-12-12
US60/255,021 2000-12-12
PCT/US2001/048726 WO2002061037A2 (fr) 2000-12-12 2001-12-12 Administration d'une sequence d'acides amines a un animal femelle

Publications (2)

Publication Number Publication Date
CA2430921A1 CA2430921A1 (fr) 2002-08-08
CA2430921C true CA2430921C (fr) 2016-06-07

Family

ID=22966509

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2430921A Expired - Lifetime CA2430921C (fr) 2000-12-12 2001-12-12 Utilisation d'un vecteur codant pour un peptide de ghrh destine a ameliorer la croissance dans de multiples portees de la progeniture d'animaux femelles

Country Status (10)

Country Link
EP (1) EP1364004A4 (fr)
KR (1) KR20040039187A (fr)
CN (1) CN1575301A (fr)
AR (1) AR035671A1 (fr)
AU (1) AU2002248194B2 (fr)
BR (1) BR0116472A (fr)
CA (1) CA2430921C (fr)
MX (1) MXPA03005236A (fr)
PL (1) PL366116A1 (fr)
WO (1) WO2002061037A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003038112A2 (fr) 2001-10-26 2003-05-08 Baylor College Of Medicine Composition et methode permettant de modifier la masse maigre et les proprietes osseuses d'un sujet
MXPA04007638A (es) 2002-02-07 2004-12-06 Baylor College Medicine Desarrollo modificado de la glandula pituitaria en productos de madres animales prenadas, tratadas con terapia de hormona liberadora de hormona del crecimiento.
AU2003249208B2 (en) 2002-07-16 2010-03-04 Vgx Pharmaceuticals, Llc Codon optimized synthetic plasmids
DE10240418A1 (de) * 2002-09-02 2004-03-11 Avontec Gmbh Formulierung zur Einschleusung von Nukleinsäuren in eukaryotische Zellen
AU2003295366B2 (en) * 2002-11-04 2011-11-24 Advisys, Inc. Synthetic muscle promoters with activities exceeding naturally occurring regulatory sequences in cardiac cells
US20040204358A1 (en) * 2003-01-28 2004-10-14 Advisys, Inc. Reducing culling in herd animals growth hormone releasing hormone (GHRH)
CN102127545A (zh) * 2010-11-24 2011-07-20 山东农业大学 一种骨骼肌特异性ckm启动子及其应用
CN104031930B (zh) * 2014-05-30 2017-09-22 华南农业大学 一种提高母猪乳中营养及免疫物质含量的方法
CN105219774B (zh) * 2015-10-10 2019-04-30 广西大学 猪胰岛素特异性表达启动子pip2及其应用
CN105617404A (zh) * 2016-01-27 2016-06-01 广州市科虎生物技术研究开发中心 Grf表达质粒在制备降低仔猪出生弱仔率的药物中的用途
DE202018105142U1 (de) * 2018-04-29 2018-10-08 Kalmarna Limited - CCS Trustees Limited Zusammensetzungen zur oralen Verabreichung zum Beeinflussen der Nachkommenschaft von Säugetieren

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2622455B1 (fr) * 1987-11-04 1991-07-12 Agronomique Inst Nat Rech Application du facteur de stimulation de la secretion de l'hormone de croissance humaine, de ses fragments actifs et des analogues correspondants, pour augmenter la production laitiere et le poids des nouveau-nes chez les mammiferes
ZA914983B (en) * 1990-06-29 1992-03-25 Hoffmann La Roche His-grf-analogs
US6165755A (en) * 1997-01-23 2000-12-26 University Of Victoria Innovation And Development Corporation Chicken neuropeptide gene useful for improved poultry production
AU8589998A (en) * 1997-07-24 1999-02-16 Valentis, Inc. Ghrh expression system and methods of use
EP1204321B1 (fr) * 1999-07-26 2005-11-09 Baylor College Of Medicine Analogue superactif de la somatostatine porcine

Also Published As

Publication number Publication date
EP1364004A4 (fr) 2005-11-09
AU2002248194B2 (en) 2007-04-05
PL366116A1 (en) 2005-01-24
WO2002061037A2 (fr) 2002-08-08
EP1364004A2 (fr) 2003-11-26
BR0116472A (pt) 2005-04-05
WO2002061037B1 (fr) 2004-01-15
AR035671A1 (es) 2004-06-23
CN1575301A (zh) 2005-02-02
MXPA03005236A (es) 2005-04-08
WO2002061037A3 (fr) 2003-10-02
KR20040039187A (ko) 2004-05-10
CA2430921A1 (fr) 2002-08-08

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Effective date: 20211213