WO1996013512B1 - Nucleosides de l-ribofuranosyle - Google Patents

Nucleosides de l-ribofuranosyle

Info

Publication number
WO1996013512B1
WO1996013512B1 PCT/US1995/013716 US9513716W WO9613512B1 WO 1996013512 B1 WO1996013512 B1 WO 1996013512B1 US 9513716 W US9513716 W US 9513716W WO 9613512 B1 WO9613512 B1 WO 9613512B1
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
carbon atoms
substituted
compound
base
Prior art date
Application number
PCT/US1995/013716
Other languages
English (en)
Other versions
WO1996013512A3 (fr
WO1996013512A2 (fr
Filing date
Publication date
Priority claimed from US08/328,304 external-priority patent/US5559101A/en
Application filed filed Critical
Priority to CA 2203672 priority Critical patent/CA2203672A1/fr
Priority to EP95938871A priority patent/EP0788506A2/fr
Priority to MX9702932A priority patent/MX9702932A/es
Priority to JP8514695A priority patent/JPH10507772A/ja
Publication of WO1996013512A2 publication Critical patent/WO1996013512A2/fr
Publication of WO1996013512A3 publication Critical patent/WO1996013512A3/fr
Publication of WO1996013512B1 publication Critical patent/WO1996013512B1/fr

Links

Abstract

L'invention concerne des nucléosides de α et β-L-ribofuranosyle, des procédés servant à les préparer, des compositions pharmaceutiques les contenant et des procédés servant à les utiliser, afin de traiter différentes maladies chez les mammifères.
PCT/US1995/013716 1994-10-24 1995-10-24 Nucleosides de l-ribofuranosyle WO1996013512A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA 2203672 CA2203672A1 (fr) 1994-10-24 1995-10-24 Nucleosides de l-ribofuranosyle
EP95938871A EP0788506A2 (fr) 1994-10-24 1995-10-24 Nucleosides de l-ribofuranosyle
MX9702932A MX9702932A (es) 1994-10-24 1995-10-24 L-ribofuranosilnucleosidos.
JP8514695A JPH10507772A (ja) 1994-10-24 1995-10-24 Ｌ−リボフラノシルヌクレオシド

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/328,304 US5559101A (en) 1994-10-24 1994-10-24 L-ribofuranosyl nucleosides
US08/328,304 1994-10-24

Publications (3)

Publication Number Publication Date
WO1996013512A2 WO1996013512A2 (fr) 1996-05-09
WO1996013512A3 WO1996013512A3 (fr) 1997-02-06
WO1996013512B1 true WO1996013512B1 (fr) 1997-03-27

Family

ID=23280423

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/013716 WO1996013512A2 (fr) 1994-10-24 1995-10-24 Nucleosides de l-ribofuranosyle

Country Status (5)

Country Link
US (1) US5559101A (fr)
EP (1) EP0788506A2 (fr)
JP (1) JPH10507772A (fr)
MX (1) MX9702932A (fr)
WO (1) WO1996013512A2 (fr)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020120130A1 (en) * 1993-09-10 2002-08-29 Gilles Gosselin 2' or 3' -deoxy and 2', 3' -dideoxy-beta-L-pentofuranonucleo-side compounds, method of preparation and application in therapy, especially as anti- viral agents
US6025335A (en) * 1995-09-21 2000-02-15 Lipitek International, Inc. L-Nucleoside Dimer Compounds and therapeutic uses
EP1072607A3 (fr) * 1996-10-16 2001-09-12 ICN Pharmaceuticals, Inc. Analogues de nucléosides-L-purine et leurs utilisations
EP1302474A1 (fr) * 1996-10-16 2003-04-16 Ribapharm, Inc. L-nucléosides monocycliques, analogues et leurs utilisations
DE69729887T2 (de) * 1996-10-16 2005-07-28 ICN Pharmaceuticals, Inc., Costa Mesa Purin-L-Nukleoside, Analoga und deren Verwendung
SI20076A (sl) * 1996-10-16 2000-04-30 Icn Pharmaceuticals, Inc. Monociklični L-nukleozidi, analogi in uporaba od teh
US6509320B1 (en) * 1996-10-16 2003-01-21 Icn Pharmaceuticals, Inc. Purine L-nucleosides, analogs and uses thereof
US6090602A (en) * 1998-02-18 2000-07-18 Promelas Research Corporation Levo-monosaccharide in a nucleoside analog for use as an anti-retroviral agent
JP2002506036A (ja) * 1998-03-11 2002-02-26 リピテック インターナショナル， インコーポレイテッド 疾患を処置するにおける新規ヌクレオシドアナログおよびその使用
US6444652B1 (en) * 1998-08-10 2002-09-03 Novirio Pharmaceuticals Limited β-L-2'-deoxy-nucleosides for the treatment of hepatitis B
CN101120947B (zh) * 1998-08-10 2010-11-24 艾丹尼克斯(开曼)有限公司 用于治疗乙型肝炎的β-L-2′-脱氧-核苷
DK1104436T3 (da) * 1998-08-10 2006-04-03 Centre Nat Rech Scient Beta-L-2'-deoxy-nukleosider til behandling af hepatitis B-virus
AU2004201286B2 (en) * 1998-08-10 2007-06-21 Centre National De La Recherche Scientifique (Cnrs) Beta-L-2'-Deoxy Nucleosides for the Treatment of Hepatitis B
AU2011211428B2 (en) * 1998-08-10 2013-02-07 Centre National De La Recherche Scientifique Beta-L-2'-Deoxy Nucleosides for the treatment of Hepatitis B
AU2007216721B2 (en) * 1998-08-10 2011-05-19 Centre National De La Recherche Scientifique Beta-L-2'-Deoxy Nucleosides for the Treatment of Hepatitis B
CA2348470C (fr) 1998-11-05 2007-06-05 Centre National De La Recherche Scientifique Nucleosides possedant une activite dirigee contre le virus de l'hepatite b
US6407077B1 (en) 1998-11-05 2002-06-18 Emory University β-L nucleosides for the treatment of HIV infection
DE60033927T2 (de) * 1999-05-04 2007-11-29 Santaris Pharma A/S L-ribo-lna analoge
EP1600451A3 (fr) * 1999-11-12 2008-09-10 Pharmasset, Inc. Synthèse de 2'-déoxy-L-nucléosides
IL149592A0 (en) * 1999-11-12 2002-11-10 Pharmasset Ltd Synthesis of 2'-deoxy-l-nucleosides
KR100385281B1 (ko) * 2000-02-15 2003-05-23 이승기 새로운 세포 주기 조절 인자 억제제
US6822089B1 (en) * 2000-03-29 2004-11-23 Isis Pharmaceuticals, Inc. Preparation of deoxynucleosides
US6787526B1 (en) 2000-05-26 2004-09-07 Idenix Pharmaceuticals, Inc. Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
MY141594A (en) * 2000-06-15 2010-05-14 Novirio Pharmaceuticals Ltd 3'-PRODRUGS OF 2'-DEOXY-ß-L-NUCLEOSIDES
US6875751B2 (en) * 2000-06-15 2005-04-05 Idenix Pharmaceuticals, Inc. 3′-prodrugs of 2′-deoxy-β-L-nucleosides
CN101250194B (zh) * 2000-11-29 2011-05-04 三井化学株式会社 L-核酸衍生物及其合成方法
CN102241720B (zh) * 2000-11-29 2014-01-29 三井化学株式会社 L-核酸衍生物及其合成方法
AU2002351077A1 (en) * 2001-11-05 2003-05-19 Exiqon A/S Oligonucleotides modified with novel alpha-l-rna analogues
EP1569658A4 (fr) 2001-12-20 2007-05-30 Pharmassett Ltd Traitement du virus d'epstein-barr, infection a l'herpesvirus lie au sarcome de kaposi et proliferation cellulaire anormale associee
SE521676C2 (sv) * 2002-01-02 2003-11-25 Dilafor Ab Användning av glykosaminoglykaner för prevention och behandling av värksvaghet vid fullgången graviditet
TWI244393B (en) * 2002-08-06 2005-12-01 Idenix Pharmaceuticals Inc Crystalline and amorphous forms of beta-L-2'-deoxythymidine
KR100855907B1 (ko) * 2002-09-13 2008-09-02 노파르티스 아게 내성 ＨＢＶ 균주 치료용 β-Ｌ-2'-데옥시뉴클레오시드 및병용 요법
CN101415719A (zh) 2003-03-20 2009-04-22 微生物化学及药品有限公司 生产2’-脱氧-β-L-核苷的方法
CN1812995A (zh) * 2003-04-28 2006-08-02 艾登尼科斯（开曼）有限公司 工业化规模的核苷合成
EP2345659A1 (fr) 2003-05-30 2011-07-20 Pharmasset, Inc. Analogues de nucléosides fluores modifiés
EP1639121A4 (fr) 2003-06-30 2008-04-16 Idenix Cayman Ltd Synthese de nucleosides beta l-2-desoxy
WO2005037214A2 (fr) 2003-10-14 2005-04-28 Intermune, Inc. Acylsulfonamides et acides carboxyliques macrocycliques utilises en tant qu'inhibiteurs de la replication du virus de l'hepatite c
GB0400290D0 (en) 2004-01-08 2004-02-11 Medivir Ab dUTPase inhibitors
CN101023094B (zh) 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
EP1809301B1 (fr) 2004-09-14 2019-11-06 Gilead Pharmasset LLC Intermédiaires de d-ribonolactone à substitution 2-fluoro-2-alkyl
BRPI0613796A2 (pt) 2005-06-07 2011-02-15 Univ Yale composicões farmacêuticas e seus usos, e métodos de tratamento de cáncer e outras condições ou estados patológicos, por meio do uso de clevudina (lfmau) e telbivudina (ldt)
CN108969767A (zh) * 2005-06-07 2018-12-11 耶鲁大学 使用克来夫定和替比夫定治疗癌症和其它病症或疾病状态的方法
US7951788B2 (en) 2005-12-02 2011-05-31 Yale University Method of treating cancer and other conditions or disease states using L-cytosine nucleoside analogs
EP2054076A2 (fr) * 2006-08-21 2009-05-06 United Therapeutics Corporation Polytherapie destinée a traiter des infections virales
WO2010039801A2 (fr) 2008-10-02 2010-04-08 The J. David Gladstone Institutes Méthodes de traitement d’une infection par le virus de l’hépatite c
EP2408449A4 (fr) 2009-03-18 2012-08-08 Univ Leland Stanford Junior Méthodes et compositions pour traiter l'infection par un virus de la famille des flaviviridae
JP5663576B2 (ja) * 2010-07-06 2015-02-04 上西　秀則 神経突起伸長剤
CN102649788B (zh) * 2011-02-28 2015-03-25 四川大学 β-L-2’-脱氧-胸腺嘧啶核苷衍生物及其制备方法和用途

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1620185C3 (de) * 1966-03-02 1982-01-14 Robugen Gmbh Pharmazeutische Fabrik Esslingen A.N., 7300 Esslingen 5-Äthyl- und 5-Propyl-2'-deoxyuridin, Verfahren zur Herstellung dieser Verbindungen und diese Verbindungen enthaltende Arzneimittel
US3457255A (en) * 1967-05-17 1969-07-22 Syntex Corp Novel ribo and lyxo nucleoside derivatives and a process for their preparation
CS164401B1 (en) * 1971-10-07 1975-11-07 Jiri Beranek Method of 1-beta-d-arabinofuranosylcytosine's preparation
US3817982A (en) * 1971-12-29 1974-06-18 Syntex Inc 2{40 ,3{40 -unsaturated nucleosides and method of making
CA1135258A (fr) * 1979-06-15 1982-11-09 Richard D'souza Procede d'obtention de 5'-desoxy-5- fluorouridine
FR2528311B1 (fr) * 1982-06-14 1985-06-14 Synthelabo Compositions pharmaceutiques a base de xylosides et lyxosides de bases puriques et pyrimidiques
CA1285935C (fr) * 1985-03-16 1991-07-09 Janet Lister Rideout Nucleosides therapeutiques
ES8801303A1 (es) * 1985-05-15 1987-12-16 Wellcome Found Un procedimiento para preparar una formulacion farmaceutica que contiene un 2'3'-didesoxi-nucleosido.
SE8602981D0 (sv) * 1986-07-04 1986-07-04 Astra Laekemedel Ab Novel medicinal use
KR960001372B1 (ko) * 1986-09-24 1996-01-26 예일 유니버시티 레트로비루스로 감염된 환자의 치료에 사용되는 2',3'-디디옥시사이티딘-2'-엔(2',3'-디디옥시-2',3'-디디하이드로사이티딘)의 항생물질
US4918056A (en) * 1986-10-14 1990-04-17 Health Research, Inc. (Roswell Park Division) 2-substituted arabinopyranosyl nucleosides and nucleotides
US4880782A (en) * 1986-11-21 1989-11-14 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V. Method of treating viral infections in humans and compositions therefor
SE8605503D0 (sv) * 1986-12-19 1986-12-19 Astra Laekemedel Ab Novel medicinal use
EP0285884A3 (fr) * 1987-03-20 1990-07-04 Bristol-Myers Squibb Company Procédé pour la préparation de nucléosides 2',3'-didéoxy
SE8704298D0 (sv) * 1987-11-03 1987-11-03 Astra Ab Compounds for use in therapy
SE8802687D0 (sv) * 1988-07-20 1988-07-20 Astra Ab Nucleoside derivatives
DE3900964A1 (de) * 1989-01-14 1990-07-19 Boehringer Mannheim Gmbh Neue nukleoside, verfahren zu deren herstellung sowie arzneimittel, die diese verbindungen enthalten
DD296281A5 (de) * 1990-07-01 1991-11-28 Akademie Der Wissenschaften Der Ddr,De Verfahren zur herstellung von neuen purinnukleosiden
SE9003151D0 (sv) * 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
IT1246983B (it) * 1990-11-13 1994-12-12 Consiglio Nazionale Ricerche L-2'-desossiuridine e composizioni farmaceutiche che le contengono.
WO1993003733A1 (fr) * 1991-08-12 1993-03-04 Basco, Ltd. Synthese, composition pharmaceutique et procede d'application d'analogues de (2'-5') oligoadenylate
US5627160A (en) * 1993-05-25 1997-05-06 Yale University L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents
FR2709754B1 (fr) * 1993-09-10 1995-12-01 Centre Nat Rech Scient Composés 2' ou 3'-déoxy- et 2', 3'-didéoxy-beta-L-pentofuranonucléosides, procédé de préparation et application thérapeutique, notamment anti-virale.

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