UY25177A1 - 5-(2-etil-2-h-tetrazol-5-il)-1-metil-1,2,3,6-tetrahidropiridina - Google Patents
5-(2-etil-2-h-tetrazol-5-il)-1-metil-1,2,3,6-tetrahidropiridinaInfo
- Publication number
- UY25177A1 UY25177A1 UY25177A UY25177A UY25177A1 UY 25177 A1 UY25177 A1 UY 25177A1 UY 25177 A UY25177 A UY 25177A UY 25177 A UY25177 A UY 25177A UY 25177 A1 UY25177 A1 UY 25177A1
- Authority
- UY
- Uruguay
- Prior art keywords
- maleic acid
- acid addition
- addition salt
- tetrahydropyridine
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención tiene por objetivo proporcionar una forma sólida farmacéuticamente aceptable del compuesto 5-(2-etil-2-H-tetrazol-5-il)-1-metil-1,2,3,6-tetrahidropiridina adecuado para la producción a gran escala de entidades farmacéuticas sólidas, por ejemplo tabletas o cápsulas. De acuerdo a la presente invención, se han suministrado sal de adición de ácido maleico de 5-(2-etil-2-H-tetrazol-5-il)-1-metil-1,2,3,6-tetrahidropiridina y las composiciones farmacéuticas que contienen la sal de adición ácida y el uso de las mismas para el tratamiento de trastornos causados por un mal funcionamiento de la acetilcolina(AcCh) o del sistema muscarínico. Por lo tanto se utiliza, por ejemplo, para tratar el mal de Alzheimer, lesiones traumáticas de cerebro o trastornos psicóticos. La sal de adición de ácido maleico, de acuerdo con la invención, puede obtenerese mediante tratamiento de 5-(2-etil-2-H-tetrazol-5-il)-1-metil-1,2,3,6-tetrahidropiridina o un derivado de sal de la misma con ácido maleico en un solvente inerte, seguido de precipitación, separación y opcionalmente recristalización mediante métodos conocidos y si se desea seguido de micronización del producto cristalino mediante molido húmedo, en seco o mediante cualquier otro proceso conveniente o mediante preparación de partículas de un proceso de emulsificación-disolvente. La precipitación de sal de maleato se realiza en un disolvente aprótico inerte, preferentemente tetrahidrofurano (THF). La sal de adición de ácido maleico es la sal de adición de ácido mono-maleico.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK78197 | 1997-07-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY25177A1 true UY25177A1 (es) | 2000-12-29 |
Family
ID=8097489
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY25069A UY25069A1 (es) | 1997-07-01 | 1998-06-29 | Procedimiento para preparación de 5-(etil-2-h-tetrazol-5-il)-1-metil-1,2,3,6-tetrahidropiridina |
UY25177A UY25177A1 (es) | 1997-07-01 | 1998-09-10 | 5-(2-etil-2-h-tetrazol-5-il)-1-metil-1,2,3,6-tetrahidropiridina |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY25069A UY25069A1 (es) | 1997-07-01 | 1998-06-29 | Procedimiento para preparación de 5-(etil-2-h-tetrazol-5-il)-1-metil-1,2,3,6-tetrahidropiridina |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP0994869A1 (es) |
JP (1) | JP2002507215A (es) |
KR (1) | KR20010014297A (es) |
CN (1) | CN1261361A (es) |
AR (1) | AR013096A1 (es) |
AU (1) | AU735751B2 (es) |
BG (1) | BG103933A (es) |
BR (1) | BR9810331A (es) |
CA (1) | CA2293324A1 (es) |
CO (1) | CO4940483A1 (es) |
EA (1) | EA200000081A1 (es) |
HU (1) | HUP0002876A2 (es) |
IL (1) | IL133093A0 (es) |
IS (1) | IS5278A (es) |
JO (1) | JO2031B1 (es) |
MA (1) | MA25138A1 (es) |
NO (1) | NO996580L (es) |
PE (1) | PE116099A1 (es) |
PL (1) | PL337184A1 (es) |
SK (1) | SK187399A3 (es) |
TN (1) | TNSN98120A1 (es) |
TR (1) | TR199903283T2 (es) |
UY (2) | UY25069A1 (es) |
WO (1) | WO1999001448A1 (es) |
ZA (1) | ZA985498B (es) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8714789D0 (en) * | 1987-06-24 | 1987-07-29 | Lundbeck & Co As H | Heterocyclic compounds |
CA2234824A1 (en) * | 1995-11-06 | 1997-05-15 | Brian R. Pike | Treatment of traumatic brain injury |
-
1998
- 1998-06-18 AR ARP980102925A patent/AR013096A1/es not_active Application Discontinuation
- 1998-06-24 ZA ZA985498A patent/ZA985498B/xx unknown
- 1998-06-25 PE PE1998000563A patent/PE116099A1/es not_active Application Discontinuation
- 1998-06-25 JO JO19982031A patent/JO2031B1/en active
- 1998-06-26 CO CO98036576A patent/CO4940483A1/es unknown
- 1998-06-29 UY UY25069A patent/UY25069A1/es not_active Application Discontinuation
- 1998-06-30 TN TNTNSN98120A patent/TNSN98120A1/fr unknown
- 1998-07-01 SK SK1873-99A patent/SK187399A3/sk unknown
- 1998-07-01 EP EP98930655A patent/EP0994869A1/en not_active Withdrawn
- 1998-07-01 KR KR1019997012429A patent/KR20010014297A/ko not_active Application Discontinuation
- 1998-07-01 CN CN98806497A patent/CN1261361A/zh active Pending
- 1998-07-01 TR TR1999/03283T patent/TR199903283T2/xx unknown
- 1998-07-01 CA CA002293324A patent/CA2293324A1/en not_active Abandoned
- 1998-07-01 JP JP50616699A patent/JP2002507215A/ja active Pending
- 1998-07-01 MA MA25155A patent/MA25138A1/fr unknown
- 1998-07-01 WO PCT/DK1998/000294 patent/WO1999001448A1/en not_active Application Discontinuation
- 1998-07-01 IL IL13309398A patent/IL133093A0/xx unknown
- 1998-07-01 AU AU81020/98A patent/AU735751B2/en not_active Ceased
- 1998-07-01 HU HU0002876A patent/HUP0002876A2/hu unknown
- 1998-07-01 PL PL98337184A patent/PL337184A1/xx unknown
- 1998-07-01 EA EA200000081A patent/EA200000081A1/ru unknown
- 1998-07-01 BR BR9810331-8A patent/BR9810331A/pt not_active Application Discontinuation
- 1998-09-10 UY UY25177A patent/UY25177A1/es not_active Application Discontinuation
-
1999
- 1999-11-30 IS IS5278A patent/IS5278A/is unknown
- 1999-11-30 BG BG103933A patent/BG103933A/xx unknown
- 1999-12-30 NO NO996580A patent/NO996580L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
KR20010014297A (ko) | 2001-02-26 |
CN1261361A (zh) | 2000-07-26 |
AR013096A1 (es) | 2000-12-13 |
IL133093A0 (en) | 2001-03-19 |
JO2031B1 (en) | 1999-05-15 |
PL337184A1 (en) | 2000-08-14 |
JP2002507215A (ja) | 2002-03-05 |
EP0994869A1 (en) | 2000-04-26 |
AU8102098A (en) | 1999-01-25 |
MA25138A1 (fr) | 2001-04-02 |
PE116099A1 (es) | 1999-11-23 |
TNSN98120A1 (fr) | 2005-03-15 |
IS5278A (is) | 1999-11-30 |
ZA985498B (en) | 1999-01-20 |
EA200000081A1 (ru) | 2000-08-28 |
BG103933A (en) | 2000-07-31 |
NO996580D0 (no) | 1999-12-30 |
CA2293324A1 (en) | 1999-01-14 |
AU735751B2 (en) | 2001-07-12 |
CO4940483A1 (es) | 2000-07-24 |
WO1999001448A1 (en) | 1999-01-14 |
TR199903283T2 (xx) | 2000-06-21 |
SK187399A3 (en) | 2000-06-12 |
BR9810331A (pt) | 2000-09-05 |
HUP0002876A2 (hu) | 2001-06-28 |
UY25069A1 (es) | 1998-12-21 |
NO996580L (no) | 1999-12-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
109 | Application deemed to be withdrawn |
Effective date: 20101008 |