UY33447A - Procedimiento de sintesis de la ferroquina por animacion reductora convergente - Google Patents

Procedimiento de sintesis de la ferroquina por animacion reductora convergente

Info

Publication number
UY33447A
UY33447A UY0001033447A UY33447A UY33447A UY 33447 A UY33447 A UY 33447A UY 0001033447 A UY0001033447 A UY 0001033447A UY 33447 A UY33447 A UY 33447A UY 33447 A UY33447 A UY 33447A
Authority
UY
Uruguay
Prior art keywords
railway
formula
synthesis procedure
reaction
convergent
Prior art date
Application number
UY0001033447A
Other languages
English (en)
Inventor
Vincent Ferey
Mateos-Cara Julia
Mondiere Regis
Philippe Vayron
Sylvie Vigne
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of UY33447A publication Critical patent/UY33447A/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F17/00Metallocenes
    • C07F17/02Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/47064-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms
    • C07D215/42Nitrogen atoms attached in position 4
    • C07D215/46Nitrogen atoms attached in position 4 with hydrocarbon radicals, substituted by nitrogen atoms, attached to said nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/02Iron compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)

Abstract

La invención se refiere a un procedimiento de síntesis de la ferroquina de fórmula (F) o de su metabolito de fórmula (Fm): que comprende una reacción de animación reductora, comprendiendo dicha reacción: (i) una etapa de condensación de aldehído-amino ferroceno de fórmula (1), en la que R representa a un átomo de hidrógeno o un grupo metilo, con la 7-cloroquinolein ?4-amina (2) tales como se representan a continuación, seguido (ii) de una etapa de reducción del producto de condensación obtenido en la etapa anterior (iii) después, de una etapa de hidrólisis del medio de reacción en presencia de una disolución de amoníaco o de ácido cítrico.
UY0001033447A 2010-06-11 2011-06-10 Procedimiento de sintesis de la ferroquina por animacion reductora convergente UY33447A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1054625A FR2961209B1 (fr) 2010-06-11 2010-06-11 Procede de synthese de la ferroquine par amination reductrice convergente.

Publications (1)

Publication Number Publication Date
UY33447A true UY33447A (es) 2012-01-31

Family

ID=42752115

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001033447A UY33447A (es) 2010-06-11 2011-06-10 Procedimiento de sintesis de la ferroquina por animacion reductora convergente

Country Status (24)

Country Link
US (1) US8497375B2 (es)
EP (1) EP2580224B1 (es)
JP (2) JP5916721B2 (es)
KR (1) KR101839634B1 (es)
CN (1) CN102939297B (es)
AP (1) AP3020A (es)
AR (1) AR081593A1 (es)
AU (1) AU2011263354B2 (es)
BR (1) BR112012031159A2 (es)
CA (1) CA2802161C (es)
CL (1) CL2012003455A1 (es)
CO (1) CO6602116A2 (es)
EA (1) EA020392B1 (es)
FR (1) FR2961209B1 (es)
IL (1) IL223521A (es)
JO (1) JO2928B1 (es)
MA (1) MA34363B1 (es)
MX (1) MX2012014473A (es)
NZ (1) NZ605608A (es)
SG (1) SG186247A1 (es)
TW (1) TWI485136B (es)
UY (1) UY33447A (es)
WO (1) WO2011154923A1 (es)
ZA (1) ZA201209328B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2961209B1 (fr) 2010-06-11 2013-03-01 Sanofi Aventis Procede de synthese de la ferroquine par amination reductrice convergente.
CN103242379B (zh) * 2013-05-20 2015-09-02 洛阳师范学院 2-二茂铁基-芳基喹啉及其制备方法
CN103242378B (zh) * 2013-05-20 2015-06-03 洛阳师范学院 二茂铁基嘧啶钳形配体及其制备方法
CN103254250B (zh) * 2013-05-20 2015-06-10 洛阳师范学院 二茂铁基吡嗪环钯氮杂环卡宾化合物及其制备方法和用途
EP2821412A1 (en) * 2013-07-01 2015-01-07 Universität Zürich Organometallic 2-cyano-2-aminobenzoate-propyl derivates and their use as anthelmintics
CN103848872A (zh) * 2014-03-20 2014-06-11 内蒙古大学 一种含二茂铁基团的中氮茚化合物的制备方法
US10370395B2 (en) 2015-01-02 2019-08-06 University Of Vermont And State Agricultural College Cymanquine compounds and derivatives thereof and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3856850B2 (ja) * 1994-08-18 2006-12-13 生化学工業株式会社 光学活性アミノケトン及びアミノアルコールの製造方法
FR2733985B1 (fr) * 1995-05-10 1997-07-18 Univ Lille Sciences Tech Complexes organometalliques du fer antipaludiques
JP3921703B2 (ja) * 1995-07-12 2007-05-30 住友化学株式会社 N−(α−アルキルベンジリデン)−α−フェニルアルキルアミン
JPH09124576A (ja) * 1995-10-27 1997-05-13 Sumitomo Chem Co Ltd イミン類の製造方法
US6777427B2 (en) * 2000-09-14 2004-08-17 Kaken Pharmaceutical Co., Ltd. Tetrahydroquinoline compounds
BR0215593A (pt) * 2002-02-07 2004-12-21 Sumitomo Chemical Co Processo para produzir ácido (r)-3-hidróxi-3-(2-feniletil)-hexanóico e seu intermediário
FR2884715B1 (fr) * 2005-04-20 2007-06-15 Sanofi Aventis Sa Association entre la ferroquine et un derive d'artemisinine pour le traitement du paludisme
FR2961209B1 (fr) 2010-06-11 2013-03-01 Sanofi Aventis Procede de synthese de la ferroquine par amination reductrice convergente.

Also Published As

Publication number Publication date
KR20130122709A (ko) 2013-11-08
JO2928B1 (en) 2015-09-15
JP5916721B2 (ja) 2016-05-18
CA2802161C (en) 2018-08-14
FR2961209A1 (fr) 2011-12-16
IL223521A (en) 2015-02-26
KR101839634B1 (ko) 2018-04-26
CO6602116A2 (es) 2013-01-18
AP2012006595A0 (en) 2012-12-31
JP2013529597A (ja) 2013-07-22
BR112012031159A2 (pt) 2016-11-08
AP3020A (en) 2014-10-31
AR081593A1 (es) 2012-10-03
EA201291209A1 (ru) 2013-04-30
EP2580224A1 (en) 2013-04-17
WO2011154923A1 (en) 2011-12-15
FR2961209B1 (fr) 2013-03-01
MA34363B1 (fr) 2013-07-03
EP2580224B1 (en) 2014-05-28
NZ605608A (en) 2014-09-26
EA020392B1 (ru) 2014-10-30
CL2012003455A1 (es) 2013-07-26
JP2016145214A (ja) 2016-08-12
MX2012014473A (es) 2013-02-21
US8497375B2 (en) 2013-07-30
TW201204702A (en) 2012-02-01
CN102939297B (zh) 2015-09-16
ZA201209328B (en) 2014-02-26
CA2802161A1 (en) 2011-12-15
AU2011263354A1 (en) 2013-01-31
US20130096306A1 (en) 2013-04-18
AU2011263354B2 (en) 2015-09-24
TWI485136B (zh) 2015-05-21
SG186247A1 (en) 2013-01-30
CN102939297A (zh) 2013-02-20

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20200807