WO1996020926A1 - Substituted imides as tnf inhibitors - Google Patents
Substituted imides as tnf inhibitors Download PDFInfo
- Publication number
- WO1996020926A1 WO1996020926A1 PCT/US1995/015384 US9515384W WO9620926A1 WO 1996020926 A1 WO1996020926 A1 WO 1996020926A1 US 9515384 W US9515384 W US 9515384W WO 9620926 A1 WO9620926 A1 WO 9620926A1
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- WO
- WIPO (PCT)
- Prior art keywords
- carbon atoms
- alkyl
- substituted
- amino
- grams
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 18
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 17
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 16
- 125000001424 substituent group Chemical group 0.000 claims description 15
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 14
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
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-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2003-7016455A KR20040007729A (ko) | 1994-12-30 | 1995-11-20 | Ｔｎｆ 저해제로 사용되는 치환된 이미드 |
| JP52098696A JP4118329B2 (ja) | 1994-12-30 | 1995-11-20 | Ｔｎｆ阻害剤としての置換イミド類 |
| SK868-97A SK86897A3 (en) | 1994-12-30 | 1995-11-20 | Substituted imides compounds as tnf-alpha inhibitors, pharmaceutical composition and use such compounds |
| PL95321065A PL185361B1 (pl) | 1994-12-30 | 1995-11-20 | N-podstawione związki ftalimidowe jako inhibitory TNF |
| NZ297324A NZ297324A (en) | 1994-12-30 | 1995-11-20 | Substituted phthalimido or 1-oxo-isoindolinyl derivatives and medicaments as TNF alpha inhibitors |
| EP95940847A EP0800514B1 (en) | 1994-12-30 | 1995-11-20 | Substituted imides as tnf inhibitors |
| AU42463/96A AU709719B2 (en) | 1994-12-30 | 1995-11-20 | Substituted imides as TNF inhibitors |
| CA002208671A CA2208671C (en) | 1994-12-30 | 1995-11-20 | Substituted imides as tnf inhibitors |
| CZ972036A CZ203697A3 (en) | 1994-12-30 | 1995-11-20 | Substituted imide compounds functioning as tnf inhibitors, pharmaceutical composition containing thereof and the use of such compounds |
| DE69535195T DE69535195T2 (de) | 1994-12-30 | 1995-11-20 | Substituierte imide als tnf inhibitoren |
| FI972709A FI972709A (fi) | 1994-12-30 | 1997-06-23 | Substituoituja imideja TNF-inhibiittoreina |
| HK98101231A HK1004674A1 (en) | 1994-12-30 | 1998-02-17 | Substituted imides as tnf inhibitors |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/366,679 | 1994-12-30 | ||
| US08/366,679 US6429221B1 (en) | 1994-12-30 | 1994-12-30 | Substituted imides |
Publications (2)
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| WO1996020926A1 true WO1996020926A1 (en) | 1996-07-11 |
| WO1996020926A9 WO1996020926A9 (en) | 1996-09-26 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1995/015384 WO1996020926A1 (en) | 1994-12-30 | 1995-11-20 | Substituted imides as tnf inhibitors |
Country Status (20)
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| EP1468991A1 (en) * | 1995-12-26 | 2004-10-20 | Celgene Corporation | Imides as PDE III, PDE IV and TNF inhibitors |
| EP0818439A2 (en) * | 1996-07-02 | 1998-01-14 | Nisshin Flour Milling Co., Ltd. | Imide derivatives |
| EP0818439A3 (en) * | 1996-07-02 | 1998-01-28 | Nisshin Flour Milling Co., Ltd. | Imide derivatives |
| US5847123A (en) * | 1996-07-02 | 1998-12-08 | Nisshin Flour Milling Co., Ltd. | Imide derivatives for inhibiting the production of interleukin-1β and the production of tumor necrosis factor α |
| US6130226A (en) * | 1996-08-12 | 2000-10-10 | Celgene Corporation | Immunotherapeutic agents |
| WO1998006692A1 (en) * | 1996-08-12 | 1998-02-19 | Celgene Corporation | Novel immunotherapeutic agents and their use in the reduction of cytokine levels |
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| US6262101B1 (en) | 1996-08-12 | 2001-07-17 | Celgene Corporation | Immunotherapeutic agents |
| US6515129B1 (en) | 1996-08-16 | 2003-02-04 | Ishihara Sangyo Kaisha Ltd. | Pharmaceutical composition |
| US6429212B1 (en) * | 1996-08-16 | 2002-08-06 | Ishihara Sangyo Kaisha Ltd. | Medicinal composition |
| WO1998007421A1 (fr) * | 1996-08-16 | 1998-02-26 | Ishihara Sangyo Kaisha, Ltd. | Composition medicinale |
| CN100372836C (zh) * | 1996-12-03 | 2008-03-05 | 赛尔金有限公司 | 新的免疫治疗剂亚酰胺/酰胺类 |
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| EP0933360A1 (en) * | 1997-12-22 | 1999-08-04 | Pharmachemie B.V. | Synthesis of new beta-lactams |
| US6225463B1 (en) | 1997-12-22 | 2001-05-01 | Pharmachemie B.V. | Synthesis of new β-lactams |
| WO1999053944A1 (es) * | 1998-04-17 | 1999-10-28 | Universidad Complutense De Madrid Rectorado | Metodo para el tratamiento del 'shock' endotoxico en mamiferos |
| ES2138561A1 (es) * | 1998-04-17 | 2000-01-01 | Univ Madrid Complutense | Uno de los peptidos vip pacap en el tratamiento del abock endotoxico en mamiferos. |
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Also Published As
| Publication number | Publication date |
|---|---|
| KR100466838B1 (ko) | 2005-09-02 |
| AU4246396A (en) | 1996-07-24 |
| JP4118329B2 (ja) | 2008-07-16 |
| DE69535195D1 (de) | 2006-10-05 |
| FI972709A (fi) | 1997-08-29 |
| PT800514E (pt) | 2006-12-29 |
| FI972709A0 (fi) | 1997-06-23 |
| CZ203697A3 (en) | 1997-11-12 |
| RU2162078C2 (ru) | 2001-01-20 |
| CA2208671C (en) | 2009-02-10 |
| CA2208671A1 (en) | 1996-07-11 |
| ES2271948T3 (es) | 2007-04-16 |
| AU709719B2 (en) | 1999-09-02 |
| US20020143027A1 (en) | 2002-10-03 |
| US7329761B2 (en) | 2008-02-12 |
| EP0800514A1 (en) | 1997-10-15 |
| NZ297324A (en) | 2000-03-27 |
| EP0800514B1 (en) | 2006-08-23 |
| PL185361B1 (pl) | 2003-04-30 |
| DE69535195T2 (de) | 2007-07-12 |
| HK1004674A1 (en) | 1998-12-04 |
| US6429221B1 (en) | 2002-08-06 |
| KR980700968A (ko) | 1998-04-30 |
| ATE337301T1 (de) | 2006-09-15 |
| US6844359B2 (en) | 2005-01-18 |
| HUT77124A (hu) | 1998-03-02 |
| KR20040007729A (ko) | 2004-01-24 |
| DK0800514T3 (da) | 2006-12-27 |
| JPH10511946A (ja) | 1998-11-17 |
| US20050090516A1 (en) | 2005-04-28 |
| SK86897A3 (en) | 1998-01-14 |
| PL321065A1 (en) | 1997-11-24 |
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