WO2001032679A3 - Novel glycosides comprising pentose mono-, di-, tri-, or oligosaccharides and phytosterols and/or phytostanols - Google Patents

Novel glycosides comprising pentose mono-, di-, tri-, or oligosaccharides and phytosterols and/or phytostanols Download PDF

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Publication number
WO2001032679A3
WO2001032679A3 PCT/CA2000/001272 CA0001272W WO0132679A3 WO 2001032679 A3 WO2001032679 A3 WO 2001032679A3 CA 0001272 W CA0001272 W CA 0001272W WO 0132679 A3 WO0132679 A3 WO 0132679A3
Authority
WO
WIPO (PCT)
Prior art keywords
oligosaccharides
phytostanols
phytosterols
tri
carbohydrate moiety
Prior art date
Application number
PCT/CA2000/001272
Other languages
French (fr)
Other versions
WO2001032679A2 (en
WO2001032679A9 (en
Inventor
James P Kutney
Radka K Milanova
Honming Chen
Nikolay Mintchev Stoynov
Original Assignee
Forbes Medi Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forbes Medi Tech Inc filed Critical Forbes Medi Tech Inc
Priority to CA002389670A priority Critical patent/CA2389670A1/en
Priority to AU11223/01A priority patent/AU1122301A/en
Publication of WO2001032679A2 publication Critical patent/WO2001032679A2/en
Publication of WO2001032679A3 publication Critical patent/WO2001032679A3/en
Publication of WO2001032679A9 publication Critical patent/WO2001032679A9/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J17/005—Glycosides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

A novel glycoside compound for use in treating or preventing cardiovascular disease and it's underlying conditions such as atherosclersis and hypercholeterolemia comprises a carbohydrate moiety and a non-carbohydrate moiety wherein the carbohydrate moiety is selected from the group consisting of pentose monosaccharides, disaccharides, trisaccharides and oligosaccharides and their acylated derivatives and the non-carbohydrate moiety is either a phytosterol, a phytostanol or a derivative thereof.
PCT/CA2000/001272 1999-11-01 2000-11-01 Novel glycosides comprising pentose mono-, di-, tri-, or oligosaccharides and phytosterols and/or phytostanols WO2001032679A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA002389670A CA2389670A1 (en) 1999-11-01 2000-11-01 Novel glycosides comprising pentose mono-, di-, tri-, or oligosaccharides and phytosterols and/or phytostanols
AU11223/01A AU1122301A (en) 1999-11-01 2000-11-01 Novel glycosides comprising pentose mono-, di-, tri-, or oligosaccharides and phytosterols and/or phytostanols

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43283699A 1999-11-01 1999-11-01
US09/432,836 1999-11-01

Publications (3)

Publication Number Publication Date
WO2001032679A2 WO2001032679A2 (en) 2001-05-10
WO2001032679A3 true WO2001032679A3 (en) 2001-10-25
WO2001032679A9 WO2001032679A9 (en) 2002-08-29

Family

ID=23717787

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2000/001272 WO2001032679A2 (en) 1999-11-01 2000-11-01 Novel glycosides comprising pentose mono-, di-, tri-, or oligosaccharides and phytosterols and/or phytostanols

Country Status (3)

Country Link
AU (1) AU1122301A (en)
CA (1) CA2389670A1 (en)
WO (1) WO2001032679A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0513881D0 (en) 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors III
US20080182801A1 (en) 2003-12-22 2008-07-31 Btg International Limited Core 2 glcnac-t inhibitors
GB0329667D0 (en) 2003-12-22 2004-01-28 King S College London Core 2 GlcNAc-T inhibitor
GB0513888D0 (en) 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors II
EP2710022A4 (en) * 2011-05-20 2014-12-03 Univ Putra Malaysia A use of a composition comprising of acylated steryl glucoside in the manufacture of a product
FR2984256B1 (en) 2011-12-19 2016-09-02 Valeo Systemes Dessuyage PLASTIC AND THERMOCONDUCTIVE COMPONENT OF A SYSTEM FOR THE SUPPLY AND / OR DISTRIBUTION OF ICE WASTE LIQUID OF A MOTOR VEHICLE

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1298047A (en) * 1970-03-18 1972-11-29 Liebenberg R W Therapeutic agent
US3933789A (en) * 1972-03-17 1976-01-20 Roelof Wilke Liebenberg Extraction of sterolins from plant material
US4188379A (en) * 1976-12-30 1980-02-12 Roecar Holdings (Netherlands Antilles) N.V. Sterolins and their use
US4254111A (en) * 1978-07-05 1981-03-03 Roecar Holdings (Netherlands Antilles) Nv Sterolin products
US4929603A (en) * 1984-01-14 1990-05-29 Rooperal (Na) Nv Use of phytosteryl glycosides for the treatment of epoxycholesterol levels
WO1993007167A1 (en) * 1991-10-04 1993-04-15 The Procter & Gamble Company Cholesterol lowering compounds and process for making them
WO1994000480A1 (en) * 1992-06-26 1994-01-06 Pfizer Inc. Steroidal glycosides for treating hypercholesterolemia
GB2304106A (en) * 1995-08-08 1997-03-12 Merck & Co Inc Steroidal glycosides

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1298047A (en) * 1970-03-18 1972-11-29 Liebenberg R W Therapeutic agent
US3933789A (en) * 1972-03-17 1976-01-20 Roelof Wilke Liebenberg Extraction of sterolins from plant material
US4188379A (en) * 1976-12-30 1980-02-12 Roecar Holdings (Netherlands Antilles) N.V. Sterolins and their use
US4254111A (en) * 1978-07-05 1981-03-03 Roecar Holdings (Netherlands Antilles) Nv Sterolin products
US4929603A (en) * 1984-01-14 1990-05-29 Rooperal (Na) Nv Use of phytosteryl glycosides for the treatment of epoxycholesterol levels
WO1993007167A1 (en) * 1991-10-04 1993-04-15 The Procter & Gamble Company Cholesterol lowering compounds and process for making them
WO1994000480A1 (en) * 1992-06-26 1994-01-06 Pfizer Inc. Steroidal glycosides for treating hypercholesterolemia
GB2304106A (en) * 1995-08-08 1997-03-12 Merck & Co Inc Steroidal glycosides

Non-Patent Citations (24)

* Cited by examiner, † Cited by third party
Title
ACTA POL. PHARM. (1987), 44(6), 560-2 *
CHEMICAL ABSTRACTS, vol. 98, no. 7, 14 February 1983, Columbus, Ohio, US; abstract no. 46750, V. N. MIRANOVA ET AL: "Hypolipemic effect of beta-sitosterol beta-D-glucoside" page 55; column 1; XP002167095 *
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; AGNIHOTRI, VINOD KUMAR: "Poriferasterol-3-rhamnoside, a new saponin from the stem bark of Amoora rohituka", XP002167103, retrieved from STN Database accession no. 108:72082 *
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ALIAGA, A. ET AL: "Identification of sterols and fatty acids from squill bulbs (Urginea maritima)", XP002167102, retrieved from STN Database accession no. 110:36742 *
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ANJANEYULU, V. ET AL: "Isolation of 24-methylenecholesterol-3-O-.alpha.-L-fucopyranoside and 24-methylenecholest-7-ene-3.beta.,6.alpha.,9.alpha.,11.alpha.- tetrol from a soft coral of the Andaman and Nicobar Islands", XP002167101, retrieved from STN Database accession no. 120:187483 *
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; CHAO, YU-CHOU ET AL: "Extracts from the heartwood of Ali-shan elm", XP002167105, retrieved from STN Database accession no. 94:1995 *
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; DELLA GRECA, MARINA ET AL: "Studies on aquatic plants. Part 19. Acylglycosyl sterols from Pistia stratiotes", XP002167097, retrieved from STN Database accession no. 115:110661 *
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; IRIBARREN, ADOLFO M. ET AL: "Sitosterol 3-O-.beta.-D-xylopyranoside from Bauhinia candicans", XP002167099, retrieved from STN Database accession no. 102:3244 *
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KALINOVSKAYA, N. I. ET AL: "Steroidal glycosides from Far East holothurian Stichopus japonicus Selenka", XP002167096, retrieved from STN Database accession no. 91:207739 *
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KIM, HA-KUNG ET AL: "Synthesis of stigmasterol-.alpha.-L-arabinopyranoside", XP002167100, retrieved from STN Database accession no. 74:142276 *
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; SRIVASTAVA, SAVITRI D.: "Chemical constituents of Cleome viscosa", XP002167104, retrieved from STN Database accession no. 96:214280 *
DATABASE CHEMABS [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; TANDON, MAMTA ET AL: "Steroid glycosides from Asparagus adscendens", XP002167098, retrieved from STN Database accession no. 114:78620 *
DENINNO MICHAEL P ET AL: "Steroidal glycoside cholesterol absorption inhibitors.", JOURNAL OF MEDICINAL CHEMISTRY, vol. 40, no. 16, 1997, pages 2547 - 2554, XP002167094, ISSN: 0022-2623 *
FARMAKOL. TOKSIKOL., vol. 45, no. 6, 1982, Moscow, RU, pages 45 - 47 *
HUA HSUEH (1979), (3), 56-9 *
INDIAN J. CHEM., SECT. B (1982), 21B(2), 165-7 *
INDIAN J. CHEM., SECT. B (1994), 33B(2), 144-7 *
INDIAN J. PHARM. SCI. (1987), 49(4), 149-50 *
LLOYDIA (1970), 33(4), 484-5 *
MAKARIEVA, TATYANA N. ET AL: "Biosynthetic studies of marine lipids. 42. Biosynthesis of steroid and triterpenoid metabolites in the sea cucumber Eupentacta fraudatrix", STEROIDS (1993), 58(11), 508-17, XP002167093 *
PHYTOCHEMISTRY (1984), 23(9), 2087-8 *
PHYTOCHEMISTRY (1990), 29(9), 2957-9 *
PHYTOCHEMISTRY (1991), 30(7), 2422-4 *
SYMP. PAP. - IUPAC INT. SYMP. CHEM. NAT. PROD., 11TH (1978), VOLUME 2, 443-6. EDITOR(S): MAREKOV, N.;OGNYANOV, I.; ORAHOVATS, A. PUBLISHER: IZD. BAN, SOFIA, BULG. *

Also Published As

Publication number Publication date
CA2389670A1 (en) 2001-05-10
WO2001032679A2 (en) 2001-05-10
WO2001032679A9 (en) 2002-08-29
AU1122301A (en) 2001-05-14

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