UY29053A1 - Procedimiento para preparar las formas enantiómeras de derivados de ácido 3-hidroxiciclohexanocarboxílico con configuración cis - Google Patents

Procedimiento para preparar las formas enantiómeras de derivados de ácido 3-hidroxiciclohexanocarboxílico con configuración cis

Info

Publication number
UY29053A1
UY29053A1 UY29053A UY29053A UY29053A1 UY 29053 A1 UY29053 A1 UY 29053A1 UY 29053 A UY29053 A UY 29053A UY 29053 A UY29053 A UY 29053A UY 29053 A1 UY29053 A1 UY 29053A1
Authority
UY
Uruguay
Prior art keywords
hydroxiciclohexanocarboxylic
enantiomic
prepare
procedure
forms
Prior art date
Application number
UY29053A
Other languages
English (en)
Inventor
Dr Stefanie Keil
Dr Wolfgang Holla
Dr Christoph Tappertzhofen
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of UY29053A1 publication Critical patent/UY29053A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se describe un procedimiento para preparar ciclohexanoles o derivados de ciclohexanol de fórmulas (la) y (lb) con configuración cis, quirales, no racémicos, en donde los radocales y sustituyentes son tales como se han especificados en la Memoria Descriptiva, mediante resolución enzimática de racematos.
UY29053A 2004-08-07 2005-08-05 Procedimiento para preparar las formas enantiómeras de derivados de ácido 3-hidroxiciclohexanocarboxílico con configuración cis UY29053A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004038403A DE102004038403B4 (de) 2004-08-07 2004-08-07 Verfahren zur Herstellung der enantiomeren Formen von cis-konfigurierten 3-Hydroxycyclohexancarbonsäure-Derivaten

Publications (1)

Publication Number Publication Date
UY29053A1 true UY29053A1 (es) 2006-02-24

Family

ID=35610188

Family Applications (1)

Application Number Title Priority Date Filing Date
UY29053A UY29053A1 (es) 2004-08-07 2005-08-05 Procedimiento para preparar las formas enantiómeras de derivados de ácido 3-hidroxiciclohexanocarboxílico con configuración cis

Country Status (18)

Country Link
US (1) US20070197788A1 (es)
EP (1) EP1805316B1 (es)
JP (1) JP2008509102A (es)
KR (1) KR20070041564A (es)
CN (1) CN1989253A (es)
AR (1) AR050100A1 (es)
AT (1) ATE428795T1 (es)
AU (1) AU2005270447A1 (es)
CA (1) CA2576080A1 (es)
DE (2) DE102004038403B4 (es)
DK (1) DK1805316T3 (es)
ES (1) ES2324945T3 (es)
IL (1) IL180873A0 (es)
MX (1) MX2007000996A (es)
PT (1) PT1805316E (es)
TW (1) TW200619389A (es)
UY (1) UY29053A1 (es)
WO (1) WO2006015716A2 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004040736B4 (de) * 2004-08-23 2007-01-11 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von Diarylcycloalkylderivaten
AR108838A1 (es) 2016-06-21 2018-10-03 Bristol Myers Squibb Co Ácidos de carbamoiloximetil triazol ciclohexilo como antagonistas de lpa
CN108456213B (zh) * 2017-02-22 2021-01-15 浙江九洲药业股份有限公司 一种3-氟-4-羟基环己烷羧酸酯的制备方法
ES2938863T3 (es) 2017-12-19 2023-04-17 Bristol Myers Squibb Co Triazol azoles de ácido ciclohexilo como antagonistas de ácido lisofosfatídico (LPA)
US11180488B2 (en) 2017-12-19 2021-11-23 Bristol-Myers Squibb Company Isoxazole o-linked carbamoyl cyclohexyl acids as LPA antagonists
CN112055711A (zh) 2017-12-19 2020-12-08 百时美施贵宝公司 作为lpa拮抗剂的环己基酸三唑吖嗪类
EA202091506A1 (ru) 2017-12-19 2020-09-22 Бристол-Маерс Сквибб Компани Триазол n-связанные карбамоил циклогексильные кислоты в качестве антагонистов lpa
CA3085347A1 (en) 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Pyrazole n-linked carbamoyl cyclohexyl acids as lpa antagonists

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0469375A (ja) * 1990-07-06 1992-03-04 Sankyo Co Ltd 光学活性なシクロヘキシルカルボキシラート類及びその製法
DE10004926A1 (de) * 2000-02-04 2001-08-09 Gruenenthal Gmbh Verfahren zur enzymatischen Racematspaltung von Aminomethyl-Aryl-Cyclohexanol-Derivaten
CA2458210C (en) * 2001-08-31 2011-09-20 Aventis Pharma Deutschland Gmbh Diaryl cycloalkyl derivatives, method for producing the same and the use thereof as ppar-activators
DE10308350B4 (de) * 2003-02-27 2006-06-01 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung der enantiomeren Formen von cis-konfigurierten 1,3-Cyclohexandiol-Derivaten
US7173151B2 (en) * 2003-02-27 2007-02-06 Sanofi-Aventisdeutschand Gmbh Cycloalkyl-substituted alkanoic acid derivatives, processes for their preparation and their use as pharmaceuticals
DE10308355A1 (de) * 2003-02-27 2004-12-23 Aventis Pharma Deutschland Gmbh Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel

Also Published As

Publication number Publication date
ATE428795T1 (de) 2009-05-15
AU2005270447A1 (en) 2006-02-16
PT1805316E (pt) 2009-07-06
DE102004038403A1 (de) 2006-02-23
WO2006015716A3 (de) 2006-06-22
DK1805316T3 (da) 2009-08-10
US20070197788A1 (en) 2007-08-23
DE102004038403B4 (de) 2006-08-31
TW200619389A (en) 2006-06-16
CA2576080A1 (en) 2006-02-16
CN1989253A (zh) 2007-06-27
MX2007000996A (es) 2007-04-16
DE502005007103D1 (de) 2009-05-28
AR050100A1 (es) 2006-09-27
JP2008509102A (ja) 2008-03-27
ES2324945T3 (es) 2009-08-20
KR20070041564A (ko) 2007-04-18
WO2006015716A2 (de) 2006-02-16
EP1805316B1 (de) 2009-04-15
IL180873A0 (en) 2007-07-04
EP1805316A2 (de) 2007-07-11

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Effective date: 20120424