WO1997018814A1 - Pharmaceutical formulations - Google Patents
Pharmaceutical formulations Download PDFInfo
- Publication number
- WO1997018814A1 WO1997018814A1 PCT/EP1996/005020 EP9605020W WO9718814A1 WO 1997018814 A1 WO1997018814 A1 WO 1997018814A1 EP 9605020 W EP9605020 W EP 9605020W WO 9718814 A1 WO9718814 A1 WO 9718814A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- formulation
- molecular weight
- polyethylene oxide
- range
- low molecular
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
Definitions
- This invention relates to controlled-release oral pharmaceutical formulations
- Controlled-release oral pharmaceutical formulations are known Their purpose is to modify the rate of drug release, for example to produce a constant rate of release of a drug into the gastrointestinal tract of a patient, or to delay the release of a drug into the gastrointestinal tract of a patient (see 'Sustained and Controlled Release Drug Delivery Systems', pp 3-6, edited by J R Robinson, published by Marcel Dekker Inc)
- US Patent N° 4,765,989 discloses an osmotic delivery device for delivering inter alia nifedipi ⁇ e or doxazosin It has a perforated semipermeable wall enclosing a drug composition which includes an osmopolymer, and a pusher composition containing a second osmopolymer
- a drug composition which includes an osmopolymer
- a pusher composition containing a second osmopolymer The performance of this prior art device is satisfactory, but it has the disadvantage that it is very complicated, leading to high manufacturing costs
- UK Patent Application 2,123,291 discloses a sustained release formulation of suloctidil which is a two-part tablet a first part is a prompt-release portion and a second part is a slow-release portion, which must contain a surface-active agent to promote bio-erosion
- US Patent N° 5,393,765 discloses an erodibie pharmaceutical composition providing a zero order controlled release profile, comprising low viscosity hydroxypropylmethyl cellulose
- a controlled-release pharmaceutical formulation for oral administration consisting essentially of an active drug compound low molecular weight polyethylene oxide, hydroxypropylmethyl cellulose tabletting excipients and optionally one or more enteric polymers
- formulations of the present invention may also be administered buccally (i e placed behind the top lip and allowed to dissolve) and the term includes such formulations "Consisting essentially of means that at least 95% by weight of the formulation is made up of the listed components. At least 99% by weight of uncoated formulations, and the cores of coated formulations, are preferably made up of the listed components.
- Polymerized ethylene oxide having a number average molecular weight less than 100,000 is sometimes referred to as "polyethylene glycol".
- polyethylene glycol Polyethylene glycol
- low molecular weight polyethylene oxide is used to refer to polymerized ethylene oxide in the number average molecular weight range of interest, namely 15,000 to 750,000.
- Tabletting excipients making up formulations according to the invention may be conven ⁇ tional tabletting excipients, for example dibasic calcium phosphate, lactose and magnesium stearate.
- the first class is weakly basic compounds. Examples of this class include dipyridamole, noscapine, papaverine, doxazosin, sildenafil and prazosin. Doxazosin and its pharmaceutically acceptable salts are of particular interest.
- the second class are compounds having high solubility in aqueous media.
- this class include salbutamol, metoprolol, propanolol, aminophylline, isosorbide mono- and dinitrate, glyceryl trinitrate, verapamil, captopril, diltiazem, morphine, chlorpheni- ramine, promethazine, eletriptan, darifenacin and fluconazole.
- the third class are compounds having low solubility in aqueous media.
- Examples of this class include nifedipine, griseofulvin, carbamazepine, felodipine, nimodipine and megestrol.
- solubility in aqueous media and “low solubility in aqueous media” will be understood by those skilled in the art. However, the former may be defined as a solubility
- Formulations according to the invention have the advantage that they produce a constant rate of release of drugs that are weakly basic and/or have a high solubility in aqueous media in in vitro models of the gastrointestinal tract, and so are expected to produce a constant rate of release of the drug in the gastrointestinal tract of a patient.
- the formulations of the invention have the advantage that they produce a delayed or pulsed release of the drug.
- the formulations are very simple and so can be manufactured at a compara ⁇ tively low cost.
- the hydroxypropylmethyl cellulose has a number average molecular weight in the range 80,000-250,000.
- the hydroxypropylmethyl cellulose has a degree of methyl substitution in the range 19-30 %.
- the hydroxypropylmethyl cellulose has a degree of hydroxy substitution in the range 4-12 %.
- a number of hydroxypropylme- thyl cellulose polymers are available commercially under the brand name Methocel®, and some of those suitable for use in formulations according to the invention are given in the table below:
- Methocel® K4M has characteristics of particular interest.
- the low molecular weight polyethylene oxide has a number average molecular weight in the range 20,000 to 500,000, more preferably 100,000-300,000.
- Polyethylene oxide with a number average molecular weight above 100,000 is a powder, which makes it easier to handle than lower molecular weight polyethylene oxide, which has a lower melting point.
- polyethylene oxide with a number average molecular weight of 6000 has a melting point of 60-63°C It will be apparent to those skilled in the art that the polyethylene oxide may consist of molecules of different chain lengths, but that the average chain length gives a molecular weight in the range stated. The same applies to the hydroxypropylmethyl cellulose.
- Formulations according to the invention may contain an enteric polymer admixed with the other components of the formulation.
- formulations according to the invention are preferably provided with a coating of an enteric polymer.
- Enteric polymers that may be mentioned are phthalate derivatives (including cellulose acetate phthalate, polyvinyiacetate phthalate and hydroxypropylmethyl cellulose phthalate), polyacrylic acid derivatives (including methacrylic acid copolymer), and vinyl acetate and crotonic acid copolymers. Methacrylic acid copolymer is of particular interest.
- the formulation contains up to 50% by weight of active drug compound, for example 1-20%.
- formulations of the invention contain 5-30% by weight of low molecular weight polyethylene oxide, for example 8-10%.
- the formulations of the invention contain 10-60% by weight of hydroxypropyl- methyl cellulose, for example 25-35%.
- Formulations having enteric polymer admixed with the other components of the formula ⁇ tion preferably have 10-40% by weight of admixed enteric polymer, for example 25-35%.
- the mass ratio of low molecular weight polyethylene oxide:hydroxypropylmethyl cellulose is in the range 2:1- 1 :5.
- the mass ratio of (low molecular weight polyethylene ox- ide+hydroxypropylmethyl cellulose):admixed enteric polymer is in the range 1 :2-6: 1 , more preferably 1 :2-2:1.
- the enteric coating (where present) makes up 2-15% by weight of the formulation, more preferably 5-10% by weight of the formulation.
- the use of low molecular weight polyethylene oxide in an oral controlled-release pharmaceutical formulation having a hydroxypropylmethyl cellulose matrix, to enhance the erosion of the matrix after a predetermined period of time following administration of the formulation to a patient
- the predetermined period of time is 6 hours In this way, a constant rate of drug release can be achieved in the gastrointestinal tract of a patient despite the varying conditions which exist along its length
- a process for the production of a pharmaceutical formulation as defined in claim 1 which comprises mixing an active drug compound, low molecular weight polyethylene oxide, hydroxypropylmethyl cellulose, tabletting excipients, and optionally one or more enteric polymers, followed by pressing into tablets
- formulations according to the present invention may be measured in a model of the gastrointestinal tract such as Apparatus 1 of USP 22, page
- Figure 1 shows the percentage of drug compound released v time from formulations according to the invention [as prepared in Examples 1 (a) and 1 (b)] in comparison with a control [as prepared in Example 6] using simple dissolution testing
- Figure 2 shows the percentage of drug compound released v time from a formulation according to the invention [as prepared in Example 2(a)] using dissolution testing with first an acidic and then a neutral dissolution medium
- Methacrylic acid copolymer type C a 6 500
- Example 5 Sustained release formulations of fluconazole (suitable for buccal administration.
- Example 1 The tablets of Examples 1 (a), 1 (b) and 6 were dissolved using Apparatus 1 of USP 22, page 1578, Method 1 (baskets)
- the dissolution fluid was 900ml of water at 37°C
- the rotation speed of the baskets was 100 rpm
- the drug compound released was detected by UV spectroscopy at a wavelength of 246 nm
- the percentage of drug compound released v time for each tablet type is shown in Figure 1
- Example 2(a) The tablets of Example 2(a) were dissolved using Apparatus 1 of USP 22, page 1578, Method 1 (baskets)
- the rotation speed of the baskets was 200 rpm, and the drug compound released was detected by UV spectros- copy at a wavelength of 246 nm
- the percentage of drug compound released v time is shown in Figure 2
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9519364A JPH10513481A (ja) | 1995-11-21 | 1996-11-11 | 医薬製剤 |
KR1019980703777A KR19990071505A (ko) | 1995-11-21 | 1996-11-11 | 약학 제제 |
EP96938215A EP0862437A1 (en) | 1995-11-21 | 1996-11-11 | Pharmaceutical formulations |
NZ322053A NZ322053A (en) | 1995-11-21 | 1996-11-11 | Controlled release pharmaceutical formulation comprising an active, a low MW polyethylene oxide, HPMC and one or more enteric polymers |
PL96326981A PL326981A1 (en) | 1995-11-21 | 1996-11-11 | Pharmaceutic preparations |
SK630-98A SK63098A3 (en) | 1995-11-21 | 1996-11-11 | Controlled-release pharmaceutical formulation, process for its preparation and use of polyethyleneoxide |
HU9903734A HUP9903734A3 (en) | 1995-11-21 | 1996-11-11 | Controlled-release pharmaceutical formulations for oral administration and method for preparing this |
AU75721/96A AU709560B2 (en) | 1995-11-21 | 1996-11-11 | Pharmaceutical formulations |
BR9611626A BR9611626A (pt) | 1995-11-21 | 1996-11-11 | Formulações farmacéuticas |
IS4706A IS4706A (is) | 1995-11-21 | 1998-03-31 | Lyfjasamsetningar |
BG102438A BG102438A (en) | 1995-11-21 | 1998-05-08 | Medicamentous form |
NO982302A NO982302L (no) | 1995-11-21 | 1998-05-20 | Farmas°ytisk sammensetning |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9523752.5 | 1995-11-21 | ||
GBGB9523752.5A GB9523752D0 (en) | 1995-11-21 | 1995-11-21 | Pharmaceutical formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997018814A1 true WO1997018814A1 (en) | 1997-05-29 |
Family
ID=10784188
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1996/005020 WO1997018814A1 (en) | 1995-11-21 | 1996-11-11 | Pharmaceutical formulations |
Country Status (29)
Country | Link |
---|---|
EP (1) | EP0862437A1 (es) |
JP (1) | JPH10513481A (es) |
KR (1) | KR19990071505A (es) |
CN (1) | CN1215993A (es) |
AP (1) | AP718A (es) |
AR (1) | AR004335A1 (es) |
AU (1) | AU709560B2 (es) |
BG (1) | BG102438A (es) |
BR (1) | BR9611626A (es) |
CA (1) | CA2232715A1 (es) |
CO (1) | CO4480020A1 (es) |
CZ (1) | CZ155498A3 (es) |
GB (1) | GB9523752D0 (es) |
HR (1) | HRP960554A2 (es) |
HU (1) | HUP9903734A3 (es) |
IS (1) | IS4706A (es) |
MA (1) | MA26410A1 (es) |
MX (1) | MX9804008A (es) |
NO (1) | NO982302L (es) |
NZ (1) | NZ322053A (es) |
OA (1) | OA10687A (es) |
PE (1) | PE22898A1 (es) |
PL (1) | PL326981A1 (es) |
SK (1) | SK63098A3 (es) |
TN (1) | TNSN96141A1 (es) |
TR (1) | TR199800902T2 (es) |
WO (1) | WO1997018814A1 (es) |
YU (1) | YU62096A (es) |
ZA (1) | ZA969722B (es) |
Cited By (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999030697A2 (en) * | 1997-12-16 | 1999-06-24 | Pfizer Products Inc. | Combination effective for the treatment of impotence |
EP0960621A2 (en) * | 1998-05-15 | 1999-12-01 | Pfizer Inc. | Pharmaceutical formulations comprising sildenafil |
EP0974343A1 (en) * | 1998-07-22 | 2000-01-26 | Pharma Pass LLC | Metoprolol composition and processes for manufacturing the same |
EP0987020A1 (en) * | 1998-09-04 | 2000-03-22 | Pharma Pass LLC | Metoprolol composition and processes for manufacturing the same |
WO2000024383A1 (en) * | 1998-10-23 | 2000-05-04 | Pfizer Research And Development Company, N.V./S.A. | Controlled-release pharmaceutical formulations containing a cgmp pde-5 inhibitor |
US6475521B1 (en) | 1998-03-19 | 2002-11-05 | Bristol-Myers Squibb Co. | Biphasic controlled release delivery system for high solubility pharmaceuticals and method |
EP1293196A2 (en) * | 2001-09-14 | 2003-03-19 | Pharma Pass II LLC | Pharmaceutical composition comprising doxazosin |
US6723340B2 (en) | 2001-10-25 | 2004-04-20 | Depomed, Inc. | Optimal polymer mixtures for gastric retentive tablets |
WO2005037247A2 (en) * | 2003-10-17 | 2005-04-28 | Ranbaxy Laboratories Limited | Oral matrix formulations of doxazosin |
WO2005107702A2 (en) * | 2004-05-11 | 2005-11-17 | Glenmark Pharmaceuticals Limited | Sustained release, mucoadhesive vaginal pharmaceutical compositions |
JP2006298945A (ja) * | 1998-10-14 | 2006-11-02 | Novartis Ag | 徐放性医薬組成物および薬学的活性剤の放出の方法 |
WO2010071320A2 (ko) | 2008-12-17 | 2010-06-24 | 동아제약 주식회사 | 유데나필 함유 서방성 제제를 제조하기 위한 제어방출 조성물 |
US7759368B2 (en) * | 2004-05-28 | 2010-07-20 | Hanmi Pharm. Co., Ltd | Sustained release composition for oral administration of niacin |
WO2010123930A2 (en) | 2009-04-20 | 2010-10-28 | Elcelyx Therapeutics, Inc. | Chemosensory receptor ligand-based therapies |
US20110150989A1 (en) * | 2009-12-22 | 2011-06-23 | Mallinkckrodt Inc. | Methods of Producing Stabilized Solid Dosage Pharmaceutical Compositions Containing Morphinans |
WO2012006398A2 (en) | 2010-07-09 | 2012-01-12 | Bhv Pharma, Inc. | Combination immediate/delayed release delivery system for short half-life pharmaceuticals including remogliflozin |
US8329217B2 (en) | 2001-11-06 | 2012-12-11 | Osmotica Kereskedelmi Es Szolgaltato Kft | Dual controlled release dosage form |
US8333991B2 (en) | 2001-10-25 | 2012-12-18 | Depomed, Inc. | Gastric retained gabapentin dosage form |
US8372432B2 (en) | 2008-03-11 | 2013-02-12 | Depomed, Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
US8377453B2 (en) | 2008-03-11 | 2013-02-19 | Depomed, Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
US8440232B2 (en) | 2001-10-25 | 2013-05-14 | Depomed, Inc. | Methods of treatment using a gastric retained gabapentin dosage |
WO2013158928A2 (en) | 2012-04-18 | 2013-10-24 | Elcelyx Therapeutics, Inc. | Chemosensory receptor ligand-based therapies |
US8592481B2 (en) | 2005-12-29 | 2013-11-26 | Depomed, Inc. | Gastric retentive gabapentin dosage forms and methods for using same |
US8741885B1 (en) | 2011-05-17 | 2014-06-03 | Mallinckrodt Llc | Gastric retentive extended release pharmaceutical compositions |
US8821930B2 (en) | 2006-04-26 | 2014-09-02 | Supernus Pharmaceuticals, Inc. | Modified release preparations containing oxcarbazepine and derivatives thereof |
US8828953B2 (en) | 2009-04-20 | 2014-09-09 | NaZura BioHealth, Inc. | Chemosensory receptor ligand-based therapies |
US8858963B1 (en) | 2011-05-17 | 2014-10-14 | Mallinckrodt Llc | Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia |
US9050335B1 (en) | 2011-05-17 | 2015-06-09 | Mallinckrodt Llc | Pharmaceutical compositions for extended release of oxycodone and acetaminophen resulting in a quick onset and prolonged period of analgesia |
US9198861B2 (en) | 2009-12-22 | 2015-12-01 | Mallinckrodt Llc | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
US9321791B2 (en) | 2002-08-21 | 2016-04-26 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
US9415016B2 (en) | 2008-04-03 | 2016-08-16 | Boehringer Ingelheim International Gmbh | DPP-IV inhibitor combined with a further antidiabetic agent, tablets comprising such formulations, their use and process for their preparation |
US9421178B2 (en) | 2011-12-02 | 2016-08-23 | Synchroneuron, Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
US9457029B2 (en) | 2009-11-27 | 2016-10-04 | Boehringer Ingelheim International Gmbh | Treatment of genotyped diabetic patients with DPP-IV inhibitors such as linagliptin |
US9486526B2 (en) | 2008-08-06 | 2016-11-08 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients inappropriate for metformin therapy |
US9486463B2 (en) | 2010-10-19 | 2016-11-08 | Ambra Bioscience Llc | Chemosensory receptor ligand-based therapies |
US9493462B2 (en) | 2006-05-04 | 2016-11-15 | Boehringer Ingelheim International Gmbh | Polymorphs |
US9499546B2 (en) | 2004-11-05 | 2016-11-22 | Boehringer Ingelheim International Gmbh | Process for the preparation of chiral 8-(3-aminopiperidin-1-yl)-xanthines |
US9526728B2 (en) | 2014-02-28 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Medical use of a DPP-4 inhibitor |
US9526730B2 (en) | 2012-05-14 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Use of a DPP-4 inhibitor in podocytes related disorders and/or nephrotic syndrome |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
US9603851B2 (en) | 2010-05-05 | 2017-03-28 | Boehringer Ingelheim International Gmbh | Combination therapy |
US9713618B2 (en) | 2012-05-24 | 2017-07-25 | Boehringer Ingelheim International Gmbh | Method for modifying food intake and regulating food preference with a DPP-4 inhibitor |
US9901551B2 (en) | 2009-04-20 | 2018-02-27 | Ambra Bioscience Llc | Chemosensory receptor ligand-based therapies |
US20180185291A1 (en) | 2011-03-07 | 2018-07-05 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions |
US10076498B2 (en) | 2006-08-25 | 2018-09-18 | Purdue Pharma L.P. | Tamper resistant dosage forms |
US10080754B2 (en) | 2006-05-04 | 2018-09-25 | Boehringer Ingelheim International Gmbh | Uses of DPP IV inhibitors |
US10155000B2 (en) | 2016-06-10 | 2018-12-18 | Boehringer Ingelheim International Gmbh | Medical use of pharmaceutical combination or composition |
US10166207B2 (en) | 2013-06-05 | 2019-01-01 | Synchroneuron, Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
US10406172B2 (en) | 2009-02-13 | 2019-09-10 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
EP3763419A1 (en) | 2011-01-07 | 2021-01-13 | Anji Pharma (US) LLC | Chemosensory receptor ligand-based therapies |
US11033552B2 (en) | 2006-05-04 | 2021-06-15 | Boehringer Ingelheim International Gmbh | DPP IV inhibitor formulations |
US11911388B2 (en) | 2008-10-16 | 2024-02-27 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral or non-oral antidiabetic drug |
US11911387B2 (en) | 2010-11-15 | 2024-02-27 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100679111B1 (ko) * | 2004-11-20 | 2007-02-07 | 대우약품공업주식회사 | 독사조신을 포함하는 서방성 정제 |
CN102198273A (zh) * | 2005-08-22 | 2011-09-28 | 诺瓦提斯公司 | 包含pH依赖性药物、pH调节剂和阻滞剂的药物组合物 |
CN100396282C (zh) * | 2006-07-25 | 2008-06-25 | 山东省医药工业研究所 | 甲磺酸多沙唑嗪缓释胶囊及制备方法 |
CN102058555A (zh) * | 2011-01-13 | 2011-05-18 | 北京汇诚瑞祥医药技术有限公司 | 一种多沙唑嗪控释片 |
CN102188431A (zh) * | 2011-05-09 | 2011-09-21 | 浙江九旭药业有限公司 | 甲磺酸多沙唑嗪缓释片及其制备方法 |
CN105616378A (zh) * | 2014-10-31 | 2016-06-01 | 康普药业股份有限公司 | 一种氟康唑胶囊及其制备方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2123291A (en) * | 1982-07-06 | 1984-02-01 | Lepetit Spa | Suloctidil compositions |
US4765989A (en) * | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
US4837111A (en) * | 1988-03-21 | 1989-06-06 | Alza Corporation | Dosage form for dispensing drug for human therapy |
WO1992001445A1 (en) * | 1990-07-23 | 1992-02-06 | Alza Corporation | Oral osmotic device for delivering nicotine |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL92966A (en) * | 1989-01-12 | 1995-07-31 | Pfizer | Hydrogel-operated release devices |
-
1995
- 1995-11-21 GB GBGB9523752.5A patent/GB9523752D0/en active Pending
-
1996
- 1996-11-11 PL PL96326981A patent/PL326981A1/xx unknown
- 1996-11-11 TR TR1998/00902T patent/TR199800902T2/xx unknown
- 1996-11-11 HU HU9903734A patent/HUP9903734A3/hu unknown
- 1996-11-11 SK SK630-98A patent/SK63098A3/sk unknown
- 1996-11-11 AU AU75721/96A patent/AU709560B2/en not_active Ceased
- 1996-11-11 NZ NZ322053A patent/NZ322053A/xx unknown
- 1996-11-11 EP EP96938215A patent/EP0862437A1/en not_active Withdrawn
- 1996-11-11 KR KR1019980703777A patent/KR19990071505A/ko not_active Application Discontinuation
- 1996-11-11 JP JP9519364A patent/JPH10513481A/ja active Pending
- 1996-11-11 WO PCT/EP1996/005020 patent/WO1997018814A1/en not_active Application Discontinuation
- 1996-11-11 CZ CZ981554A patent/CZ155498A3/cs unknown
- 1996-11-11 BR BR9611626A patent/BR9611626A/pt not_active Application Discontinuation
- 1996-11-11 CN CN96198486A patent/CN1215993A/zh active Pending
- 1996-11-11 CA CA002232715A patent/CA2232715A1/en not_active Abandoned
- 1996-11-20 PE PE1996000831A patent/PE22898A1/es not_active Application Discontinuation
- 1996-11-20 YU YU62096A patent/YU62096A/sh unknown
- 1996-11-20 MA MA24397A patent/MA26410A1/fr unknown
- 1996-11-20 AR ARP960105252A patent/AR004335A1/es unknown
- 1996-11-20 ZA ZA9609722A patent/ZA969722B/xx unknown
- 1996-11-20 TN TNTNSN96141A patent/TNSN96141A1/fr unknown
- 1996-11-21 HR HR9523752.5A patent/HRP960554A2/hr not_active Application Discontinuation
- 1996-11-21 AP APAP/P/1996/000883A patent/AP718A/en active
- 1996-11-21 CO CO96061449A patent/CO4480020A1/es unknown
-
1998
- 1998-03-31 IS IS4706A patent/IS4706A/is unknown
- 1998-05-08 BG BG102438A patent/BG102438A/xx unknown
- 1998-05-19 OA OA9800058A patent/OA10687A/en unknown
- 1998-05-20 MX MX9804008A patent/MX9804008A/es unknown
- 1998-05-20 NO NO982302A patent/NO982302L/no not_active Application Discontinuation
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2123291A (en) * | 1982-07-06 | 1984-02-01 | Lepetit Spa | Suloctidil compositions |
US4765989A (en) * | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
US4837111A (en) * | 1988-03-21 | 1989-06-06 | Alza Corporation | Dosage form for dispensing drug for human therapy |
WO1992001445A1 (en) * | 1990-07-23 | 1992-02-06 | Alza Corporation | Oral osmotic device for delivering nicotine |
Cited By (120)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999030697A3 (en) * | 1997-12-16 | 1999-08-26 | Pfizer Prod Inc | Combination effective for the treatment of impotence |
WO1999030697A2 (en) * | 1997-12-16 | 1999-06-24 | Pfizer Products Inc. | Combination effective for the treatment of impotence |
US6660300B1 (en) | 1998-03-19 | 2003-12-09 | Bristol-Myers Squibb Co. | Method of use of a biphasic controlled release delivery system for high solubility pharmaceuticals and method |
EP2332522A2 (en) | 1998-03-19 | 2011-06-15 | Bristol-Myers Squibb Company | Biphasic controlled release delivery system for high solubility pharmaceuticals and method |
US6475521B1 (en) | 1998-03-19 | 2002-11-05 | Bristol-Myers Squibb Co. | Biphasic controlled release delivery system for high solubility pharmaceuticals and method |
EP0960621A2 (en) * | 1998-05-15 | 1999-12-01 | Pfizer Inc. | Pharmaceutical formulations comprising sildenafil |
EP0960621A3 (en) * | 1998-05-15 | 2000-01-05 | Pfizer Inc. | Pharmaceutical formulations comprising sildenafil |
SG79255A1 (en) * | 1998-05-15 | 2001-03-20 | Pfizer | Pharmaceutical formulations |
AU753478B2 (en) * | 1998-05-15 | 2002-10-17 | Pfizer Inc. | Pharmaceutical formulations |
EP0974343A1 (en) * | 1998-07-22 | 2000-01-26 | Pharma Pass LLC | Metoprolol composition and processes for manufacturing the same |
EP0987020A1 (en) * | 1998-09-04 | 2000-03-22 | Pharma Pass LLC | Metoprolol composition and processes for manufacturing the same |
JP2006298945A (ja) * | 1998-10-14 | 2006-11-02 | Novartis Ag | 徐放性医薬組成物および薬学的活性剤の放出の方法 |
BG65323B1 (bg) * | 1998-10-23 | 2008-02-29 | Pfizer Research And Development Company, N.V./S.A. | ФАРМАЦЕВТИЧНИ СЪСТАВИ С ПОСТОЯННО ОСВОБОЖДАВАНЕ, СЪДЪРЖАЩИ cGMP PDE-5 ИНХИБИТОР |
US6964780B1 (en) | 1998-10-23 | 2005-11-15 | Pfizer Inc. | Controlled-release pharmaceutical formulations |
WO2000024383A1 (en) * | 1998-10-23 | 2000-05-04 | Pfizer Research And Development Company, N.V./S.A. | Controlled-release pharmaceutical formulations containing a cgmp pde-5 inhibitor |
JP2002528408A (ja) * | 1998-10-23 | 2002-09-03 | ファイザー・インク | cGMPPDE−5阻害剤を含有する制御放出性医薬製剤 |
AU756509B2 (en) * | 1998-10-23 | 2003-01-16 | Pfizer Ireland Pharmaceuticals | Controlled-release pharmaceutical formulations containing a cGMP PDE-5 inhibitor |
EP1293196A3 (en) * | 2001-09-14 | 2004-01-02 | Pharma Pass II LLC | Pharmaceutical composition comprising doxazosin |
EP1293196A2 (en) * | 2001-09-14 | 2003-03-19 | Pharma Pass II LLC | Pharmaceutical composition comprising doxazosin |
EP1446106A4 (en) * | 2001-10-25 | 2006-06-07 | Depomed Inc | OPTIMAL POLYMERGEMIC FOR MAGIC-RESISTANT TABLETS |
US8475813B2 (en) | 2001-10-25 | 2013-07-02 | Depomed, Inc. | Methods of treatment using a gastric retained gabapentin dosage |
US8529955B2 (en) | 2001-10-25 | 2013-09-10 | Depomed, Inc. | Methods of treatment using a gastric retained gabapentin dosage |
US8440232B2 (en) | 2001-10-25 | 2013-05-14 | Depomed, Inc. | Methods of treatment using a gastric retained gabapentin dosage |
US8580303B2 (en) | 2001-10-25 | 2013-11-12 | Depomed, Inc. | Gastric retained gabapentin dosage form |
US8333991B2 (en) | 2001-10-25 | 2012-12-18 | Depomed, Inc. | Gastric retained gabapentin dosage form |
US8802157B2 (en) | 2001-10-25 | 2014-08-12 | Depomed, Inc. | Methods of treatment using a gastric retained gabapentin dosage form |
US8409613B2 (en) | 2001-10-25 | 2013-04-02 | Depomed, Inc. | Gastric retained gabapentin dosage form |
EP1446106A2 (en) * | 2001-10-25 | 2004-08-18 | DepoMed, Inc. | Optimal polymer mixtures for gastric retentive tablets |
EP2260832A2 (en) | 2001-10-25 | 2010-12-15 | DepoMed, Inc. | Optimal polymer mixtures for gastric retentive tablets |
EP2260832A3 (en) * | 2001-10-25 | 2010-12-29 | DepoMed, Inc. | Optimal polymer mixtures for gastric retentive tablets |
US6723340B2 (en) | 2001-10-25 | 2004-04-20 | Depomed, Inc. | Optimal polymer mixtures for gastric retentive tablets |
US8333992B2 (en) | 2001-10-25 | 2012-12-18 | Depomed, Inc. | Gastric retained gabapentin dosage form |
US8329217B2 (en) | 2001-11-06 | 2012-12-11 | Osmotica Kereskedelmi Es Szolgaltato Kft | Dual controlled release dosage form |
US8591947B2 (en) | 2001-11-06 | 2013-11-26 | Osmotica Kereskedelmi és Szolgáltató KFT | Dual controlled release dosage form |
US9556175B2 (en) | 2002-08-21 | 2017-01-31 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and thier use as pharmaceutical compositions |
US10023574B2 (en) | 2002-08-21 | 2018-07-17 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
US9321791B2 (en) | 2002-08-21 | 2016-04-26 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
US10202383B2 (en) | 2002-08-21 | 2019-02-12 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
WO2005037247A2 (en) * | 2003-10-17 | 2005-04-28 | Ranbaxy Laboratories Limited | Oral matrix formulations of doxazosin |
WO2005037247A3 (en) * | 2003-10-17 | 2005-06-30 | Ranbaxy Lab Ltd | Oral matrix formulations of doxazosin |
WO2005107702A2 (en) * | 2004-05-11 | 2005-11-17 | Glenmark Pharmaceuticals Limited | Sustained release, mucoadhesive vaginal pharmaceutical compositions |
WO2005107702A3 (en) * | 2004-05-11 | 2006-10-05 | Glenmark Pharmaceuticals Ltd | Sustained release, mucoadhesive vaginal pharmaceutical compositions |
US7759368B2 (en) * | 2004-05-28 | 2010-07-20 | Hanmi Pharm. Co., Ltd | Sustained release composition for oral administration of niacin |
US9499546B2 (en) | 2004-11-05 | 2016-11-22 | Boehringer Ingelheim International Gmbh | Process for the preparation of chiral 8-(3-aminopiperidin-1-yl)-xanthines |
US9751855B2 (en) | 2004-11-05 | 2017-09-05 | Boehringer Ingelheim International Gmbh | Process for the preparation of chiral 8-(3-aminopiperidin-1-yl)-xanthines |
US8592481B2 (en) | 2005-12-29 | 2013-11-26 | Depomed, Inc. | Gastric retentive gabapentin dosage forms and methods for using same |
US9370525B2 (en) | 2006-04-26 | 2016-06-21 | Supernus Pharmaceuticals, Inc. | Modified release preparations containing oxcarbazepine and derivatives thereof |
US11896599B2 (en) | 2006-04-26 | 2024-02-13 | Supernus Pharmaceuticals, Inc. | Modified release preparations containing oxcarbazepine and derivatives thereof |
US10220042B2 (en) | 2006-04-26 | 2019-03-05 | Supernus Pharmaceuticals, Inc. | Modified release preparations containing oxcarbazepine and derivatives thereof |
US11166960B2 (en) | 2006-04-26 | 2021-11-09 | Supernus Pharmaceuticals, Inc. | Modified release preparations containing oxcarbazepine and derivatives thereof |
US9855278B2 (en) | 2006-04-26 | 2018-01-02 | Supernus Pharmaceuticals, Inc. | Modified release preparations containing oxcarbazepine and derivatives thereof |
US8821930B2 (en) | 2006-04-26 | 2014-09-02 | Supernus Pharmaceuticals, Inc. | Modified release preparations containing oxcarbazepine and derivatives thereof |
US9351975B2 (en) | 2006-04-26 | 2016-05-31 | Supernus Pharmaceuticals, Inc. | Modified release preparations containing oxcarbazepine and derivatives thereof |
US9119792B2 (en) | 2006-04-26 | 2015-09-01 | Supernus Pharmaceuticals, Inc. | Modified release preparations containing oxcarbazepine and derivatives thereof |
US9119791B2 (en) | 2006-04-26 | 2015-09-01 | Supernus Pharmaceuticals, Inc. | Modified release preparations containing oxcarbazepine and derivatives thereof |
US11084819B2 (en) | 2006-05-04 | 2021-08-10 | Boehringer Ingelheim International Gmbh | Polymorphs |
US9493462B2 (en) | 2006-05-04 | 2016-11-15 | Boehringer Ingelheim International Gmbh | Polymorphs |
US11291668B2 (en) | 2006-05-04 | 2022-04-05 | Boehringer Ingelheim International Gmbh | Uses of DPP IV inhibitors |
US10301313B2 (en) | 2006-05-04 | 2019-05-28 | Boehringer Ingelheim International Gmbh | Polymorphs |
US11919903B2 (en) | 2006-05-04 | 2024-03-05 | Boehringer Ingelheim International Gmbh | Polymorphs |
US11033552B2 (en) | 2006-05-04 | 2021-06-15 | Boehringer Ingelheim International Gmbh | DPP IV inhibitor formulations |
US10080754B2 (en) | 2006-05-04 | 2018-09-25 | Boehringer Ingelheim International Gmbh | Uses of DPP IV inhibitors |
US9815837B2 (en) | 2006-05-04 | 2017-11-14 | Boehringer Ingelheim International Gmbh | Polymorphs |
US10076499B2 (en) | 2006-08-25 | 2018-09-18 | Purdue Pharma L.P. | Tamper resistant dosage forms |
US11904055B2 (en) | 2006-08-25 | 2024-02-20 | Purdue Pharma L.P. | Tamper resistant dosage forms |
US11304909B2 (en) | 2006-08-25 | 2022-04-19 | Purdue Pharma L.P. | Tamper resistant dosage forms |
US11964056B1 (en) | 2006-08-25 | 2024-04-23 | Purdue Pharma L.P | Tamper resistant dosage forms |
US11826472B2 (en) | 2006-08-25 | 2023-11-28 | Purdue Pharma L.P. | Tamper resistant dosage forms |
US10076498B2 (en) | 2006-08-25 | 2018-09-18 | Purdue Pharma L.P. | Tamper resistant dosage forms |
US11298322B2 (en) | 2006-08-25 | 2022-04-12 | Purdue Pharma L.P. | Tamper resistant dosage forms |
US11938225B2 (en) | 2006-08-25 | 2024-03-26 | Purdue Pharm L.P. | Tamper resistant dosage forms |
US11304908B2 (en) | 2006-08-25 | 2022-04-19 | Purdue Pharma L.P. | Tamper resistant dosage forms |
US8394408B2 (en) | 2008-03-11 | 2013-03-12 | Depomed, Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
US8668929B2 (en) | 2008-03-11 | 2014-03-11 | Depomed, Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
US8372432B2 (en) | 2008-03-11 | 2013-02-12 | Depomed, Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
US8377453B2 (en) | 2008-03-11 | 2013-02-19 | Depomed, Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
US9415016B2 (en) | 2008-04-03 | 2016-08-16 | Boehringer Ingelheim International Gmbh | DPP-IV inhibitor combined with a further antidiabetic agent, tablets comprising such formulations, their use and process for their preparation |
US10973827B2 (en) | 2008-04-03 | 2021-04-13 | Boehringer Ingelheim International Gmbh | DPP-IV inhibitor combined with a further antidiabetic agent, tablets comprising such formulations, their use and process for their preparation |
US10022379B2 (en) | 2008-04-03 | 2018-07-17 | Boehringer Ingelheim International Gmbh | DPP-IV inhibitor combined with a further antidiabetic agent, tablets comprising such formulations, their use and process for their preparation |
US9486526B2 (en) | 2008-08-06 | 2016-11-08 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients inappropriate for metformin therapy |
US10034877B2 (en) | 2008-08-06 | 2018-07-31 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients inappropriate for metformin therapy |
US11911388B2 (en) | 2008-10-16 | 2024-02-27 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral or non-oral antidiabetic drug |
WO2010071320A2 (ko) | 2008-12-17 | 2010-06-24 | 동아제약 주식회사 | 유데나필 함유 서방성 제제를 제조하기 위한 제어방출 조성물 |
RU2480240C2 (ru) * | 2008-12-17 | 2013-04-27 | Донг-А Фарм.Ко., Лтд. | Композиция с контролируемым высвобождением для производства препарата замедленного высвобождения, содержащего уденафил |
US10406172B2 (en) | 2009-02-13 | 2019-09-10 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
US8828953B2 (en) | 2009-04-20 | 2014-09-09 | NaZura BioHealth, Inc. | Chemosensory receptor ligand-based therapies |
US9901551B2 (en) | 2009-04-20 | 2018-02-27 | Ambra Bioscience Llc | Chemosensory receptor ligand-based therapies |
WO2010123930A2 (en) | 2009-04-20 | 2010-10-28 | Elcelyx Therapeutics, Inc. | Chemosensory receptor ligand-based therapies |
US9457029B2 (en) | 2009-11-27 | 2016-10-04 | Boehringer Ingelheim International Gmbh | Treatment of genotyped diabetic patients with DPP-IV inhibitors such as linagliptin |
US10092571B2 (en) | 2009-11-27 | 2018-10-09 | Boehringer Ingelheim International Gmbh | Treatment of genotyped diabetic patients with DPP-IV inhibitors such as linagliptin |
US9198861B2 (en) | 2009-12-22 | 2015-12-01 | Mallinckrodt Llc | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
US20110150989A1 (en) * | 2009-12-22 | 2011-06-23 | Mallinkckrodt Inc. | Methods of Producing Stabilized Solid Dosage Pharmaceutical Compositions Containing Morphinans |
US9603851B2 (en) | 2010-05-05 | 2017-03-28 | Boehringer Ingelheim International Gmbh | Combination therapy |
US10004747B2 (en) | 2010-05-05 | 2018-06-26 | Boehringer Ingelheim International Gmbh | Combination therapy |
WO2012006398A2 (en) | 2010-07-09 | 2012-01-12 | Bhv Pharma, Inc. | Combination immediate/delayed release delivery system for short half-life pharmaceuticals including remogliflozin |
US9486463B2 (en) | 2010-10-19 | 2016-11-08 | Ambra Bioscience Llc | Chemosensory receptor ligand-based therapies |
US11911387B2 (en) | 2010-11-15 | 2024-02-27 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
EP3763419A1 (en) | 2011-01-07 | 2021-01-13 | Anji Pharma (US) LLC | Chemosensory receptor ligand-based therapies |
US10596120B2 (en) | 2011-03-07 | 2020-03-24 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions |
US20180185291A1 (en) | 2011-03-07 | 2018-07-05 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions |
US11564886B2 (en) | 2011-03-07 | 2023-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions |
US9539328B2 (en) | 2011-05-17 | 2017-01-10 | Mallinckrodt Llc | Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia |
US8741885B1 (en) | 2011-05-17 | 2014-06-03 | Mallinckrodt Llc | Gastric retentive extended release pharmaceutical compositions |
US8858963B1 (en) | 2011-05-17 | 2014-10-14 | Mallinckrodt Llc | Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia |
US9050335B1 (en) | 2011-05-17 | 2015-06-09 | Mallinckrodt Llc | Pharmaceutical compositions for extended release of oxycodone and acetaminophen resulting in a quick onset and prolonged period of analgesia |
US9433582B2 (en) | 2011-05-17 | 2016-09-06 | Mallinckrodt Llc | Gastric retentive extended release pharmaceutical compositions |
US9468636B2 (en) | 2011-05-17 | 2016-10-18 | Mallinckrodt Llc | Combination composition comprising oxycodone and acetaminophen for rapid onset and extended duration of analgesia |
US9629837B2 (en) | 2011-05-17 | 2017-04-25 | Mallinckrodt Llc | Pharmaceutical compositions for extended release of oxycodone and acetaminophen resulting in a quick onset and prolonged period of analgesia |
US9427420B2 (en) | 2011-12-02 | 2016-08-30 | Synchroneuron, Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
US9421179B2 (en) | 2011-12-02 | 2016-08-23 | Synchroneuron, Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
US9421178B2 (en) | 2011-12-02 | 2016-08-23 | Synchroneuron, Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
US10512621B2 (en) | 2011-12-02 | 2019-12-24 | Synchroneuron, Inc. | Methods of treating posttraumatic stress disorder with acamprosate salts |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
WO2013158928A2 (en) | 2012-04-18 | 2013-10-24 | Elcelyx Therapeutics, Inc. | Chemosensory receptor ligand-based therapies |
US9526730B2 (en) | 2012-05-14 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Use of a DPP-4 inhibitor in podocytes related disorders and/or nephrotic syndrome |
US10195203B2 (en) | 2012-05-14 | 2019-02-05 | Boehringr Ingelheim International GmbH | Use of a DPP-4 inhibitor in podocytes related disorders and/or nephrotic syndrome |
US9713618B2 (en) | 2012-05-24 | 2017-07-25 | Boehringer Ingelheim International Gmbh | Method for modifying food intake and regulating food preference with a DPP-4 inhibitor |
US10166207B2 (en) | 2013-06-05 | 2019-01-01 | Synchroneuron, Inc. | Acamprosate formulations, methods of using the same, and combinations comprising the same |
US9526728B2 (en) | 2014-02-28 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Medical use of a DPP-4 inhibitor |
US10155000B2 (en) | 2016-06-10 | 2018-12-18 | Boehringer Ingelheim International Gmbh | Medical use of pharmaceutical combination or composition |
Also Published As
Publication number | Publication date |
---|---|
MX9804008A (es) | 1998-09-30 |
MA26410A1 (fr) | 2004-12-20 |
AU7572196A (en) | 1997-06-11 |
AR004335A1 (es) | 1998-11-04 |
OA10687A (en) | 2002-11-27 |
BR9611626A (pt) | 1999-06-01 |
NZ322053A (en) | 1999-11-29 |
PE22898A1 (es) | 1998-05-07 |
AU709560B2 (en) | 1999-09-02 |
BG102438A (en) | 1999-01-29 |
NO982302L (no) | 1998-07-17 |
CA2232715A1 (en) | 1997-05-29 |
IS4706A (is) | 1998-03-31 |
SK63098A3 (en) | 1999-05-07 |
HRP960554A2 (en) | 1998-02-28 |
ZA969722B (en) | 1998-05-20 |
TNSN96141A1 (fr) | 2005-03-15 |
TR199800902T2 (xx) | 1998-09-21 |
KR19990071505A (ko) | 1999-09-27 |
AP9600883A0 (en) | 1997-01-31 |
HUP9903734A2 (hu) | 2000-03-28 |
EP0862437A1 (en) | 1998-09-09 |
JPH10513481A (ja) | 1998-12-22 |
CO4480020A1 (es) | 1997-07-09 |
PL326981A1 (en) | 1998-11-09 |
HUP9903734A3 (en) | 2000-04-28 |
YU62096A (sh) | 1999-03-04 |
AP718A (en) | 1999-01-06 |
CN1215993A (zh) | 1999-05-05 |
NO982302D0 (no) | 1998-05-20 |
CZ155498A3 (cs) | 1999-03-17 |
GB9523752D0 (en) | 1996-01-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU709560B2 (en) | Pharmaceutical formulations | |
AU736243B2 (en) | Film coated tablet compositions having enhanced disintegration characteristics | |
US5948440A (en) | Modified release matrix formulation of cefaclor and cephalexin | |
AU2003260336C1 (en) | Sustained release formulations comprising lamotrigine | |
NZ542303A (en) | A process for preparing sustained release tablets | |
HU218673B (hu) | Opioid analgetikumot tartalmazó elnyújtott hatóanyag-felszabadítású orális gyógyszerkészítmény és eljárás előállítására | |
ZA200200344B (en) | Method for making granules with masked taste and instant release of the active particle. | |
JPH11505542A (ja) | 毎日一回投与するための、非晶質活性成分の一定のかつ制御された放出を行う三相型医薬製剤 | |
US7163696B2 (en) | Pharmaceutical formulations | |
BG107372A (bg) | Препарати със забавено действие на хинолонови антибиотици и метод за получаването им | |
WO2006103551A1 (en) | Controlled release formulations of oxycodone | |
JP2003508420A (ja) | 経口投与に適した、制御された放出の経口用量 | |
JP2002536318A (ja) | pH非依存延長放出性医薬組成物 | |
WO2008044111A1 (en) | Pharmaceutical formulation tablet | |
WO2011064797A2 (en) | Controlled release pharmaceutical compositions of galantamine | |
JP5826456B2 (ja) | コーティングされていない分離したユニットおよび延長放出マトリクスを含む制御放出配合物 | |
WO2009087663A2 (en) | Oral controlled release coated tablet | |
AU2003267216A1 (en) | Mannitol formulation for integrin receptor antagonist | |
EP1434570B1 (en) | Pharmaceutical formulations for the controlled release of 4-amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline | |
JPH04273816A (ja) | パルス放出型有核錠 | |
US20080206338A1 (en) | Controlled release formulations of an alpha-adrenergic receptor antagonist | |
WO2008050188A2 (en) | Sustained release pharmaceutical compositions of alfuzosin and process for preparation thereof | |
GB2334212A (en) | Modified release matrix formulation for cefaclor and cephalexin | |
JP2707023C (es) | ||
WO2007069061A2 (en) | Controlled release compositions containing zolpidem |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 96198486.4 Country of ref document: CN |
|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AU BG BR BY CA CN CZ HU IL IS JP KR KZ LK LV MX NO NZ PL RO RU SG SI SK TR UA US UZ VN |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN ML MR NE SN TD TG |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 322053 Country of ref document: NZ |
|
ENP | Entry into the national phase |
Ref document number: 2232715 Country of ref document: CA Ref document number: 2232715 Country of ref document: CA Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1996938215 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1199800402 Country of ref document: VN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 63098 Country of ref document: SK |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/1998/004008 Country of ref document: MX Ref document number: PV1998-1554 Country of ref document: CZ Ref document number: 1019980703777 Country of ref document: KR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1998/00902 Country of ref document: TR |
|
WWP | Wipo information: published in national office |
Ref document number: 1996938215 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: PV1998-1554 Country of ref document: CZ |
|
WWP | Wipo information: published in national office |
Ref document number: 1019980703777 Country of ref document: KR |
|
WWR | Wipo information: refused in national office |
Ref document number: PV1998-1554 Country of ref document: CZ |
|
WWR | Wipo information: refused in national office |
Ref document number: 1019980703777 Country of ref document: KR |
|
WWW | Wipo information: withdrawn in national office |
Ref document number: 1996938215 Country of ref document: EP |