WO1990012607A1 - Antithrombotic blood treating system - Google Patents

Antithrombotic blood treating system Download PDF

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Publication number
WO1990012607A1
WO1990012607A1 PCT/JP1990/000536 JP9000536W WO9012607A1 WO 1990012607 A1 WO1990012607 A1 WO 1990012607A1 JP 9000536 W JP9000536 W JP 9000536W WO 9012607 A1 WO9012607 A1 WO 9012607A1
Authority
WO
WIPO (PCT)
Prior art keywords
antithrombotic
blood
treating system
polyethylene oxide
contacting surface
Prior art date
Application number
PCT/JP1990/000536
Other languages
English (en)
French (fr)
Inventor
Ryozo Terada
Kazumi Tanaka
Tetsunosuke Kunitomo
Original Assignee
Toray Industries, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Industries, Inc. filed Critical Toray Industries, Inc.
Priority to JP2506366A priority Critical patent/JP2926984B2/ja
Priority to EP90906364A priority patent/EP0423369B1/en
Priority to KR1019900702662A priority patent/KR920700048A/ko
Priority to DE69013457T priority patent/DE69013457T2/de
Publication of WO1990012607A1 publication Critical patent/WO1990012607A1/ja

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/76—Macromolecular material not specifically provided for in a single one of groups B01D71/08 - B01D71/74
    • B01D71/82—Macromolecular material not specifically provided for in a single one of groups B01D71/08 - B01D71/74 characterised by the presence of specified groups, e.g. introduced by chemical after-treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/068—Use of macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3672—Means preventing coagulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3672—Means preventing coagulation
    • A61M1/3673—Anticoagulant coating, e.g. Heparin coating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/021—Manufacturing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/02—Hollow fibre modules
    • B01D63/021—Manufacturing thereof
    • B01D63/0233—Manufacturing thereof forming the bundle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/08—Hollow fibre membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/30—Polyalkenyl halides
    • B01D71/301—Polyvinylchloride
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/40—Polymers of unsaturated acids or derivatives thereof, e.g. salts, amides, imides, nitriles, anhydrides, esters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/40—Polymers of unsaturated acids or derivatives thereof, e.g. salts, amides, imides, nitriles, anhydrides, esters
    • B01D71/401—Polymers based on the polymerisation of acrylic acid, e.g. polyacrylate
    • B01D71/4011—Polymethylmethacrylate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/52—Polyethers
    • B01D71/521—Aliphatic polyethers
    • B01D71/5211—Polyethylene glycol or polyethyleneoxide
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/76—Macromolecular material not specifically provided for in a single one of groups B01D71/08 - B01D71/74
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/04—Liquids
    • A61M2202/0413—Blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/02—General characteristics of the apparatus characterised by a particular materials
    • A61M2205/0238—General characteristics of the apparatus characterised by a particular materials the material being a coating or protective layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/13—Specific connectors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/30—Polyalkenyl halides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D71/00—Semi-permeable membranes for separation processes or apparatus characterised by the material; Manufacturing processes specially adapted therefor
    • B01D71/06—Organic material
    • B01D71/52—Polyethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Manufacturing & Machinery (AREA)
  • Materials For Medical Uses (AREA)
  • External Artificial Organs (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PCT/JP1990/000536 1989-04-25 1990-04-25 Antithrombotic blood treating system WO1990012607A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2506366A JP2926984B2 (ja) 1989-04-25 1990-04-25 抗血栓性血液処理システム
EP90906364A EP0423369B1 (en) 1989-04-25 1990-04-25 Antithrombotic blood treating system
KR1019900702662A KR920700048A (ko) 1989-04-25 1990-04-25 항혈전성 혈액처리 시스템
DE69013457T DE69013457T2 (de) 1989-04-25 1990-04-25 Antithrombotisches blutbehandlungssystem.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10619689 1989-04-25
JP1/106196 1989-04-25

Publications (1)

Publication Number Publication Date
WO1990012607A1 true WO1990012607A1 (en) 1990-11-01

Family

ID=14427423

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1990/000536 WO1990012607A1 (en) 1989-04-25 1990-04-25 Antithrombotic blood treating system

Country Status (7)

Country Link
US (1) US5254249A (ja)
EP (1) EP0423369B1 (ja)
KR (1) KR920700048A (ja)
AT (1) ATE112967T1 (ja)
DE (1) DE69013457T2 (ja)
ES (1) ES2061030T3 (ja)
WO (1) WO1990012607A1 (ja)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5182317A (en) * 1988-06-08 1993-01-26 Cardiopulmonics, Inc. Multifunctional thrombo-resistant coatings and methods of manufacture
US5945457A (en) * 1997-10-01 1999-08-31 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science Process for preparing biologically compatible polymers and their use in medical devices
JP2002534223A (ja) * 1999-01-12 2002-10-15 ガンブロ、インコーポレイテッド 連続腎臓代償療法における熱損失補償
JP2004008693A (ja) * 2002-06-11 2004-01-15 Toyobo Co Ltd 血液適合性血液浄化システム
JP2005074149A (ja) * 2003-09-03 2005-03-24 Porien Project Kk 流体管路用接続装置
JP2006124714A (ja) * 1992-09-29 2006-05-18 Toray Ind Inc 耐汚染性材料および耐汚染性半透膜
WO2017154527A1 (ja) * 2016-03-08 2017-09-14 テルモ株式会社 医療用具
JP2018057852A (ja) * 2016-09-30 2018-04-12 東レ株式会社 血液処理装置

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5338770A (en) * 1988-06-08 1994-08-16 Cardiopulmonics, Inc. Gas permeable thrombo-resistant coatings and methods of manufacture
EP0773805A1 (en) * 1993-02-18 1997-05-21 Baxter International Inc. Apheresis system incorporating alternative site for anticoagulant addition
SE502222C2 (sv) * 1994-01-17 1995-09-18 Althin Medical Ab Sätt vid dialys
EP0952168A4 (en) * 1996-07-16 2000-05-24 Toray Industries GRAFT POLYMERS AND THEIR USE IN MEDICAL APPARATUS
US5891196A (en) * 1997-04-16 1999-04-06 Baxter International Inc. Method for actively binding heparin to crosslinked biological tissues
US5955353A (en) * 1997-05-22 1999-09-21 Excorp Medical, Inc. Hollow fiber bioreactor with an extrafilament flow plug
JP3940546B2 (ja) 1999-06-07 2007-07-04 株式会社東芝 パターン形成方法およびパターン形成材料
JP4404445B2 (ja) * 2000-05-17 2010-01-27 テルモ株式会社 血液フィルターおよび血液フィルターの製造方法
US20050045554A1 (en) * 2003-08-28 2005-03-03 Gambro Lundia Ab Membrane unit element, semipermeable membrane, filtration device, and processes for manufacturing the same
CN105979910B (zh) * 2014-02-12 2018-05-18 东丽株式会社 人工血管
US20160045932A1 (en) * 2014-08-18 2016-02-18 Fenwal, Inc. Anti-Thrombogenic Porous Membranes And Methods For Manufacturing Such Membranes
US11672898B2 (en) 2018-06-08 2023-06-13 Oregon State University Microfluidic removal of excess bilirubin from blood
US20210346580A1 (en) * 2020-05-11 2021-11-11 Qisda Corporation Hemodialyzer and hemodialysis system

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS565542B2 (ja) * 1973-05-31 1981-02-05
JPS5714358A (en) * 1980-07-02 1982-01-25 Toray Industries Antithrombus medical material
JPS5778862A (en) * 1980-11-04 1982-05-17 Kogyo Gijutsuin Blood pump having antithrombus property
JPS585320A (ja) * 1981-07-01 1983-01-12 Toray Ind Inc グラフト共重合体
JPS5897367A (ja) * 1981-12-02 1983-06-09 ベクトン・デイツキンソン・アンド・カンパニ− 一段式凝固防止コ−テイング
JPS63220878A (ja) * 1987-03-09 1988-09-14 住友ベークライト株式会社 抗凝血性医用成形体の製造方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3673612A (en) * 1970-08-28 1972-07-04 Massachusetts Inst Technology Non-thrombogenic materials and methods for their preparation
US3844989A (en) * 1971-12-23 1974-10-29 Toray Industries Shampooer with rotary foam generating means anti-thrombogenic polymer compositions with internally bound heparin
US4269712A (en) * 1979-05-14 1981-05-26 Cordis Dow Corp. Hollow fiber separatory element and method of making same
US4425234A (en) * 1979-07-30 1984-01-10 Hospal Ltd. Hollow fiber separatory device
DE3071275D1 (en) * 1980-09-01 1986-01-16 Teijin Ltd Heparin derivative, its production and methods for imparting antithrombotic activity to biomedical materials
JPS6022901A (ja) * 1983-07-05 1985-02-05 Toray Ind Inc 選択透過性中空繊維
SE444950B (sv) * 1984-09-28 1986-05-20 Ytkemiska Inst Ytbelagd artikel, forfarande och medel for framstellning derav samt anvendning derav
SE443584B (sv) * 1985-03-07 1986-03-03 Gambro Dialysatoren Sett att framstella en semipermeabel halfiber
WO1986007541A1 (en) * 1985-06-19 1986-12-31 Yasushi Zyo Composition which can impart antithrombotic ability and medical apparatus to be in contact with blood
US4871357A (en) * 1986-01-21 1989-10-03 Baxter International Inc. Ionic heparin coating
JP2510540B2 (ja) * 1986-11-19 1996-06-26 東レ株式会社 ポリアクリロニトリル系半透膜及びその製造法
DE3777128D1 (de) * 1986-12-25 1992-04-09 Sumitomo Electric Industries Verfahren zur herstellung eines medizinischen vinylchloridharzmaterials.
US4906465A (en) * 1987-10-19 1990-03-06 Massachusetts Institute Of Technology Antithrombogenic devices containing polysiloxanes
NL8800577A (nl) * 1988-03-08 1989-10-02 Stichting Tech Wetenschapp Werkwijze voor het aanbrengen van een bloedcompatibele bekleding op polyetherurethaanvormstukken.
US4888109A (en) * 1988-11-17 1989-12-19 Manohar Namala L Hemofilter for use in a continuous arterio-venous hemofiltration

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS565542B2 (ja) * 1973-05-31 1981-02-05
JPS5714358A (en) * 1980-07-02 1982-01-25 Toray Industries Antithrombus medical material
JPS5778862A (en) * 1980-11-04 1982-05-17 Kogyo Gijutsuin Blood pump having antithrombus property
JPS585320A (ja) * 1981-07-01 1983-01-12 Toray Ind Inc グラフト共重合体
JPS5897367A (ja) * 1981-12-02 1983-06-09 ベクトン・デイツキンソン・アンド・カンパニ− 一段式凝固防止コ−テイング
JPS63220878A (ja) * 1987-03-09 1988-09-14 住友ベークライト株式会社 抗凝血性医用成形体の製造方法

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5182317A (en) * 1988-06-08 1993-01-26 Cardiopulmonics, Inc. Multifunctional thrombo-resistant coatings and methods of manufacture
JP2006124714A (ja) * 1992-09-29 2006-05-18 Toray Ind Inc 耐汚染性材料および耐汚染性半透膜
US5945457A (en) * 1997-10-01 1999-08-31 A.V. Topchiev Institute Of Petrochemical Synthesis, Russian Academy Of Science Process for preparing biologically compatible polymers and their use in medical devices
JP2002534223A (ja) * 1999-01-12 2002-10-15 ガンブロ、インコーポレイテッド 連続腎臓代償療法における熱損失補償
JP2004008693A (ja) * 2002-06-11 2004-01-15 Toyobo Co Ltd 血液適合性血液浄化システム
JP2005074149A (ja) * 2003-09-03 2005-03-24 Porien Project Kk 流体管路用接続装置
WO2017154527A1 (ja) * 2016-03-08 2017-09-14 テルモ株式会社 医療用具
JPWO2017154527A1 (ja) * 2016-03-08 2019-01-17 テルモ株式会社 医療用具
EP3427788A4 (en) * 2016-03-08 2019-11-27 Terumo Kabushiki Kaisha MEDICAL INSTRUMENT
US10751521B2 (en) 2016-03-08 2020-08-25 Terumo Kabushiki Kaisha Medical instrument
JP2018057852A (ja) * 2016-09-30 2018-04-12 東レ株式会社 血液処理装置
JP7242167B2 (ja) 2016-09-30 2023-03-20 東レ株式会社 血液処理装置

Also Published As

Publication number Publication date
EP0423369B1 (en) 1994-10-19
EP0423369A4 (en) 1991-10-02
DE69013457T2 (de) 1995-02-23
DE69013457D1 (de) 1994-11-24
ATE112967T1 (de) 1994-11-15
KR920700048A (ko) 1992-02-19
EP0423369A1 (en) 1991-04-24
US5254249A (en) 1993-10-19
ES2061030T3 (es) 1994-12-01

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