WO1997028741A1 - Schneidvorrichtung für haut zur schmerzarmen gewinnung kleiner blutmengen - Google Patents

Schneidvorrichtung für haut zur schmerzarmen gewinnung kleiner blutmengen Download PDF

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Publication number
WO1997028741A1
WO1997028741A1 PCT/EP1997/000501 EP9700501W WO9728741A1 WO 1997028741 A1 WO1997028741 A1 WO 1997028741A1 EP 9700501 W EP9700501 W EP 9700501W WO 9728741 A1 WO9728741 A1 WO 9728741A1
Authority
WO
WIPO (PCT)
Prior art keywords
blade
tissue
movement
cutting edge
less
Prior art date
Application number
PCT/EP1997/000501
Other languages
German (de)
English (en)
French (fr)
Inventor
Dirk BÖCKER
Heinrich Fruhstorfer
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Priority to US09/117,527 priority Critical patent/US5997561A/en
Priority to DE59711425T priority patent/DE59711425D1/de
Priority to EP97902323A priority patent/EP0879017B1/de
Priority to JP52813297A priority patent/JP2001503284A/ja
Priority to AT97902323T priority patent/ATE261702T1/de
Priority to AU16006/97A priority patent/AU1600697A/en
Publication of WO1997028741A1 publication Critical patent/WO1997028741A1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150442—Blade-like piercing elements, e.g. blades, cutters, knives, for cutting the skin
    • A61B5/150458—Specific blade design, e.g. for improved cutting and penetration characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A61B5/150106—Means for reducing pain or discomfort applied before puncturing; desensitising the skin at the location where body is to be pierced
    • A61B5/150137—Means for reducing pain or discomfort applied before puncturing; desensitising the skin at the location where body is to be pierced by vibration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150175—Adjustment of penetration depth
    • A61B5/15019—Depth adjustment mechanism using movable stops located inside the piercing device housing and limiting the travel of the drive mechanism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15103—Piercing procedure
    • A61B5/15107—Piercing being assisted by a triggering mechanism
    • A61B5/15113—Manually triggered, i.e. the triggering requires a deliberate action by the user such as pressing a drive button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15115—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
    • A61B5/15117—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids comprising biased elements, resilient elements or a spring, e.g. a helical spring, leaf spring, or elastic strap
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15115—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids
    • A61B5/15121—Driving means for propelling the piercing element to pierce the skin, e.g. comprising mechanisms based on shape memory alloys, magnetism, solenoids, piezoelectric effect, biased elements, resilient elements, vacuum or compressed fluids comprising piezos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15101—Details
    • A61B5/15126—Means for controlling the lancing movement, e.g. 2D- or 3D-shaped elements, tooth-shaped elements or sliding guides
    • A61B5/15132—Means for controlling the lancing movement, e.g. 2D- or 3D-shaped elements, tooth-shaped elements or sliding guides comprising tooth-shaped elements, e.g. toothed wheel or rack and pinion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/151—Devices specially adapted for taking samples of capillary blood, e.g. by lancets, needles or blades
    • A61B5/15186—Devices loaded with a single lancet, i.e. a single lancet with or without a casing is loaded into a reusable drive device and then discarded after use; drive devices reloadable for multiple use
    • A61B5/15188—Constructional features of reusable driving devices

Definitions

  • the object of the present invention was to propose a device which causes less pain in blood collection than in lancet devices of the prior art is the case. Furthermore, it was an object of the invention to provide a blood lancet with which the depth of penetration into the tissue is more accurately and better reproducibly possible than with known devices.
  • Figure 1 1 Representation of the relationship between the exit width (A), deformation (D) and penetration depth (E)
  • a coordinate system is shown in FIG. 10 to define the directions of movement of the lancet.
  • the surface of the fabric lies in the XZ plane.
  • the lancet In order to penetrate the tissue, the lancet must perform a movement that has a Y component, i. H. the movement must have a portion perpendicular to the tissue surface.
  • the cutting edge (2) is on the Z axis and the blade (1) is within the YZ plane.
  • the blade can now be vertical, i.e. H. in the direction of the negative Y axis, into the tissue or it can also be moved within a plane E which is tilted against the YZ plane.
  • the epidermis Due to the oscillatory movement, the epidermis is cut open and the speed at which the blade is lowered into the epidermis and corum can be chosen to be very small, in contrast to the lancets commonly used today 2 it can be seen that in the context of this embodiment a blade shape can be used, with which a sufficiently wide section d of the tissue is cut with a very small depth of penetration into the center due to the arrangement of the hairpin-shaped blood vessels and other microvessels occurring in this region in the region Corium these are d The oscillation movement of the blade is effectively cut. To obtain a sufficient amount of blood, only a cutting width d of 300 to 900 ⁇ m is required. To obtain larger amounts of blood, correspondingly longer blades can of course be used according to the invention
  • the blade In order to achieve a painless penetration of the blade into the tissue, it has turned out to be important that the blade carries out an oscillation substantially parallel to the cutting edge, the frequency of which is above 500 Hz.
  • the cutting device according to the invention could be significantly improved by increasing the frequency of the oscillating movement Raised above 700 Hz
  • Particularly efficient cutting processes are achieved with frequencies in the kilo-heart range or above 900 Hz Pain sensation during the cutting process is also largely determined by the amplitude of the oscillating movement. It has been found that the amplitude of the oscillating movements should be below 500 ⁇ m. It is preferably below 300 ⁇ m and particularly preferably below 250 ⁇ m.
  • Oscillators with which the described requirements can be met are, in particular, piezo elements, ultrasound ceramics, electrodynamic transducers and mechanical transducers.
  • piezo elements have proven to be oscillators that change length when an electrical voltage is applied. Since these changes in length are generally only one or a few ⁇ m, a mechanical transmission is necessary in order to achieve larger vibration amplitudes.
  • This rod should have the lowest possible mass in order to keep damping of the vibration low.
  • the rod is preferably made of a rigid material to ensure good energy transfer from the oscillator to the blade.
  • the rod and piezo element are non-positively attached to a counter mass.
  • stacks composed of a multiplicity of piezo elements in which the changes in length of the individual elements add up.
  • spring-mass oscillators that cause the blade to oscillate are so-called spring-mass oscillators. This includes, for example, a tuning fork on one leg of which the blade or a holder with a blade is located.
  • the vibrator is preferably rubbed at a resonance frequency, since the deflection of the blade is particularly great here.
  • Blades in which the length of the cutting edge is less than 10 mm are suitable for cutting devices for obtaining small amounts of blood. Cut edges with a length of 0.2 to 2 mm, preferably 0.4 to 1.5 mm, have been found to be suitable for obtaining blood quantities in the range of 100 ⁇ l. Cut edges with a length of 0.5 to 1.0 mm are particularly suitable.
  • the materials used for the blade are, in particular, the materials customary for lancets in the prior art, such as. B. steel proven.
  • metals, glasses, ceramic materials and also plastics can be used.
  • Plastics that can be processed by injection molding and cools are particularly suitable have a sufficient hardness.
  • a machining step for sharpening the blade may be omitted if the injection mold is selected appropriately. It has been found that coating the blades with substances that reduce the friction between the blade and the fabric is advantageous. By reducing the friction between the blade and the tissue, the mechanical energy input into the tissue and thus pain caused by heating can be avoided
  • the rod and blade form a mechanical unit that can be exchanged.
  • the unit in the medical field, it is desirable for hygienic reasons to design the unit as a disposable part so that it can be exchanged after each cutting operation rod and blade can either be made of different materials, or advantageously consist of the same material
  • FIG. 3 shows a blood lancet according to the invention, with a housing in which the blade and the oscillator are arranged.
  • the housing has an outer casing (10) which is used by the user to handle the device. Inside this casing there is a rod (12) to which the blade (13) is attached.
  • a piezo crystal (14), which is connected to the rod (12), is controlled by an electronic vibration generator (15), so that the blade (13) carries out oscillatory movements essentially parallel to the cutting edge (13a).
  • the cutting device is equipped with an adjusting device , which specifies the maximum and the minimum distance by which the blade projects beyond the contact surface.
  • the range of the interval is preferably chosen such that its lower limit is greater than 200 ⁇ m and its upper limit is less than 2500 ⁇ m.
  • An adjustment range between 0.5 and 2.0 mm or even better between 0.7 and 1.3 mm is preferred
  • the rod (12) consists of a material with a sufficiently high modulus of elasticity to transmit the energy of the piezo vibration to the blade (13). Suitable materials for the rod are, for example, glass, spring steels, plastics and ceramics.
  • the weight of the vibrating components (rod and blade) is small compared to the weight on the opposite side of the piezo element.
  • the piezo element is connected to the inner casing (11) via a connecting piece (11a), so that it is effective as a mass. It is particularly advantageous to operate the apparatus in such a way that the rod and blade are connected to one another Vibrate resonance frequency
  • FIG 4 shows an example of an embodiment in which the manual movement, which is necessary with the apparatus shown in Figure 3, is replaced by the action of a spring element (20).
  • the spring (20) is connected to a rail (21), the one Has Ausneh ⁇ mung, in which a lever (22) engages.
  • the lever (22) has a push button outside the housing, so that when this push button is pressed, the locking mechanism is released and the inner casing (11) is displaced relative to the outer casing. As a result, the blade (13) arrives outside the outer housing.
  • the distance X between the edge of the inner housing (11) and the inside of the contact surface (16) in the starting position the depth of cut by which the blade penetrates the tissue can be regulated.
  • the arrangement can, for example, also be chosen so that the blade is fixed and the skin contact surface is on the end face of a sleeve which is resiliently mounted against an adjustable stop.
  • the setting mechanism for setting the penetration depth is preferably designed such that it can be set in stages, the step spacing being at least about 0.4 mm and at least about 0.2 mm, preferably 0.3 mm, at least in the setting ranges mentioned above.
  • the setting range can also go beyond the above-mentioned upper limits and thus also encompass greater puncture depths in order to take into account the requirements of the relatively few people who do not have a sufficient amount of blood with the low puncture depths mentioned (for example because of a particularly thick horny layer) can be won.
  • the puncture depth it is also important that the blade be held in such a precise position in its holder. It is niert that the position of the blade end in the direction of the piercing movement relative to the blade holder is reproducible if several blades are fastened in succession in the blade holder
  • FIG. 4a shows the inner sleeve (11) from FIG. 4 with a somewhat modified arrangement of oscillator, rod and blade.
  • the piezo crystal (14) and the blade (13) are arranged on different sides of the axis (18) .
  • the oscillation movement has both a component parallel to the cutting edge and a component perpendicular to it.
  • FIG. 11 shows how the step width of the lancet from the cutting device and the depth of penetration into the tissue are related.
  • Figure 1 1 A shows the initial state of the system, in which the blade (1) is completely in the housing (51) and the housing is pressed onto a skin area (50).
  • FIG. 1 IB shows a state in which the blade displaces the skin without cutting through it. The deformation of the skin is denoted by (D).
  • FIG. 11 C represents a state in which the blade has severed the skin.
  • the width of the blade (A) from the housing results in a deformation (D) and a depth of penetration (E) into the tissue.
  • the deformation (D) can fluctuate individually and also with the same individual, so that the penetration depth (E) also fluctuates strongly with a constant exit width, which is undesirable.
  • the deformation (D) is very small for the reasons already mentioned, so that fluctuations of (D) are also very small and therefore the depth of penetration (E) into the skin is very accurate given a defined outlet width (A) can be predetermined
  • the insertion depth should be easily and precisely adjustable by the user.
  • the setting range preferably includes unusually low penetration depths between 0.5 and 2.0 mm, the range between 0.7 mm and 1.3 mm being of particular importance.
  • the amount of blood required in practice for the analysis which is usually between 1 and 50 .mu.l, in the majority of cases between 5 and 30 .mu.l, surprisingly already in the majority of people
  • Such low puncture depths with significantly reduced pain can be obtained if one ensures that the depth of the puncture is reproducible with a certain, unchanged setting of the device.
  • successive cutting processes should vary in the maximum depth of cut achieved by less than 0.15 mm, preferably 0.1 mm and particularly preferably 0.05 mm.
  • FIG. 5A shows a blood lancet in which the rod (12) on which the blade (13) is located is attached to a weight (41).
  • the weight (41) is located in an inner sleeve (23), which in turn is arranged displaceably in the outer sleeve (10).
  • the rod (12) is inserted through the weight (41) and is rigidly connected to the weight (41), for example by means of an adhesive or screw connection.
  • a piezo element (14) is integrated in the rod (12) and sets the rod (12) and the blade (13) in vibration.
  • a bead (42) can advantageously be attached, which extends around the opening for the blade to exit. This bead serves to tension and fix the area of skin that is cut by the blade (13). It has proven to be advantageous if the bead (42) projects 0.2 to 0.3 mm beyond the contact surface (16).
  • FIG. 5 A also shows an advantageous drive mechanism for moving the blade into the tissue.
  • This drive device has an eccentric disc (25) to which a lifting rod (26) is attached via an axis, which is in turn connected to the rod (12) via an axis.
  • Figure 5B shows the eccentric disc (25) from the rear. On this side the eccentric disc has a gearwheel (27) which is driven by a rack (28).
  • the device shown in FIG. 5 has the advantage that when the rack (28) is pressed by the user, the blade is lowered into the tissue and also is pulled out again. Since the user only has to carry out a single pressure movement, the handling of the cutting device is made easier.
  • a spring element (29) can be provided, which is compressed when the toothed rack is pressed down and serves to move the toothed rack back into its starting position.
  • a free wheel for the gearwheel (27) can advantageously also be provided, so that when the toothed rack moves back into its rest position, the eccentric disc (25) is not rotated and the blade is not lowered again into the tissue.
  • FIG. 5C shows the rod (12) with an integrated piezo element (14).
  • the piezo element is such that it changes length along its longitudinal axis when an electrical alternating voltage is applied. These changes in length cause the rod to bend, analogous to a bimetallic strip.
  • a mechanical oscillation of the rod (12) can be caused by electrical signals of suitable frequency that are applied to the piezo element
  • FIG. 6 shows three embodiments of blades preferred according to the invention.
  • FIG. 6A shows a trapezoidal blade with a straight cutting edge.
  • FIG. 6B shows a blade in the form of a knife and the blade in FIG. 6C tapers.
  • Each of these 3 types of blades can have different cross-sectional shapes.
  • Figure 7 shows two cross sections A and B along the section line aa ', which are possible.
  • Each of the blades shown in FIGS. 6A to 6C can have one of these two cross sections.
  • the section line is given in FIGS. 6A to 6C
  • the basic shapes of the blade can be, for example, trapezoidal, circular and semicircular, square, polygonal, tapering or knife-shaped.
  • the following types of grinding are possible, for example:
  • the invention also includes an embodiment in which the blade is set into an oscillating movement perpendicular to the surface of the fabric.
  • the microscopic movements of the blade are therefore essentially parallel due to the oscillating movement and the movement for inserting the blade into the tissue.
  • korinen advantageously tapered blades and also blades with multiple edges are used.
  • the latter type of blades can be achieved, for example, by a facet cut.
  • needles can also be used which taper to a point and advantageously have a facet cut
  • the oscillation of the oscillator is advantageously coupled to the blade via a rigid connection, which, if possible, avoids lateral displacement or oscillation of the blade and only allows vertical oscillation to the skin surface.
  • the oscillation amplitude of the blade is smaller vertically to the skin surface than 300 ⁇ m, preferably less than 100 ⁇ m, preferably less than 50 ⁇ m
  • mechanical oscillation generators, electrodynamic transducers, piezo oscillators and the like can be used as the oscillator.
  • FIG. 8 schematically shows a device as to how this second embodiment of the invention can be implemented.
  • the rod (30) is slidably arranged in a sleeve (31).
  • the piezo crystal is arranged in such a way that its vibrations move the blade (33) in the longitudinal direction of the rod cause the double arrow shown above the rod. It is important that the weight of the vibrating components (rod and blade) is small relative to the mass on the other side of the oscillator, ie on the side of the rod (30).
  • the piezo crystal (32) is first set in vibration and the blade (33) is then lowered onto the tissue by sliding the rod (30). After a sufficiently large cut has been made, the rod (30) is moved in the opposite direction and the blade (33) is pulled out of the tissue.
  • pointed blades have proven to be advantageous.
  • flat blades with a cross-section have been found 7A or 7B advantageous.
  • the oscillation frequency of the blade transverse to the tissue surface should be above 100 Hz, so that the pain sensation during the cutting process is small. Increasing the frequencies to over 500 Hz is another Reduction of pain sensation possible. For the same reason, the amplitude of the oscillating movement should also be below 100 ⁇ m, preferably below 50 ⁇ m
  • the oscillation of the blade (33) necessary for the functioning of the device is achieved by a suitable geometric arrangement of masses, with which a so-called resonance increase in the amplitude is generated
  • FIG. 8 The apparatus shown schematically in FIG. 8 can be combined, for example, with the drive mechanisms described in FIGS. 4 and 5 for moving the blade transversely to the tissue surface
  • FIG. 9 shows a particularly simple embodiment in which there is an electronic vibration generator (15) inside a housing (40) which is driven by a battery (17).
  • the vibration generator (15) moves the piezo crystal (32) in Vibrations.
  • the blade (33) is coupled directly to the piezo crystal. The user himself leads the oscillating blade (33) to the tissue section to be cut and makes a cut of the desired depth.
PCT/EP1997/000501 1996-02-06 1997-02-04 Schneidvorrichtung für haut zur schmerzarmen gewinnung kleiner blutmengen WO1997028741A1 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US09/117,527 US5997561A (en) 1996-02-06 1997-02-04 Skin cutter for painless extraction of small blood amounts
DE59711425T DE59711425D1 (de) 1996-02-06 1997-02-04 Schneidevorrichtung für haut zur schmerzarmen gewinnung kleiner blutmengen
EP97902323A EP0879017B1 (de) 1996-02-06 1997-02-04 Schneidevorrichtung für haut zur schmerzarmen gewinnung kleiner blutmengen
JP52813297A JP2001503284A (ja) 1996-02-06 1997-02-04 ほとんど痛みがない方法で少量の血液サンプルを採取するための皮膚用カッティング器具
AT97902323T ATE261702T1 (de) 1996-02-06 1997-02-04 Schneidevorrichtung für haut zur schmerzarmen gewinnung kleiner blutmengen
AU16006/97A AU1600697A (en) 1996-02-06 1997-02-04 Skin cutter for painless extraction of small blood amounts

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19604156A DE19604156A1 (de) 1996-02-06 1996-02-06 Schneidvorrichtung für Haut zur schmerzarmen Entnahme kleiner Blutmengen
DE19604156.2 1996-02-06

Publications (1)

Publication Number Publication Date
WO1997028741A1 true WO1997028741A1 (de) 1997-08-14

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Family Applications (1)

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PCT/EP1997/000501 WO1997028741A1 (de) 1996-02-06 1997-02-04 Schneidvorrichtung für haut zur schmerzarmen gewinnung kleiner blutmengen

Country Status (14)

Country Link
US (2) US5997561A (zh)
EP (1) EP0879017B1 (zh)
JP (1) JP2001503284A (zh)
KR (1) KR19990082310A (zh)
CN (1) CN1214623A (zh)
AT (1) ATE261702T1 (zh)
AU (1) AU1600697A (zh)
CA (1) CA2245574A1 (zh)
DE (2) DE19604156A1 (zh)
ES (1) ES2217387T3 (zh)
MX (1) MX9806339A (zh)
TW (1) TW347315B (zh)
WO (1) WO1997028741A1 (zh)
ZA (1) ZA97926B (zh)

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US6139562A (en) * 1998-03-30 2000-10-31 Agilent Technologies, Inc. Apparatus and method for incising
US6231531B1 (en) 1999-04-09 2001-05-15 Agilent Technologies, Inc. Apparatus and method for minimizing pain perception
US6740058B2 (en) 2001-06-08 2004-05-25 Wisconsin Alumni Research Foundation Surgical tool with integrated pressure and flow sensors
DE19846250B4 (de) * 1997-10-14 2005-12-08 Agilent Technologies, Inc. (n.d.Ges.d.Staates Delaware), Palo Alto Blutentnahmevorrichtung zur minimal-invasiven Blutentnahme
US8197423B2 (en) 2002-04-19 2012-06-12 Pelikan Technologies, Inc. Method and apparatus for penetrating tissue
US8690796B2 (en) 2002-04-19 2014-04-08 Sanofi-Aventis Deutschland Gmbh Method and apparatus for penetrating tissue
US8845550B2 (en) 2001-06-12 2014-09-30 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
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US8905945B2 (en) 2002-04-19 2014-12-09 Dominique M. Freeman Method and apparatus for penetrating tissue
US8945910B2 (en) 2003-09-29 2015-02-03 Sanofi-Aventis Deutschland Gmbh Method and apparatus for an improved sample capture device
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US9261476B2 (en) 2004-05-20 2016-02-16 Sanofi Sa Printable hydrogel for biosensors
US9314194B2 (en) 2002-04-19 2016-04-19 Sanofi-Aventis Deutschland Gmbh Tissue penetration device
US9351680B2 (en) 2003-10-14 2016-05-31 Sanofi-Aventis Deutschland Gmbh Method and apparatus for a variable user interface
US9375169B2 (en) 2009-01-30 2016-06-28 Sanofi-Aventis Deutschland Gmbh Cam drive for managing disposable penetrating member actions with a single motor and motor and control system
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MX9806339A (es) 1998-10-31
ZA97926B (en) 1998-08-19
ES2217387T3 (es) 2004-11-01
KR19990082310A (ko) 1999-11-25
DE59711425D1 (de) 2004-04-22
EP0879017B1 (de) 2004-03-17
ATE261702T1 (de) 2004-04-15
US5997561A (en) 1999-12-07
AU1600697A (en) 1997-08-28
CN1214623A (zh) 1999-04-21
DE19604156A1 (de) 1997-08-07
EP0879017A1 (de) 1998-11-25
CA2245574A1 (en) 1997-08-14
US6210421B1 (en) 2001-04-03
TW347315B (en) 1998-12-11
JP2001503284A (ja) 2001-03-13

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