WO1998025629A1 - Agent prophylactique et therapeutique pour les maladies intestinales inflammatoires - Google Patents

Agent prophylactique et therapeutique pour les maladies intestinales inflammatoires Download PDF

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Publication number
WO1998025629A1
WO1998025629A1 PCT/JP1997/004544 JP9704544W WO9825629A1 WO 1998025629 A1 WO1998025629 A1 WO 1998025629A1 JP 9704544 W JP9704544 W JP 9704544W WO 9825629 A1 WO9825629 A1 WO 9825629A1
Authority
WO
WIPO (PCT)
Prior art keywords
lower alkyl
therapeutic agent
hydrogen atom
intestinal diseases
alkyl group
Prior art date
Application number
PCT/JP1997/004544
Other languages
English (en)
French (fr)
Inventor
Toshikazu Yoshikawa
Norimasa Yoshida
Hironobu Murase
Original Assignee
Cci Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cci Corporation filed Critical Cci Corporation
Priority to EP97947879A priority Critical patent/EP0965344B1/en
Priority to AT97947879T priority patent/ATE260109T1/de
Priority to US09/319,647 priority patent/US6174864B1/en
Priority to CA002274575A priority patent/CA2274575C/en
Priority to DE69727836T priority patent/DE69727836T2/de
Publication of WO1998025629A1 publication Critical patent/WO1998025629A1/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

Claims

2 3
下記一般式 （1 )
請 のCH2 ) n ( ) m
Figure imgf000025_0001
囲
(ただし、 式中、 R1 R2、 R3および R4は同一または異なる水素原 子または低級アルキル基を表し、 R 5は水素原子、 低級アルキル基ま たは低級ァシル基を表し、 Xは糖残基中の水酸基の水素原子が低級ァ ルキル基または低級ァシル基で置換されていてもよい単糖残基または オリゴ糖残基を表し、 nは 0〜6の整数であり、 および mは 1〜6の 整数である） で表されるクロマノール配糖体を有効成分とする炎症性 腸疾患予防および治療剤。
2 . 前記クロマノ一ル配糖体は 2— （a— D—ダルコピラノシル） メチ ル—2， 5， 7， 8—テトラメチルクロマン一 6 _オールである請求 の範囲第 1項記載の炎症性腸疾患予防および治療剤。
3 . 前記炎症性腸疾患は潰瘍性大腸炎またはクローン病である請求の範 囲第 1項または第 2項記載の炎症性腸疾患予防および治療剤。
4 . 水性製剤である請求の範囲第 1〜 3項記載の炎症性腸疾患予防およ び治療剤。
PCT/JP1997/004544 1996-12-10 1997-12-10 Agent prophylactique et therapeutique pour les maladies intestinales inflammatoires WO1998025629A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP97947879A EP0965344B1 (en) 1996-12-10 1997-12-10 Prophylactic and therapeutic agent for inflammatory intestinal diseases
AT97947879T ATE260109T1 (de) 1996-12-10 1997-12-10 Darmentzündungen vorbeugendes und therapeutisches arzneimittel
US09/319,647 US6174864B1 (en) 1996-12-10 1997-12-10 Methods for the prevention or treatment of inflammatory bowel diseases
CA002274575A CA2274575C (en) 1996-12-10 1997-12-10 Preventive and curative agent for inflammatory bowel diseases
DE69727836T DE69727836T2 (de) 1996-12-10 1997-12-10 Darmentzündungen vorbeugendes und therapeutisches arzneimittel

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8329901A JPH10168095A (ja) 1996-12-10 1996-12-10 炎症性腸疾患予防および治療剤
JP8/329901 1996-12-10

Publications (1)

Publication Number Publication Date
WO1998025629A1 true WO1998025629A1 (fr) 1998-06-18

Family

ID=18226533

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1997/004544 WO1998025629A1 (fr) 1996-12-10 1997-12-10 Agent prophylactique et therapeutique pour les maladies intestinales inflammatoires

Country Status (9)

Country Link
US (1) US6174864B1 (ja)
EP (1) EP0965344B1 (ja)
JP (1) JPH10168095A (ja)
KR (1) KR100467470B1 (ja)
CN (1) CN1125640C (ja)
AT (1) ATE260109T1 (ja)
CA (1) CA2274575C (ja)
DE (1) DE69727836T2 (ja)
WO (1) WO1998025629A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1174140A1 (en) * 1999-03-31 2002-01-23 Cci Corporation Skin preparations for external use
EP1151753A4 (en) * 1999-02-02 2006-06-07 Cci Corp PREVENTIVE AND CURATIVE AGENTS AGAINST ARTERIOSCLEROSIS

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE493993T1 (de) * 2002-03-26 2011-01-15 Tsutomu Kagiya Chromanol glucoside zur verbesserung der chemischen krebsbehandlung
US20040097433A1 (en) * 2002-11-15 2004-05-20 Sekhar Boddupalli Chroman derivatives for the reduction of inflammation symptoms
WO2005011658A2 (en) * 2003-02-27 2005-02-10 Wisconsin Alumni Research Foundation Chroman-derivated anti-androgens for treatment of androgen-mediated disorders
JP2004269460A (ja) * 2003-03-11 2004-09-30 Cci Corp 消化性潰瘍の予防および治療剤
DE102004025791A1 (de) * 2004-05-19 2005-12-15 Schering Ag Chromanol-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
CN103156845B (zh) * 2005-03-15 2015-11-18 翁科诺克斯有限公司 具有免疫调节活性的化合物
ATE541469T1 (de) † 2005-12-29 2012-02-15 Hills Pet Nutrition Inc Verfahren zum modifizieren der darmflora bei tieren
ITMI20080846A1 (it) * 2008-05-09 2009-11-10 Andrea Balsari Composti a struttura glicosidica attivi nella terapia di stati infiammatori locali e sistemici
JP5652963B2 (ja) * 2009-03-31 2015-01-14 シーシーアイ株式会社 腹膜肥厚抑制剤
WO2019235577A1 (ja) * 2018-06-07 2019-12-12 国立大学法人大阪大学 酸化ストレスに起因する疾患の予防又は治療剤
KR101993780B1 (ko) 2018-09-03 2019-07-01 서형바이클랙주식회사 가정용 자전거 거치대
KR102081084B1 (ko) 2019-06-25 2020-02-25 박흥일 탈부착용 자전거 리프트 랙
KR102231742B1 (ko) 2020-06-01 2021-03-24 박흥일 도난방지 기능을 구비한 자전거 주차정산 시스템

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05246847A (ja) * 1992-03-04 1993-09-24 Eisai Co Ltd 潰瘍性大腸炎治療・予防剤
JPH05294834A (ja) * 1990-02-09 1993-11-09 Teijin Ltd 活性型ビタミンｄ含有治療剤
JPH0665222A (ja) * 1992-05-29 1994-03-08 Otsuka Pharmaceut Co Ltd チアゾール誘導体
JPH06157310A (ja) * 1992-07-07 1994-06-03 Eli Lilly & Co 炎症性腸疾患の治療薬
JPH07112980A (ja) * 1993-08-24 1995-05-02 Ono Pharmaceut Co Ltd 縮合フェノール誘導体およびその誘導体を有効成分として含有する薬剤
JPH07118287A (ja) * 1993-02-10 1995-05-09 C C I Kk 新規なクロマノール配糖体およびその製造方法
JPH07316150A (ja) * 1994-05-24 1995-12-05 Ono Pharmaceut Co Ltd 縮合フェノール誘導体
JPH08253466A (ja) * 1995-03-06 1996-10-01 Bayer Ag Ｎ−（３−ベンゾフラニル）ウレア−誘導体
JPH08510253A (ja) * 1993-05-10 1996-10-29 セプラコール・インコーポレーテッド 光学的に純粋な（−）‐ジロイトンを用いて、喘息、アテローム性動脈硬化症および炎症性疾患を治療する方法および組成

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0550292A1 (en) * 1992-01-02 1993-07-07 Merrell Dow Pharmaceuticals Inc. Tissue protective tocopherol analogs
US5639770A (en) 1992-05-29 1997-06-17 Otsuka Pharmaceutical Co., Ltd. Thiazole derivatives
EP0640609A1 (en) 1993-08-24 1995-03-01 Ono Pharmaceutical Co., Ltd. Fused phenol derivatives having inhibitory activity on TXA2 synthetase, and 5-lipoxygenase and scavenging activity on oxygen species
JP3703875B2 (ja) * 1995-04-03 2005-10-05 シーシーアイ株式会社 クロマノール配糖体およびその製造方法

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05294834A (ja) * 1990-02-09 1993-11-09 Teijin Ltd 活性型ビタミンｄ含有治療剤
JPH05246847A (ja) * 1992-03-04 1993-09-24 Eisai Co Ltd 潰瘍性大腸炎治療・予防剤
JPH0665222A (ja) * 1992-05-29 1994-03-08 Otsuka Pharmaceut Co Ltd チアゾール誘導体
JPH06157310A (ja) * 1992-07-07 1994-06-03 Eli Lilly & Co 炎症性腸疾患の治療薬
JPH07118287A (ja) * 1993-02-10 1995-05-09 C C I Kk 新規なクロマノール配糖体およびその製造方法
JPH08510253A (ja) * 1993-05-10 1996-10-29 セプラコール・インコーポレーテッド 光学的に純粋な（−）‐ジロイトンを用いて、喘息、アテローム性動脈硬化症および炎症性疾患を治療する方法および組成
JPH07112980A (ja) * 1993-08-24 1995-05-02 Ono Pharmaceut Co Ltd 縮合フェノール誘導体およびその誘導体を有効成分として含有する薬剤
JPH07316150A (ja) * 1994-05-24 1995-12-05 Ono Pharmaceut Co Ltd 縮合フェノール誘導体
JPH08253466A (ja) * 1995-03-06 1996-10-01 Bayer Ag Ｎ−（３−ベンゾフラニル）ウレア−誘導体

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1151753A4 (en) * 1999-02-02 2006-06-07 Cci Corp PREVENTIVE AND CURATIVE AGENTS AGAINST ARTERIOSCLEROSIS
EP1174140A1 (en) * 1999-03-31 2002-01-23 Cci Corporation Skin preparations for external use
EP1174140A4 (en) * 1999-03-31 2004-01-21 Cci Corp PREPARATIONS FOR THE SKIN FOR EXTERNAL USE
US6939859B1 (en) 1999-03-31 2005-09-06 Cci Corp. Skin preparations for external use

Also Published As

Publication number Publication date
CA2274575A1 (en) 1998-06-18
DE69727836D1 (de) 2004-04-01
US6174864B1 (en) 2001-01-16
KR100467470B1 (ko) 2005-01-24
EP0965344B1 (en) 2004-02-25
ATE260109T1 (de) 2004-03-15
CN1245430A (zh) 2000-02-23
JPH10168095A (ja) 1998-06-23
DE69727836T2 (de) 2004-12-30
KR20000057457A (ko) 2000-09-15
CN1125640C (zh) 2003-10-29
EP0965344A1 (en) 1999-12-22
CA2274575C (en) 2009-11-24
EP0965344A4 (en) 2003-05-02

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