WO1999066881A2 - Kosmetische wirkstoffzubereitung mit hohem radikalschutzfaktor - Google Patents
Kosmetische wirkstoffzubereitung mit hohem radikalschutzfaktor Download PDFInfo
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- WO1999066881A2 WO1999066881A2 PCT/DE1999/001851 DE9901851W WO9966881A2 WO 1999066881 A2 WO1999066881 A2 WO 1999066881A2 DE 9901851 W DE9901851 W DE 9901851W WO 9966881 A2 WO9966881 A2 WO 9966881A2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
- A61K8/9722—Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
Definitions
- free radicals such as superoxide ions, hydroxy radicals, oxides
- the proteins and lipids of the cell membranes are destroyed, the DNA damaged and a key substance of the skin, hyaluronic acid, is also broken down.
- the stress factors from the outside such as aggressive atmosphere, tobacco smoke, ultraviolet radiation, etc. overwhelm these body's defense systems and disturb the balance in favor of free radicals.
- a number of products have already been proposed for this purpose, which often contain vitamin mixtures with vitamins A, C and E or additives of superoxide disase or extracts from certain plant or animal organisms.
- a cosmetic composition is known from US Pat. No. 5,629,185 which contains ultrasound digestion products of yeasts or other cell dispersions.
- a cosmetic is known from WO96 / 29048 which contains condensed degradation products of plant or animal origin.
- There are also a large number of publications which describe the use of pure plant extracts for cosmetic purposes, such as, for example, in WO97 / 45100 with a mixture of seven different extracts to fight cellulite. The search for other effective substances is an essential element of cosmetic research.
- Another object of the invention is to provide an active substance preparation which maintains its radical protection potential over a long period of time.
- a further object of the invention is to provide special cosmetic compositions which contain this active substance preparation and especially those active substance preparations which achieve a further improvement in properties, in particular with regard to the opening of the skin pores.
- the cosmetic active ingredient preparation with a high radical protection factor is characterized by a (a) a product obtained by extraction of the bark of Ouebracho blanco and subsequent enzymatic hydrolysis, which contains at least 90% by weight of proanthocyanidin oligomers and at most 10% by weight of gallic acid, where the content of (a), which is present in an active substance concentration of 2% by weight bound to microcapsules, is in the range from 0.1 to 10% by weight;
- the active substance preparation can furthermore contain
- the constituents of the preparation are present as follows: active ingredient capsules according to (a) in the range from 0.1 to 10% by weight, hydro- Gel according to (b) in the range from 0.1 to 5% by weight, encapsulated retinyl palmitate according to (h) 0.001 to 5% by weight, encapsulated tocopheryl acetate according to (h) 0.001 to 2% by weight, free retinyl palmitate according to (h) 0 , 1 to 5% by weight, phospholipids 0, 2 to 5% by weight, water as the remaining constituent up to 100% by weight and / or other auxiliaries and carriers.
- the quebracho bark extract according to the invention or its Hydrolysis product contains a very high proportion of proanthocyanidins, which are condensed tannins.
- proanthocyanidins which are condensed tannins.
- these compounds which occur in the form of oligomers and the small proportion of gallic acid show a clear radical protection effect which far exceeds the effect of superoxide dismutase (SOD).
- SOD superoxide dismutase
- the extract (a) preferably contains at least 95% by weight of proanthocyanidin oligomers and at most 5% by weight of gallic acid, in particular at least 99% by weight of proanthocyanidin oligomers and at most 1% by weight of gallic acid.
- the content of (a) is 1 to 10% by weight, the active ingredient from the quebracho bark being enclosed in microcapsules.
- the microcapsules consist e.g. from petrolatum, sodium tristearate, agar, phenonip and water.
- the silkworm extract (b) is obtained by extracting the silkworm (Bombyx mori) with propylene glycol and contains vitamins, amino acids and the peptide cecropine, which has a special antibacterial activity. In recent years, a series of studies on the hemolymph and cuticular matrix of the silk worm have shown that it contains not only antibacterial peptides but also inhibitors of fungal proteases in particular. Furthermore, such extracts show oxygen-consuming properties, as a result of which they activate the cell metabolism, and they have moisture-retaining properties, a clear healing effect on skin lesions by shortening the healing time and a smoothing effect on the skin.
- the extract (b) preferably contains the amino acids aspartic acid, asparagine, threonine, serine, glutamic acid, proline, glycine, alanine, valine, cysteine, methionine, isoleucine, leucine, tyrosine, phenylalanine, lysine, histidine, arginine.
- the extract (b) further preferably contains a vitamin mixture with the vitamins BB 2 , B 5 , B 6 , B ⁇ , B 9 , B 12 , PP, A, E and C.
- the components (a) and (b) are preferably present in concentrations of 0.1 to 3% by weight in the active substance preparation, in particular 0.5 to 3% by weight.
- the gel according to the invention which can also be a mixture of different gels, is a hydrogel which is water-soluble at temperatures of higher than about 40 to 50 ° C and which forms the gel structure at lower temperatures between 10 and 30 ° C.
- examples of such gels are nonionic polymers such as polyvinyl alcohol, polyvinylpyrrolidone-modified starch and hydroxyethyl cellulose; cationic polymers such as cationic guar, cationic cellulose, synthetic cationic polymers; or gels such as gelatin, carrageenan, bentonite gels, copolymer gels such as carbomer.
- the phospholipids contained according to the invention are selected from phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidyl ⁇ erine, phosphatidic acid and lysolecithins and mixtures thereof.
- Known products are, for example, Phoslipon ® .
- the proportion of the phospholipids is in the range from 0.1 to 30% by weight, preferably 0.5 to 20% by weight.
- association complex The components (a) and (b) of the active substance preparation presumably form association-like structures of different molecules with the phospholipids (d), which in turn are deposited in a largely uniform distribution in the developing structure of the gel (c) + (e) and are referred to here overall as an "association complex".
- association complex Parts of the SOD-containing yeast digestion product and the acerola extract and certain plant extracts can also be integrated therein.
- Extract Extract, retinyl palmitate and tocopheryl acetate are included
- the content of retinyl palmitate and tocopheryl acetate can advantageously be in the range from 0.001 to 1% by weight.
- the proportion of phospholipids in this encapsulated mixture is generally between 5 and 40% by weight.
- the active ingredient preparation in the form of the association complex can additionally contain a mixture of vitamins A, B and C and additionally SOD and / or extracts of acerola fruits.
- vitamins and other antioxidants can also be present in the overall composition of the cosmetic preparation.
- the active substance preparation can furthermore comprise various plant extracts, such as citrus peel or leaf extracts (Citrus bigaradia, Citrus hystrix, Citrus aurantifolia, Citrofununella microcarpa, Citrus aurantium, Citrus reticulata) , Bitter orange extract (peel or fruit), cherry extract of Spanish cherry, kiwi extract (Actinidia chinensis), papaya fruit extract (Caricae papayae), tea extract [leaves of green or black tea, leaves or bark of New Jersey tea (Ceanthus velutinas)], coffee bean extract (INCI- name: Coffee Bean Extract; from green or roasted beans), Prunus extract (Prunus armeniaca, Prunus dulcis, Prunus persica, Prunu ⁇ do estica, Prunus spinosa, Prunu ⁇ serotina, Prunus virginiana), extracts of the bark of the Mexican skin tree (Mimos
- Plant extracts of this type are commercially available, for example from DRAGOCO, Holzminden, Germany.
- the content of these plant extracts can be between 0 and 40% by weight, preferably 0.1 to 40% by weight, in particular 0.5 to 20% by weight, mixtures of these extracts and mixtures with the components (f) and (g ) the preparation of the active ingredient may be included.
- the addition of the above-mentioned plant extracts can increase the radical protection factor by several times depending on the plant and the amount added, presumably resulting in synergistic interactions, the relationships of which have not yet been fully clarified.
- the antioxidants which can be used in the invention include vitamins such as vitamin C and derivatives thereof, for example ascorbylacetates, phosphates and palmitates; Vitamin A and derivatives thereof; Folic acid and its derivatives, vitamin E and its derivatives, such as tocopheryl acetate; Flavones or flavonoids; Amino acids such as histidine, glycine, tyrosine, tryprophan and derivatives thereof; Carotenoids and carotenes, such as, for example, carotene, ⁇ -carotene; Uric acid and derivatives thereof; -Hydroxy acids such as citric acid, lactic acid, malic acid; Stilbene and its derivative, etc.
- Vitamins can also be contained in a mixture with enzymes as a further proportion in the preparation of the active substance or in the cosmetic composition in addition to the preparation of the active substance.
- the content can be at least 0.5% by weight of a mixture of enzymes and vitamins, which contains at least 150 units / ml (U / ml) superoxide dismutase (SOD).
- the mixture of enzymes and vitamins used is preferably a digestion product of a yeast produced by ultrasound treatment, the digestion product containing SOD, proteases, vitamin B 2 , vitamin B 6 , vitamin B 12 , vitamin D 2 and vitamin E. It preferably contains at least 150 U / ml SOD, protease and vitamins B and D, the ratio of SODt protease as international units being at least in the range from 3: 1 to 8: 1.
- a digestion process using ultrasound which is described in DE 4241154C1 and in which a cell dispersion or suspension is conducted in an ultrasound flow cell, in which the sonotrode is half to half, is particularly advantageous for the production of the enzyme / vitamin mixture
- Two thirds of its length protrudes into the flow cell and is immersed in the medium to be sonicated.
- the sonotrode has an angle of 80.5 to 88.5 °, and the ratio of the immersion length of the sonotrode in mm to the sound volume in ml is set to a value from 1: 1.1 to 1:20.
- the solid component in the medium to be sonicated is in the range from 1: 0.02 to 1: 2.2 (% by weight).
- Yeasts such as baker's yeast, brewer's yeast, wine yeast and specially treated yeasts, such as, for example, can be used as cell dispersion SOD-enriched yeasts can be used.
- An advantageous cell dispersion contains z.
- the addition of e.g. 1% by weight of such a yeast digestion product from baker's yeast as an optional component of the association complex can contain the radical protection factor, which is already high, e.g. Increase 1620 by about 2 times to 3150. More details are given below on the radical protection factor.
- the active ingredient preparation in the form of the association complex can also contain an extract of acerola fruits (Malpi ⁇ hia punidifolia) in addition to the components mentioned above.
- Acerola is a small tree native to the West Indies, northern South America, Central America, Florida and Texas and rich in vitamin C and other active ingredients such as vitamin A, thiamine, riboflavin and niacin, which together with various other components such as phosphorus, iron Calcium can have a complex effect.
- the aqueous acerola extract is usually in the form of a powdered product.
- natural and synthetic polymers selected from chitosan glycolate, condensation products of milk powder and activated fatty acids; (4) hard magnetic single crystals made of barium hexaferrite with a coercive field strength of 3000-5000 Oe and a grain size of 50-1200 nm embedded in or in a mixture with asymmetrical ellal aggregates of phospholipids and fluorocarbons; and (5) further active substances and carriers, selected from hyaluronic acid, Omega CH activator, betrimonium chloride, passion flower oil and modified kaolin.
- the modified kaolin mentioned is contained in accordance with W096 / 17588 and is modified with spherical Ti0 2 or Si0 2 particles with a particle size ⁇ 5 ⁇ m, the spherical particles having a share in the kaolin mixture of 0.5 to 10% by weight. This gives the preparation a very soft skin feel and additional anti-inflammatory activity.
- the modified kaolin can have a proportion of 0.1 to 6% by weight, based on the total amount of the cosmetic.
- the aforementioned hard magnetic particles for promoting blood circulation can be those as described in WO95 / 03061 or such with smaller particle sizes and in a mixture with asymmetrical lamellar aggregates which are loaded with oxygen up to the saturation pressure, the proportion of the magnetic particles being related the total composition of the cosmetic can range from 0.01 to 10% by weight.
- the asymmetrical lamellar aggregates mentioned are known from WO94 / 00098 and consist of phospholipids and fluorocarbon or fluorocarbon mixture loaded with oxygen.
- the fluorocarbon content is in the range from 0.2 to 100% weight / volume, the phospholipid having a phosphatidylcholine content of more than 30 to 99% by weight, and these aggregates penetrating the skin depending on the critical solubility temperature of the fluorocarbons have.
- the aggregates can also be present in the cosmetic preparation alone loaded with oxygen. The proportion can be between 2.5 and 20% by weight, based on the total composition of the cosmetic. These aggregates are oxygen carriers and allow the oxygen to penetrate into the skin and thus a better supply of oxygen to the skin.
- the preparation according to the invention further contains cosmetic auxiliaries and carriers, as are usually used in such preparations, e.g. Water, glycerin, propylene glycol, preservatives, dyes, pigments with a coloring effect, thickeners, softening substances, moisturizing substances, fragrances, alcohols, polyols, electrolytes, polar and non-polar oils, polymers, copolymers, emulsifiers, waxes, stabilizers, colored plant extracts , such as fat-soluble gardenia extract, fat-soluble carrot extract, paprika LS extract, ß-carotene, lithospermum extract ⁇ and active deodorants.
- cosmetic auxiliaries and carriers e.g. Water, glycerin, propylene glycol, preservatives, dyes, pigments with a coloring effect, thickeners, softening substances, moisturizing substances, fragrances, alcohols, polyols, electrolytes, polar and non-polar oils, polymers
- oil-soluble UVB filters include 4-aminobenzoic acid derivatives such as 4- (dimethylamino) benzoic acid (2-ethylhexyl) ester; Esters of cinnamic acid such as 4-methoxycinnamic acid (2-ethylhexyl) ester, benzophenone derivatives such as 2-hydroxy-4-methoxybenzophenone; 3-benzylidene camphor derivatives such as 3-benzylidene camphor.
- 4-aminobenzoic acid derivatives such as 4- (dimethylamino) benzoic acid (2-ethylhexyl) ester
- Esters of cinnamic acid such as 4-methoxycinnamic acid (2-ethylhexyl) ester
- benzophenone derivatives such as 2-hydroxy-4-methoxybenzophenone
- 3-benzylidene camphor derivatives such as 3-benzylidene camphor.
- UVB filters are e.g. Sulfonic acid derivatives of benzophenone or of 3-benzylidene camphor or salts such as the Na or K salt of 2-phenylbenzimidazole-5-sulfonic acid.
- UVA filters include dibenzoylmethane derivatives such as 1-phenyl-4- (4'-isopropylphenyl) propane-1,3-dione.
- Inorganic pigments based on metal oxides such as Ti0 2 , Si0 2 , ZnO, Fe 2 0 3 , Zr0 2 , MnO, A1 2 0 3 , which can also be used in a mixture with one another or with organic filters, are preferred as sun protection filters.
- inorganic pigments agglomerated substrates of Ti0 2 and / or ZnO which have a content of spherical and porous Si0 2 particles, the SiO 2 particles having a particle size in the range from 0.05 ⁇ m to 1.5 ⁇ m, and in addition to the Si0 2 -Particles other inorganic see particulate substances with a spherical structure, the spherical Si0 2 particles with the other inorganic substances forming defined agglomerates with a particle size in the range from 0.06 ⁇ m to 5 ⁇ m.
- Pigments, pigment mixtures or powders with a pigment-like effect can further include, for example, mica, kaolin, talc, mica-titanium oxide, mica-titanium oxide-iron oxide, bismuth oxychloride, nylon beads, ceramic beads, expanded and unexpanded synthetic polymer powders, powdered natural organic compounds such as ground solid algae, encapsulated and unencapsulated cereal starches and mica-titanium oxide organic dye.
- a large number of compounds can normally be used as emollients, such as stearyl alcohol, glyceryl monoricinoleate, glyceryl onostearate, propane-1,2-diol, butane-1,3-diol, cetyl alcohol, isopropyl isostearate, stearic acid, isobutyl palate, oleyl alcohol, isopropyl laurate Decylolate, octadecan-2-ol, isocetyl alcohol, cetyl palmitate, silicone oils such as dimethylpolysiloxane, isopropyl yristate, isopropyl palmitate, polyethylene glycol, lanolin, cocoa butter, vegetable oils such as corn oil, cottonseed oil, olive oil, mineral oils, etc., butyl mymitate, butyl mymitate Cosmetic compositions with the active ingredient preparation according to the invention can be present as 0 / W or W / O emulsions.
- Suitable emulsifiers for O / W emulsions are, for example, adducts of 2-30 mol of ethylene oxide with linear C 8 -C 22 fatty alcohols, with C 12 -C 22 fatty acids and with C 8 -C 15 alkylphenols; C 12 -C 22 fatty acid monoesters and diesters of adducts of 1-30 moles of ethylene oxide with glycerol; Glycerol monoesters and diesters and sorbitan monoesters and diesters of C 6 -C 22 fatty acids; Polyol and polyglycerol esters; Adducts of ethylene oxide with castor oil; Betaines such as cocoalkyl dimethylammonium glycinate or cocoacylaminoethylhydroxyethyl carboxymethylglycinate (CTFA: cocamidopropyl betaine) and ampholytic surfactants.
- CTFA cocamidopropyl betaine
- Suitable emulsifiers for W / O emulsions are, for example, adducts of 2-15 moles of ethylene oxide with castor oil; Esters of C 12 -C 22 fatty acids and glycerol, polyglycerol, pentaerythritol, sugar alcohols (eg sorbitol), polyglucosides (eg cellulose); Polyalkylene glycols; Wool wax alcohols; Copolymers of polysiloxane-polyalkyl polyether.
- the water content of a preparation with the active ingredient complex can vary within wide ranges and is preferably 5 to 90% by weight, with low water contents of approximately 0.5-8% by weight being recorded, in particular in the case of lipsticks.
- the particularly advantageous cosmetic preparation with the active ingredient component (f) protects in a particularly effective manner against the attack of free radicals on the skin both alone and in combination with other active ingredients, and it shows a surprising effect on the opening of the skin pores similar to the action of a cleaning agent (peeling).
- a cleaning agent peeling
- other properties due to further ingredients of the cosmetic preparation such as sustained improved moisturization and smoothing of the skin, and thus an even more enhanced, long-lasting improvement in the overall condition of the skin come into play.
- the retinyl palmitate which is present in both encapsulated and unencapsulated form becomes effective at the same time in the upper and in the deeper skin layers, and this effectiveness remains stable over a longer period of time and increases the repair effect of the association complex. The latter appears to be due to the simultaneous presence of tocopheryl acetate, since only in this combination was the simultaneous and persistent effect observed.
- the radical protection factor determines the activity of a substance for binding free radicals in relation to a test substance.
- This test substance consists of a very reactive, semi-stable radical that reacts with all known antioxidants.
- radicals include nitroxides such as Proxo (2,2,5,5-tetramethyl-l-dihydropyrroline-oxy-nitroxide), Tempol (2,2,6,6-6-tetramethyl-l-piperidinoxy-4-ol-nitroxide) , DTBN (di-tert-butyl nitroxide or preferably DPPH (1,1-diphenyl-2-picryl-hydrazyl).
- the RPF is measured in such a way that the signal amplitude of the test radical is measured by electron spin resonance (ESR / EPR) before and after mixing with an antioxidant, and the RPF is calculated therefrom.
- the RPF is known for a number of standard antioxidants; it is 827 for all-trans-retinol and 196 for all-trans-retinol acetate; for DL- tocopherol at 41200 and for ⁇ -tocopherol acetate at 48, each x 10 14 radicals / mg.
- the cosmetic active ingredient preparation according to the invention which, when it is present as an "association complex" of the components (a) to (e), has an RPF of 1255 at a concentration of (a) and (b) of 10% by weight and is therefore at the same level very high compared to common active ingredients in cosmetic formulations with declared radical scavengers, which reach values of around 4 to 40.
- the actual active ingredients are in (a) and (b) only present in a maximum concentration of 2% by weight.
- RC is the amount of the test substance, i.e. the well-known
- RPF N x 10 u [radicals per mg], where N is a positive real number, and the RPF can easily be reduced to the numerical value of N. This shortening is used in the examples of the present invention.
- the radical protection factor can be determined by means of a handy and very simply constructed ESR spectrometer (GALENUS GmbH, Berlin, Germany) and is a new parameter for labeling cosmetic products with regard to their ability to bind free radicals. The process is an in vitro process in which no individual properties of the cosmetic user influence the antioxidants.
- the cosmetic preparation according to the invention can be used, for example, in sun creams, sun gels, after-sun products, day creams, night creams, masks, body lotions, cleansing milk, make-up's, lipsticks, eye cosmetics, hair masks, hair rinses, hair shampoo, shower gels, shower oils, bath oils and other common products.
- the active substance preparation according to the invention with the optional component (f) is particularly advantageously present in a cream, lotion, make-up, fluid, gel or lipstick.
- Advantageous cosmetic preparations also include toothpastes and mouthwashes with the special aspect of neutralizing free radicals in the mouth of smokers, and as a special cream for the hands and face of smokers. Such products are manufactured in a manner known to those skilled in the art.
- Corresponding pharmaceutical preparations can also be prepared if appropriate carriers are selected.
- the invention furthermore relates to a cosmetic preparation which contains plant extracts, which are selected from the group consisting of citrus extract, bitter orange extract, cherry extract of Spanish cherry cherry, papaya extract, tea extract, coffee bean extract, prune extract, skin tree extract, Angelica extract and mixtures thereof, as have already been defined in more detail above, with a proportion of 0.5 to 40% by weight, and 99.5 to 60% by weight of further active substances or carriers or mixtures of active substances and carriers , each based on the total composition.
- the substances already mentioned can be used as active substances and carriers.
- Example 1 Day Cream Phase A: Carbomer 0.2; Glycerin 2.0; Propylene glycol 1.0; de ⁇ t. Water qs ad 100; Phase B: C 12 -C 15 alkyl cetyl alcohol 3.7; Stearate 0.5; Jojoba oil 1.0;
- Phase C triethanolamine 0.2;
- Phase D active ingredient complex with (a) - (f) 3.5; Perfume 0.5; Preservative 0.3.
- Phases A and B were heated to 65 ⁇ 2 ° C. with stirring and phase B was homogenized in phase A. This was followed by the addition of phase C and appropriate homogenization. The mixture was then cooled to about 35 ° C. with stirring and phase D was added with thorough mixing.
- the active ingredient complex contained 1.0% of baker's yeast and SOD-containing enzyme / vitamin product obtained by the ultrasonic method of DE 4241154C1.
- the added active ingredient complex contained 1% dry gel, 7% phospholipids, 2% quebracho extract, 1% silkworm extract, 1% SOD from yeast digestion product.
- the radical protection factor of the active ingredient complex was 1925 and the RPF in the formulation was 49.
- Asymmetric lamellar aggregates according to Example 2 of WO94 / 00109 10.5; AOCS with Ba hexaferrite single crystals according to Example 1 of WO95 / 03061 2.0; Modified kaolin according to Example 1 of WO96 / 17588 0.3.
- Phases A and B were heated to 65 ⁇ 2 ° C. with stirring and phase B was homogenized in phase A. Thereafter, the mixture was cooled to about 35 ° C. with stirring and phase C was added with thorough mixing.
- the active ingredient complex contained 1.0% from wine yeast and SOD-containing enzyme / vitamin product obtained by the ultrasonic process of DE 4241154C1, as well as 0.5% vitamin E and 0.5% vitamin C.
- the basic components of the active ingredient complex contained 0.5 % dry gel, 10% phospholipids, 1% quebracho extract, 2% silkworm extract.
- the radical Protection factor of the active ingredient complex was 2120, and the RPF in the formulation was 41.5.
- Phase C Peptide preparation MAP-X ® according to PCT / DE97 / 02941 1.0; ZnO 2.0; Ti0 2 5.0; Si0 2 1.0; Shellac (20% aqueous solution) 1.0; Phase D: active ingredient complex with (a) - (f) 3.5;
- Phase A was heated to 60 ⁇ 2 ° C. with stirring and homogenized and cooled to 45 ° C.
- Phase B was homogenized in phase A.
- phase C was added and thorough homogenization was carried out.
- the mixture was then cooled to about 35 ° C. with stirring and phases D and E were added with thorough mixing and further stirring.
- the active ingredient complex contained 1.0% from brewer's yeast and SOD-containing enzyme / vitamin product obtained according to the ultrasonic method of DE 4241154C1, as well as 0.5% vitamin E, vitamin C and vitamin A in each case.
- the basic constituents of the active ingredient complex contained 0.15% dry Gel, 20% phospholipids, 5% quebracho extract, 3% silkworm extract.
- the radical protection factor of the active ingredient complex was 3050.
- Example 5 sun cream
- Example 6 A composition according to Example 1 was produced, phase 3 additionally containing 3% TiO 2 and 7.5% benzophenone-3.
- the active ingredient complex contained 5% coffee bean extract from roasted coffee beans and 2% kiwi extract instead of 1% SOD from yeast digestion.
- the radical protection factor of the active ingredient complex was 3200.
- Example 7 A composition according to Example 1 was produced, phase A additionally containing 1% TiO 2 and 0.5% ZnO. Instead of 1% SOD from yeast digestion, the active ingredient complex contained 1% tea extract from green tea, 2% coffee bean extract from green coffee beans, 1% vitamin C and 1% vitamin E (tocopherol acetate). The radical protection factor of the active ingredient complex was 5600.
- Example 7 Comparative Example
- guar propyl triammonium chloride gel
- 20% phospholipids 0.1% triethanolamine; 1.0% vitamin E; 0.1% vitamin C; 78.65% water.
- the radical protection factor of the total composition was 2.
- Example 8 Emulsion-based fluid with increased vitamin A content (vitamin A 1 ) phase A: carbomer 0.05; Glycerin 2.5; Propylene glycol 0.5; least Water qs ad 100;
- Phases A and B were heated to 65 ⁇ 2 ° C. with stirring and phase B was homogenized in phase A. Thereafter, phase C was added at about 50 ° C. and homogenized accordingly. The mixture was then cooled to about 30 ° C. with stirring, and phase D and phase E were added with thorough mixing and homogenized.
- the radical protection factor (RPF) of the complex was 2100 and the RPF of the fluid was 20.
- Phase A Sorbitan monostearate 4; Avocado Oil 3; Oleyl oleate 8;
- Phase B water q.s. ad 100; Propylene glycol 2; Glycerin 5;
- Phase B1 NaOH 0.4;
- Phase C preservative 0.4
- Phase D active ingredient complex with (a) - (f) with vitamins A, E, C, B 5;
- Phase E Perfume oil 0.5
- the cream is for smokers' skin with a repair effect and also serves as a preventive measure for the day.
- Phase A Vaseline 8.5; Jojoba oil 3.0; Stearic acid 3.8;
- Phase B water q.s. ad 100; Glycerin 5; Carbomer; 0.3
- Phase C triethanolamine 0.3;
- Phase D preservative 0.4
- Phase E active ingredient complex with (a) - (f) with vitamins A, E, C, B and 2% aloe vera 10.0; Perfume oil 0.1.
- Phase A Cetyl alcohol 8.5; Stearic acid 3.8; Phase B: water q.s. ad 100; Glycerin 2; Carbomer 0.9;
- Phase C triethanolamine 0.3;
- Phase D Vitamin E 1.0; Aloe vera 1.0; Preservative
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Mycology (AREA)
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Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/720,335 US6426080B1 (en) | 1998-06-24 | 1999-06-22 | Cosmetic preparation of active substances with high protection factor against free radicals |
CA002335149A CA2335149A1 (en) | 1998-06-24 | 1999-06-22 | Cosmetic preparation of active substances with high protection factor against free radicals |
IL13984199A IL139841A (en) | 1998-06-24 | 1999-06-22 | Cosmetic preparation of active substances with high protection factor against free radicals |
AU55034/99A AU753819B2 (en) | 1998-06-24 | 1999-06-22 | Cosmetic preparation of active substances with high protection factor against free radicals |
PL99345413A PL193840B1 (pl) | 1998-06-24 | 1999-06-22 | Preparat kosmetyczny substancji czynnych o wysokim współczynniku ochrony przed wolnymi rodnikami oraz zastosowanie tego preparatu |
NZ508533A NZ508533A (en) | 1998-06-24 | 1999-06-22 | Cosmetic preparation of active substances with high protection factor against free radicals containing Quebracho blanco and silkworm extracts |
JP2000555568A JP4137379B2 (ja) | 1998-06-24 | 1999-06-22 | フリーラジカルに対する高度な防御因子を持つ活性物質の化粧品製剤 |
DE59907732T DE59907732D1 (de) | 1998-06-24 | 1999-06-22 | Kosmetische wirkstoffzubereitung mit hohem radikalschutzfaktor |
EP99941385A EP1087749B1 (de) | 1998-06-24 | 1999-06-22 | Kosmetische wirkstoffzubereitung mit hohem radikalschutzfaktor |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19830004A DE19830004B4 (de) | 1998-06-24 | 1998-06-24 | Kosmetische Wirkstoffzubereitung mit hohem Radikalschutzfaktor und deren Verwendung |
DE19830004.2 | 1998-06-24 | ||
DE19860754.7 | 1998-12-23 | ||
DE19860754A DE19860754B4 (de) | 1998-06-24 | 1998-12-23 | Kosmetische Zubereitung |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1999066881A2 true WO1999066881A2 (de) | 1999-12-29 |
WO1999066881A3 WO1999066881A3 (de) | 2000-02-10 |
Family
ID=26047209
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/DE1999/001851 WO1999066881A2 (de) | 1998-06-24 | 1999-06-22 | Kosmetische wirkstoffzubereitung mit hohem radikalschutzfaktor |
Country Status (12)
Country | Link |
---|---|
US (1) | US6426080B1 (de) |
EP (1) | EP1087749B1 (de) |
JP (1) | JP4137379B2 (de) |
CN (1) | CN1154474C (de) |
AU (1) | AU753819B2 (de) |
CA (1) | CA2335149A1 (de) |
DE (2) | DE19860754B4 (de) |
ES (1) | ES2211148T3 (de) |
IL (1) | IL139841A (de) |
NZ (1) | NZ508533A (de) |
PL (1) | PL193840B1 (de) |
WO (1) | WO1999066881A2 (de) |
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Also Published As
Publication number | Publication date |
---|---|
CA2335149A1 (en) | 1999-12-29 |
US6426080B1 (en) | 2002-07-30 |
AU5503499A (en) | 2000-01-10 |
WO1999066881A3 (de) | 2000-02-10 |
EP1087749A2 (de) | 2001-04-04 |
JP2003517435A (ja) | 2003-05-27 |
NZ508533A (en) | 2003-10-31 |
ES2211148T3 (es) | 2004-07-01 |
PL193840B1 (pl) | 2007-03-30 |
DE59907732D1 (de) | 2003-12-18 |
CN1306419A (zh) | 2001-08-01 |
CN1154474C (zh) | 2004-06-23 |
JP4137379B2 (ja) | 2008-08-20 |
IL139841A0 (en) | 2002-02-10 |
DE19860754A1 (de) | 2000-06-29 |
DE19860754B4 (de) | 2004-10-28 |
EP1087749B1 (de) | 2003-11-12 |
PL345413A1 (en) | 2001-12-17 |
AU753819B2 (en) | 2002-10-31 |
IL139841A (en) | 2004-07-25 |
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