WO1995019922A1 - Emballage thermoforme - Google Patents

Emballage thermoforme Download PDF

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Publication number
WO1995019922A1
WO1995019922A1 PCT/EP1994/004335 EP9404335W WO9519922A1 WO 1995019922 A1 WO1995019922 A1 WO 1995019922A1 EP 9404335 W EP9404335 W EP 9404335W WO 9519922 A1 WO9519922 A1 WO 9519922A1
Authority
WO
WIPO (PCT)
Prior art keywords
pack according
film
cover film
blister pack
layer
Prior art date
Application number
PCT/EP1994/004335
Other languages
German (de)
English (en)
Inventor
Horst Von Borries
Jozef Verplaetse
Original Assignee
Ingenieurbüro Von Borries
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ingenieurbüro Von Borries filed Critical Ingenieurbüro Von Borries
Publication of WO1995019922A1 publication Critical patent/WO1995019922A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2575/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D2575/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by association or interconnecting two or more sheets or blanks
    • B65D2575/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D2575/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D2575/3209—Details
    • B65D2575/3218—Details with special means for gaining access to the contents
    • B65D2575/3227—Cuts or weakening lines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2585/00—Containers, packaging elements or packages specially adapted for particular articles or materials
    • B65D2585/56—Containers, packaging elements or packages specially adapted for particular articles or materials for medicinal tablets or pills

Definitions

  • the invention relates to a push-through pack for small parts, in particular a push-through pack for medicaments such as tablets, dragees, capsules, suppositories or medical aids, such as injection needles, which consists of a base film with deep-drawn troughs for holding the small parts, which has a cover film in the area of the individual Troughs separating webs are connected.
  • medicaments such as tablets, dragees, capsules, suppositories or medical aids, such as injection needles
  • EP 543775 AI also relates to a pure blister pack. With this packaging, the top film has weaknesses or separations that have been introduced mechanically or chemically. The top film is mechanically
  • the cover material is preferably separated through its entire thickness, the severing or weakening being in the region of the sealing seam.
  • the Cover film does not only have to be subjected to a special treatment; afterwards it must also be ensured that the dividing or weakening lines fall exactly in the area of the weld seams, because otherwise the packs are not closed properly.
  • a package can also be found in DE-Ul 9103973, in which the bottom and top films consist of the same plastic.
  • This packaging is a blister pack in which the base film is advantageously provided with perforations.
  • WO 84-01556 describes a packaging which consists of two webs which are sealed against one another, at least one of which is a laminate which consists of one layer of tear-resistant material, for example polyester film, and a second layer of easily penetrable material, for example aluminum foil . Perforations or continuous cuts are made in the tear-resistant layer, which are covered by the penetrable layer. The slits or perforations must be introduced into the cover film before they are lacquered. An additional work step is also required for this.
  • AT-PS 188271 describes a collective packaging which has weakening lines produced by separation welding for easier separation of the individual packs.
  • the lines of weakness have approximately the same shape as the outline of the portion pack, the line of weakness advantageously running such that a tongue is formed for tearing open. To ensure that the individual packs can be released easily and safely, the lines of weakness are arranged around each individual pack.
  • DE-A1 4113714 proposes to create predetermined breaking points by irradiation with laser beams, at which the package can be opened, that is to say can possibly be pierced.
  • the radiation is very complex and also requires additional safety precautions. It is unsuitable for packaging small parts that often change in size.
  • the invention is therefore based on the object of creating a push-through packaging for small parts which can be produced inexpensively without additional effort and can be easily disposed of, ie reprocessed.
  • this task is solved by the characterizing features of the main claim.
  • thermoformable, elastic polymer as the base film with a cover film made of a brittle, thermostable polymer ensures that the cover film can be easily pierced.
  • the puncturing is generally possible with the packaged goods, for example a tablet. It is also ensured that the same plastics can be used, the disposal and thus the reuse of the raw material is ensured.
  • the elastic polymer of the base film is expediently an unstretched polyolefin, preferably an unstretched polypropylene.
  • the brittle polymer of the cover film is advantageously a stretched polyolefin, expediently a monaxially stretched polyolefin, in particular a polypropylene.
  • the sealable layer can expediently have been applied as a lacquer; for better environmental compatibility, it should preferably have been applied from a dispersion in order to avoid solvents and their vapors during production.
  • the dispersion consists of contains as a layering agent, expediently polyvinylidene chloride, acrylic resin or polyvinyl alcohol, and water as a carrier medium.
  • a preferred embodiment of the invention provides before that the sealable layer was coextruded. This embodiment of the invention saves one work step, the coating, and also eliminates the energy-consuming drying process.
  • the coextruded layer that is to say the sealing layer, is preferably a propylene copolymer.
  • the thickness of the base film is expediently between 80 ⁇ m and 1000 ⁇ m, in particular between 150 ⁇ m and 400 ⁇ m; the thickness of the cover film between 20 ⁇ m and 100 ⁇ m, in particular between 25 ⁇ m and 50 ⁇ m.
  • the sealing layer advantageously has a thickness of 1 ⁇ m to 3 ⁇ m.
  • the invention provides that the bottom and / or cover film is provided with a barrier layer.
  • the barrier layer advantageously consists of a polyvinylidene chloride (PVDC), a polyvinyl alcohol (PVOH) or an ethyl vinyl alcohol (EVOH).
  • the thickness of the barrier layer is expediently between 0.1. ⁇ m and 20 ⁇ m.
  • the cover is deformed by the seal in the area of the webs.
  • the deformation is advantageously a point and / or line-by-line weakening of the cover film in the sealing area. It was expediently carried out by profiled sealing jaws.
  • the depth of penetration of the sealing bar profile is preferably 20 to 80% of the thickness of the cover film.
  • the sealing profile is advantageously a line or point profile. At least one sealing jaw is processed accordingly, e.g. milled out. The welding is therefore still essentially flat, which is necessary for the strength and tightness of the pack, but at the same time it enables the packaged small part to be easily pushed through the weakened cover film.
  • the distance between the individual line or point rows or the diamond rows is between 0.5 and 1.5 mm. This ensures that the package is both tight and easy to open.
  • a preferred method for producing corresponding push-through packs provides that the base film is covered with a brittle, multilayer cover film and is sealed in the region of the webs separating the troughs by means of a profiled sealing jaw. It is essential that the profiled sealing jaw deforms the lid film of the pack. An additional deformation of the base film is possible, but does not bring any significant advantage due to its greater thickness.
  • the profile jaws in the area of the webs expediently emboss a line, point or diamond pattern into the cover film, but it can also extend over the entire trough covered with the cover film without the package being damaged thereby. In practice, however, the weakened area will only extend slightly inward beyond the trough, since the area outside the webs lacks the necessary back pressure for the jaw.
  • the rows of lines or dots preferably run essentially parallel to the orientation direction of the cover film.
  • Push-through packs for tablets were manufactured on a Uhlmann model and packing machine, model UPS 200, the individual tablet packs having a size of 90 by 40 mm.
  • this pack there were 10 deep-drawn round troughs with a diameter of 15 mm, at a depth of 8 mm, the tablets had a height of 5 mm, so that 2 tablets could be packed in a well.
  • the web width between the troughs was 2 mm at the narrowest point.
  • An unstretched polypropylene film with a thickness of 250 ⁇ m was used as the base film
  • Roll width was 200 mm, the roll length 200 m. 2 packs could be accommodated on a roll width.
  • the machine speed was 100 packs / min, the mold temperature for the base film was 200 degrees C.
  • the wells were deep-drawn using compressed air of 3.5 bar.
  • the cover film was passed over the base film with the filled depressions, pressed on and sealed with the base film in the region of the webs.
  • the sealing temperature was 150 degrees C
  • the sealing time was 0.5 seconds.
  • An oriented polypropylene film which had a thickness of 30 ⁇ m and was provided on one side with a sealing layer on the side facing the bottom film was used as the cover film.
  • the layer had been produced by painting on one side of the cover film. This film is under the name Rayopp RGP from UCB Packaging Ltd. to acquire.
  • the layer thickness was 2 ⁇ m.
  • the ribs of the sealing jaw penetrated 10 ⁇ m into the cover film, whereby this, starting from the web area, was weakened in the direction of the inner surface of the troughs. Because of this weakening, the tablets were easy to push through. After the first tablet had been removed from a well, there was still an unstable closure of the well, so that the second tablet which was still in it was held in its position by the perforated cover film.
  • Example 2 Push-through packs for capsules were produced on a Uhlann model UPS 200 model automatic packaging machine, the individual capsule packs having a size of 90 by 40 mm. In this pack there were 10 deep-drawn oval troughs with a length of 15 mm and a width of 10 mm, with a depth of 8 mm. The capsules had a height of 5 mm, so that 2 capsules could be packed in one well. The web width between the troughs was 2 mm at the narrowest point. An unstretched polypropylene film with a thickness of 250 ⁇ m was used as the base film, the roll width was 200 mm, the roll length was 200 m. Two packs could be accommodated on one roll width. The machine speed was 100 packs / min, the mold temperature for the bottom sheet was 200 degrees C. The work was carried out with compressed air of 3.5 bar.
  • the cover sheet was passed over the base sheet with the filled depressions, pressed on and sealed with the base sheet in the area of the webs.
  • the sealing temperature was 150 degrees C
  • the sealing time was 0.5 seconds.
  • a coextruded, biaxially stretched polypropylene film was used as the cover film, which had a propylene / ethylene copolymer layer on one side as the sealing layer.
  • the total thickness was 30 ⁇ m.
  • the copolymer layer was arranged on the side facing the base film. This film is available from UCB Transpac under the name Rayopp RGP.
  • the ribs of the sealing jaw penetrated 12 ⁇ m into the cover film, as a result of which, proceeding from the web area, in the direction of the inner surface of the Troughs has been weakened. Because of this weakening, the capsules were easy to push through. After the first capsule had been removed from a well, there was still an unstable closure of the well, so that the second capsule, which was still in it, was held in its position by the perforated cover film.
  • Push-through packs for tablets were manufactured on a Uhlmann model and packing machine, model UPS 200, whereby the individual tablet packs had a size of 90 by 40 mm. There were 10 deep-drawn round troughs with a diameter of 15 in this pack mm, at a depth of 4 mm, the tablets had a height of 5 mm, so that 1 tablet could be packed in a well.
  • the web width between the troughs was 2 mm at the narrowest point.
  • An unstretched polypropylene film with a thickness of 250 ⁇ m was used as the base film, the roll width was 200 mm, the roll length 200 m. Two packs could be accommodated on a roll width.
  • the machine speed was 100 packs / min, the mold temperature for the base sheet was 200 degrees C.
  • the pressure was 3.5 bar.
  • the cover film was passed over the base film with the filled depressions, pressed on and sealed with the base film in the region of the webs.
  • the sealing temperature was 150 degrees C
  • the sealing time was 0.5 seconds.
  • An oriented polypropylene film was used as the lid film, which had a thickness of 30 ⁇ m and had one side - on the side facing the bottom film - with a Sealing layer was provided.
  • a barrier layer - barrier layer - was applied. The layer was applied to one side of the lidding film by evaporation using the PVD method. A metal, aluminum, was used as the evaporation material. This film can be obtained under the name Propafoil VG met 30 from Imperial Chemical Industrie (ICI).
  • the layer thickness of the barrier layer was 0.03-0.04 ⁇ m.
  • the ribs of the sealing jaw penetrated 10 ⁇ m into the cover film, whereby this, starting from the web area, was weakened in the direction of the inner surface of the troughs. Because of this weakening, the tablets were easy to push through.
  • Push-through packs for button cells were manufactured on a Uhlmann model and packing machine, model UPS 200, the individual packs being 90 by 20 mm in size. In this pack there were 12 deep-drawn round troughs with a diameter of 5 mm, at a depth of 4.5 mm. The button cells had a height of 5 mm, so that 1 cell could be packed in each well. The web width between the troughs was 5 mm at the narrowest point. An unstretched polypropylene film with a thickness of 250 ⁇ m was used as the base film, the roll width was 200 mm, the roll length 200 m. Two packs could be accommodated on a roll width. The machine speed was 100 packs / min, the molding temperature for the base film 200 degrees C. Working with compressed air of 3.5 bar.
  • the cover film was passed over the base film with the filled depressions, pressed on and sealed with the base film in the region of the webs.
  • the sealing temperature was 150 degrees C
  • the sealing time was 0.5 seconds.
  • An oriented polypropylene film which had a thickness of 30 ⁇ m and was provided on one side with a sealing layer on the side facing the bottom film was used as the cover film.
  • a barrier layer - barrier layer - was present.
  • the layer was applied to one side of the cover film by vapor deposition using the CVD method.
  • the metal used as the vapor deposition material was aluminum, which was converted into aluminum oxide during the application. This film is available from Toyo Inc. under the designation GT-10000 N.
  • the layer thickness of the sealing layer was 2 ⁇ m, that of the barrier layer 0.05 ⁇ m.
  • the ribs of the sealing jaw penetrated 15 ⁇ m into the cover film, whereby this, starting from the web area, was weakened in the direction of the inner surface of the depressions. Because of this weakening, the tablets were easy to push through.
  • Press-through packs for tablets were produced on a Uhlmann model and packing machine, model UPS 200, whereby the individual tablet packs had a size of 90 by 40 mm. There were 10 deep-drawn round troughs with a diameter of 15 in this pack mm, at a depth of 4 mm. The tablets had a height of 5 mm, so that 1 tablet could be packed in a well. The footbridge width between the troughs was 2 mm at the narrowest point. An unstretched polypropylene film with a thickness of 250 ⁇ m was used as the base film, the roll width was 200 mm, the roll length 200 m. 2 packs could be accommodated on a roll width. The machine speed was 100 packs / min, the mold temperature for the base film was 200 degrees C. The pressure was 3.5 bar.
  • the cover film was passed over the base film with the filled depressions, pressed on and sealed with the base film in the region of the webs.
  • the sealing temperature was 150 degrees C
  • the sealing time was 0.5 seconds.
  • An oriented polypropylene film which had a thickness of 30 ⁇ m and was provided on one side with a sealing layer on the side facing the bottom film was used as the cover film.
  • a barrier layer - barrier layer - was present.
  • the layer was applied to one side of the cover film by vapor deposition using the CVD method. Silicon was used as the vapor deposition material, which was converted into silicon oxide during the deposition. This film is under the name Camclear from Camvac Ltd. UK related.
  • the layer thickness of the sealing layer was 2 ⁇ m, that of the barrier layer 0.03 ⁇ m.
  • FIG. 1 shows in perspective representation
  • FIGS. 2, 3 and 4 Schematic diagram of a tablet filling and packaging system FIGS. 2, 3 and 4 in section, the side view through a trough area of the package FIG. 5 the top view of an individual sealed one
  • Button cells Figure 8 as a side view in section of a Phillips screwdriver insert in the
  • cover film 1 and the bottom film 4 are fed from unrolling devices, not shown, to a packaging device 14, in which the bottom film 4 is deep-drawn under the influence of heat by means of compressed air, as a result of which the troughs 3 are formed Cover film 1 passed over the base film 4 and sealed in the area of the webs 2 and the edge area 15 of the pack 16.
  • one tablet 10 - as shown in Figure 2 - is in a trough 3, but as shown in Figure 3, several, e.g.

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  • Chemical & Material Sciences (AREA)
  • Composite Materials (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Packages (AREA)

Abstract

Un emballage thermoformé pour petits objets, notamment pour médicaments sous forme de comprimés (10), de dragées, de capsules (11), de suppositoires ou d'accessoires tels qu'aiguilles d'injection (12), comprend une feuille de fond (4) avec des évidements (3) emboutis profond pour recevoir les petits objets. La feuille de fond est reliée à une feuille de couverture (1) dans la zone des parties jointives (2) qui séparent les différents évidements (3). La feuille de fond (4) est constituée d'un polymère élastique susceptible d'être embouti profond et la feuille de couverture (1) est constituée d'une pellicule composite en un polymère thermostable vitreux, pourvue au moins d'un côté d'une couche scellable (6).
PCT/EP1994/004335 1994-01-25 1994-12-29 Emballage thermoforme WO1995019922A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4402038.4 1994-01-25
DE19944402038 DE4402038A1 (de) 1994-01-25 1994-01-25 Durchdrückpackung

Publications (1)

Publication Number Publication Date
WO1995019922A1 true WO1995019922A1 (fr) 1995-07-27

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ID=6508602

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1994/004335 WO1995019922A1 (fr) 1994-01-25 1994-12-29 Emballage thermoforme

Country Status (2)

Country Link
DE (1) DE4402038A1 (fr)
WO (1) WO1995019922A1 (fr)

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US8871444B2 (en) 2004-10-08 2014-10-28 Medical Research Council In vitro evolution in microfluidic systems
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US9017623B2 (en) 2007-02-06 2015-04-28 Raindance Technologies, Inc. Manipulation of fluids and reactions in microfluidic systems
US9068699B2 (en) 2007-04-19 2015-06-30 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
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US9150852B2 (en) 2011-02-18 2015-10-06 Raindance Technologies, Inc. Compositions and methods for molecular labeling
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US9448172B2 (en) 2003-03-31 2016-09-20 Medical Research Council Selection by compartmentalised screening
US9498759B2 (en) 2004-10-12 2016-11-22 President And Fellows Of Harvard College Compartmentalized screening by microfluidic control
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US9839890B2 (en) 2004-03-31 2017-12-12 National Science Foundation Compartmentalised combinatorial chemistry by microfluidic control
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US11174509B2 (en) 2013-12-12 2021-11-16 Bio-Rad Laboratories, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
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US11268887B2 (en) 2009-03-23 2022-03-08 Bio-Rad Laboratories, Inc. Manipulation of microfluidic droplets
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JP6301064B2 (ja) 2013-03-21 2018-03-28 東洋アルミニウム株式会社 プレススルーパックの蓋材およびプレススルーパック包装体
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