WO2002059626A1 - Pipettiervorrichtung - Google Patents
Pipettiervorrichtung Download PDFInfo
- Publication number
- WO2002059626A1 WO2002059626A1 PCT/CH2002/000013 CH0200013W WO02059626A1 WO 2002059626 A1 WO2002059626 A1 WO 2002059626A1 CH 0200013 W CH0200013 W CH 0200013W WO 02059626 A1 WO02059626 A1 WO 02059626A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- pipette
- carrier
- cable
- pipetting device
- hollow profile
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N2035/1025—Fluid level sensing
Definitions
- the invention relates to a pipetting device, as seen in chemical, biological and medical laboratories.
- a generic pipetting device is known in which the cable connecting the liquid detector to a control device runs essentially directly from the pipette tip to the carrier.
- the position of the cables used is difficult to control, all the more so since they usually have low rigidity. This can cause them to get caught and the
- the invention is based on the object of improving the known pipetting device in the simplest possible way in such a way that malfunctions due to cables are excluded. This object is achieved by the invention as characterized in the characterizing part of claim 1. Further, inventive features result from the dependent claims.
- the cables are guided in such a way that they are always under control and cannot interfere with the processes. This is all the more important the more complicated the movements to which the pipettes are subjected.
- FIG. 1 is a side view of a carrier of a pipetting device according to the invention, with various parts, especially the housing, being at least partially removed,
- Fig. 3 enlarges a section of a section along III-III in
- FIG. 1 Fig. 4 enlarges a section of Fig. 3 and
- the pipetting device comprises (FIGS. 1, 2) an elongated carrier 1 with a two shells 2a, b and a housing arranged above it and connected to the same, comprising a C-profile 3, which is suspended so that it can be moved across a work surface the z.
- B. microtiter plates are positioned can be moved in a controlled manner.
- a carriage 4 is mounted in the carrier 1 so as to be longitudinally displaceable and carries eight pipettes 5 arranged in a row. However, more or fewer pipettes 5 can also be arranged in such a row.
- the carriage 4 can be moved longitudinally in the carrier 1 by parallel movement of two toothed belts 6, 7, rollers 8 arranged on both sides in three rows one above the other rolling on rails 9 fastened in the housing.
- Each of the pipettes 5 (see also FIGS. 3, 5) is mounted in a vertically displaceable manner on a holder 10 designed as a vertical profile and comprises a pipette housing the vertical hollow profile 12 enclosing a channel 11, which is guided in the holder 10 between two guide arms 13a, b with mutually facing grooves 14 into which webs 15 of the hollow profile 12 engage. It has an external toothing 16 which extends from the upper end to the vicinity of the lower end and with which a drive wheel 17 designed as a gearwheel engages.
- the same is attached to one of a total of eight profile rods 18 extending over the length of the carrier 1, which are preferably individually driven by a motor (not shown), but cannot be rotated longitudinally, so that it is also displaced by the holder 10.
- the hollow profile 12 can therefore be raised and lowered by rotating the corresponding profile rod 18 and thus the drive wheel 17, which engages with its external toothing 16.
- the external toothing 15 breaks off just above the lower end of the hollow profile 12 and it then has an opening 19 through which the channel 11 is accessible.
- a pipette head 20 is attached, which (see FIG. 4) comprises a base plate 21 made of metal, on which a molded part 22 made of an electrically insulating material, preferably plastic, is attached.
- a vertically continuous channel 23 penetrates both the base plate 21 and the molded part 22.
- a lower sleeve 24 made of metal is arranged, which surrounds a connecting hose 25 made of plastic. Both are passed through the base plate 21 and protrude beyond the underside thereof.
- a pipette tip 26 is plugged onto the lower sleeve 24 with a tube 27 narrowing downwards, which projects into the channel 23 within the connecting hose 25, and a conical sleeve 28, which bears against the outside of the lower sleeve 24 and one at the lower end of a recess the sleeve 28, which receives the lower part of the lower sleeve 24, arranged ring 29, which consists of electrically conductive material.
- the tube 27 consists of electrically conductive plastic or metal and is electrically conductively connected to the base plate 21 via the ring 29 and the lower sleeve 24.
- Above the lower sleeve 24 is the connecting hose 25 from surrounded by an upper sleeve 30 made of metal, the lower part of which lies in the channel 23 and which projects into the hollow profile 12.
- the upper sleeve 30 is spaced from the lower sleeve 24 and is electrically isolated. It is electrically conductively connected via a tab 31 to an external contact of a plug 32, which is inserted into a recess in the molded part 22 which extends as far as the base plate 21.
- a shielded cable 33 extends from the plug 32, which leads to a circuit 34 (FIGS. 1, 2), and whose grounded shield is electrically conductively connected to the upper sleeve 30 via the external contact of the plug 32 and the tab 31, while its Soul with the base plate 21 and via this with the tube 27 of the pipette tip 26 is connected.
- the pipette head 20 further comprises a slider 35 which can be displaced vertically to a limited extent relative to the base plate 21 and the molded part 22 and which is acted upon by a downward force by a spiral spring 36 which is supported on the tab 31 and presses against a transverse bolt 37. However, it is held in place by the attached pipette tip 26.
- Control of the pipetting device can be used. For example, the lowering of the corresponding pipette tip can be stopped and the liquid can be sucked in. If no pipette tip is plugged on, the slide 35 is in a lower position (not shown), in which the transverse bolt 37 rests on the base plate 21, so that a short circuit is produced by the spiral spring 36, which is also from the circuit 33 is registered.
- the slide 35 At the upper end of the hollow profile 12 is connected to an elastic sleeve 38, which is connected to the hollow profile 12 by means of a connecting sleeve 39, the lower part of which is slipped onto the hollow profile 12 and over the narrower upper part of the sleeve 38 a vertical starting direction is stamped.
- the envelope tube 38 is guided to the carrier 1, more precisely to the top of the C-profile 3, where its opposite end is fixed.
- the fastening can also be designed in such a way that it impresses an approximately perpendicular starting direction on the adjoining section of the casing tube 38.
- the connecting hose 25 runs through the channel 11 in the hollow profile 12 and further inside the casing tube 38 and an opening in the C-profile 3 inside the same, where it is guided to the end of the carrier 1.
- the cable 33 originating from the plug 32 is also pulled through the opening 19 in the lower end of the hollow profile 12 into the channel 11, through which it also reaches the upper end of the hollow profile 12 and further inside the casing tube 38 into the interior of the C- Profile 3 runs, from where it is drawn through further openings in the same and in the shell 2a to the circuit 34.
- the length and the rigidity of the enveloping tube 38 are each selected such that it forms a relatively tight arc at every position of the pipette from which it originates, so that it does not hinder the movements of the pipette, but also does not itself carry out any uncontrolled movements .
- the envelope tube 38 is preferably made of plastic. It can be provided with an embossed helical structure and / or be reinforced by a braid.
- the enveloping tubes 38 ensure secure and controlled guidance, above all of the cables 33, but also of the connecting tubes 25, which should therefore be relatively soft and flexible, and protect the pipetting device from malfunctions which would otherwise result from cables getting caught on others Parts could be caused.
- an enveloping tube other solutions are also conceivable, e.g. B.
- a differently designed support structure or a differently designed support member such as an elastic flap made of plastic, on which the cable and the connecting hose at one point or preferably on are fixed in several places or continuously.
- the connecting hose itself to be relatively rigid and to use it to support the softer, more flexible cable.
- the cable can, for example, be attached to the connecting hose with clips and / or wound around it.
- the cable does not extend from the pipette head 20, but from the upper end of the pipette housing. This significantly reduces the risk of undesirable effects on the movements of other parts of the pipetting device.
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Devices For Use In Laboratory Experiments (AREA)
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02734828A EP1354211A1 (de) | 2001-01-25 | 2002-01-10 | Pipettiervorrichtung |
US10/466,504 US20040076550A1 (en) | 2001-01-25 | 2002-01-10 | Pipetting device |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1292001 | 2001-01-25 | ||
CH129/01 | 2001-01-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002059626A1 true WO2002059626A1 (de) | 2002-08-01 |
Family
ID=4387602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CH2002/000013 WO2002059626A1 (de) | 2001-01-25 | 2002-01-10 | Pipettiervorrichtung |
Country Status (3)
Country | Link |
---|---|
US (1) | US20040076550A1 (de) |
EP (1) | EP1354211A1 (de) |
WO (1) | WO2002059626A1 (de) |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1477815A1 (de) * | 2003-05-14 | 2004-11-17 | Tecan Trading AG | Vorrichtung zum präzisen Anfahren von Mikroplatten-Wells |
DE102005060862B3 (de) * | 2005-12-20 | 2007-06-28 | Stratec Biomedical Systems Ag | Verfahren und Vorrichtung zur Beurteilung eines Dosiervorgangs |
WO2009032601A1 (en) | 2007-08-28 | 2009-03-12 | Schlumberger Canada Limited | Calibrating an accelerometer on a seismic cable |
DE202008006338U1 (de) | 2008-05-12 | 2009-03-26 | Matthias, Torsten, Dr. | Analysegerät |
CH699374B1 (de) * | 2006-04-28 | 2010-02-26 | Tecan Trading Ag | Träger zum Positionieren von Objekten gegenüber Laborartikeln. |
US7976794B2 (en) | 2006-07-21 | 2011-07-12 | Stratec Biomedical Systems Ag | Positioning device for the positioning of pipettes |
US7988934B2 (en) | 2006-04-28 | 2011-08-02 | Tecan Trading Ag | Carrier for positioning objects in relation to laboratory articles |
US8142719B2 (en) | 2008-05-12 | 2012-03-27 | Torsten Matthias | Analysis device |
DE102011117273A1 (de) | 2011-10-31 | 2013-05-02 | Torsten Matthias | Automatische Strukturbestimmung |
WO2013064237A2 (de) | 2011-10-31 | 2013-05-10 | Torsten Matthias | Automatische strukturbestimmung |
US8772036B2 (en) | 2010-06-29 | 2014-07-08 | Roche Molecular Systems, Inc. | Automated method for sample distribution and isolation of an analyte with a solid support |
US8900527B2 (en) | 2010-06-29 | 2014-12-02 | Roche Molecular Systems Inc. | Pipetting device with independently movable pipette units |
EP2810716A1 (de) * | 2013-06-06 | 2014-12-10 | Tecan Trading AG | Pipettiervorrichtung |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20020106308A1 (en) * | 2001-02-02 | 2002-08-08 | Zweifel Ronald A. | Microdrop dispensing apparatus |
EP1464965B1 (de) * | 2004-01-15 | 2006-03-08 | Agilent Technologies Inc. a Delaware Corporation | Positionierungssystem und Verfahren für eine Flüssigkeitstransfereinrichtung |
WO2009023448A1 (en) | 2007-08-13 | 2009-02-19 | Polyone Corporation | Electrically conductive polyolefin blends |
FR2920675B1 (fr) * | 2007-09-10 | 2010-12-03 | Gilson Sas | Systeme de pipetage multicanaux comprenant un porte-pistons a guidage ameliore |
US9459272B2 (en) | 2010-03-22 | 2016-10-04 | BioNex Solutions, Inc. | Transfer or interrogation of materials by carrier and receiving devices moving independently and simultaneously on multiple axes |
WO2011157303A1 (en) | 2010-06-18 | 2011-12-22 | Tecan Trading Ag | Spread sheare |
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US5443791A (en) * | 1990-04-06 | 1995-08-22 | Perkin Elmer - Applied Biosystems Division | Automated molecular biology laboratory |
US5550059A (en) * | 1994-02-23 | 1996-08-27 | Bayer Corporation | Fluid sensing pipette |
US5866426A (en) * | 1996-12-17 | 1999-02-02 | Akzo Nobel N.V. | Device and method for determining liquid-probe contact |
US6148666A (en) * | 1997-10-29 | 2000-11-21 | Boehringer Mannheim Gmbh | Method and device for liquid transfer with an analysis apparatus |
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JP2969935B2 (ja) * | 1990-11-30 | 1999-11-02 | 東ソー株式会社 | 液定量取出し装置 |
DE4203638A1 (de) * | 1992-02-08 | 1993-08-12 | Boehringer Mannheim Gmbh | Fluessigkeitstransfereinrichtung fuer ein analysegeraet |
JPH08338849A (ja) * | 1995-04-11 | 1996-12-24 | Precision Syst Sci Kk | 液体の吸引判別方法およびこの方法により駆動制御される分注装置 |
US5811306A (en) * | 1995-09-04 | 1998-09-22 | Fuji Photo Film Co., Ltd. | Liquid spotting method |
US20040047765A1 (en) * | 1998-10-16 | 2004-03-11 | Gordon Steven J. | Automated robotic workstation and methods of operation thereof |
DE19919305A1 (de) * | 1999-04-28 | 2000-11-02 | Roche Diagnostics Gmbh | Verfahren und Vorrichtung zum Flüssigkeitstransfer mit einem Analysegerät |
US6270726B1 (en) * | 1999-09-30 | 2001-08-07 | Dpc Cirrus, Inc. | Tube bottom sensing for small fluid samples |
JP2001183382A (ja) * | 1999-12-28 | 2001-07-06 | Roche Diagnostics Gmbh | 分注機の動作確認装置および確認方法 |
DE10017790A1 (de) * | 2000-04-10 | 2001-10-11 | Basf Ag | Verfahren zur Herstellung von Biopolymer-Feldern mit Echtzeitkontrolle |
DE10017791A1 (de) * | 2000-04-10 | 2001-10-11 | Basf Ag | Verfahren und Vorrichtung zur Mikrodosierung kleinster Flüssigkeitsmengen für Biopolymerarrays |
US20030013200A1 (en) * | 2001-07-12 | 2003-01-16 | Su-Cheng Pai | Liquid sample take-up device |
JP2005516220A (ja) * | 2002-01-25 | 2005-06-02 | イノベイダイン・テクノロジーズ・インコーポレーテッド | 低容量かつ非接触な液体の分注方法 |
EP1596169B1 (de) * | 2004-05-14 | 2012-05-30 | F. Hoffmann-La Roche AG | Füllstandssensor zum Feststellen des Kontakts einer Pipettiernadel mit einer Flüssigkeit in einem Behälter |
-
2002
- 2002-01-10 WO PCT/CH2002/000013 patent/WO2002059626A1/de not_active Application Discontinuation
- 2002-01-10 US US10/466,504 patent/US20040076550A1/en not_active Abandoned
- 2002-01-10 EP EP02734828A patent/EP1354211A1/de not_active Withdrawn
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US5443791A (en) * | 1990-04-06 | 1995-08-22 | Perkin Elmer - Applied Biosystems Division | Automated molecular biology laboratory |
US5550059A (en) * | 1994-02-23 | 1996-08-27 | Bayer Corporation | Fluid sensing pipette |
US5866426A (en) * | 1996-12-17 | 1999-02-02 | Akzo Nobel N.V. | Device and method for determining liquid-probe contact |
US6148666A (en) * | 1997-10-29 | 2000-11-21 | Boehringer Mannheim Gmbh | Method and device for liquid transfer with an analysis apparatus |
Cited By (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1477815A1 (de) * | 2003-05-14 | 2004-11-17 | Tecan Trading AG | Vorrichtung zum präzisen Anfahren von Mikroplatten-Wells |
US7694591B2 (en) | 2005-12-20 | 2010-04-13 | Stratec Biomedical Systems Ag | Method and apparatus for evaluating a dosing operation |
DE102005060862B3 (de) * | 2005-12-20 | 2007-06-28 | Stratec Biomedical Systems Ag | Verfahren und Vorrichtung zur Beurteilung eines Dosiervorgangs |
US7988934B2 (en) | 2006-04-28 | 2011-08-02 | Tecan Trading Ag | Carrier for positioning objects in relation to laboratory articles |
CH699374B1 (de) * | 2006-04-28 | 2010-02-26 | Tecan Trading Ag | Träger zum Positionieren von Objekten gegenüber Laborartikeln. |
DE102007018483B4 (de) * | 2006-04-28 | 2010-04-01 | Tecan Trading Ag | Träger zum Positionieren von Objekten gegenüber Laborartikeln |
DE102006034245C5 (de) * | 2006-07-21 | 2014-05-28 | Stratec Biomedical Systems Ag | Positioniereinrichtung zur Positionierung von Pipetten |
US7976794B2 (en) | 2006-07-21 | 2011-07-12 | Stratec Biomedical Systems Ag | Positioning device for the positioning of pipettes |
WO2009032601A1 (en) | 2007-08-28 | 2009-03-12 | Schlumberger Canada Limited | Calibrating an accelerometer on a seismic cable |
US8142719B2 (en) | 2008-05-12 | 2012-03-27 | Torsten Matthias | Analysis device |
DE202008006338U1 (de) | 2008-05-12 | 2009-03-26 | Matthias, Torsten, Dr. | Analysegerät |
US9244087B2 (en) | 2010-06-29 | 2016-01-26 | Roche Molecular Systems, Inc. | Methods for using a pipetting device with independently movable pipette units |
US9383379B2 (en) | 2010-06-29 | 2016-07-05 | Roche Molecular Systems, Inc. | Sample distribution in a method for isolating analytes in fluid samples in an automated system |
US8772036B2 (en) | 2010-06-29 | 2014-07-08 | Roche Molecular Systems, Inc. | Automated method for sample distribution and isolation of an analyte with a solid support |
US8900527B2 (en) | 2010-06-29 | 2014-12-02 | Roche Molecular Systems Inc. | Pipetting device with independently movable pipette units |
US9383378B2 (en) | 2010-06-29 | 2016-07-05 | Roche Molecular Systems, Inc. | Sample distribution in an analytical system for processing an analyte |
US9101922B2 (en) | 2010-06-29 | 2015-08-11 | Roche Molecular Systems, Inc. | Methods for using a pipetting device with independently movable pipette units |
DE102011117273A1 (de) | 2011-10-31 | 2013-05-02 | Torsten Matthias | Automatische Strukturbestimmung |
WO2013064237A2 (de) | 2011-10-31 | 2013-05-10 | Torsten Matthias | Automatische strukturbestimmung |
US9333499B2 (en) | 2013-06-06 | 2016-05-10 | Tecan Trading Ag | Pipetting apparatus |
EP2810716A1 (de) * | 2013-06-06 | 2014-12-10 | Tecan Trading AG | Pipettiervorrichtung |
Also Published As
Publication number | Publication date |
---|---|
US20040076550A1 (en) | 2004-04-22 |
EP1354211A1 (de) | 2003-10-22 |
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