WO1998042204A1 - Agent prophylactique et therapeutique contre les maladies infectieuses chez les poissons et les crustaces - Google Patents
Agent prophylactique et therapeutique contre les maladies infectieuses chez les poissons et les crustaces Download PDFInfo
- Publication number
- WO1998042204A1 WO1998042204A1 PCT/JP1998/001145 JP9801145W WO9842204A1 WO 1998042204 A1 WO1998042204 A1 WO 1998042204A1 JP 9801145 W JP9801145 W JP 9801145W WO 9842204 A1 WO9842204 A1 WO 9842204A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fish
- shellfish
- fucoidan
- feed
- shellfishes
- Prior art date
Links
- 241000251468 Actinopterygii Species 0.000 title claims abstract description 34
- 235000015170 shellfish Nutrition 0.000 title claims abstract description 25
- 208000035473 Communicable disease Diseases 0.000 title claims abstract description 12
- 208000015181 infectious disease Diseases 0.000 title abstract description 18
- 230000002554 disease preventive effect Effects 0.000 title abstract 2
- 150000004676 glycans Chemical class 0.000 claims abstract description 14
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 14
- 239000005017 polysaccharide Substances 0.000 claims abstract description 14
- 239000004480 active ingredient Substances 0.000 claims abstract description 4
- 229920000855 Fucoidan Polymers 0.000 claims description 20
- 238000000034 method Methods 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 241000700605 Viruses Species 0.000 description 17
- 241000238557 Decapoda Species 0.000 description 13
- 201000010099 disease Diseases 0.000 description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 230000004083 survival effect Effects 0.000 description 8
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 7
- 229920001525 carrageenan Polymers 0.000 description 7
- 229940113118 carrageenan Drugs 0.000 description 7
- 235000010418 carrageenan Nutrition 0.000 description 7
- 239000000679 carrageenan Substances 0.000 description 7
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 7
- 238000009395 breeding Methods 0.000 description 6
- 230000009385 viral infection Effects 0.000 description 6
- 241000048284 Potato virus P Species 0.000 description 5
- 239000013535 sea water Substances 0.000 description 5
- 244000052616 bacterial pathogen Species 0.000 description 4
- 230000001488 breeding effect Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 208000035143 Bacterial infection Diseases 0.000 description 3
- 241000195628 Chlorophyta Species 0.000 description 3
- 241000701372 Iridovirus Species 0.000 description 3
- 241001124325 Marsupenaeus japonicus Species 0.000 description 3
- 208000022362 bacterial infectious disease Diseases 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 230000000069 prophylactic effect Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 241001474374 Blennius Species 0.000 description 2
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 2
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241001282110 Pagrus major Species 0.000 description 2
- 241000276699 Seriola Species 0.000 description 2
- 208000007107 Stomach Ulcer Diseases 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 241000607598 Vibrio Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 231100000673 dose–response relationship Toxicity 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 208000010824 fish disease Diseases 0.000 description 2
- 201000005917 gastric ulcer Diseases 0.000 description 2
- 238000000703 high-speed centrifugation Methods 0.000 description 2
- 244000045947 parasite Species 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- WZYRMLAWNVOIEX-MOJAZDJTSA-N (2s)-2-[(2r,3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyacetaldehyde Chemical compound O=C[C@@H](O)[C@@H]1OC[C@H](O)[C@H]1O WZYRMLAWNVOIEX-MOJAZDJTSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 244000025254 Cannabis sativa Species 0.000 description 1
- 241001609213 Carassius carassius Species 0.000 description 1
- 241000132536 Cirsium Species 0.000 description 1
- 241000238424 Crustacea Species 0.000 description 1
- 241000252233 Cyprinus carpio Species 0.000 description 1
- 208000004449 DNA Virus Infections Diseases 0.000 description 1
- 241000582762 Eugomontia Species 0.000 description 1
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 description 1
- 229930186217 Glycolipid Natural products 0.000 description 1
- 241000590002 Helicobacter pylori Species 0.000 description 1
- 241000701377 Iridoviridae Species 0.000 description 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
- 241001327682 Oncorhynchus mykiss irideus Species 0.000 description 1
- 241000282376 Panthera tigris Species 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 241000046110 Penaeid rod-shaped DNA virus Species 0.000 description 1
- 241000199919 Phaeophyceae Species 0.000 description 1
- 241000269908 Platichthys flesus Species 0.000 description 1
- 241001600434 Plectroglyphidodon lacrymatus Species 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000206572 Rhodophyta Species 0.000 description 1
- 241000277331 Salmonidae Species 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 241000276707 Tilapia Species 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 206010047642 Vitiligo Diseases 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 238000012364 cultivation method Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000013505 freshwater Substances 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 230000003394 haemopoietic effect Effects 0.000 description 1
- 229940037467 helicobacter pylori Drugs 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 229960001438 immunostimulant agent Drugs 0.000 description 1
- 239000003022 immunostimulating agent Substances 0.000 description 1
- 230000003308 immunostimulating effect Effects 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 235000011962 puddings Nutrition 0.000 description 1
- 235000014102 seafood Nutrition 0.000 description 1
- 230000009528 severe injury Effects 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K61/00—Culture of aquatic animals
- A01K61/10—Culture of aquatic animals of fish
- A01K61/13—Prevention or treatment of fish diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K61/00—Culture of aquatic animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K61/00—Culture of aquatic animals
- A01K61/50—Culture of aquatic animals of shellfish
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K61/00—Culture of aquatic animals
- A01K61/80—Feeding devices
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management
- Y02A40/81—Aquaculture, e.g. of fish
Definitions
- the present invention relates to a drug for preventing and treating infectious diseases caused by pathogenic bacteria and viruses of fish and shellfish, a feed containing the same, and a method of cultivating fish and shellfish by feeding the feed.
- PRDV Penaeid Rod-Shaped DNA Virus infection
- PRDV Penaeid Rod-Shaped DNA Virus infection
- Propagated throughout Japan As a result, severe damage has occurred in all areas except Okino, but no effective preventive and therapeutic measures have been established.
- PRDV the causative virus of this disease
- the problem is not limited to prawn virus infection, but also other fish and shellfish bacterial infections.
- fish diseases include iridovirus infections such as red sea bream, puli and amberjack, infectious hematopoietic soil death in salmonids, streptococcal disease in Puri, vibrio disease in Madipuri, and Venedetia in Puri. Parasitosis and the like.
- antibiotics are mainly administered for bacterial infections, but at present, sufficient effects have not been obtained.
- the use of antibiotics has led to the emergence of resistant bacteria, and there is concern that they may affect the human body. Therefore, safe alternatives to these substances have been desired.
- an object of the present invention is to provide a safe substance having a prophylactic and therapeutic effect against infection of viruses, pathogenic bacteria, and parasites, and to improve the survival rate of fish and shellfish in a farm.
- the present inventors have conducted intensive studies and found that sulfated polysaccharides are effective in preventing and treating infectious diseases of fish and shellfish caused by viruses and pathogenic bacteria.
- the present invention has been completed.
- the present invention provides a prophylactic / therapeutic agent for infection of fish and shellfish containing a sulfated polysaccharide as an active ingredient.
- the present invention also provides a feed for culturing fish and shellfish, which comprises a sulfated polysaccharide.
- the present invention also provides a method for cultivating fish and shellfish, which comprises feeding the fish culture feed.
- FIG. 1 is a graph showing the survival rate of prawns after virus infection.
- FIG. 2 is a diagram showing the survival rate of yellowtail after virus infection.
- Examples of the sulfated polysaccharide which is the active ingredient of the present invention include fucoidan, rhamnan sulfate, carrageenan and the like.
- Fucoidan is a sulfated polysaccharide composed mainly of fucose and having a molecular weight of around hundreds of thousands of thousands. It is harmless.
- Rhamnan sulfate is a sulfated polysaccharide mainly composed of rhamnose and having a molecular weight of about tens of thousands to hundreds of thousands, and is contained in green algae, such as green algae and green grass (Eugomontia sp.).
- carrageenan is a sulfated polysaccharide having a molecular weight of about hundreds of thousands and containing a major component of galactose, anhydrogalactose, sulfuric acid, etc., and is a red alga, Kirinsai (Euche Kasumi a sp.). , Ibaranori (Hiynea sp.), And Suginori (Gigrt ina sp.).
- fucoidan has the effect of inhibiting the colonization of Helicobacter pylori, which is believed to be the cause of gastric ulcer, on the gastric mucosa, and as a treatment for preventing gastric ulcer and gastric cancer. Although its use has been reported, its use as a prophylactic and therapeutic agent for fish and shellfish infectious diseases is unknown.
- fucoidan, rhamnan sulfate, and carrageenan are contained in brown algae, green algae, red algae, etc., these may be fed directly as pulverized or the like.
- An extraction method has been established for fucoidan, rhamnan sulfate, and carrageenan, and the extract can be suitably used.
- the extraction method include powers such as an acid extraction method and a hot water extraction method, and are not limited thereto, and can be extracted by various methods.
- Fucoidan, rhamnan sulfate, and carrageenan are used in the present invention after being reduced in molecular weight or oligosaccharified by hydrolysis of a high molecular weight extract from seaweed, for example, by treatment with a weak acid. Is also good.
- Fucoidan, rhamnan sulfate and carrageenan may be fed directly with seaweeds or dried extracts containing them, but are preferably used by mixing or blending them with feed materials usually used for aquaculture.
- the mixing amount when these are mixed or mixed with the feed varies depending on the fish and shellfish and the cultivation method, but in general, it is preferably about 0.5 to 50 g Zkg for prevention of infection. Also, the feed amount of feed containing these should be about 3% by weight of fish and shellfish a day.
- the fish and shellfishes to which the present invention can be applied are not particularly limited, and include freshwater fish, eel, koi, rainbow trout, va, tilapia, crucian carp, etc.
- Invertebrates such as crosoy, trough and amberjack include kuruma prawns, black tigers, ⁇ shevids, ⁇ lajevi, and thistles.
- Infectious diseases that can be applied include viral infections such as iridovirus, birnavirus, and PRDV, and bacterial infections such as vibrio, pseudomonas, streptococci, and syringoid disease.
- fucoidan The mechanism of infection and treatment by fucoidan, rhamnan sulfate, and carrageenan has not been elucidated yet, but glycolipids and sugar chains on the surface of bacterial viruses play an important role in attaching and infecting cells in the body. .
- fucose residues of fucoidan are involved in this, and it seems to protect against infection.
- Test prawns Using shrimp with an average body weight of 8 g obtained from Mitsui Norin, preliminarily reared for one week until the start of the test, and then subjected to experiments.
- a bottom filtration device was attached to a 60 ⁇ 40 ⁇ 30 cm water tank, and the animals were bred with sufficient airing.
- test specimens 28 in control group, 26 in fucoidan mixed amount 0.5 g / kg feed group, 26 in fucoidan mixed region 1.0 g / kg feed group 26, fucoidan mixed amount 3
- Virus was infected on the 8th day after feeding, and the survival rate on the 10th day after the challenge was determined.
- the infection was carried out by homogenizing the head and thorax of prawns infected with the virus in sterile seawater and then performing high-speed centrifugation. The obtained supernatant was suspended in seawater so as to be diluted about 800-fold.
- the prawn was put into this solution, and immersed for 2 hours while air aging to infect.
- the water temperature during the breeding period was 23 degrees.
- the prawns that died during the experimental period were tested for virus using the PCR method, and confirmed to have died due to the virus.
- Figure 1 shows the survival rate after infection.
- Test fish Average fish weight: 400 g.
- Test fish Average fish weight: 400 g.
- the animals were preliminarily reared for 14 days before the start of the test and then used for the test.
- Breeding method A 100 liter circular pan-light aquarium was installed, and the breeding seawater was recycled. Airlanyon was applied sufficiently. Number of test tails: For the test, 150 prey healthy fish (30 tails in each test group) were provided.
- Feed Control plots use pre-moist pellets, and test plots use a mixture of moist pellets with fucoidan at 1.0, 1.5, 2.0, and 2.5 g / kg, respectively. did. Feeding was performed at 10 o'clock on a daily basis, and the set feeding rate was 44% per body weight of Puri fish.
- Test method The test feed was administered for 39 consecutive days. Preliminary breeding was performed for 14 days, and on the end of preliminary breeding, a challenge virus infection was carried out with the virus. The test period was set at 25 days, and the survival rate of the pri was determined.
- challenge infection the iridovirus-infected site is homogenized in sterile seawater, and the supernatant obtained by high-speed centrifugation is diluted 800-fold with seawater to prepare a suspension. A test fish was put into the dish, and immersion was performed for 2 hours while air-rating.
- the water temperature during the test period was set at 20 ° C, and the presence of iridovirus infection was confirmed by the PCR method for all prids that died during the period. As a result, all the causes of death were due to infection with irid virus.
- Figure 2 shows the survival rates after infection. As a result, administration of fucoidan was able to prevent dose-dependent death from Puri viridovirus. Industrial applicability
- infectious diseases of fish and shellfish can be prevented or treated safely and stably, and cultured fish etc. can be stably supplied to the market.
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Marine Sciences & Fisheries (AREA)
- Biodiversity & Conservation Biology (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Insects & Arthropods (AREA)
- Birds (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
- Farming Of Fish And Shellfish (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Agent prophylactique et thérapeutique contre les maladies infectieuses chez les poissons et les crustacés contenant en tant qu'ingrédient actif un polysaccharide sulfaté, et aliment de culture des poissons et des crustacés contenant un polysaccharide sulfaté. Ce polysaccharide sulfaté sert à prévenir ou à traiter efficacement les maladies infectieuses chez les poissons et les crustacés.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019997007938A KR20000075860A (ko) | 1997-03-21 | 1998-03-18 | 어패류의 감염증 예방 ·치료제 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9/67973 | 1997-03-21 | ||
JP6797397 | 1997-03-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1998042204A1 true WO1998042204A1 (fr) | 1998-10-01 |
Family
ID=13360450
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP1998/001145 WO1998042204A1 (fr) | 1997-03-21 | 1998-03-18 | Agent prophylactique et therapeutique contre les maladies infectieuses chez les poissons et les crustaces |
Country Status (5)
Country | Link |
---|---|
KR (1) | KR20000075860A (fr) |
CN (1) | CN1290429C (fr) |
ID (1) | ID22487A (fr) |
TW (1) | TW513289B (fr) |
WO (1) | WO1998042204A1 (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004307346A (ja) * | 2003-04-02 | 2004-11-04 | Yakult Honsha Co Ltd | 魚類の感染予防・治療剤 |
CN105247043A (zh) * | 2013-05-31 | 2016-01-13 | 英特维特国际股份有限公司 | 鳞片脱落疾病(sdd)致病病毒及其衍生物 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CL2015000876A1 (es) * | 2015-04-08 | 2015-08-28 | Maqui New Life S A | Composición veterinaria de extracto de algas marinas con al menos 5% de fucoidianos y extracto de planta andrographis sp con al menos 5% de andrografolidos, útil en el control y prevención de infecciones producidas por microorganismos intracelulares en peces. |
CN105454722A (zh) * | 2015-12-12 | 2016-04-06 | 重庆华楷水产养殖有限公司 | 一种预防鱼类自由基诱发疾病的固体饲料 |
CN106360139A (zh) * | 2016-08-31 | 2017-02-01 | 霍山县新元生态农业有限公司 | 一种草鱼饲料添加剂 |
WO2021162742A1 (fr) | 2020-02-12 | 2021-08-19 | HP Ingredients Corp. | Additif alimentaire amélioré pour l'aquaculture |
KR102629623B1 (ko) | 2020-11-18 | 2024-01-29 | 주식회사 에프알에스아이 | 패류 질병 치료용 마이크로 캡슐, 이의 제조방법 및 이를 포함하는 패류 질병 치료용 조성물 |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0379603A (ja) * | 1989-08-23 | 1991-04-04 | Zeria Pharmaceut Co Ltd | パロチンコンドロイチン硫酸及び該化合物を含有する魚介類の成長促進剤 |
JPH0670696A (ja) * | 1992-06-30 | 1994-03-15 | Senju Pharmaceut Co Ltd | 魚介類投与用組成物および魚介類育成用水における水汚濁抑制方法 |
JPH06181656A (ja) * | 1992-12-16 | 1994-07-05 | Ajinomoto Co Inc | 魚類・甲殻類のウイルス病予防治療剤及び飼料 |
JPH0741505A (ja) * | 1993-07-27 | 1995-02-10 | Nippon Oil Co Ltd | 抗ウイルス物質 |
JPH07108859B2 (ja) * | 1992-06-08 | 1995-11-22 | 三菱化学株式会社 | 魚類の感染症予防用薬剤 |
JPH07108858B2 (ja) * | 1992-06-08 | 1995-11-22 | 三菱化学株式会社 | 魚類の感染症の予防用薬剤 |
JPH08325158A (ja) * | 1995-05-26 | 1996-12-10 | Maruha Corp | ウイルス病予防治療剤および飼料 |
JPH0967265A (ja) * | 1995-08-31 | 1997-03-11 | Nippon Oil Co Ltd | 魚類病原ウイルスに対する抗ウイルス剤 |
JPH09206067A (ja) * | 1996-02-08 | 1997-08-12 | Kyushu Medical:Kk | 甲殻類のウィルス感染症防除剤、この防除剤の甲殻類への投与方法、及びこの防除剤を構成する微生物の培養液 |
JPH1045600A (ja) * | 1996-08-02 | 1998-02-17 | Maruha Corp | 甲殻類又は魚類の感染症予防治療剤及びそれを含有する飼料 |
-
1998
- 1998-03-18 KR KR1019997007938A patent/KR20000075860A/ko active Search and Examination
- 1998-03-18 CN CNB988035715A patent/CN1290429C/zh not_active Expired - Fee Related
- 1998-03-18 ID IDW991052A patent/ID22487A/id unknown
- 1998-03-18 WO PCT/JP1998/001145 patent/WO1998042204A1/fr not_active Application Discontinuation
- 1998-03-20 TW TW087104212A patent/TW513289B/zh not_active IP Right Cessation
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0379603A (ja) * | 1989-08-23 | 1991-04-04 | Zeria Pharmaceut Co Ltd | パロチンコンドロイチン硫酸及び該化合物を含有する魚介類の成長促進剤 |
JPH07108859B2 (ja) * | 1992-06-08 | 1995-11-22 | 三菱化学株式会社 | 魚類の感染症予防用薬剤 |
JPH07108858B2 (ja) * | 1992-06-08 | 1995-11-22 | 三菱化学株式会社 | 魚類の感染症の予防用薬剤 |
JPH0670696A (ja) * | 1992-06-30 | 1994-03-15 | Senju Pharmaceut Co Ltd | 魚介類投与用組成物および魚介類育成用水における水汚濁抑制方法 |
JPH06181656A (ja) * | 1992-12-16 | 1994-07-05 | Ajinomoto Co Inc | 魚類・甲殻類のウイルス病予防治療剤及び飼料 |
JPH0741505A (ja) * | 1993-07-27 | 1995-02-10 | Nippon Oil Co Ltd | 抗ウイルス物質 |
JPH08325158A (ja) * | 1995-05-26 | 1996-12-10 | Maruha Corp | ウイルス病予防治療剤および飼料 |
JPH0967265A (ja) * | 1995-08-31 | 1997-03-11 | Nippon Oil Co Ltd | 魚類病原ウイルスに対する抗ウイルス剤 |
JPH09206067A (ja) * | 1996-02-08 | 1997-08-12 | Kyushu Medical:Kk | 甲殻類のウィルス感染症防除剤、この防除剤の甲殻類への投与方法、及びこの防除剤を構成する微生物の培養液 |
JPH1045600A (ja) * | 1996-08-02 | 1998-02-17 | Maruha Corp | 甲殻類又は魚類の感染症予防治療剤及びそれを含有する飼料 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004307346A (ja) * | 2003-04-02 | 2004-11-04 | Yakult Honsha Co Ltd | 魚類の感染予防・治療剤 |
CN105247043A (zh) * | 2013-05-31 | 2016-01-13 | 英特维特国际股份有限公司 | 鳞片脱落疾病(sdd)致病病毒及其衍生物 |
Also Published As
Publication number | Publication date |
---|---|
KR20000075860A (ko) | 2000-12-26 |
CN1251020A (zh) | 2000-04-19 |
TW513289B (en) | 2002-12-11 |
CN1290429C (zh) | 2006-12-20 |
ID22487A (id) | 1999-10-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20220039429A1 (en) | Supplemented fish feed | |
Manilal et al. | In vivo therapeutic potentiality of red seaweed, Asparagopsis (Bonnemaisoniales, Rhodophyta) in the treatment of Vibriosis in Penaeus monodon Fabricius | |
CN102006785A (zh) | 改善虾健康的材料和方法 | |
CN110178973A (zh) | 一种防治凡纳滨对虾肝肠胞虫的药饵添加剂 | |
KR101817817B1 (ko) | 어류의 기생충 구제제 및 구제 방법 | |
CN111110718B (zh) | 一种对虾肝肠胞虫专杀药物及其制备方法与应用 | |
CN1331534C (zh) | 防治水产养殖动物疾病的复合菌苗及其制法 | |
Wahjuningrum et al. | Feeding duration of dietary Nodulisporium sp. KT29 to prevent the infection of Vibrio harveyi on Pacific white shrimp Litopenaeus vannamei | |
WO2000010558A1 (fr) | Substances naturelles physiologiquement actives agissant contre des maladies des poissons et aliments pour poissons contenant ces substances | |
WO1998042204A1 (fr) | Agent prophylactique et therapeutique contre les maladies infectieuses chez les poissons et les crustaces | |
KR101934350B1 (ko) | 흰반점 바이러스에 대한 항바이러스 활성을 갖는 조성물 | |
JP4331824B2 (ja) | 魚介類の感染症予防・治療剤 | |
WO2018018170A1 (fr) | Utilisation d'extraits de quillaja saponaria pour prévenir et lutter contre des infections bactériennes chez les poissons | |
JP2000281568A (ja) | 寄生虫症予防治療剤 | |
JP2001008636A (ja) | 感染症防止用飼料組成物 | |
JP4294326B2 (ja) | 魚介類の感染予防及び/又は治療剤 | |
WO2019146827A1 (fr) | Composition pour la prévention ou le traitement d'infections parasitaires chez le poisson, comprenant un extrait d'helianthus tuberosus et un extrait de sophora flavescens aiton | |
CA2972174C (fr) | Utilisation d'extraits de quillaja saponaria en vue de la prevention et du controle d'infections bacteriennes chez les poissons | |
CN107812002A (zh) | 一种用于观赏鱼细菌、病毒、寄生虫综合治疗的药品 | |
TWI744983B (zh) | 針對多巴脫羧酵素之雙股rna的用途 | |
KR100373147B1 (ko) | 스쿠치카충 감염증의 치료제 | |
Liao et al. | The use of chemicals in aquaculture in Taiwan, Province of China | |
JPH05308908A (ja) | 魚類甲殻類の養殖用飼料、養殖方法および治療方法 | |
JPS62221624A (ja) | 魚類のウイルス病予防.治療方法 | |
CN114028436A (zh) | 东北贯众提取物在防治弓形虫病的应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 98803571.5 Country of ref document: CN |
|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): CN ID JP KR |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 1019997007938 Country of ref document: KR |
|
WWP | Wipo information: published in national office |
Ref document number: 1019997007938 Country of ref document: KR |
|
WWR | Wipo information: refused in national office |
Ref document number: 1019997007938 Country of ref document: KR |