WO2002028872A1 - Derives de glucopyranosiloxybenzylbenzene et compositions therapeutiques contenant ces composes - Google Patents
Derives de glucopyranosiloxybenzylbenzene et compositions therapeutiques contenant ces composes Download PDFInfo
- Publication number
- WO2002028872A1 WO2002028872A1 PCT/JP2001/008239 JP0108239W WO0228872A1 WO 2002028872 A1 WO2002028872 A1 WO 2002028872A1 JP 0108239 W JP0108239 W JP 0108239W WO 0228872 A1 WO0228872 A1 WO 0228872A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- lower alkoxy
- same
- compositions containing
- medicinal compositions
- glucopyranosyloxybenzylbenzene derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Priority Applications (25)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
MXPA03002779A MXPA03002779A (es) | 2000-09-29 | 2001-09-21 | Derivados de glucopiranosiloxibencilbenceno y composiciones medicinales conteniendo los mismos. |
BR0114310-7A BR0114310A (pt) | 2000-09-29 | 2001-09-21 | Derivados do glicopiranosiloxibenzilbenzeno e composições medicinais contendo os mesmos |
UA2003032735A UA73606C2 (en) | 2000-09-29 | 2001-09-21 | Glucopyranosyloxybenzylbenzene derivatives and medicinal compositions containing them |
CNB018165605A CN1293087C (zh) | 2000-09-29 | 2001-09-21 | 吡喃葡糖氧基苄基苯衍生物及其药物组合物 |
IL15507101A IL155071A0 (en) | 2000-09-29 | 2001-09-21 | Glucopyranosyloxybenzylbenzene derivatives and medical compositions containing the same |
NZ524917A NZ524917A (en) | 2000-09-29 | 2001-09-21 | Glucopyranosyloxybenzylbenzene derivatives and medicinal compositions containing the same |
EP01970186A EP1329456B1 (en) | 2000-09-29 | 2001-09-21 | Glucopyranosyloxybenzylbenzene derivatives and medicinal compositions containing the same |
SK334-2003A SK287811B6 (sk) | 2000-09-29 | 2001-09-21 | Glukopyranozyloxybenzylbenzénový derivát, farmaceutická kompozícia a ľudský SGLT2-inhibítor tento derivát obsahujúci a použitie tohto derivátu |
JP2002532454A JP3798375B2 (ja) | 2000-09-29 | 2001-09-21 | グルコピラノシルオキシベンジルベンゼン誘導体およびそれを含有する医薬組成物 |
CA2423568A CA2423568C (en) | 2000-09-29 | 2001-09-21 | Glucopyranosyloxybenzylbenzene derivatives and medicinal compositions containing the same |
SI200130638T SI1329456T1 (sl) | 2000-09-29 | 2001-09-21 | Glukopiranoziloksibenzilbenzenski derivati in zdravilni sestavki, ki vsebujejo te spojine |
KR1020037004588A KR100647204B1 (ko) | 2000-09-29 | 2001-09-21 | 글루코피라노실옥시벤질벤젠 유도체 및 그것을 함유하는의약조성물 |
DE60122193T DE60122193T2 (de) | 2000-09-29 | 2001-09-21 | Glucopyranosyloxybenzylbenzol derivate und medizinische zusammensetzungen, die diese verbindungen enthalten |
US10/381,846 US6872706B2 (en) | 2000-09-29 | 2001-09-21 | Glucopyranosyloxybenzylbenzene derivatives and medicinal compositions containing the same |
PL362177A PL205607B1 (pl) | 2000-09-29 | 2001-09-21 | Pochodna glukopiranozyloksybenzylobenzenu, kompozycja farmaceutyczna zawierająca tą pochodną oraz zastosowanie tej pochodnej do wytwarzania kompozycji farmaceutycznej |
AU2001290257A AU2001290257B2 (en) | 2000-09-29 | 2001-09-21 | Glucopyranosyloxybenzylbenzene derivatives and medicinal compositions containing the same |
AU9025701A AU9025701A (en) | 2000-09-29 | 2001-09-21 | Glucopyranosyloxybenzylbenzene derivatives and medicinal compositions containingthe same |
EA200300316A EA005994B1 (ru) | 2000-09-29 | 2001-09-21 | Производные глюкопиранозилоксибензилбензола и содержащие их лекарственные композиции |
HU0301178A HUP0301178A3 (en) | 2000-09-29 | 2001-09-21 | Glucopyranosyloxybenzylbenzene derivatives and pharmaceutical compositions containing the same |
IL155071A IL155071A (en) | 2000-09-29 | 2003-03-25 | History of glucopyranosyloxybenzylbenzene and their use and pharmaceutical preparations containing them |
BG107674A BG66015B1 (bg) | 2000-09-29 | 2003-03-26 | Глюкопиранозилоксибензилбензенови производни и съдържащи ги фармацевтични състави |
NO20031407A NO327182B1 (no) | 2000-09-29 | 2003-03-27 | Glukopyranosyloksybenzylbenzen-derivater og medisinske sammensetninger inneholdende det samme |
HK04104109A HK1061037A1 (en) | 2000-09-29 | 2004-06-09 | Glucopyranosyloxybenzylbenzene derivatives and medicinal compositions containing the same |
US10/916,548 US20050065098A1 (en) | 2000-09-29 | 2004-08-12 | Glucopyranosyloxybenzylbenzene derivatives and medicinal compositions containing the same |
CY20061101571T CY1106076T1 (el) | 2000-09-29 | 2006-11-01 | Παραγωγα γλυκοπυρανοσυλοξυβενζυλο βενζολιου και ιατρικες συνθεσεις που πepιεχουν τα ιδια |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000-301523 | 2000-09-29 | ||
JP2000301523 | 2000-09-29 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US10/381,846 Continuation US6872706B2 (en) | 2000-09-29 | 2001-09-21 | Glucopyranosyloxybenzylbenzene derivatives and medicinal compositions containing the same |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2002028872A1 true WO2002028872A1 (fr) | 2002-04-11 |
Family
ID=18783054
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2001/008239 WO2002028872A1 (fr) | 2000-09-29 | 2001-09-21 | Derives de glucopyranosiloxybenzylbenzene et compositions therapeutiques contenant ces composes |
Country Status (33)
Country | Link |
---|---|
US (2) | US6872706B2 (ja) |
EP (1) | EP1329456B1 (ja) |
JP (1) | JP3798375B2 (ja) |
KR (1) | KR100647204B1 (ja) |
CN (1) | CN1293087C (ja) |
AR (1) | AR030816A1 (ja) |
AT (1) | ATE335753T1 (ja) |
AU (2) | AU9025701A (ja) |
BG (1) | BG66015B1 (ja) |
BR (1) | BR0114310A (ja) |
CA (1) | CA2423568C (ja) |
CY (1) | CY1106076T1 (ja) |
CZ (1) | CZ303544B6 (ja) |
DE (1) | DE60122193T2 (ja) |
DK (1) | DK1329456T3 (ja) |
EA (1) | EA005994B1 (ja) |
ES (1) | ES2269456T3 (ja) |
HK (1) | HK1061037A1 (ja) |
HU (1) | HUP0301178A3 (ja) |
IL (2) | IL155071A0 (ja) |
MX (1) | MXPA03002779A (ja) |
MY (1) | MY129023A (ja) |
NO (1) | NO327182B1 (ja) |
NZ (1) | NZ524917A (ja) |
PE (1) | PE20020476A1 (ja) |
PL (1) | PL205607B1 (ja) |
PT (1) | PT1329456E (ja) |
SI (1) | SI1329456T1 (ja) |
SK (1) | SK287811B6 (ja) |
TW (1) | TWI284641B (ja) |
UA (1) | UA73606C2 (ja) |
WO (1) | WO2002028872A1 (ja) |
ZA (1) | ZA200302283B (ja) |
Cited By (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003080635A1 (fr) * | 2002-03-22 | 2003-10-02 | Kissei Pharmaceutical Co., Ltd. | Cristaux de derive de glucopyranosyloxybenzylbenzene |
JP2004196788A (ja) * | 2002-12-04 | 2004-07-15 | Kissei Pharmaceut Co Ltd | ベンジルフェノール誘導体、それを含有する医薬組成物およびその医薬用途 |
US6872706B2 (en) | 2000-09-29 | 2005-03-29 | Kissei Pharmaceutical Co., Ltd. | Glucopyranosyloxybenzylbenzene derivatives and medicinal compositions containing the same |
JPWO2004050122A1 (ja) * | 2002-12-04 | 2006-03-30 | キッセイ薬品工業株式会社 | 高血糖症に起因する疾患の予防又は治療剤 |
JP2006510644A (ja) * | 2002-12-12 | 2006-03-30 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 新しい複素環フルオログリコシド誘導体、該化合物を含有する医薬品、およびその使用 |
JP2006510643A (ja) * | 2002-12-12 | 2006-03-30 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 新しい芳香族フルオログリコシド誘導体、該化合物を含有する医薬品、およびその使用 |
JP2006232825A (ja) * | 2005-01-31 | 2006-09-07 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
JP2007518682A (ja) * | 2003-08-01 | 2007-07-12 | 田辺製薬株式会社 | 新規化合物 |
WO2007128761A2 (de) | 2006-05-04 | 2007-11-15 | Boehringer Ingelheim International Gmbh | Verwendungen von dpp iv inhibitoren |
WO2007147478A1 (de) | 2006-06-23 | 2007-12-27 | Merck Patent Gmbh | 3 -amino- imidazo [1, 2-a] pyridinderivate als sglt inhibitoren |
WO2008016132A1 (en) | 2006-08-04 | 2008-02-07 | Daiichi Sankyo Company, Limited | Benzyl phenyl glucopyranoside derivative |
JPWO2005095429A1 (ja) * | 2004-03-31 | 2008-02-21 | キッセイ薬品工業株式会社 | フェノール誘導体、それを含有する医薬組成物及びその医薬用途 |
JPWO2006009149A1 (ja) * | 2004-07-21 | 2008-05-01 | キッセイ薬品工業株式会社 | 肝臓脂肪の異常蓄積に起因する疾患の進展抑制剤 |
WO2008070692A2 (en) | 2006-12-06 | 2008-06-12 | Smithkline Beecham Corporation | Bicyclic compounds and use as antidiabetics |
DE102007008420A1 (de) | 2007-02-21 | 2008-08-28 | Merck Patent Gmbh | Benzimidazolderivate |
DE102007048716A1 (de) | 2007-10-11 | 2009-04-23 | Merck Patent Gmbh | Imidazo[1,2-a]pyrimidinderivate |
US7541341B2 (en) | 2001-02-14 | 2009-06-02 | Kissei Pharmaceutical Co., Ltd. | Glucopyranosyloxybenzylbenzene derivatives and medicinal use thereof |
WO2009096503A1 (ja) * | 2008-01-31 | 2009-08-06 | Daiichi Sankyo Company, Limited | ベンジルフェニルグルコピラノシド誘導体 |
DE102008017590A1 (de) | 2008-04-07 | 2009-10-08 | Merck Patent Gmbh | Glucopyranosidderivate |
US7767651B2 (en) | 2005-01-28 | 2010-08-03 | Chugai Seiyaku Kabushiki Kaisha | Spiroketal derivatives and use thereof as diabetic medicine |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2012025857A1 (en) | 2010-08-23 | 2012-03-01 | Hetero Research Foundation | Cycloalkyl methoxybenzyl phenyl pyran derivatives as sodium dependent glucose co transporter (sglt2) inhibitors |
EP2774619A1 (de) | 2013-03-04 | 2014-09-10 | BioActive Food GmbH | Zusammensetzung zur Behandlung von hyperglykämischen Erkrankungen |
US8853385B2 (en) | 2008-01-17 | 2014-10-07 | Mitsubishi Tanabe Pharma Corporation | Combination therapy comprising SGLT inhibitors and DPP4 inhibitors |
US9061060B2 (en) | 2008-07-15 | 2015-06-23 | Theracos Inc. | Deuterated benzylbenzene derivatives and methods of use |
EP2944311A1 (de) | 2014-05-16 | 2015-11-18 | BioActive Food GmbH | Kombination von biologisch aktiven Substanzen zur Behandlung von hyperglykämischen Erkrankungen |
US10414787B2 (en) | 2013-03-14 | 2019-09-17 | Mars, Incorporated | Flavor composition containing HMG glucosides |
Families Citing this family (38)
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CN1020944C (zh) | 1990-01-30 | 1993-05-26 | 阿图尔-费希尔股份公司费希尔厂 | 紧固件 |
JP4212891B2 (ja) * | 2000-11-30 | 2009-01-21 | キッセイ薬品工業株式会社 | グルコピラノシルオキシベンジルベンゼン誘導体、それを含有する医薬組成物およびその製造中間体 |
EP1528066A4 (en) * | 2002-08-09 | 2007-05-02 | Taisho Pharmaceutical Co Ltd | ARYL-t-THIO-B-GLUCOPYRANOSIDE DERIVATIVES AND DIABETES CONTAINING THEM |
PL1730131T3 (pl) * | 2004-03-16 | 2012-10-31 | Boehringer Ingelheim Int | Glukopiranozylo-podstawione pochodne benzenu, środki lecznicze zawierające te związki, ich zastosowanie i sposób ich wytwarzania |
TW200606129A (en) | 2004-07-26 | 2006-02-16 | Chugai Pharmaceutical Co Ltd | Novel cyclohexane derivative, its prodrug, its salt and diabetic therapeutic agent containing the same |
CA2587639A1 (en) * | 2004-12-16 | 2006-06-22 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted benzene derivatives, medicaments containing such compounds, their use and process for their manufacture |
EP1856082B1 (en) * | 2005-02-23 | 2009-10-14 | Boehringer Ingelheim International GmbH | Glucopyranosyl-substituted ((hetero)arylethynyl-benzyl)-benzene derivatives and use thereof as sodium-dependent glucose cotransporter 2 (sglt2) inhibitors |
WO2006108842A1 (en) * | 2005-04-15 | 2006-10-19 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted (heteroaryloxy-benzyl)-benzene derivatives as sglt inhibitors |
US7723309B2 (en) * | 2005-05-03 | 2010-05-25 | Boehringer Ingelheim International Gmbh | Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments |
UA91546C2 (uk) * | 2005-05-03 | 2010-08-10 | Бьорінгер Інгельхайм Інтернаціональ Гмбх | КРИСТАЛІЧНА ФОРМА 1-ХЛОР-4-(β-D-ГЛЮКОПІРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГІДРОФУРАН-3-ІЛОКСИ)-БЕНЗИЛ]-БЕНЗОЛУ, СПОСІБ ЇЇ ОДЕРЖАННЯ ТА ЇЇ ЗАСТОСУВАННЯ ПРИ ПРИГОТУВАННІ ЛІКАРСЬКИХ ЗАСОБІВ |
US7772191B2 (en) | 2005-05-10 | 2010-08-10 | Boehringer Ingelheim International Gmbh | Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein |
ES2346347T3 (es) * | 2005-07-27 | 2010-10-14 | Boehringer Ingelheim International Gmbh | Derivados de ((hetero)cicloalquiletinil-bencil)-benceno y su uso como inhibidores del cotransportador de glucosa dependiente de sodio (sglt). |
JP5175191B2 (ja) * | 2005-08-30 | 2013-04-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | グリコピラノシル置換ベンジルベンゼン誘導体、該化合物を含有する医薬品及びその使用と製造方法 |
RU2008113050A (ru) * | 2005-09-08 | 2009-10-20 | БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) | КРИСТАЛЛИЧЕСКИЕ ФОРМЫ 1-ХЛОР-4-(β-D-ГЛЮКОПИРАНОЗ-1-ИЛ)-2-(4-ЭТИНИЛБЕНЗИН)-БЕНЗОЛА, СПОСОБ ЕГО ПОЛУЧЕНИЯ И ЕГО ПРИМЕНЕНИЕ ДЛЯ ПРИГОТОВЛЕНИЯ ЛЕКАРСТВЕННЫХ СРЕДСТВ |
AR056195A1 (es) * | 2005-09-15 | 2007-09-26 | Boehringer Ingelheim Int | Procedimientos para preparar derivados de (etinil-bencil)-benceno sustituidos de glucopiranosilo y compuestos intermedios de los mismos |
CA2635838A1 (en) * | 2006-02-15 | 2007-08-23 | Boehringer Ingelheim International Gmbh | Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture |
PE20080697A1 (es) * | 2006-05-03 | 2008-08-05 | Boehringer Ingelheim Int | Derivados de benzonitrilo sustituidos con glucopiranosilo, composiciones farmaceuticas que contienen compuestos de este tipo, su uso y procedimiento para su fabricacion |
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US8163704B2 (en) | 2009-10-20 | 2012-04-24 | Novartis Ag | Glycoside derivatives and uses thereof |
WO2011048148A2 (en) | 2009-10-20 | 2011-04-28 | Novartis Ag | Glycoside derivative and uses thereof |
PT2496583E (pt) | 2009-11-02 | 2015-01-14 | Pfizer | Derivados de dioxa-biciclo[3.2.1]octano-2,3,4-triol |
AR079438A1 (es) | 2009-12-09 | 2012-01-25 | Panacea Biotec Ltd | Derivados de azucar, composiciones farmaceuticas y sus usos |
UY33937A (es) | 2011-03-07 | 2012-09-28 | Boehringer Ingelheim Int | Composiciones farmacéuticas que contienen inhibidores de dpp-4 y/o sglt-2 y metformina |
WO2012140596A1 (en) | 2011-04-14 | 2012-10-18 | Novartis Ag | Glycoside derivatives and uses thereof |
US8614195B2 (en) | 2011-04-14 | 2013-12-24 | Novartis Ag | Glycoside derivatives and uses thereof |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
US9192617B2 (en) | 2012-03-20 | 2015-11-24 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
US20140303097A1 (en) | 2013-04-05 | 2014-10-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
PT2981271T (pt) | 2013-04-05 | 2019-02-19 | Boehringer Ingelheim Int | Utilizações terapêuticas de empagliflozina |
US11813275B2 (en) | 2013-04-05 | 2023-11-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
EP4000608A1 (en) | 2013-04-18 | 2022-05-25 | Boehringer Ingelheim International GmbH | Pharmaceutical composition, methods for treating and uses thereof |
Citations (2)
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EP0598359A1 (en) * | 1992-11-12 | 1994-05-25 | Tanabe Seiyaku Co., Ltd. | Hypoglycemic dihydrochalcone derivatives |
WO2001068660A1 (fr) * | 2000-03-17 | 2001-09-20 | Kissei Pharmaceutical Co., Ltd. | Derives glucopyranosyloxybenzylbenzene, preparations medicinales les contenant et intermediaires pour la preparation desdits derives |
Family Cites Families (4)
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US6683056B2 (en) | 2000-03-30 | 2004-01-27 | Bristol-Myers Squibb Company | O-aryl glucoside SGLT2 inhibitors and method |
PL205607B1 (pl) | 2000-09-29 | 2010-05-31 | Kissei Pharmaceutical | Pochodna glukopiranozyloksybenzylobenzenu, kompozycja farmaceutyczna zawierająca tą pochodną oraz zastosowanie tej pochodnej do wytwarzania kompozycji farmaceutycznej |
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