WO1986003751A3 - Purification, production et utilisation de facteurs necrotiques tumoraux - Google Patents
Purification, production et utilisation de facteurs necrotiques tumorauxInfo
- Publication number
- WO1986003751A3 WO1986003751A3 PCT/EP1985/000721 EP8500721W WO8603751A3 WO 1986003751 A3 WO1986003751 A3 WO 1986003751A3 EP 8500721 W EP8500721 W EP 8500721W WO 8603751 A3 WO8603751 A3 WO 8603751A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- tnf
- polypeptides
- tumor necrosis
- necrosis factors
- tnfs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP61500550A JP2557053B2 (ja) | 1984-12-21 | 1985-12-19 | 腫瘍壊死因子の精製、製造および使用法 |
DE8686900138T DE3585690D1 (de) | 1984-12-21 | 1985-12-19 | Reinigung, herstellung und verwendung von tumor-nekrosisfaktoren. |
AT86900138T ATE73856T1 (de) | 1984-12-21 | 1985-12-19 | Reinigung, herstellung und verwendung von tumor- nekrosisfaktoren. |
DK399786A DK399786D0 (da) | 1984-12-21 | 1986-08-21 | Rensning, fremstilling og anvendelse af tumornekrosefaktorer |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68459584A | 1984-12-21 | 1984-12-21 | |
US684,595 | 1984-12-21 | ||
US785,847 | 1985-10-05 | ||
US78584785A | 1985-10-09 | 1985-10-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1986003751A2 WO1986003751A2 (fr) | 1986-07-03 |
WO1986003751A3 true WO1986003751A3 (fr) | 1986-08-14 |
Family
ID=27103367
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1985/000721 WO1986003751A2 (fr) | 1984-12-21 | 1985-12-19 | Purification, production et utilisation de facteurs necrotiques tumoraux |
Country Status (16)
Country | Link |
---|---|
US (1) | US5487984A (fr) |
EP (3) | EP0216786B1 (fr) |
JP (4) | JP2557053B2 (fr) |
KR (1) | KR940010865B1 (fr) |
AT (1) | ATE73856T1 (fr) |
AU (2) | AU601675B2 (fr) |
DE (1) | DE3585690D1 (fr) |
DK (1) | DK399786D0 (fr) |
ES (1) | ES8705521A1 (fr) |
FI (1) | FI86194C (fr) |
HU (1) | HUT40702A (fr) |
IE (1) | IE58709B1 (fr) |
NO (1) | NO855216L (fr) |
NZ (1) | NZ214711A (fr) |
PT (1) | PT81754B (fr) |
WO (1) | WO1986003751A2 (fr) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5288852A (en) * | 1984-03-06 | 1994-02-22 | Dainippon Pharmaceutical Co., Ltd. | Human tumor necrosis factor polypeptides |
JPS6248634A (ja) * | 1985-07-23 | 1987-03-03 | Mochida Pharmaceut Co Ltd | 新規アミノ酸組成物、その製造方法及び該アミノ酸組成物を含有する医療組成物 |
US5059530A (en) * | 1985-09-30 | 1991-10-22 | Suntory Ltd. | Expression vector for human TNF |
JPH0698004B2 (ja) * | 1985-09-30 | 1994-12-07 | サントリー株式会社 | Tnf発現用新規プラスミド |
US4894439A (en) * | 1986-05-22 | 1990-01-16 | Cetus Corporation | N-terminal derivatives of tumor necrosis factor purified by microporous PTFE membranes |
US4677197A (en) * | 1985-10-30 | 1987-06-30 | Cetus Corporation | Purification method for tumor necrosis factor |
NZ219027A (en) * | 1986-01-24 | 1989-09-27 | Genentech Inc | Antiviral composition containing interferon tumour necrosis factor and/or lymphotoxin |
US5081021A (en) * | 1986-02-04 | 1992-01-14 | Mizuno Den Ichi | DNA encoding HTNF variants exhibiting enhanced activity |
US4894225A (en) * | 1987-03-02 | 1990-01-16 | Cetus Corporation | Combination therapy using antitumor immunotoxins with tumor necrosis factor |
GB2217325B (en) * | 1988-04-08 | 1991-11-20 | British Bio Technology | Synthetic gene for tumour necrosis factor alpha. |
CA2067821A1 (fr) * | 1989-10-24 | 1991-04-25 | Cetus Oncology Corporation | Mecanisme infectieux d'administration d'un medicament faisant appel a des vecteurs retroviraux recombinants |
US6420374B1 (en) | 1990-11-30 | 2002-07-16 | Fred Hutchinson Cancer Research Center | Use of xanthines as immunosuppressants and to inhibit allograft reactions |
US5715835A (en) * | 1992-11-19 | 1998-02-10 | Anticancer, Inc. | Methods for treating and reducing the potential for cardiovascular disease using methioninase compositions |
US5891704A (en) * | 1992-11-19 | 1999-04-06 | Anticancer, Inc. | Method to produce high levels of methioninase |
ES2184756T3 (es) * | 1992-11-19 | 2003-04-16 | Anticancer Inc | Uso de metioninasa como agente antitumoral en quimioterapia antimetionina. |
US6461851B1 (en) | 1992-11-19 | 2002-10-08 | Anticancer, Inc. | High expression modules containing two or more tandem copies of a methioninase encoding sequence |
US5888814A (en) * | 1994-06-06 | 1999-03-30 | Chiron Corporation | Recombinant host cells encoding TNF proteins |
AU3818095A (en) * | 1994-10-20 | 1996-05-15 | Industrial Research Limited | Separation of amino acids and peptides from protein hydrolysates |
AU761216B2 (en) * | 1996-03-14 | 2003-05-29 | Human Genome Sciences, Inc. | Human tumor necrosis factor delta and epsilon |
US6541224B2 (en) | 1996-03-14 | 2003-04-01 | Human Genome Sciences, Inc. | Tumor necrosis factor delta polypeptides |
AU2003236393B2 (en) * | 1996-03-14 | 2006-02-02 | Human Genome Sciences, Inc. | Methods of Treating or Preventing Inflammation or Rheumatoid Arthritis |
US7217788B2 (en) * | 1996-03-14 | 2007-05-15 | Human Genome Sciences, Inc. | Human tumor necrosis factor delta polypeptides |
US6509170B1 (en) | 1996-03-14 | 2003-01-21 | Human Genome Sciences, Inc. | Polynucleotides encoding human tumor necrosis factor delta |
CA2247285C (fr) * | 1996-03-14 | 2011-11-08 | Human Genome Sciences, Inc. | Facteurs de necrose tumorale delta et epsilon chez l'homme |
US6617171B2 (en) * | 1998-02-27 | 2003-09-09 | The General Hospital Corporation | Methods for diagnosing and treating autoimmune disease |
US6395273B1 (en) | 1998-06-10 | 2002-05-28 | Promega Corporation | Prevention and treatment of inflammatory bowel disease |
US6599710B1 (en) | 1999-03-10 | 2003-07-29 | The General Hospital Corporation | Treatment of autoimmune disease |
EP1401870A4 (fr) * | 2001-05-24 | 2006-04-19 | Human Genome Sciences | Anticorps contre le facteur de necrose tumorale delta (april) |
US7628988B2 (en) | 2002-06-27 | 2009-12-08 | The General Hospital Corporation | Methods and compositions for treating type 1 diabetes |
US7582313B2 (en) | 2002-06-27 | 2009-09-01 | The General Hospital Corporation | Methods of organ regeneration using Hox 11-expressing pluripotent cells |
AU2003290948A1 (en) * | 2002-11-15 | 2004-06-15 | The General Hospital Corporation | Screening methods to identify treatments for autoimmune disease |
CA2508375C (fr) * | 2002-12-02 | 2014-05-27 | Abgenix, Inc. | Anticorps agissant sur le facteur de necrose des tumeurs (tnf) et leurs utilisation |
JP2005132795A (ja) * | 2003-10-31 | 2005-05-26 | Genichiro Soma | 抗悪性神経膠腫剤及び動物用抗悪性神経膠腫剤 |
US20080102054A1 (en) * | 2005-01-18 | 2008-05-01 | Faustman Denise L | Compositions Containing Agm Cells And Methods Of Use Thereof |
DK2953634T3 (da) | 2013-02-07 | 2021-08-30 | Massachusetts Gen Hospital | Fremgangsmåder til udvidelse eller udtømning af regulerende t-celler |
US11111284B2 (en) * | 2014-08-21 | 2021-09-07 | The General Hospital Corporation | Tumor necrosis factor superfamily and TNF-like ligand muteins and methods of preparing |
WO2016187068A1 (fr) | 2015-05-15 | 2016-11-24 | The General Hospital Corporation | Anticorps antagonistes de la superfamille du récepteur du facteur de nécrose anti-tumoral |
EP3355914B1 (fr) | 2015-09-29 | 2024-03-06 | The General Hospital Corporation | Une composition comprenant bcg pour réduire le cholesterol. |
WO2017197331A2 (fr) | 2016-05-13 | 2017-11-16 | The General Hospital Corporation | Anticorps antagonistes de la superfamille du récepteur du facteur de nécrose contre les tumeurs |
CN111747950B (zh) * | 2019-03-29 | 2024-01-23 | 深圳福沃药业有限公司 | 用于治疗癌症的嘧啶衍生物 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3227262A1 (de) * | 1981-07-21 | 1983-03-03 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo, Okayama | Verfahren zur herstellung von target-zellen-lysis-faktor und dessen verwendung |
EP0131789A2 (fr) * | 1983-06-27 | 1985-01-23 | Sloan-Kettering Institute For Cancer Research | Composition contenant le facteur de nécrose de tumeurs purifié en association avec l'interféron humain et son application |
EP0146026A2 (fr) * | 1983-12-02 | 1985-06-26 | Dainippon Pharmaceutical Co., Ltd. | ADN codant pour TNF de lapin, vecteur dans lequel cet ADN est inséré, hôte transformé par ce vecteur, polypeptide TNF de lapin et procédé pour sa préparation |
EP0148311A1 (fr) * | 1983-12-26 | 1985-07-17 | Asahi Kasei Kogyo Kabushiki Kaisha | Un polypeptide nouveau physiologiquement actif |
EP0170843A1 (fr) * | 1984-06-23 | 1986-02-12 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Mélanges synergiques d'interférons et d'un facteur provoquant la nécrose de tumeurs |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4332892A (en) | 1979-01-15 | 1982-06-01 | President And Fellows Of Harvard College | Protein synthesis |
NL7903195A (nl) | 1979-04-24 | 1980-10-28 | Philips Nv | Inrichting voor kunstmatige nagalm. |
US4425437A (en) | 1979-11-05 | 1984-01-10 | Genentech, Inc. | Microbial polypeptide expression vehicle |
US4309418A (en) * | 1980-03-25 | 1982-01-05 | Sloan-Kettering Research Institute For Cancer | Anti-tumor agent from human serum and process |
US4338397A (en) | 1980-04-11 | 1982-07-06 | President And Fellows Of Harvard College | Mature protein synthesis |
EP0041767B1 (fr) | 1980-06-06 | 1993-03-03 | Biogen, Inc. | Vecteurs améliorés, méthodes de construction de tels vecteurs et d'expression de gènes clonés |
WO1984001288A1 (fr) * | 1982-10-06 | 1984-04-12 | Takeshi Makitsubo | Procede d'extraction du facteur de necrose de tumeur a partir d'un macrophage |
EP0155549B1 (fr) * | 1984-03-06 | 1991-03-20 | Dainippon Pharmaceutical Co., Ltd. | ADN codant pour le facteur humain de nécrose de tumeur et le polypeptide du facteur humain de nécrose de tumeur |
JPS60185799A (ja) * | 1984-03-06 | 1985-09-21 | Dainippon Pharmaceut Co Ltd | ヒト癌壊死因子 |
US4879226A (en) * | 1984-04-06 | 1989-11-07 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel human physiologically active polypeptide |
IL75318A (en) * | 1984-05-31 | 1994-08-26 | Genentech Inc | Recombinant human memotoxin and methods for its recombinant production |
GR851626B (fr) * | 1984-07-05 | 1985-11-26 | Genentech Inc | |
US4677064A (en) * | 1984-11-09 | 1987-06-30 | Cetus Corporation | Human tumor necrosis factor |
JPS61124392A (ja) * | 1984-11-22 | 1986-06-12 | Asahi Chem Ind Co Ltd | 遺伝子組換体の産生する生理活性物質の精製法 |
US4677663A (en) * | 1985-07-05 | 1987-06-30 | Melita Electronic Labs, Inc. | Telephone answering and call forwarding improvement |
JPH0698004B2 (ja) * | 1985-09-30 | 1994-12-07 | サントリー株式会社 | Tnf発現用新規プラスミド |
US5182196A (en) * | 1985-10-09 | 1993-01-26 | Biogen, Inc. | Expression systems for overproduction of desired proteins |
-
1985
- 1985-12-19 EP EP86900138A patent/EP0216786B1/fr not_active Expired - Lifetime
- 1985-12-19 WO PCT/EP1985/000721 patent/WO1986003751A2/fr active IP Right Grant
- 1985-12-19 DE DE8686900138T patent/DE3585690D1/de not_active Expired - Fee Related
- 1985-12-19 AT AT86900138T patent/ATE73856T1/de not_active IP Right Cessation
- 1985-12-19 EP EP89123527A patent/EP0368367A1/fr not_active Withdrawn
- 1985-12-19 JP JP61500550A patent/JP2557053B2/ja not_active Expired - Lifetime
- 1985-12-19 AU AU53014/86A patent/AU601675B2/en not_active Ceased
- 1985-12-19 EP EP88119116A patent/EP0313104A3/fr not_active Withdrawn
- 1985-12-20 NO NO855216A patent/NO855216L/no unknown
- 1985-12-20 US US06/811,654 patent/US5487984A/en not_active Expired - Fee Related
- 1985-12-20 ES ES550260A patent/ES8705521A1/es not_active Expired
- 1985-12-20 HU HU854929A patent/HUT40702A/hu unknown
- 1985-12-20 IE IE327385A patent/IE58709B1/en not_active IP Right Cessation
- 1985-12-20 FI FI855130A patent/FI86194C/fi not_active IP Right Cessation
- 1985-12-23 PT PT81754A patent/PT81754B/pt unknown
- 1985-12-23 NZ NZ214711A patent/NZ214711A/xx unknown
- 1985-12-23 KR KR1019850009745A patent/KR940010865B1/ko not_active IP Right Cessation
-
1986
- 1986-08-21 DK DK399786A patent/DK399786D0/da not_active Application Discontinuation
-
1990
- 1990-05-17 AU AU55104/90A patent/AU5510490A/en not_active Abandoned
-
1995
- 1995-01-19 JP JP7026273A patent/JP2548527B2/ja not_active Expired - Lifetime
- 1995-01-19 JP JP7026271A patent/JP2548525B2/ja not_active Expired - Lifetime
- 1995-01-19 JP JP7026272A patent/JP2548526B2/ja not_active Expired - Lifetime
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3227262A1 (de) * | 1981-07-21 | 1983-03-03 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo, Okayama | Verfahren zur herstellung von target-zellen-lysis-faktor und dessen verwendung |
EP0131789A2 (fr) * | 1983-06-27 | 1985-01-23 | Sloan-Kettering Institute For Cancer Research | Composition contenant le facteur de nécrose de tumeurs purifié en association avec l'interféron humain et son application |
EP0146026A2 (fr) * | 1983-12-02 | 1985-06-26 | Dainippon Pharmaceutical Co., Ltd. | ADN codant pour TNF de lapin, vecteur dans lequel cet ADN est inséré, hôte transformé par ce vecteur, polypeptide TNF de lapin et procédé pour sa préparation |
EP0148311A1 (fr) * | 1983-12-26 | 1985-07-17 | Asahi Kasei Kogyo Kabushiki Kaisha | Un polypeptide nouveau physiologiquement actif |
EP0170843A1 (fr) * | 1984-06-23 | 1986-02-12 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Mélanges synergiques d'interférons et d'un facteur provoquant la nécrose de tumeurs |
Non-Patent Citations (9)
Title |
---|
Gene, Volume 18, No. 3, June 1982, N. CASNA et al.: "Bacteriophage T4 as a Generalized DNA-Cloning Vehicle", pages 297-307, see page 306 * |
Infection and Immunity, Volume 28, No. 1, April 1980, Washington, DC, (US) D.N. MANNEL et al.: "Generation and Characterization of al Lipopolysaccharide-Induced and Serum-Derived Cytotoxic Factor for Tumor Cells", see pages 204-211, page 209, left-hand column, lines 9-15; figure 7 * |
Infection and Immunity, Volume 30, No. 2, November 1980, Washington, D.C., (US) D.N. MANNEL et al.: "Macrophages as a Source of Tumoricidal Activity (Tumor Necrotizing Factor)", see pages 523-530, page 527, left-hand column, lines 22-35; page 528; figure 4 (cited in the application) * |
Infection and Immunity, Volume 31, No. 1, January 1981, Washington, D.C., (US) M.R. RUFF et al.: "Rabbit Tumor Necrosis Factor: Mechanism of Action", see pages 380-385, see page 381, right-hand column, lines 7-12 (cited in the appliction) * |
Nature, Volume 312, No. 5996, December - January 1984/1985, London (GB) D. PENNICA et al.: Human Tumour Necrosis Factor: Precursor Structure, Expression and Homology to Lymphotoxin", pages 724-729, see the whole document * |
Nature, Volume 312, No. 59968 December-January 1984/1985, London (GB) K. SIKORA: "Cancer Toxin Genes Cloned", pages 699-700, see the whole document * |
Proceedings of the National Academy of Sciences (USA), Volume 79, August 1982 H.M. Krisch et al.: Nucleotide Sequences Involved in Bacteriophage T4 Gene 32 Translational Self-Regulation", pages 4937-4941, see the whole document * |
See also references of EP0216786A1 * |
The Journal of Immunology, Volume 125, No. 4, October 1980, Baltimore, MD, (US) M.R. RUFF et al: "Purification and Physicochemical Characterization of Rabbit Tumor Necrosis Factor", see pages 1671-1677, page 1673, left-hand column, lines 47-53 * |
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