WO2002020500A2 - Materials and methods to potentiate cancer treatment - Google Patents
Materials and methods to potentiate cancer treatment Download PDFInfo
- Publication number
- WO2002020500A2 WO2002020500A2 PCT/US2001/026709 US0126709W WO0220500A2 WO 2002020500 A2 WO2002020500 A2 WO 2002020500A2 US 0126709 W US0126709 W US 0126709W WO 0220500 A2 WO0220500 A2 WO 0220500A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- moφholin
- phenyl
- hydroxy
- group
- dna
- Prior art date
Links
- 0 CC(C)(CCCCCCC1)CCC1c1nnc(*)c(*)n1 Chemical compound CC(C)(CCCCCCC1)CCC1c1nnc(*)c(*)n1 0.000 description 8
- WMDFCNOBELHFRN-UHFFFAOYSA-N CC(C(C1c2cc(N3CCOCC3)ccc2C(O)=O)C11NC1)=O Chemical compound CC(C(C1c2cc(N3CCOCC3)ccc2C(O)=O)C11NC1)=O WMDFCNOBELHFRN-UHFFFAOYSA-N 0.000 description 1
- SRQHCVHKUNSRGI-UHFFFAOYSA-N CCOc1cc(N2CCOCC2)ccc1C(N(C1CC1)c1ccccc1)=O Chemical compound CCOc1cc(N2CCOCC2)ccc1C(N(C1CC1)c1ccccc1)=O SRQHCVHKUNSRGI-UHFFFAOYSA-N 0.000 description 1
- SKTPFIAHXCUHPX-UHFFFAOYSA-N OC(c(ccc(CN1CCOCC1)c1)c1O)=O Chemical compound OC(c(ccc(CN1CCOCC1)c1)c1O)=O SKTPFIAHXCUHPX-UHFFFAOYSA-N 0.000 description 1
- DOGHSMTZOXLZMI-UHFFFAOYSA-N Oc1cc(CC2CCOCC2)ccc1C(c1ccc[s]1)=O Chemical compound Oc1cc(CC2CCOCC2)ccc1C(c1ccc[s]1)=O DOGHSMTZOXLZMI-UHFFFAOYSA-N 0.000 description 1
- PLHHLIDNCIRUPE-UHFFFAOYSA-N Oc1cc(N2CCOCC2)cc(OC(c2ccccc2)=C2O)c1C2=O Chemical compound Oc1cc(N2CCOCC2)cc(OC(c2ccccc2)=C2O)c1C2=O PLHHLIDNCIRUPE-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
- C07C309/66—Methanesulfonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/54—Nitrogen and either oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
- C07D295/28—Nitrogen atoms
- C07D295/30—Nitrogen atoms non-acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/6533—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6578—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and sulfur atoms with or without oxygen atoms, as ring hetero atoms
- C07F9/65785—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and sulfur atoms with or without oxygen atoms, as ring hetero atoms the ring phosphorus atom and, at least, one ring sulfur atom being part of a thiophosphonic acid derivative
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP01968164A EP1351946A2 (en) | 2000-09-01 | 2001-08-28 | Materials and methods to potentiate cancer treatment |
AU2001288432A AU2001288432A1 (en) | 2000-09-01 | 2001-08-28 | Materials and methods to potentiate cancer treatment |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22989900P | 2000-09-01 | 2000-09-01 | |
US60/229,899 | 2000-09-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002020500A2 true WO2002020500A2 (en) | 2002-03-14 |
WO2002020500A3 WO2002020500A3 (en) | 2003-07-31 |
Family
ID=22863116
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/026709 WO2002020500A2 (en) | 2000-09-01 | 2001-08-28 | Materials and methods to potentiate cancer treatment |
Country Status (4)
Cited By (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004110418A2 (en) * | 2003-06-10 | 2004-12-23 | Kalypsys, Inc. | Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease |
WO2004085418A3 (en) * | 2003-03-24 | 2005-01-27 | Icos Corp | Xanthones, thioxanthones and acridinones as dna-pk inhibitors |
US7049313B2 (en) | 2002-02-25 | 2006-05-23 | Kudos Pharmaceuticals Ltd. | ATM inhibitors |
US7105518B2 (en) | 2001-08-14 | 2006-09-12 | Cancer Research Technology Limited | Thiopyrane-4-ones as DNA protein kinase inhibitors |
WO2006117669A1 (en) * | 2005-05-03 | 2006-11-09 | Pfizer Inc. | Amide resorcinol compounds |
EP1729770A1 (en) * | 2004-03-15 | 2006-12-13 | Sunesis Pharmaceuticals, Inc. | Sns-595 and methods of using the same |
US7179912B2 (en) | 2000-09-01 | 2007-02-20 | Icos Corporation | Materials and methods to potentiate cancer treatment |
US7226918B2 (en) | 2001-08-14 | 2007-06-05 | Cancer Research Technology Limited | DNA-PK inhibitors |
US7271195B2 (en) | 2003-06-10 | 2007-09-18 | Kalypsys, Inc. | Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease |
US7402607B2 (en) | 2004-09-20 | 2008-07-22 | Kudos Pharmaceuticals Limited | DNA-PK inhibitors |
US7429660B2 (en) | 2003-08-13 | 2008-09-30 | Kudos Pharmaceuticals Limited | ATM inhibitors |
US7632838B2 (en) | 2006-02-07 | 2009-12-15 | Wyeth | 11-beta HSD1 inhibitors |
US7642254B2 (en) | 2005-02-09 | 2010-01-05 | Kudos Pharmaceuticals Limited | ATM inhibitors |
US7687499B2 (en) | 2005-09-16 | 2010-03-30 | Janssen Pharmaceutica Nv | Cyclopropyl amines as modulators of the histamine H3 receptor |
US7696203B2 (en) | 2005-04-15 | 2010-04-13 | Kudos Pharmaceuticals Limited | DNA-PK inhibitors |
US7834178B2 (en) | 2006-03-01 | 2010-11-16 | Bristol-Myers Squibb Company | Triazine 11-beta hydroxysteroid dehydrogenase type 1 inhibitors |
US7893257B2 (en) | 2006-12-14 | 2011-02-22 | Janssen Pharmaceutica Nv | Process for the preparation of piperazinyl and diazepanyl benzamide derivatives |
WO2011109387A1 (en) * | 2010-03-01 | 2011-09-09 | Intraop Medical Corporation | Radiotherapy combined with hypoxic cell sensitizers |
WO2011113512A1 (de) * | 2010-03-16 | 2011-09-22 | Merck Patent Gmbh | Morpholinylchinazoline |
WO2011123890A1 (en) | 2010-04-06 | 2011-10-13 | Peter Maccallum Cancer Institute | Radioprotector compounds and methods |
AU2006233256B2 (en) * | 2006-10-30 | 2012-01-19 | Armaron Bio Pty Ltd | Improved flavonols |
US8124773B2 (en) | 2006-06-12 | 2012-02-28 | Sunesis Pharmaceuticals, Inc. | 1,8-naphthyridine compounds for the treatment of cancer |
US8153793B2 (en) | 2005-09-27 | 2012-04-10 | Shionogi & Co., Ltd. | Sulfonamide derivative having PGD2 receptor antagonistic activity |
US8269197B2 (en) | 2009-07-22 | 2012-09-18 | Intraop Medical Corporation | Method and system for electron beam applications |
JP2013504544A (ja) * | 2009-09-11 | 2013-02-07 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
WO2013072015A1 (de) * | 2011-11-18 | 2013-05-23 | Merck Patent Gmbh | Morpholinylbenzotriazine zur anwendung in der krebstherapie |
US8518872B2 (en) | 2007-10-22 | 2013-08-27 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-OXO-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid in combination therapy |
US8580814B2 (en) | 2006-04-03 | 2013-11-12 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
WO2014159690A1 (en) * | 2013-03-12 | 2014-10-02 | Vertex Pharmaceuticals Incorporated | Dna-pk inhibitors |
WO2015058031A1 (en) * | 2013-10-17 | 2015-04-23 | Vertex Pharmaceuticals Incorporated | Dna-pk inhibitors |
CN104640852A (zh) * | 2012-04-24 | 2015-05-20 | 沃泰克斯药物股份有限公司 | Dna-pk抑制剂 |
US9133178B2 (en) | 2010-10-27 | 2015-09-15 | Proximagen Limited | Alpha-7 nicotinic receptor modulators for the treatment of pain, a psychotic disorder, cognitive impairment or alzheimer'S disease |
WO2016009296A1 (en) | 2014-07-16 | 2016-01-21 | Pfizer Inc. | N-acylpiperidine ether tropomyosin-related kinase inhibitors |
EA024384B1 (ru) * | 2013-06-27 | 2016-09-30 | Институт Нефтехимических Процессов Им. Академика Ю. Мамедалиева, Нан Азербайджана | Применение комплексной соли 2-морфолилметил-5-метилфенола в качестве пестицида против оидиума в плодах и листьях винограда |
US9815850B2 (en) | 2016-02-05 | 2017-11-14 | Denali Therapeutics Inc. | Compounds, compositions and methods |
US10005720B2 (en) | 2013-04-05 | 2018-06-26 | North Carolina Central University | Compounds useful for the treatment of metabolic disorders and synthesis of the same |
US10039761B2 (en) | 2013-10-17 | 2018-08-07 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
CN111978139A (zh) * | 2020-09-04 | 2020-11-24 | 许昌学院 | 一种水相中光催化一锅法合成苯酚或其衍生物的方法 |
US11072618B2 (en) | 2016-12-09 | 2021-07-27 | Denali Therapeutics Inc. | Compounds, compositions and methods |
US11110108B2 (en) | 2016-09-27 | 2021-09-07 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of DNA-damaging agents and DNA-PK inhibitors |
US11129828B2 (en) | 2011-08-22 | 2021-09-28 | Takeda Pharmaceutical Company Limited | Pyridazinone compounds and their use as DAAO inhibitors |
US11168068B2 (en) | 2016-07-18 | 2021-11-09 | Janssen Pharmaceutica Nv | Tau PET imaging ligands |
US11413255B2 (en) * | 2015-06-29 | 2022-08-16 | Montefiore Medical Center | Multifunctional cytoprotectant for treatment of pathogenic processes mediated by oxidative stress and toxic electrophiles |
CN114933528A (zh) * | 2022-05-30 | 2022-08-23 | 湖南大学 | 一种制备芳酰氧基烷基碘化物及其转化应用方法的新方法 |
US11603523B2 (en) | 2019-01-18 | 2023-03-14 | Astrazeneca Ab | PCSK9 inhibitors and methods of use thereof |
US11980633B2 (en) | 2021-07-29 | 2024-05-14 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of DNA-damaging agents and DNA-PK inhibitors |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2302106T3 (es) * | 2000-09-11 | 2008-07-01 | Novartis Vaccines And Diagnostics, Inc. | Procedimiento de preparacion de derivados de bencimidazol-2-il quinolina. |
US20030028018A1 (en) * | 2000-09-11 | 2003-02-06 | Chiron Coporation | Quinolinone derivatives |
US6875165B2 (en) * | 2001-02-22 | 2005-04-05 | Retinalabs, Inc. | Method of radiation delivery to the eye |
WO2002082988A2 (en) * | 2001-04-16 | 2002-10-24 | The Johns Hopkins University | Method for imaging and spectroscopy of tumors and determination of the efficacy of anti-tumor drug therapies |
AU2003288899B2 (en) * | 2002-08-23 | 2009-09-03 | Novartis Vaccines And Diagnostics, Inc. | Benzimidazole quinolinones and uses thereof |
US7825132B2 (en) | 2002-08-23 | 2010-11-02 | Novartis Vaccines And Diagnostics, Inc. | Inhibition of FGFR3 and treatment of multiple myeloma |
US20060058313A1 (en) * | 2002-11-12 | 2006-03-16 | Hohneker John A | Treatment of mesothelioma |
EP1565187A4 (en) * | 2002-11-13 | 2010-02-17 | Novartis Vaccines & Diagnostic | CANCER TREATMENT METHODS AND RELATED METHODS |
US7273445B2 (en) * | 2003-04-30 | 2007-09-25 | Board Of Trustees Of The University Of Illinois | Intraocular brachytherapy device and method |
JP4724665B2 (ja) * | 2003-11-07 | 2011-07-13 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | キノリノン化合物を合成する方法 |
WO2005079915A1 (en) * | 2004-02-12 | 2005-09-01 | Neo Vista, Inc. | Methods and apparatus for intraocular brachytherapy |
US7803103B2 (en) * | 2005-02-11 | 2010-09-28 | Neovista Inc. | Methods and apparatus for intraocular brachytherapy |
CA2556872C (en) * | 2004-02-20 | 2015-05-12 | Chiron Corporation | Modulation of inflammatory and metastatic processes |
ES2374570T3 (es) * | 2005-01-27 | 2012-02-17 | Novartis Vaccines And Diagnostics, Inc. | Tratamiento de tumores metastalizados. |
US20060234959A1 (en) * | 2005-04-14 | 2006-10-19 | Advanced Photodynamic Technologies, Inc. | Photodynamic therapy utilizing multiple duty cycle light modulation |
MX2007014206A (es) | 2005-05-13 | 2008-02-07 | Novartis Ag | Metodos para tratar cancer resistente a los farmacos. |
KR101324863B1 (ko) * | 2005-05-17 | 2013-11-01 | 노파르티스 아게 | 헤테로고리 화합물의 합성 방법 |
KR101368519B1 (ko) | 2005-05-23 | 2014-02-27 | 노파르티스 아게 | 결정형 및 기타 형태의 4-아미노-5-플루오로-3-[6-(4-메틸피페라진-1-일)-1h-벤즈이미다졸-2-일]-1h-퀴놀린-2-온 락트산염 |
US8093246B2 (en) * | 2006-12-14 | 2012-01-10 | Lexicon Pharmaceuticals, Inc. | O-linked pyrimidin-4-amine-based compounds, compositions comprising them, and methods of their use to treat cancer |
CA2679882C (en) | 2007-03-08 | 2015-12-29 | The Board Of Trustees Of The Leland Stanford Junior University | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof |
EP2170338A2 (en) * | 2007-07-06 | 2010-04-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Dna-pkcs modulates energy regulation and brain function |
TW200924762A (en) | 2007-11-02 | 2009-06-16 | Vertex Pharma | Kinase inhibitors |
EP3108933B1 (en) | 2008-01-07 | 2019-09-18 | Salutaris Medical Devices, Inc. | Devices for minimally-invasive extraocular delivery of radiation to the posterior portion of the eye |
US8608632B1 (en) | 2009-07-03 | 2013-12-17 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive extraocular delivery of radiation and/or pharmaceutics to the posterior portion of the eye |
US8353812B2 (en) | 2008-06-04 | 2013-01-15 | Neovista, Inc. | Handheld radiation delivery system |
ES2477552T3 (es) | 2008-09-08 | 2014-07-17 | The Board Of Trustees Of The Leland Stanford Junior University | Moduladores de la actividad de la aldehidodeshidrogenasa y métodos de uso de los mismos |
US7825392B2 (en) * | 2008-10-08 | 2010-11-02 | Rodney Wayne Prosser | Cleaning process for radiopharmaceutical reusable pigs |
EP2349279A4 (en) | 2008-10-28 | 2013-12-25 | Univ Leland Stanford Junior | ALDEHYDE DEHYDROGENASE MODULATORS AND METHOD OF USE THEREOF |
US8663210B2 (en) | 2009-05-13 | 2014-03-04 | Novian Health, Inc. | Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy |
US8642007B2 (en) | 2010-09-20 | 2014-02-04 | Yanping Kong | Method and compound for treatment of cancer using phosphorous-32 labeled DNA |
US10457659B2 (en) | 2011-04-29 | 2019-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
CN105358531B (zh) | 2013-03-14 | 2017-11-14 | 利兰-斯坦福大学初级学院的董事会 | 线粒体醛脱氢酶‑2调节剂和其使用方法 |
CN105884827B (zh) * | 2015-02-13 | 2018-03-13 | 山东轩竹医药科技有限公司 | 嘧啶酰胺衍生物及其盐 |
Citations (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1355173A (fr) * | 1962-04-12 | 1964-03-13 | Science Union & Cie | Préparation de nouveaux dérivés de l'acide salicylique |
FR8298M (US07179912-20070220-C00074.png) * | 1967-07-20 | 1970-11-16 | ||
DE2922488A1 (de) * | 1979-06-01 | 1980-12-11 | Thiemann Chem Pharm Fab | 2-hydroxy-4-methyl-benzolverbindungen, verfahren zu ihrer herstellung und ihre verwendung |
EP0078241A2 (de) * | 1981-10-28 | 1983-05-04 | Ciba-Geigy Ag | Furane |
GB2109373A (en) * | 1981-10-28 | 1983-06-02 | Ciba Geigy Ag | Aminophenol acetic acid |
EP0106800A1 (de) * | 1982-10-08 | 1984-04-25 | Ciba-Geigy Ag | Furane |
EP0107620A1 (de) * | 1982-10-13 | 1984-05-02 | Ciba-Geigy Ag | Phenol-Derivate |
EP0342665A2 (en) * | 1988-05-20 | 1989-11-23 | Takeda Chemical Industries, Ltd. | Physiologically active substance tan-931, its derivatives, their production and use |
WO1992020666A1 (en) * | 1991-05-24 | 1992-11-26 | Taiho Pharmaceutical Company, Limited | Benzothiadiazine derivative |
WO1995020652A1 (de) * | 1994-01-28 | 1995-08-03 | Medigene Gmbh | Verfahren zur bestimmung der aktivität eines regulatorischen faktors sowie verwendung dieses verfahrens |
DE4424712A1 (de) * | 1994-07-13 | 1996-01-18 | Basf Ag | Verwendung von Benzaldehyden zum Markieren von Kohlenwasserstoffen |
WO1997008133A1 (en) * | 1995-08-22 | 1997-03-06 | Japan Tobacco Inc. | Amide compounds and use of the same |
WO1997031891A1 (en) * | 1996-03-01 | 1997-09-04 | Merck & Co., Inc. | Process for regioselective substitution of trifluorobenzoate or trifluorobenzonitrile |
WO1998013502A2 (en) * | 1996-09-27 | 1998-04-02 | Icos Corporation | Method to identify compounds for disrupting protein/protein interactions |
GB2326410A (en) * | 1997-06-18 | 1998-12-23 | Merck & Co Inc | Tocolytic Oxytocin Receptor Antagonists |
WO1999014212A1 (en) * | 1997-09-18 | 1999-03-25 | Astrazeneca Ab | Substituted chroman derivatives |
WO1999029705A2 (en) * | 1997-12-08 | 1999-06-17 | Glycomed Incorporated | Sialyl lewis x and sialyl lewis a glycomimetics |
WO2000000644A1 (en) * | 1998-06-30 | 2000-01-06 | Sloan-Kettering Institute For Cancer Research | Uses of dna-pk |
WO2000017386A1 (en) * | 1998-09-21 | 2000-03-30 | Fox Chase Cancer Center | Assays and novel cellular targets for therapeutic agents to treat retroviral infection |
WO2000018750A2 (en) * | 1998-09-28 | 2000-04-06 | Kimberly-Clark Worldwide, Inc. | Chelates comprising chinoid groups as photoinitiators |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5138245B2 (US07179912-20070220-C00074.png) * | 1973-05-22 | 1976-10-20 | ||
US3904631A (en) * | 1973-05-29 | 1975-09-09 | Parke Davis & Co | Novel thioxanthenone compounds and means of producing the same |
US4003699A (en) * | 1974-11-22 | 1977-01-18 | Henkel & Cie G.M.B.H. | Oxidation hair dyes based upon tetraaminopyrimidine developers |
DE2737207A1 (de) * | 1977-08-18 | 1979-03-01 | Basf Ag | Farbbildner fuer kopierverfahren |
DE2807761A1 (de) * | 1978-02-23 | 1979-08-30 | Basf Ag | Cumarinderivate |
JPS5544830A (en) | 1978-09-27 | 1980-03-29 | Hodogaya Chem Co Ltd | Pressure-sensitive copying paper |
DE2950291A1 (de) | 1979-12-14 | 1981-06-19 | Basf Ag, 6700 Ludwigshafen | Neue cumarinverbindungen und verfahren zur herstellung von cumarinverbindungen |
JPS5788455A (en) * | 1980-11-22 | 1982-06-02 | Canon Inc | Electrophotographic receptor |
DE3141970A1 (de) | 1981-10-22 | 1983-05-05 | Vsesojuznyj naučno-issledovatel'skij institut lekarstvennych rastenij, Vilar, Moskovskaja oblast' | Arzneimittel zur behandlung der durch den virus der herpes-gruppe erzeugten erkrankungen |
US4539412A (en) * | 1982-07-08 | 1985-09-03 | Rensselaer Polytechnic Institute | 7-Hydroxylucanthone, 7-hydroxhycanthone and their analogs |
DE3800577A1 (de) * | 1988-01-12 | 1989-07-20 | Basf Ag | 3-(4-amino-2-hydroxyphenyl)-1-oxo-isoindolenine, verfahren zu deren herstellung und deren verseifung zu 2-(4-amino-2-hydroxybenzoyl)-benzoesaeuren |
WO1990014008A1 (en) | 1989-05-25 | 1990-11-29 | Sloan-Kettering Institute For Cancer Research | Methods and compositions for inhibiting tumor cell growth |
GB9018044D0 (en) | 1990-08-16 | 1990-10-03 | Ici Plc | Tricyclic heterocyclic derivatives |
WO1992016517A1 (en) | 1991-03-22 | 1992-10-01 | Xenova Limited | Pharmaceutical xanthone derivatives |
US5262549A (en) * | 1991-05-30 | 1993-11-16 | Polaroid Corporation | Benzpyrylium dyes, and processes for their preparation and use |
US5558043A (en) * | 1994-10-06 | 1996-09-24 | Givens; Donovan J. | Lightweight, portable animal grooming stall |
EP0793476B1 (fr) | 1994-11-25 | 2001-10-10 | Laboratoires De Biologie Vegetale Yves Rocher | Utilisation de la mangiférine ou ses dérivés pour une application cosmétique |
DE19501303A1 (de) | 1995-01-18 | 1996-07-25 | Henkel Kgaa | Arylketone zum Färben keratinhaltiger Fasern |
JPH11106371A (ja) * | 1997-07-04 | 1999-04-20 | Nisshin Flour Milling Co Ltd | アシルヒドラゾン誘導体 |
JP4531149B2 (ja) | 1997-10-17 | 2010-08-25 | 富山化学工業株式会社 | 含窒素三・四環式化合物およびそれを含有する抗ウイルス剤 |
US6555593B1 (en) * | 1998-01-30 | 2003-04-29 | Albemarle Corporation | Photopolymerization compositions including maleimides and processes for using the same |
AU756965B2 (en) * | 1998-03-12 | 2003-01-30 | Microbial Chemistry Research Foundation | Benzofurylpyrone derivatives |
US6407092B1 (en) * | 1999-04-23 | 2002-06-18 | Pharmacia & Upjohn Company | Tetracyclic azepinoindole compounds |
US6297242B1 (en) * | 1999-08-12 | 2001-10-02 | Ortho-Mcneil Pharmaceutical, Inc. | N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof |
GB9920912D0 (en) | 1999-09-03 | 1999-11-10 | Indena Spa | Novel derivatives of flavones,xanthones and coumarins |
US6535593B1 (en) * | 2000-02-28 | 2003-03-18 | Simplified Development Corp. | System and method for billing communications services provisioned on demand in converging telecommunications network |
JP2001247459A (ja) * | 2000-03-03 | 2001-09-11 | Oakland Uniservices Ltd | 癌の組み合わせ療法 |
EP1351946A2 (en) * | 2000-09-01 | 2003-10-15 | Icos Corporation | Materials and methods to potentiate cancer treatment |
JP3968978B2 (ja) | 2000-09-20 | 2007-08-29 | 三菱化学株式会社 | 有機電界発光素子 |
AU2002352443A1 (en) | 2001-12-21 | 2003-07-15 | Consejo Superior De Investigaciones Cientificas | Compounds and their therapeutic use related to the phosphorylating activity of the enzyme gsk-3 |
-
2001
- 2001-08-28 EP EP01968164A patent/EP1351946A2/en not_active Withdrawn
- 2001-08-28 US US09/941,897 patent/US7179912B2/en not_active Expired - Fee Related
- 2001-08-28 WO PCT/US2001/026709 patent/WO2002020500A2/en active Application Filing
- 2001-08-28 AU AU2001288432A patent/AU2001288432A1/en not_active Abandoned
-
2007
- 2007-02-16 US US11/708,163 patent/US8242115B2/en not_active Expired - Fee Related
Patent Citations (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1355173A (fr) * | 1962-04-12 | 1964-03-13 | Science Union & Cie | Préparation de nouveaux dérivés de l'acide salicylique |
FR8298M (US07179912-20070220-C00074.png) * | 1967-07-20 | 1970-11-16 | ||
DE2922488A1 (de) * | 1979-06-01 | 1980-12-11 | Thiemann Chem Pharm Fab | 2-hydroxy-4-methyl-benzolverbindungen, verfahren zu ihrer herstellung und ihre verwendung |
EP0078241A2 (de) * | 1981-10-28 | 1983-05-04 | Ciba-Geigy Ag | Furane |
GB2109373A (en) * | 1981-10-28 | 1983-06-02 | Ciba Geigy Ag | Aminophenol acetic acid |
EP0106800A1 (de) * | 1982-10-08 | 1984-04-25 | Ciba-Geigy Ag | Furane |
EP0107620A1 (de) * | 1982-10-13 | 1984-05-02 | Ciba-Geigy Ag | Phenol-Derivate |
EP0342665A2 (en) * | 1988-05-20 | 1989-11-23 | Takeda Chemical Industries, Ltd. | Physiologically active substance tan-931, its derivatives, their production and use |
WO1992020666A1 (en) * | 1991-05-24 | 1992-11-26 | Taiho Pharmaceutical Company, Limited | Benzothiadiazine derivative |
WO1995020652A1 (de) * | 1994-01-28 | 1995-08-03 | Medigene Gmbh | Verfahren zur bestimmung der aktivität eines regulatorischen faktors sowie verwendung dieses verfahrens |
DE4424712A1 (de) * | 1994-07-13 | 1996-01-18 | Basf Ag | Verwendung von Benzaldehyden zum Markieren von Kohlenwasserstoffen |
WO1997008133A1 (en) * | 1995-08-22 | 1997-03-06 | Japan Tobacco Inc. | Amide compounds and use of the same |
WO1997031891A1 (en) * | 1996-03-01 | 1997-09-04 | Merck & Co., Inc. | Process for regioselective substitution of trifluorobenzoate or trifluorobenzonitrile |
WO1998013502A2 (en) * | 1996-09-27 | 1998-04-02 | Icos Corporation | Method to identify compounds for disrupting protein/protein interactions |
GB2326410A (en) * | 1997-06-18 | 1998-12-23 | Merck & Co Inc | Tocolytic Oxytocin Receptor Antagonists |
WO1999014212A1 (en) * | 1997-09-18 | 1999-03-25 | Astrazeneca Ab | Substituted chroman derivatives |
WO1999029705A2 (en) * | 1997-12-08 | 1999-06-17 | Glycomed Incorporated | Sialyl lewis x and sialyl lewis a glycomimetics |
WO2000000644A1 (en) * | 1998-06-30 | 2000-01-06 | Sloan-Kettering Institute For Cancer Research | Uses of dna-pk |
WO2000017386A1 (en) * | 1998-09-21 | 2000-03-30 | Fox Chase Cancer Center | Assays and novel cellular targets for therapeutic agents to treat retroviral infection |
WO2000018750A2 (en) * | 1998-09-28 | 2000-04-06 | Kimberly-Clark Worldwide, Inc. | Chelates comprising chinoid groups as photoinitiators |
Non-Patent Citations (1)
Title |
---|
M. WINDHOLZ (ED.) ET AL: "The Merck Index, ninth edition" 1976 , MERCK & CO., INC. , RAHWAY, N.J., US XP002239312 page 84, no. 658; page 159, no. 1229; page 187, no. 1458; page 193, no. 1500; page 263, no. 2050; page 474, no. 3550; page 680, no. 5043; page 847, no. 6342; page 871, no. 6521; page 936, no. 7009; page 939, no. 7031; page 1069, no. 8011; page 1080, no. 8094; page 1275, no. 9592 * |
Cited By (108)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7179912B2 (en) | 2000-09-01 | 2007-02-20 | Icos Corporation | Materials and methods to potentiate cancer treatment |
US8242115B2 (en) | 2000-09-01 | 2012-08-14 | Luitpold Pharmaceuticals, Inc. | Materials and methods to potentiate cancer treatment |
US7674823B2 (en) | 2001-08-14 | 2010-03-09 | Cancer Research Technology Limited | DNA-PK inhibitors |
US7105518B2 (en) | 2001-08-14 | 2006-09-12 | Cancer Research Technology Limited | Thiopyrane-4-ones as DNA protein kinase inhibitors |
US7226918B2 (en) | 2001-08-14 | 2007-06-05 | Cancer Research Technology Limited | DNA-PK inhibitors |
US7049313B2 (en) | 2002-02-25 | 2006-05-23 | Kudos Pharmaceuticals Ltd. | ATM inhibitors |
JP2006523681A (ja) * | 2003-03-24 | 2006-10-19 | ルイトポルド・ファーマシューティカルズ・インコーポレーテッド | Dna−pk阻害剤としてのキサントン、チオキサントンおよびアクリジノン |
US8404681B2 (en) | 2003-03-24 | 2013-03-26 | Luitpold Pharmaceuticals, Inc. | Xanthones, thioxanthones and acridinones as DNA-PK inhibitors |
WO2004085418A3 (en) * | 2003-03-24 | 2005-01-27 | Icos Corp | Xanthones, thioxanthones and acridinones as dna-pk inhibitors |
WO2004110418A2 (en) * | 2003-06-10 | 2004-12-23 | Kalypsys, Inc. | Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease |
WO2004110418A3 (en) * | 2003-06-10 | 2005-03-17 | Kalypsys Inc | Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease |
US7271195B2 (en) | 2003-06-10 | 2007-09-18 | Kalypsys, Inc. | Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease |
US7429660B2 (en) | 2003-08-13 | 2008-09-30 | Kudos Pharmaceuticals Limited | ATM inhibitors |
JP2014148535A (ja) * | 2004-03-15 | 2014-08-21 | Sunesis Pharmaceuticals Inc | Sns−595、及びその使用方法 |
JP2007529524A (ja) * | 2004-03-15 | 2007-10-25 | サネシス ファーマシューティカルズ, インコーポレイテッド | Sns−595、及びその使用方法 |
EP1729770A1 (en) * | 2004-03-15 | 2006-12-13 | Sunesis Pharmaceuticals, Inc. | Sns-595 and methods of using the same |
US8822493B2 (en) | 2004-03-15 | 2014-09-02 | Sunesis Pharmaceuticals, Inc. | SNS-595 and methods of using the same |
US7968565B2 (en) | 2004-03-15 | 2011-06-28 | Sunesis Pharmaceuticals, Inc. | Therapeutic combinations comprising (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid |
EP1729770A4 (en) * | 2004-03-15 | 2007-04-11 | Sunesis Pharmaceuticals Inc | SNS-595 AND METHODS OF USING THE SAME |
JP2012140442A (ja) * | 2004-03-15 | 2012-07-26 | Sunesis Pharmaceuticals Inc | Sns−595、及びその使用方法 |
JP2017095471A (ja) * | 2004-03-15 | 2017-06-01 | サネシス ファーマシューティカルズ, インコーポレイテッド | Sns−595、及びその使用方法 |
US9980949B2 (en) | 2004-03-15 | 2018-05-29 | Sunesis Pharmaceuticals, Inc. | SNS-595 and methods of using the same |
AU2005222607B2 (en) * | 2004-03-15 | 2010-11-25 | Sunesis Pharmaceuticals, Inc. | SNS-595 and methods of using the same |
US7732483B2 (en) | 2004-09-20 | 2010-06-08 | Kudos Pharmaceuticals Limited | DNA-PK inhibitors |
US7402607B2 (en) | 2004-09-20 | 2008-07-22 | Kudos Pharmaceuticals Limited | DNA-PK inhibitors |
US7642254B2 (en) | 2005-02-09 | 2010-01-05 | Kudos Pharmaceuticals Limited | ATM inhibitors |
US7696203B2 (en) | 2005-04-15 | 2010-04-13 | Kudos Pharmaceuticals Limited | DNA-PK inhibitors |
WO2006117669A1 (en) * | 2005-05-03 | 2006-11-09 | Pfizer Inc. | Amide resorcinol compounds |
US7910582B2 (en) | 2005-09-16 | 2011-03-22 | Janssen Pharmaceutica Nv | Cyclopropyl amines as modulators of the histamine H3 receptor |
US8026242B2 (en) | 2005-09-16 | 2011-09-27 | Carruthers Nicholas I | Cyclopropyl amines as modulators of the histamine H3 receptor |
US7687499B2 (en) | 2005-09-16 | 2010-03-30 | Janssen Pharmaceutica Nv | Cyclopropyl amines as modulators of the histamine H3 receptor |
US8153793B2 (en) | 2005-09-27 | 2012-04-10 | Shionogi & Co., Ltd. | Sulfonamide derivative having PGD2 receptor antagonistic activity |
US8993763B2 (en) | 2005-09-27 | 2015-03-31 | Shionogi & Co., Ltd. | Sulfonamide derivative having PGD2 receptor antagonistic activity |
US9440938B2 (en) | 2005-09-27 | 2016-09-13 | Shionogi & Co., Ltd. | Sulfonamide derivative having PGD2 receptor antagonistic activity |
US7632838B2 (en) | 2006-02-07 | 2009-12-15 | Wyeth | 11-beta HSD1 inhibitors |
US7834178B2 (en) | 2006-03-01 | 2010-11-16 | Bristol-Myers Squibb Company | Triazine 11-beta hydroxysteroid dehydrogenase type 1 inhibitors |
US8580814B2 (en) | 2006-04-03 | 2013-11-12 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
US8124773B2 (en) | 2006-06-12 | 2012-02-28 | Sunesis Pharmaceuticals, Inc. | 1,8-naphthyridine compounds for the treatment of cancer |
US9676774B2 (en) | 2006-06-12 | 2017-06-13 | Sunesis Pharmaceuticals, Inc. | Compounds and compositions for treatment of cancer |
US8765954B2 (en) | 2006-06-12 | 2014-07-01 | Sunesis Pharmaceuticals, Inc. | 1,8-naphthyridine compounds for the treatment of cancer |
AU2006233256B2 (en) * | 2006-10-30 | 2012-01-19 | Armaron Bio Pty Ltd | Improved flavonols |
US8680273B2 (en) | 2006-12-14 | 2014-03-25 | Janssen Pharmaceutica Nv | Process for the preparation of piperazinyl and diazepanyl benzamide derivatives |
US7893257B2 (en) | 2006-12-14 | 2011-02-22 | Janssen Pharmaceutica Nv | Process for the preparation of piperazinyl and diazepanyl benzamide derivatives |
US8518872B2 (en) | 2007-10-22 | 2013-08-27 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-OXO-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid in combination therapy |
US8269197B2 (en) | 2009-07-22 | 2012-09-18 | Intraop Medical Corporation | Method and system for electron beam applications |
US9650362B2 (en) | 2009-09-11 | 2017-05-16 | Probiodrug Ag | Inhibitors |
JP2013504544A (ja) * | 2009-09-11 | 2013-02-07 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
US9173885B2 (en) | 2009-09-11 | 2015-11-03 | Probiodrug Ag | Inhibitors |
US9656098B2 (en) | 2010-03-01 | 2017-05-23 | Intraop Medical Corporation | Radiotherapy combined with hypoxic cell sensitizers |
WO2011109387A1 (en) * | 2010-03-01 | 2011-09-09 | Intraop Medical Corporation | Radiotherapy combined with hypoxic cell sensitizers |
US9393439B2 (en) | 2010-03-01 | 2016-07-19 | Intraop Medical Corporation | Radiotherapy combined with hypoxic cell sensitizers |
CN102803227A (zh) * | 2010-03-16 | 2012-11-28 | 默克专利有限公司 | 吗啉基喹唑啉 |
WO2011113512A1 (de) * | 2010-03-16 | 2011-09-22 | Merck Patent Gmbh | Morpholinylchinazoline |
JP2013522249A (ja) * | 2010-03-16 | 2013-06-13 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | モルホリニルキナゾリン |
US9126952B2 (en) | 2010-03-16 | 2015-09-08 | Merck Patent Gmbh | Morpholinylquinazolines |
WO2011123890A1 (en) | 2010-04-06 | 2011-10-13 | Peter Maccallum Cancer Institute | Radioprotector compounds and methods |
US9133178B2 (en) | 2010-10-27 | 2015-09-15 | Proximagen Limited | Alpha-7 nicotinic receptor modulators for the treatment of pain, a psychotic disorder, cognitive impairment or alzheimer'S disease |
US11129828B2 (en) | 2011-08-22 | 2021-09-28 | Takeda Pharmaceutical Company Limited | Pyridazinone compounds and their use as DAAO inhibitors |
AU2012339196B2 (en) * | 2011-11-18 | 2017-04-27 | Merck Patent Gmbh | Morpholinyl benzotriazine for use in cancer therapy |
CN103930408A (zh) * | 2011-11-18 | 2014-07-16 | 默克专利股份公司 | 用于癌症治疗的吗啉基苯并三嗪 |
WO2013072015A1 (de) * | 2011-11-18 | 2013-05-23 | Merck Patent Gmbh | Morpholinylbenzotriazine zur anwendung in der krebstherapie |
US9187469B2 (en) | 2011-11-18 | 2015-11-17 | Merck Patent Gmbh | Morpholinylbenzotriazines for use in cancer therapy |
US11008305B2 (en) | 2012-04-24 | 2021-05-18 | Vertex Pharmaceuticals Incorporated | DNA-PK inhibitors |
US10442791B2 (en) | 2012-04-24 | 2019-10-15 | Vertex Pharmaceuticals Incorporated | DNA-PK inhibitors |
US10391095B2 (en) | 2012-04-24 | 2019-08-27 | Vertex Pharmaceuticals Incorporated | DNA-PK inhibitors |
CN104640852B (zh) * | 2012-04-24 | 2017-04-26 | 沃泰克斯药物股份有限公司 | Dna‑pk抑制剂 |
US10501439B2 (en) | 2012-04-24 | 2019-12-10 | Vertex Pharmaceuticals Incorporated | DNA-PK inhibitors |
CN104640852A (zh) * | 2012-04-24 | 2015-05-20 | 沃泰克斯药物股份有限公司 | Dna-pk抑制剂 |
US10076521B2 (en) | 2012-04-24 | 2018-09-18 | Vertex Pharamceuticals Incorporated | DNA-PK inhibitors |
US9878993B2 (en) | 2012-04-24 | 2018-01-30 | Vertex Pharmaceuticals Incorporated | DNA-PK inhibitors for treatment of cancer |
US11021465B2 (en) | 2012-04-24 | 2021-06-01 | Vertex Pharmaceuticals Incorporated | DNA-PK inhibitors |
US9925188B2 (en) | 2012-04-24 | 2018-03-27 | Vertex Pharmaceuticals Incorporated | DNA-PK inhibitors and uses thereof |
KR102216284B1 (ko) | 2013-03-12 | 2021-02-18 | 버텍스 파마슈티칼스 인코포레이티드 | Dna-pk 억제제 |
KR20150126051A (ko) * | 2013-03-12 | 2015-11-10 | 버텍스 파마슈티칼스 인코포레이티드 | Dna-pk 억제제 |
CN105246883A (zh) * | 2013-03-12 | 2016-01-13 | 沃泰克斯药物股份有限公司 | Dna-pk抑制剂 |
EP3985003A1 (en) * | 2013-03-12 | 2022-04-20 | Vertex Pharmaceuticals Incorporated | Dna-pk inhibitors |
CN107200749A (zh) * | 2013-03-12 | 2017-09-26 | 沃泰克斯药物股份有限公司 | Dna‑pk抑制剂 |
WO2014159690A1 (en) * | 2013-03-12 | 2014-10-02 | Vertex Pharmaceuticals Incorporated | Dna-pk inhibitors |
AU2018236800B2 (en) * | 2013-03-12 | 2020-04-09 | Vertex Pharmaceuticals Incorporated | DNA-PK inhibitors |
AU2014244555B2 (en) * | 2013-03-12 | 2018-06-28 | Vertex Pharmaceuticals Incorporated | DNA-PK inhibitors |
JP2016516706A (ja) * | 2013-03-12 | 2016-06-09 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Dna−pk阻害剤 |
CN107200749B (zh) * | 2013-03-12 | 2019-09-03 | 沃泰克斯药物股份有限公司 | Dna-pk抑制剂 |
EP3527563A1 (en) * | 2013-03-12 | 2019-08-21 | Vertex Pharmaceuticals Incorporated | Dna-pk inhibitors |
RU2676259C2 (ru) * | 2013-03-12 | 2018-12-27 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы днк-пк |
US10005720B2 (en) | 2013-04-05 | 2018-06-26 | North Carolina Central University | Compounds useful for the treatment of metabolic disorders and synthesis of the same |
EA024384B1 (ru) * | 2013-06-27 | 2016-09-30 | Институт Нефтехимических Процессов Им. Академика Ю. Мамедалиева, Нан Азербайджана | Применение комплексной соли 2-морфолилметил-5-метилфенола в качестве пестицида против оидиума в плодах и листьях винограда |
JP2016533366A (ja) * | 2013-10-17 | 2016-10-27 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Dna−pk阻害剤 |
WO2015058031A1 (en) * | 2013-10-17 | 2015-04-23 | Vertex Pharmaceuticals Incorporated | Dna-pk inhibitors |
US10039761B2 (en) | 2013-10-17 | 2018-08-07 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
CN105636958B (zh) * | 2013-10-17 | 2018-01-05 | 沃泰克斯药物股份有限公司 | Dna‑pk抑制剂 |
US10716789B2 (en) | 2013-10-17 | 2020-07-21 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
CN105636958A (zh) * | 2013-10-17 | 2016-06-01 | 沃泰克斯药物股份有限公司 | Dna-pk抑制剂 |
WO2016009296A1 (en) | 2014-07-16 | 2016-01-21 | Pfizer Inc. | N-acylpiperidine ether tropomyosin-related kinase inhibitors |
US11413255B2 (en) * | 2015-06-29 | 2022-08-16 | Montefiore Medical Center | Multifunctional cytoprotectant for treatment of pathogenic processes mediated by oxidative stress and toxic electrophiles |
US10604535B2 (en) | 2016-02-05 | 2020-03-31 | Denali Therapeutics Inc. | Compounds, compositions and methods |
US9896458B2 (en) | 2016-02-05 | 2018-02-20 | Denali Therapeutics Inc. | Compounds, compositions and methods |
US9815850B2 (en) | 2016-02-05 | 2017-11-14 | Denali Therapeutics Inc. | Compounds, compositions and methods |
US10131676B2 (en) | 2016-02-05 | 2018-11-20 | Denali Therapeutics Inc. | Compounds, compositions and methods |
US11168068B2 (en) | 2016-07-18 | 2021-11-09 | Janssen Pharmaceutica Nv | Tau PET imaging ligands |
US11110108B2 (en) | 2016-09-27 | 2021-09-07 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of DNA-damaging agents and DNA-PK inhibitors |
RU2758669C2 (ru) * | 2016-09-27 | 2021-11-01 | Вертекс Фармасьютикалз Инкорпорейтед | Способ лечения рака с применением сочетания днк-поражающих агентов и ингибиторов днк-пк |
US11072618B2 (en) | 2016-12-09 | 2021-07-27 | Denali Therapeutics Inc. | Compounds, compositions and methods |
US11603523B2 (en) | 2019-01-18 | 2023-03-14 | Astrazeneca Ab | PCSK9 inhibitors and methods of use thereof |
CN111978139A (zh) * | 2020-09-04 | 2020-11-24 | 许昌学院 | 一种水相中光催化一锅法合成苯酚或其衍生物的方法 |
CN111978139B (zh) * | 2020-09-04 | 2023-04-07 | 许昌学院 | 一种水相中光催化一锅法合成苯酚或其衍生物的方法 |
US11980633B2 (en) | 2021-07-29 | 2024-05-14 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of DNA-damaging agents and DNA-PK inhibitors |
CN114933528A (zh) * | 2022-05-30 | 2022-08-23 | 湖南大学 | 一种制备芳酰氧基烷基碘化物及其转化应用方法的新方法 |
CN114933528B (zh) * | 2022-05-30 | 2024-03-29 | 湖南大学 | 一种制备芳酰氧基烷基碘化物及其转化应用方法的新方法 |
Also Published As
Publication number | Publication date |
---|---|
US20020165218A1 (en) | 2002-11-07 |
WO2002020500A3 (en) | 2003-07-31 |
US7179912B2 (en) | 2007-02-20 |
AU2001288432A1 (en) | 2002-03-22 |
US20080090782A1 (en) | 2008-04-17 |
EP1351946A2 (en) | 2003-10-15 |
US8242115B2 (en) | 2012-08-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US8242115B2 (en) | Materials and methods to potentiate cancer treatment | |
US8404681B2 (en) | Xanthones, thioxanthones and acridinones as DNA-PK inhibitors | |
US7057046B2 (en) | Lactam glycogen phosphorylase inhibitors and method of use | |
US6130217A (en) | Compounds enhancing antitumor activity of other cytotoxic agents | |
JP5745661B2 (ja) | 7−置換インドールMcl−1阻害薬 | |
AU2009322219B2 (en) | Sulfonamide derivatives as Bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases | |
CA2744708C (en) | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | |
JP5689119B2 (ja) | ジヒドロピリミジン化合物及び合成方法、医薬組成物及びその使用 | |
WO1994022846A1 (en) | Compounds enhancing antitumor activity of other cytotoxic agents | |
US7098235B2 (en) | Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds | |
US7365061B2 (en) | 2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors | |
RU2138482C1 (ru) | Производные аминостильбазола или их гидраты, или их соли и фармацевтическая композиция на их основе | |
EA015253B1 (ru) | Производные 3,6-дигидро-2-оксо-6н-1,3,4-тиадиазина | |
Madbouly et al. | Design and synthesis of novel quinazolinone–chalcone hybrids as potential apoptotic candidates targeting caspase-3 and PARP-1: in vitro, molecular docking, and SAR studies | |
US20210380558A1 (en) | Beta-catenin and b-cell lymphoma 9 (bcl9) inhibitors | |
US7226942B2 (en) | 2-amino-4-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors | |
US11345692B1 (en) | 3-vinylquinolines as cancer cells inhibitors | |
RU2663623C2 (ru) | Фталазиновые производные | |
US20060111415A1 (en) | 2-Aminonaphthalene derivatives and related glycogen phosphorylase inhibitors | |
AU2015221495B2 (en) | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | |
US10385040B2 (en) | Indoline sulfonamide inhibitors of DapE and NDM-1 and use of the same | |
KR20240057820A (ko) | 신규 피라졸로-옥소티아졸리딘 유도체 및 이를 포함하는 알칼리성 포스파타제 억제제 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2001968164 Country of ref document: EP |
|
REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
WWP | Wipo information: published in national office |
Ref document number: 2001968164 Country of ref document: EP |
|
NENP | Non-entry into the national phase |
Ref country code: JP |