KR880005925A - 소화성 궤양 치료 및 예방제 - Google Patents

소화성 궤양 치료 및 예방제 Download PDF

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Publication number
KR880005925A
KR880005925A KR870013130A KR870013130A KR880005925A KR 880005925 A KR880005925 A KR 880005925A KR 870013130 A KR870013130 A KR 870013130A KR 870013130 A KR870013130 A KR 870013130A KR 880005925 A KR880005925 A KR 880005925A
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South Korea
Prior art keywords
hydrogen atom
alkyl
group
peptic ulcer
carbon atoms
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KR870013130A
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English (en)
Inventor
찌카라 후까야
히또시 야스다
토시아끼 아끼라
마사카즈 이와이
카네미찌 오까노
카즈마사 요꼬야마
Original Assignee
원본미기재
미도리쥬지 가부시끼 가이샤
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Publication date
Priority claimed from JP27918386A external-priority patent/JPS63132830A/ja
Priority claimed from JP27918186A external-priority patent/JPS63132828A/ja
Priority claimed from JP27918286A external-priority patent/JPS63132829A/ja
Application filed by 원본미기재, 미도리쥬지 가부시끼 가이샤 filed Critical 원본미기재
Publication of KR880005925A publication Critical patent/KR880005925A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/02—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen
    • C07C47/19—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen containing hydroxy groups
    • C07C47/192—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen containing hydroxy groups containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/02—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen
    • C07C47/198—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/105—Saturated compounds containing keto groups bound to acyclic carbon atoms containing rings
    • C07C49/11—Saturated compounds containing keto groups bound to acyclic carbon atoms containing rings monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/17—Saturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/172—Saturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/175—Saturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/487—Saturated compounds containing a keto group being part of a ring containing hydroxy groups
    • C07C49/497—Saturated compounds containing a keto group being part of a ring containing hydroxy groups a keto group being part of a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/385—Saturated compounds containing a keto group being part of a ring
    • C07C49/517—Saturated compounds containing a keto group being part of a ring containing ether groups, groups, groups, or groups

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

소화성 궤양 치료 및 예방제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (8)

  1. 소화성 궤양을 치료하기 위한 치료적 및/또는 예방적 유효량의 다음 일반식(Ⅰ)의 사이클로헥산 유도체와 약제학적으로 허용 가능한 첨가제로 이루어짐을 특징으로 하는 소화성 궤양 치료 및/또는 예방제.
    상기식에서, A는의 그룹이며, X는 에티닐렌, 비닐렌 또는 에틸렌이고, Y는 옥소 또는 하이드록시그룹이며, R1, R3, R4및 R5는 각각 수소원자 또는 알킬이고, R2는 수소원자, 알킬 또는 -OR8의 그룹이고, R6은 수소원자, 알킬 또는 -OR8의 그룹이고, R7은 수소원자 또는 -OR8의 그룹이며, R8은 수소원자 또는 유기 잔기이다.
  2. 제1항에 있어서, 알킬 그룹이 1 내지 6개의 탄소원자를 함유하는 치료 및/또는 예방제.
  3. 제2항에 있어서, 알킬 그룹이 1 내지 4개의 탄소원자를 함유하는 치료 및/또는 예방제.
  4. 제1항에 있어서, 유기 잔기가 알킬, 아실, 알콕시카보닐, 알콕시카보닐알킬, 카복시알킬, 카복시 알킬카보닐, 사이클릭 아세탈 또는 1 내지 3개의 당 단위를 가진 올리고 삭카라이드 잔기인 치료 및/또는 예방제.
  5. 치료 및/또는 예방적 유효량의 다음 일반식(Ⅰ)의 사이클로헥산 유도체 및 약제학적으로 허용가능한 첨가제를 포유동물에게 투여함을 특징으로 하여 포유동물의 : 소화성 궤양을 치료하는 방법 :
    상기식에서 A는의 그룹이며, X는 에티닐렌, 비닐렌 또는 에틸렌이고, Y는 옥소 또는 하이드록시 그룹이며, R1,R3,R4및 R5는 각각 수소원자 또는 알킬이고, R2는 수소원자, 알킬 또는 -OR8의 그룹이며, R6은 수소원자, 옥소 또는 -OR8의 그룹이고, R7은 수소원자 또는 -OR8의 그룹이며, R8은 수소원자 또는 유기 잔기이다.
  6. 제5항에 있어서, 알킬 그룹이 1내지 6개의 탄소원자를 함유하는 방법.
  7. 제5항에 있어서, 알킬 그룹이 1내지 4개의 탄소원자를 함유하는 방법.
  8. 제5항에 있어서, 유기 잔기가 알킬, 아실, 알콕시카보닐, 알콕시카보닐알킬, 카복시알킬, 카복시알킬카보닐, 사이클릭 아세탈 또는 1 내지 3개의 당 단위를 갖는 올리고삭카라이드 잔기인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR870013130A 1986-11-22 1987-11-21 소화성 궤양 치료 및 예방제 KR880005925A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP61-279183 1986-11-22
JP27918386A JPS63132830A (ja) 1986-11-22 1986-11-22 消化器潰瘍治療予防剤
JP27918186A JPS63132828A (ja) 1986-11-22 1986-11-22 消化器潰瘍治療予防剤
JP61-279182 1986-11-22
JP27918286A JPS63132829A (ja) 1986-11-22 1986-11-22 消化器潰瘍治療予防剤
JP61-279181 1986-11-22

Publications (1)

Publication Number Publication Date
KR880005925A true KR880005925A (ko) 1988-07-21

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ID=27336633

Family Applications (1)

Application Number Title Priority Date Filing Date
KR870013130A KR880005925A (ko) 1986-11-22 1987-11-21 소화성 궤양 치료 및 예방제

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Country Link
US (1) US4983584A (ko)
EP (1) EP0282643A3 (ko)
KR (1) KR880005925A (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0270124A3 (en) * 1986-12-05 1990-03-21 The Green Cross Corporation Cycloalkane derivatives and anti-peptic ulcer compositions containing same
KR100418202B1 (ko) * 1994-09-09 2004-07-05 쇼죠 고야마 분자발현기능의억제방법
CA2965472C (en) 2014-10-24 2021-08-24 Josep Bassaganya-Riera Lanthionine synthetase c-like 2-based therapeutics
JP2021503936A (ja) 2017-11-30 2021-02-15 ランドス バイオファーマ インコーポレイテッド ランチオニンｃ様タンパク質２リガンドによる治療及びそれにより調製された細胞
BR112022002387A2 (pt) 2019-12-20 2022-09-06 Landos Biopharma Inc Composto da fórmula z-y-q-y' ou um sal ou éster farmaceuticamente aceitável do mesmo

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5020395B2 (ko) * 1972-04-30 1975-07-15
JPS5844658B2 (ja) * 1974-10-16 1983-10-04 サントリー株式会社 アレンジオ−ルノ セイホウ
US3995055A (en) * 1975-02-28 1976-11-30 Daiichi Seiyaku Co., Ltd. Method for treating peptic ulcers
JPS6036479A (ja) * 1983-08-08 1985-02-25 Kotobuki Seiyaku Kk １，３−ジオキサン誘導体、本化合物を有効成分とする抗潰瘍剤及びその製造方法
DE3677637D1 (de) * 1985-05-25 1991-04-04 Green Cross Corp Therapeutische und vorbeugende mittel gegen magengeschwuere, darin enthaltene verbindungen und verfahren zu deren herstellung.

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EP0282643A3 (en) 1990-08-22
EP0282643A2 (en) 1988-09-21
US4983584A (en) 1991-01-08

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