WO1995026961A1 - Procede de preparation d'hydroxy-7 taxanes - Google Patents

Procede de preparation d'hydroxy-7 taxanes Download PDF

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Publication number
WO1995026961A1
WO1995026961A1 PCT/FR1995/000420 FR9500420W WO9526961A1 WO 1995026961 A1 WO1995026961 A1 WO 1995026961A1 FR 9500420 W FR9500420 W FR 9500420W WO 9526961 A1 WO9526961 A1 WO 9526961A1
Authority
WO
WIPO (PCT)
Prior art keywords
carbon atoms
radical
radicals
alkyl
atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/FR1995/000420
Other languages
English (en)
French (fr)
Inventor
Jean-Pierre Bastart
Jean-Dominique Bourzat
Alain Commerçon
Jean-Pierre Leconte
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Rhone Poulenc Rorer SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GEAP19953432A priority Critical patent/GEP19991535B/en
Priority to US08/722,106 priority patent/US5750738A/en
Priority to JP7525467A priority patent/JPH09511245A/ja
Priority to KR1019960705643A priority patent/KR970702269A/ko
Priority to SK1264-96A priority patent/SK281075B6/sk
Priority to EP95916697A priority patent/EP0754181B1/fr
Priority to NZ284491A priority patent/NZ284491A/en
Priority to BR9507443A priority patent/BR9507443A/pt
Priority to DK95916697T priority patent/DK0754181T3/da
Priority to EE9600141A priority patent/EE03239B1/xx
Priority to DE69503366T priority patent/DE69503366T2/de
Priority to AU23097/95A priority patent/AU691916B2/en
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Priority to UA96093733A priority patent/UA45332C2/uk
Priority to RO96-01922A priority patent/RO115727B1/ro
Priority to PL95316589A priority patent/PL316589A1/xx
Publication of WO1995026961A1 publication Critical patent/WO1995026961A1/fr
Priority to NO19964104A priority patent/NO314145B1/no
Priority to MXPA/A/1996/004465A priority patent/MXPA96004465A/xx
Priority to BG100887A priority patent/BG62731B1/bg
Priority to FI964002A priority patent/FI964002A0/fi
Anticipated expiration legal-status Critical
Priority to LVP-96-393A priority patent/LV11685B/lv
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Definitions

  • Rj represents a hydrogen atom or an alkoxy radical containing 1 to 4 carbon atoms, alkoxyacetoxy in which the alkyl part contains 1 to 4 carbon atoms or alkanoyloxy containing 1 to 4 atoms of carbon
  • Z represents a hydrogen atom or a radical of general formula:
  • the suspension thus obtained is stirred for 4 hours at 20 ° C and then filtered.
  • the filtrate is washed with 2 times 500 cm 3 of a semi-saturated aqueous solution of sodium hydrogencarbonate, 2 times 500 cm 3 of distilled water and 2 times 500 cm 3 of a saturated aqueous solution of sodium chloride.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
PCT/FR1995/000420 1994-04-05 1995-04-03 Procede de preparation d'hydroxy-7 taxanes Ceased WO1995026961A1 (fr)

Priority Applications (20)

Application Number Priority Date Filing Date Title
DE69503366T DE69503366T2 (de) 1994-04-05 1995-04-03 Verfahren zu herstellung von 7-hydroxy taxane
JP7525467A JPH09511245A (ja) 1994-04-05 1995-04-03 ７−ヒドロキシタキサンの製造法
KR1019960705643A KR970702269A (ko) 1994-04-05 1995-04-03 7-하이드록시 택산의 제조 방법(process for the preparation of 7-hydroxytaxanes)
SK1264-96A SK281075B6 (sk) 1994-04-05 1995-04-03 Spôsob prípravy 7-hydroxytaxánov
EP95916697A EP0754181B1 (fr) 1994-04-05 1995-04-03 Procede de preparation d'hydroxy-7 taxanes
US08/722,106 US5750738A (en) 1994-04-05 1995-04-03 Process for the preparation of 7-hydroxytaxanes
BR9507443A BR9507443A (pt) 1994-04-05 1995-04-03 Processo de preparação de hidroxi 7 taxanos
DK95916697T DK0754181T3 (da) 1994-04-05 1995-04-03 Fremgangsmåde til fremstilling af 7-hydroxytaxaner
EE9600141A EE03239B1 (et) 1994-04-05 1995-04-03 7-hüdroksütaksaani valmistamise meetod
AU23097/95A AU691916B2 (en) 1994-04-05 1995-04-03 Process for the preparation of 7-hydroxy taxanes
NZ284491A NZ284491A (en) 1994-04-05 1995-04-03 Preparation of 7-hydroxy taxane derivatives
GEAP19953432A GEP19991535B (en) 1994-04-05 1995-04-03 Process for the Preparation of 7-Hydroxy Taxanes
UA96093733A UA45332C2 (uk) 1994-04-05 1995-04-03 Спосіб одержання 7-гідрокси-таксанів
RO96-01922A RO115727B1 (ro) 1994-04-05 1995-04-03 Procedeu de preparare a 7-hidroxitaxanilor
PL95316589A PL316589A1 (en) 1994-04-05 1995-04-03 Method of obtaining 7-hydroxytaxanes
NO19964104A NO314145B1 (no) 1994-04-05 1996-09-27 Fremgangsmåte for fremstilling av 7-hydroksy-taxaner
MXPA/A/1996/004465A MXPA96004465A (en) 1994-04-05 1996-09-30 Procedure for preparation of 7-hydroxy-taxa
BG100887A BG62731B1 (bg) 1994-04-05 1996-10-04 Метод за получаване на 7-хидрокситаксани
FI964002A FI964002A0 (fi) 1994-04-05 1996-10-04 Menetelmä 7-hydroksitaksaanien valmistamiseksi
LVP-96-393A LV11685B (en) 1994-04-05 1996-10-07 Process for the preparation of 7-hydroxy taxanes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9403980A FR2718135B1 (fr) 1994-04-05 1994-04-05 Procédé de préparation d'hydroxy-7 taxanes.
FR94/03980 1994-04-05

Publications (1)

Publication Number Publication Date
WO1995026961A1 true WO1995026961A1 (fr) 1995-10-12

Family

ID=9461748

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1995/000420 Ceased WO1995026961A1 (fr) 1994-04-05 1995-04-03 Procede de preparation d'hydroxy-7 taxanes

Country Status (31)

Country Link
US (1) US5750738A (https=)
EP (1) EP0754181B1 (https=)
JP (1) JPH09511245A (https=)
KR (1) KR970702269A (https=)
CN (1) CN1066144C (https=)
AT (1) ATE168109T1 (https=)
AU (1) AU691916B2 (https=)
BG (1) BG62731B1 (https=)
BR (1) BR9507443A (https=)
CA (1) CA2186917A1 (https=)
CZ (1) CZ284725B6 (https=)
DE (1) DE69503366T2 (https=)
DK (1) DK0754181T3 (https=)
EE (1) EE03239B1 (https=)
ES (1) ES2118592T3 (https=)
FI (1) FI964002A0 (https=)
FR (1) FR2718135B1 (https=)
GE (1) GEP19991535B (https=)
HU (1) HU214157B (https=)
LT (1) LT4186B (https=)
LV (1) LV11685B (https=)
NO (1) NO314145B1 (https=)
NZ (1) NZ284491A (https=)
PL (1) PL316589A1 (https=)
RO (1) RO115727B1 (https=)
RU (1) RU2127730C1 (https=)
SK (1) SK281075B6 (https=)
TW (1) TW285669B (https=)
UA (1) UA45332C2 (https=)
WO (1) WO1995026961A1 (https=)
ZA (1) ZA952732B (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6127555A (en) * 1996-07-09 2000-10-03 Aventis Pharma S.A. Taxane hydroxy monoacylation method
WO2011060206A2 (en) 2009-11-13 2011-05-19 U3 Pharma Gmbh Material and methods for treating or preventing her-3 associated diseases
WO2012018404A2 (en) 2010-08-06 2012-02-09 U3 Pharma Gmbh Use of her3 binding agents in prostate treatment

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2732968B1 (fr) * 1995-04-14 1997-05-16 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
HK1042302B (en) * 1999-05-17 2004-10-08 Bristol-Myers Squibb Company Novel reaction conditions for the cleavage of silyl ethers in the preparation of paclitaxel (taxol) and paclitaxel analogues
AU775373B2 (en) 1999-10-01 2004-07-29 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0336840A1 (fr) * 1988-04-06 1989-10-11 Centre National De La Recherche Scientifique (Cnrs) Procédé de préparation du taxol

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2678930B1 (fr) * 1991-07-10 1995-01-13 Rhone Poulenc Rorer Sa Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0336840A1 (fr) * 1988-04-06 1989-10-11 Centre National De La Recherche Scientifique (Cnrs) Procédé de préparation du taxol

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6127555A (en) * 1996-07-09 2000-10-03 Aventis Pharma S.A. Taxane hydroxy monoacylation method
WO2011060206A2 (en) 2009-11-13 2011-05-19 U3 Pharma Gmbh Material and methods for treating or preventing her-3 associated diseases
EP2719708A2 (en) 2009-11-13 2014-04-16 U3 Pharma GmbH Material and methods for treating or preventing HER-3 associated diseases
EP2896632A2 (en) 2009-11-13 2015-07-22 U3 Pharma GmbH Material and methods for treating or preventing HER-3 associated diseases
EP3351558A2 (en) 2009-11-13 2018-07-25 Daiichi Sankyo Europe GmbH Material and methods for treating or preventing her-3 associated diseases
EP3670539A1 (en) 2009-11-13 2020-06-24 Daiichi Sankyo Europe GmbH Material and methods for treating or preventing her-3 associated diseases
WO2012018404A2 (en) 2010-08-06 2012-02-09 U3 Pharma Gmbh Use of her3 binding agents in prostate treatment

Also Published As

Publication number Publication date
JPH09511245A (ja) 1997-11-11
LT96138A (en) 1997-02-25
NO964104L (no) 1996-09-27
PL316589A1 (en) 1997-01-20
LT4186B (en) 1997-07-25
FI964002A7 (fi) 1996-10-04
CZ284725B6 (cs) 1999-02-17
GEP19991535B (en) 1999-03-05
ES2118592T3 (es) 1998-09-16
BG100887A (en) 1998-01-30
SK126496A3 (en) 1997-05-07
HU9602736D0 (en) 1996-11-28
DK0754181T3 (da) 1998-11-16
MX9604465A (es) 1997-07-31
ZA952732B (en) 1996-01-09
CN1066144C (zh) 2001-05-23
EP0754181B1 (fr) 1998-07-08
BR9507443A (pt) 1997-09-16
KR970702269A (ko) 1997-05-13
FR2718135A1 (fr) 1995-10-06
ATE168109T1 (de) 1998-07-15
LV11685A (lv) 1997-02-20
UA45332C2 (uk) 2002-04-15
FI964002A0 (fi) 1996-10-04
US5750738A (en) 1998-05-12
HU214157B (hu) 1998-01-28
CN1145070A (zh) 1997-03-12
EP0754181A1 (fr) 1997-01-22
LV11685B (en) 1997-06-20
NZ284491A (en) 1998-01-26
FR2718135B1 (fr) 1996-04-26
TW285669B (https=) 1996-09-11
CA2186917A1 (fr) 1995-10-12
NO964104D0 (no) 1996-09-27
AU2309795A (en) 1995-10-23
AU691916B2 (en) 1998-05-28
RO115727B1 (ro) 2000-05-30
HUT75690A (en) 1997-05-28
NO314145B1 (no) 2003-02-03
CZ289996A3 (en) 1997-01-15
RU2127730C1 (ru) 1999-03-20
DE69503366D1 (de) 1998-08-13
SK281075B6 (sk) 2000-11-07
DE69503366T2 (de) 1999-01-21
BG62731B1 (bg) 2000-06-30
EE03239B1 (et) 1999-12-15

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