SK287811B6 - Glukopyranozyloxybenzylbenzénový derivát, farmaceutická kompozícia a ľudský SGLT2-inhibítor tento derivát obsahujúci a použitie tohto derivátu - Google Patents

Glukopyranozyloxybenzylbenzénový derivát, farmaceutická kompozícia a ľudský SGLT2-inhibítor tento derivát obsahujúci a použitie tohto derivátu Download PDF

Info

Publication number
SK287811B6
SK287811B6 SK334-2003A SK3342003A SK287811B6 SK 287811 B6 SK287811 B6 SK 287811B6 SK 3342003 A SK3342003 A SK 3342003A SK 287811 B6 SK287811 B6 SK 287811B6
Authority
SK
Slovakia
Prior art keywords
group
straight
branched
carbon atoms
alkoxycarbonyl
Prior art date
Application number
SK334-2003A
Other languages
English (en)
Slovak (sk)
Other versions
SK3342003A3 (en
Inventor
Hideki Fujikura
Nobuhiko Fushimi
Toshihiro Nishimura
Kazuya Tatani
Masayuki Isaji
Original Assignee
Kissei Pharmaceutical Co., Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical Co., Ltd filed Critical Kissei Pharmaceutical Co., Ltd
Publication of SK3342003A3 publication Critical patent/SK3342003A3/sk
Publication of SK287811B6 publication Critical patent/SK287811B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
SK334-2003A 2000-09-29 2001-09-21 Glukopyranozyloxybenzylbenzénový derivát, farmaceutická kompozícia a ľudský SGLT2-inhibítor tento derivát obsahujúci a použitie tohto derivátu SK287811B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000301523 2000-09-29
PCT/JP2001/008239 WO2002028872A1 (fr) 2000-09-29 2001-09-21 Derives de glucopyranosiloxybenzylbenzene et compositions therapeutiques contenant ces composes

Publications (2)

Publication Number Publication Date
SK3342003A3 SK3342003A3 (en) 2003-08-05
SK287811B6 true SK287811B6 (sk) 2011-10-04

Family

ID=18783054

Family Applications (1)

Application Number Title Priority Date Filing Date
SK334-2003A SK287811B6 (sk) 2000-09-29 2001-09-21 Glukopyranozyloxybenzylbenzénový derivát, farmaceutická kompozícia a ľudský SGLT2-inhibítor tento derivát obsahujúci a použitie tohto derivátu

Country Status (33)

Country Link
US (2) US6872706B2 (ja)
EP (1) EP1329456B1 (ja)
JP (1) JP3798375B2 (ja)
KR (1) KR100647204B1 (ja)
CN (1) CN1293087C (ja)
AR (1) AR030816A1 (ja)
AT (1) ATE335753T1 (ja)
AU (2) AU2001290257B2 (ja)
BG (1) BG66015B1 (ja)
BR (1) BR0114310A (ja)
CA (1) CA2423568C (ja)
CY (1) CY1106076T1 (ja)
CZ (1) CZ303544B6 (ja)
DE (1) DE60122193T2 (ja)
DK (1) DK1329456T3 (ja)
EA (1) EA005994B1 (ja)
ES (1) ES2269456T3 (ja)
HK (1) HK1061037A1 (ja)
HU (1) HUP0301178A3 (ja)
IL (2) IL155071A0 (ja)
MX (1) MXPA03002779A (ja)
MY (1) MY129023A (ja)
NO (1) NO327182B1 (ja)
NZ (1) NZ524917A (ja)
PE (1) PE20020476A1 (ja)
PL (1) PL205607B1 (ja)
PT (1) PT1329456E (ja)
SI (1) SI1329456T1 (ja)
SK (1) SK287811B6 (ja)
TW (1) TWI284641B (ja)
UA (1) UA73606C2 (ja)
WO (1) WO2002028872A1 (ja)
ZA (1) ZA200302283B (ja)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1020944C (zh) 1990-01-30 1993-05-26 阿图尔-费希尔股份公司费希尔厂 紧固件
ATE335753T1 (de) 2000-09-29 2006-09-15 Kissei Pharmaceutical Glucopyranosyloxybenzylbenzol derivate und medizinische zusammensetzungen, die diese verbindungen enthalten
AU2002223127A1 (en) * 2000-11-30 2002-06-11 Kissei Pharmaceutical Co., Ltd. Intellectual Property Glucopyranosyloxybenzyl benzene derivatives, medicinal compositions containing the same and intermediates in the production thereof
TWI255817B (en) 2001-02-14 2006-06-01 Kissei Pharmaceutical Glucopyranosyloxybenzylbenzene derivatives and medicinal use thereof
US7371730B2 (en) * 2002-03-22 2008-05-13 Kissei Pharmaceutical Co., Ltd. Crystals of glucopyranosyloxybenzyl benzene derivative
US7250522B2 (en) * 2002-08-09 2007-07-31 Taisho Pharmaceutical Co., Ltd. Method for selective preparation of aryl 5-thio-β-D-aldohexopyranosides
JP4651934B2 (ja) * 2002-12-04 2011-03-16 キッセイ薬品工業株式会社 ベンジルフェノール誘導体、それを含有する医薬組成物およびその医薬用途
KR20050089156A (ko) * 2002-12-04 2005-09-07 깃세이 야쿠힌 고교 가부시키가이샤 고혈당증에 기인하는 질환의 예방 또는 치료제
DE10258008B4 (de) * 2002-12-12 2006-02-02 Sanofi-Aventis Deutschland Gmbh Heterocyclische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel
DE10258007B4 (de) 2002-12-12 2006-02-09 Sanofi-Aventis Deutschland Gmbh Aromatische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel
UA86042C2 (en) * 2003-08-01 2009-03-25 Янссен Фармацевтика Н.В. Substituted indazole-o-glucosides
SI1730131T1 (sl) 2004-03-16 2012-08-31 Boehringer Ingelheim Int Glukopiranozil-substituirani benzenski derivati, zdravila, ki vsebujejo te spojine, njihova uporaba in postopek za njihovo pripravo
EP1731524A4 (en) * 2004-03-31 2009-05-20 Kissei Pharmaceutical PHENOLE DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE DERIVATIVE, AND ITS MEDICINAL USE
US20080045466A1 (en) * 2004-07-21 2008-02-21 Kenji Katsuno Progression Inhibitor For Disease Attributed To Abnormal Accumulation Of Liver Fat
TW200606129A (en) 2004-07-26 2006-02-16 Chugai Pharmaceutical Co Ltd Novel cyclohexane derivative, its prodrug, its salt and diabetic therapeutic agent containing the same
EP1828216B1 (en) * 2004-12-16 2008-09-10 Boehringer Ingelheim International GmbH Glucopyranosyl-substituted benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
TW200637869A (en) 2005-01-28 2006-11-01 Chugai Pharmaceutical Co Ltd The spiroketal derivatives and the use as therapeutical agent for diabetes of the same
JP5073948B2 (ja) * 2005-01-31 2012-11-14 田辺三菱製薬株式会社 医薬組成物
WO2006089872A1 (en) * 2005-02-23 2006-08-31 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted ( (hetero)arylethynyl-benzyd-benzene derivatives and use thereof as sodium-dependent glucose cotransporter 2 (sglt2) inhibitors
DE602006011453D1 (de) * 2005-04-15 2010-02-11 Boehringer Ingelheim Pharma Glucopyranosyl-substituierte (heteroaryloxy-benzyl)-benzen-derivate als sglt-inhibitoren
UA91546C2 (uk) * 2005-05-03 2010-08-10 Бьорінгер Інгельхайм Інтернаціональ Гмбх КРИСТАЛІЧНА ФОРМА 1-ХЛОР-4-(β-D-ГЛЮКОПІРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГІДРОФУРАН-3-ІЛОКСИ)-БЕНЗИЛ]-БЕНЗОЛУ, СПОСІБ ЇЇ ОДЕРЖАННЯ ТА ЇЇ ЗАСТОСУВАННЯ ПРИ ПРИГОТУВАННІ ЛІКАРСЬКИХ ЗАСОБІВ
US7723309B2 (en) * 2005-05-03 2010-05-25 Boehringer Ingelheim International Gmbh Crystalline forms of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((R)-tetrahydrofuran-3-yloxy)-benzyl]-benzene, a method for its preparation and the use thereof for preparing medicaments
US7772191B2 (en) 2005-05-10 2010-08-10 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
EP1910390B1 (en) * 2005-07-27 2010-05-19 Boehringer Ingelheim International GmbH Glucopyranosyl-substituted ((hetero)cycloalyklethynyl-benzyl)-benzene derivatives and use thereof as sodium-dependent glucose cotransporter (sglt) inhibitors
ATE484499T1 (de) * 2005-08-30 2010-10-15 Boehringer Ingelheim Int Glucopyranosyl-substituierte benzyl-derivate, medikamente mit solchen verbindungen, ihre verwendung und herstellungsverfahren dafür
MX2008002457A (es) * 2005-09-08 2008-04-07 Boehringer Ingelheim Int Formas cristalinas de 1-cloro-4-(??-d-clucopiranos-1-il).
AR056195A1 (es) * 2005-09-15 2007-09-26 Boehringer Ingelheim Int Procedimientos para preparar derivados de (etinil-bencil)-benceno sustituidos de glucopiranosilo y compuestos intermedios de los mismos
TW200801029A (en) * 2006-02-15 2008-01-01 Boehringer Ingelheim Int Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture
PE20080697A1 (es) 2006-05-03 2008-08-05 Boehringer Ingelheim Int Derivados de benzonitrilo sustituidos con glucopiranosilo, composiciones farmaceuticas que contienen compuestos de este tipo, su uso y procedimiento para su fabricacion
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
DE102006028862A1 (de) 2006-06-23 2007-12-27 Merck Patent Gmbh 3-Amino-imidazo[1,2-a]pyridinderivate
TW200817424A (en) 2006-08-04 2008-04-16 Daiichi Sankyo Co Ltd Benzylphenyl glucopyranoside derivatives
US20080109178A1 (en) * 2006-11-03 2008-05-08 Nikon Corporation Method and system for predicting and correcting signal fluctuations of an interferometric measuring apparatus
WO2008070692A2 (en) 2006-12-06 2008-06-12 Smithkline Beecham Corporation Bicyclic compounds and use as antidiabetics
DE102007008420A1 (de) 2007-02-21 2008-08-28 Merck Patent Gmbh Benzimidazolderivate
PE20090938A1 (es) * 2007-08-16 2009-08-08 Boehringer Ingelheim Int Composicion farmaceutica que comprende un derivado de benceno sustituido con glucopiranosilo
DE102007048716A1 (de) 2007-10-11 2009-04-23 Merck Patent Gmbh Imidazo[1,2-a]pyrimidinderivate
CL2008003653A1 (es) 2008-01-17 2010-03-05 Mitsubishi Tanabe Pharma Corp Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica.
WO2009096503A1 (ja) * 2008-01-31 2009-08-06 Daiichi Sankyo Company, Limited ベンジルフェニルグルコピラノシド誘導体
DE102008017590A1 (de) 2008-04-07 2009-10-08 Merck Patent Gmbh Glucopyranosidderivate
EP2312944B1 (en) 2008-07-15 2018-09-05 Theracos, Inc. Deuterated benzylbenzene derivatives and methods of use
ME01285A (me) * 2008-08-28 2013-06-20 Pfizer Derivati dioksa-bicikl0[3.2.1]oktan-2,3,4-triola
CN102387783A (zh) * 2009-02-13 2012-03-21 贝林格尔.英格海姆国际有限公司 包含吡喃葡萄糖基二苯基甲烷衍生物的药物组合物、其药物剂型、其制备方法及其在患者中改善血糖控制的用途
UA102429C2 (ru) 2009-02-13 2013-07-10 Бьорінгер Інгельхайм Інтернаціональ Гмбх Фармацевтическая композиция, которая включает ингибитор sglt-2, ингибитор дпп-iv и другой антидиабетический агент, и ее применение
BR112012007085B8 (pt) * 2009-09-30 2021-05-25 Boehringer Ingelheim Int processos para a preparação de derivados de benzil-benzeno substituídos com glicopiranosila
EA020798B1 (ru) * 2009-09-30 2015-01-30 Бёрингер Ингельхайм Интернациональ Гмбх СПОСОБ ПОЛУЧЕНИЯ КРИСТАЛЛИЧЕСКОЙ ФОРМЫ 1-ХЛОР-4-(β-D-ГЛЮКОПИРАНОЗ-1-ИЛ)-2-[4-((S)-ТЕТРАГИДРОФУРАН-3-ИЛОКСИ)БЕНЗИЛ]БЕНЗОЛА
UY32919A (es) * 2009-10-02 2011-04-29 Boehringer Ingelheim Int Composición farmacéutica, forma de dosificación farmacéutica, procedimiento para su preparación, mé todos para su tratamiento y sus usos
US8394772B2 (en) 2009-10-20 2013-03-12 Novartis Ag Glycoside derivative and uses thereof
US8163704B2 (en) 2009-10-20 2012-04-24 Novartis Ag Glycoside derivatives and uses thereof
CA2777857C (en) 2009-11-02 2014-12-02 Pfizer Inc. Dioxa-bicyclo[3.2.1]octane-2,3,4-triol derivatives
AR079438A1 (es) 2009-12-09 2012-01-25 Panacea Biotec Ltd Derivados de azucar, composiciones farmaceuticas y sus usos
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2012025857A1 (en) 2010-08-23 2012-03-01 Hetero Research Foundation Cycloalkyl methoxybenzyl phenyl pyran derivatives as sodium dependent glucose co transporter (sglt2) inhibitors
UY33937A (es) 2011-03-07 2012-09-28 Boehringer Ingelheim Int Composiciones farmacéuticas que contienen inhibidores de dpp-4 y/o sglt-2 y metformina
EP2697240B1 (en) 2011-04-14 2015-09-16 Novartis AG Glycoside derivatives and uses thereof
US8614195B2 (en) 2011-04-14 2013-12-24 Novartis Ag Glycoside derivatives and uses thereof
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
US9192617B2 (en) 2012-03-20 2015-11-24 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
EP2774619B1 (de) 2013-03-04 2016-05-18 BioActive Food GmbH Zusammensetzung zur Behandlung von hyperglykämischen Erkrankungen
ES2684399T3 (es) 2013-03-14 2018-10-02 Mars, Incorporated Composición de aroma que contiene glucósidos HMG
US11813275B2 (en) 2013-04-05 2023-11-14 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
HUE041709T2 (hu) 2013-04-05 2019-05-28 Boehringer Ingelheim Int Az empagliflozin terápiás alkalmazásai
US20140303097A1 (en) 2013-04-05 2014-10-09 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
HRP20220365T1 (hr) 2013-04-18 2022-05-13 Boehringer Ingelheim International Gmbh Farmaceutski pripravak, postupci za liječenje i njegove uporabe
EP2944311A1 (de) 2014-05-16 2015-11-18 BioActive Food GmbH Kombination von biologisch aktiven Substanzen zur Behandlung von hyperglykämischen Erkrankungen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2549476B1 (fr) * 1983-07-20 1986-04-25 Rech Ind Benzyl-phenyl-osides, procede de preparation et utilisation en therapeutique
CA2102591C (en) 1992-11-12 2000-12-26 Kenji Tsujihara Hypoglycemic agent
US5731292A (en) * 1992-11-12 1998-03-24 Tanabe Seiyaku Co., Ltd. Dihydrochalcone derivatives which are hypoglycemic agents
PL205605B1 (pl) * 2000-03-17 2010-05-31 Kissei Pharmaceutical Pochodna glukopiranozyloksybenzylobenzenu, kompozycja farmaceutyczna, zastosowanie tej pochodnej do wytwarzania kompozycji oraz pochodna benzylofenolu
US6683056B2 (en) * 2000-03-30 2004-01-27 Bristol-Myers Squibb Company O-aryl glucoside SGLT2 inhibitors and method
ATE335753T1 (de) 2000-09-29 2006-09-15 Kissei Pharmaceutical Glucopyranosyloxybenzylbenzol derivate und medizinische zusammensetzungen, die diese verbindungen enthalten

Also Published As

Publication number Publication date
MY129023A (en) 2007-03-30
CN1293087C (zh) 2007-01-03
US20040018998A1 (en) 2004-01-29
BG107674A (bg) 2004-01-30
PE20020476A1 (es) 2002-07-04
AU9025701A (en) 2002-04-15
KR20030036867A (ko) 2003-05-09
US20050065098A1 (en) 2005-03-24
SI1329456T1 (sl) 2006-12-31
TWI284641B (en) 2007-08-01
JP3798375B2 (ja) 2006-07-19
WO2002028872A1 (fr) 2002-04-11
JPWO2002028872A1 (ja) 2004-02-12
NZ524917A (en) 2005-01-28
DK1329456T3 (da) 2006-12-04
HUP0301178A3 (en) 2009-08-28
ATE335753T1 (de) 2006-09-15
US6872706B2 (en) 2005-03-29
HK1061037A1 (en) 2004-09-03
EA200300316A1 (ru) 2003-08-28
PL205607B1 (pl) 2010-05-31
PT1329456E (pt) 2006-12-29
EP1329456B1 (en) 2006-08-09
NO20031407L (no) 2003-04-30
HUP0301178A2 (hu) 2003-11-28
CA2423568C (en) 2011-03-15
IL155071A (en) 2010-04-15
AU2001290257B2 (en) 2007-08-30
CA2423568A1 (en) 2002-04-11
DE60122193D1 (de) 2006-09-21
MXPA03002779A (es) 2004-05-04
AR030816A1 (es) 2003-09-03
IL155071A0 (en) 2003-10-31
SK3342003A3 (en) 2003-08-05
BG66015B1 (bg) 2010-10-29
ZA200302283B (en) 2005-05-27
UA73606C2 (en) 2005-08-15
NO327182B1 (no) 2009-05-04
CN1466590A (zh) 2004-01-07
PL362177A1 (en) 2004-10-18
EP1329456A1 (en) 2003-07-23
ES2269456T3 (es) 2007-04-01
DE60122193T2 (de) 2007-07-05
CY1106076T1 (el) 2011-06-08
EP1329456A4 (en) 2005-03-30
CZ303544B6 (cs) 2012-11-28
KR100647204B1 (ko) 2006-11-17
EA005994B1 (ru) 2005-08-25
NO20031407D0 (no) 2003-03-27
BR0114310A (pt) 2003-10-14

Similar Documents

Publication Publication Date Title
SK287811B6 (sk) Glukopyranozyloxybenzylbenzénový derivát, farmaceutická kompozícia a ľudský SGLT2-inhibítor tento derivát obsahujúci a použitie tohto derivátu
US7465712B2 (en) Glucopyranosyloxy benzylbenzene derivatives, medicinal compositions containing the same and intermediates for the preparation of the derivatives
US7521430B2 (en) N-glucoside compounds having an inhibitory activity against sodium-dependent glucose transporter
CZ2002665A3 (cs) Glukopyranosyloxypyrazolové deriváty, léčivé směsi obsahující tyto látky a meziprodukty jejich výroby
JP4794285B2 (ja) ベンジルフェノール誘導体またはその塩

Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20120921