ES8403969A1 - Un metodo para producir polipetido semejante a interferon inmune humano. - Google Patents

Un metodo para producir polipetido semejante a interferon inmune humano.

Info

Publication number
ES8403969A1
ES8403969A1 ES519953A ES519953A ES8403969A1 ES 8403969 A1 ES8403969 A1 ES 8403969A1 ES 519953 A ES519953 A ES 519953A ES 519953 A ES519953 A ES 519953A ES 8403969 A1 ES8403969 A1 ES 8403969A1
Authority
ES
Spain
Prior art keywords
polypeptides
dna sequences
human immune
immune interferon
recombinant dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES519953A
Other languages
English (en)
Other versions
ES519953A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biogen NV
Original Assignee
Biogen NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen NV filed Critical Biogen NV
Publication of ES8403969A1 publication Critical patent/ES8403969A1/es
Publication of ES519953A0 publication Critical patent/ES519953A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE POLIPEPTIDOS DEL TIPO DE INTERFERON INMUNE HUMANO.CONSISTE EN EL CULTIVO DE UN ORGANISMO HOSPEDANTE TRANSFORMADO QUE SE CARACTERIZA POR UNA SECUENCIA ADN, QUE CODIFICA EL POLIPEPTIDO ENLAZADO A UNA SECUENCIA DE CONTROL DE EXPRESION, DONDE LA SECUENCIA DE ADN SE SELECCIONA ENTRE LA INSERCION DE ADN DE PHIIF-SV-GO, SECUENCIAS DE ADN QUE SE HIBRIDAN PARA DAR LA INSERCICION DE ADN, QUE CODIFICAN UN POLIPEPTIDO DEL TIPO IFN-G, Y SECUENCIAS DE ADN QUE CODIFICAN PARA EXPRESION UN POLIPEPTIDO CODIFICADO PARA EXPRESION POR CUALQUIERA DE LASSECUENCIAS ANTERIORES.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIVIRICOS, ANTITUMORALES O ANTICANCERIGENOS Y DE INMUNOMODULACION.
ES519953A 1982-02-22 1983-02-21 Un metodo para producir polipetido semejante a interferon inmune humano. Granted ES519953A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8205203 1982-02-22

Publications (2)

Publication Number Publication Date
ES8403969A1 true ES8403969A1 (es) 1984-04-01
ES519953A0 ES519953A0 (es) 1984-04-01

Family

ID=10528520

Family Applications (1)

Application Number Title Priority Date Filing Date
ES519953A Granted ES519953A0 (es) 1982-02-22 1983-02-21 Un metodo para producir polipetido semejante a interferon inmune humano.

Country Status (7)

Country Link
EP (1) EP0088540A3 (es)
JP (1) JPS5951792A (es)
AU (2) AU1167483A (es)
DK (1) DK73483A (es)
ES (1) ES519953A0 (es)
IL (1) IL67961A0 (es)
ZA (1) ZA831094B (es)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8406910D0 (en) * 1984-03-16 1984-04-18 Biogen Nv Gamma interferon
IL68100A0 (en) * 1982-03-24 1983-06-15 Takeda Chemical Industries Ltd Novel dna and use thereof
JPH0787797B2 (ja) * 1982-05-20 1995-09-27 サントリー株式会社 ヒト・ガンマ・インタ−フエロン様ポリペプチドの製造法
AU571460B2 (en) * 1982-09-27 1988-04-21 Cancer Institute Of Japanese Foundation For Cancer Research Alpha interferon dna, recombinant plasmid, engineered organism and alpha interferon polypeptide
US4966843A (en) * 1982-11-01 1990-10-30 Cetus Corporation Expression of interferon genes in Chinese hamster ovary cells
WO1984002129A1 (en) * 1982-11-22 1984-06-07 Takeda Chemical Industries Ltd Human immune interferon protein and process for its preparation
JPH0740925B2 (ja) * 1983-03-14 1995-05-10 協和醗酵工業株式会社 新規ヒトインタ−フエロン−γポリペプチド
US4476049A (en) * 1983-09-20 1984-10-09 Hoffmann-La Roche Inc. Method for the extraction of immune interferon
US4604284A (en) * 1983-09-20 1986-08-05 Hoffmann-La Roche Inc. Homogeneous immune interferon fragment
ZA846554B (en) * 1983-09-20 1985-04-24 Hoffmann La Roche Immune interferon and method for its purification
JPH0788398B2 (ja) * 1983-10-17 1995-09-27 サントリー株式会社 新規生理活性ポリペプチドおよびその製造法
US4855238A (en) * 1983-12-16 1989-08-08 Genentech, Inc. Recombinant gamma interferons having enhanced stability and methods therefor
MX9203641A (es) * 1983-12-16 1992-07-01 Genentech Inc Interferones gamma recombinantes que poseen estabilidad mejorada y metodos biotecnologicos para su obtencion.
JPS60145098A (ja) * 1984-01-09 1985-07-31 Suntory Ltd 糖付加ポリペプチドの製造法
US4758512A (en) * 1984-03-06 1988-07-19 President And Fellows Of Harvard College Hosts and methods for producing recombinant products in high yields
DE3409966A1 (de) * 1984-03-19 1985-09-26 Hoechst Ag, 6230 Frankfurt Gentechnologisches verfahren zur herstellung von human-gammainterferon und mittel zur durchfuehrung dieses verfahrens
WO1985004420A1 (en) * 1984-03-29 1985-10-10 Takeda Chemical Industries, Ltd. Novel dna and its use
EP0158198A1 (en) * 1984-03-29 1985-10-16 Takeda Chemical Industries, Ltd. DNA and use thereof
DE3414831A1 (de) * 1984-04-19 1985-10-31 Hoechst Ag, 6230 Frankfurt Herstellung von polypeptiden mit human-gammainterferon-aktivitaet
IL71691A (en) * 1984-04-27 1991-04-15 Yeda Res & Dev Production of interferon-ypsilon
WO1985005618A1 (en) * 1984-06-06 1985-12-19 Takeda Chemical Industries, Ltd. Process for preparing interferon derivative
JPS60262594A (ja) * 1984-06-11 1985-12-25 Kanegafuchi Chem Ind Co Ltd ヒトインタ−フエロン−γ
CA1302320C (en) * 1984-06-11 1992-06-02 Hideo Niwa Expression of human cromosomal interferon-_ in animal cells
GB8414911D0 (en) * 1984-06-12 1984-07-18 Searle & Co Producing human gamma interferon
GB2164650A (en) * 1984-09-25 1986-03-26 Fujisawa Pharmaceutical Co Process for production of y-interferon
JPS6188875A (ja) * 1984-10-05 1986-05-07 Kanegafuchi Chem Ind Co Ltd ヒトインタ−フエロン−γ
US4946674A (en) * 1984-10-05 1990-08-07 Bioferon Biochemische Substanzen Gmbh & Co. Process for treatment of rheumatic diseases
DE3521733A1 (de) * 1985-06-18 1986-12-18 Bioferon biochemische Substanzen GmbH & Co, 7958 Laupheim Verwendung von interferon-gamma (ifn-gamma) enthaltenden praeparationen zur systemischen behandlung von tumoren und viruserkrankungen in niedriger dosierung
IL76591A0 (en) * 1984-10-05 1986-02-28 Bioferon Biochem Substanz Pharmaceutical compositions containing ifn-ypsilon and processes for the preparation thereof
JPS61108397A (ja) * 1984-10-31 1986-05-27 Green Cross Corp:The インタ−フエロン−γ蛋白質の製造法
FR2583429B1 (fr) * 1985-06-18 1989-11-03 Transgene Sa Vecteur d'expression de l'interferon u dans les cellules de mammifere, procede pour sa mise en oeuvre et produit obtenu et composition pharmaceutique contenant l'interferon u
GB8522336D0 (en) * 1985-09-09 1985-10-16 Biogen Nv Composition for treatment of allergies
EP0302862A1 (en) * 1986-03-17 1989-02-15 Schering Corporation Treatment of cancers with gamma interferon
US4879111A (en) * 1986-04-17 1989-11-07 Cetus Corporation Treatment of infections with lymphokines
ATE132534T1 (de) * 1986-08-01 1996-01-15 Commw Scient Ind Res Org Rekombinanter impfstoff
DE3642096A1 (de) * 1986-12-10 1988-06-16 Boehringer Ingelheim Int Pferde-(gamma)-interferon
US5190751A (en) * 1987-01-20 1993-03-02 Schering Corporation Treatment of certain leukemias with a combination of gamma interferon and alpha interferon
NL8700927A (nl) * 1987-04-16 1988-11-16 Stichting Rega V Z W Anti-interferon-gamma-antilichamen; en hun therapeutische toepassing.
AUPN154295A0 (en) * 1995-03-06 1995-03-30 Commonwealth Scientific And Industrial Research Organisation Nucleic acid molecule encoding a protein with avian gamma-interferon activity
US6642032B2 (en) 1993-04-14 2003-11-04 Commonwealth Scientific And Industrial Research Organisation Uses of avian interferon gamma (IFN-γ)
EP1231943A1 (en) 1999-11-12 2002-08-21 Maxygen Holdings Ltd Interferon gamma conjugates
US7230081B1 (en) 1999-11-12 2007-06-12 Maxygen Holdings, Ltd. Interferon gamma conjugates
US6958388B2 (en) 2001-04-06 2005-10-25 Maxygen, Aps Interferon gamma polypeptide variants
US7038015B2 (en) 2001-04-06 2006-05-02 Maxygen Holdings, Ltd. Interferon gamma polypeptide variants
US7524931B2 (en) 2002-07-03 2009-04-28 Maxygen Holdings Ltd. Full-length interferon gamma polypeptide variants

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL65475A0 (en) * 1981-04-17 1982-07-30 Meloy Lab Production of immune interferon and its mrna
AU561343B2 (en) * 1981-10-19 1987-05-07 Genentech Inc. Human immune interferon by recombinant dna
JPS58110548A (ja) * 1981-12-24 1983-07-01 Asahi Chem Ind Co Ltd 新規な生理活性ペプチド
IL68100A0 (en) * 1982-03-24 1983-06-15 Takeda Chemical Industries Ltd Novel dna and use thereof
JPH0787797B2 (ja) * 1982-05-20 1995-09-27 サントリー株式会社 ヒト・ガンマ・インタ−フエロン様ポリペプチドの製造法
US4582800A (en) * 1982-07-12 1986-04-15 Hoffmann-La Roche Inc. Novel vectors and method for controlling interferon expression

Also Published As

Publication number Publication date
JPS5951792A (ja) 1984-03-26
EP0088540A3 (en) 1984-10-17
ZA831094B (en) 1983-11-30
DK73483D0 (da) 1983-02-21
DK73483A (da) 1983-08-23
AU2964489A (en) 1989-08-24
AU1167483A (en) 1983-09-01
EP0088540A2 (en) 1983-09-14
IL67961A0 (en) 1983-06-15
ES519953A0 (es) 1984-04-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980401