UY23537A1 - Benzopirano y antagonistas de ltb4 relacionados - Google Patents

Benzopirano y antagonistas de ltb4 relacionados

Info

Publication number
UY23537A1
UY23537A1 UY23537A UY23537A UY23537A1 UY 23537 A1 UY23537 A1 UY 23537A1 UY 23537 A UY23537 A UY 23537A UY 23537 A UY23537 A UY 23537A UY 23537 A1 UY23537 A1 UY 23537A1
Authority
UY
Uruguay
Prior art keywords
compounds
formula
compound
antagonists
ltb4
Prior art date
Application number
UY23537A
Other languages
English (en)
Inventor
S Melvin Lawrence Jr
Kevin Koch
A Reiter Lawrence
G Ruggeri Sally
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of UY23537A1 publication Critical patent/UY23537A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/08—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/11—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton
    • C07C255/13—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

Procedimiento para la preparación de benzopiranos y otros anillos benzo-fusionados de fórmula general (I) (figura 1), sus dales y ésteres, donde: A es O, CH2, S, NH o N(alquilo C1-6); R3 es por ejemplo, y entre otras posibilidades bencilo, 4-fluorobencilo, 4-(4-fluorofenil)bencilo; caracterizado por: reducir un compuesto de fórmula (XII) (figura 2), y si se desea, formar las sales o ésteres de estos compuestos de fórmula (I), que contienen un grupo carboxi por ejemplo por reacción con una base o alcohol C1-6. En particular pueden prepararse compuestos de fórmula (I) sustituidos en la posición c a partir del correspondiente compuesto CF3SO3 sustituido en la posición c, por reacción con un cetal de trimetilsililcetena. Ejemplo no limitante de un compuesto de fórmula (I): 2',4'-dihidroxi-3-cloropropiofenona. Los productos del procedimiento conforme a la invención son antagonistas del leucotrieno B4 (LTB4), por tanto son de alcance a composiciones farmacéuticas que contienen estos compuestos y un método de uso de estos compuestos como antagonistas de LTB4. Por tanto estos compuestos son útiles en el tratamiento de las enfermedades como trastornos inflamatorios que incluyen artritis reumatoide, osteoartritis, enfermedad inflamatoria intestinal, psoriasis y otros trastornos de la piel tales como ezcema.
UY23537A 1992-01-23 1993-01-18 Benzopirano y antagonistas de ltb4 relacionados UY23537A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82467892A 1992-01-23 1992-01-23
US89005592A 1992-05-28 1992-05-28

Publications (1)

Publication Number Publication Date
UY23537A1 true UY23537A1 (es) 1993-06-28

Family

ID=27124835

Family Applications (1)

Application Number Title Priority Date Filing Date
UY23537A UY23537A1 (es) 1992-01-23 1993-01-18 Benzopirano y antagonistas de ltb4 relacionados

Country Status (27)

Country Link
US (1) US5550152A (es)
EP (1) EP0623122B1 (es)
JP (1) JP2813464B2 (es)
KR (1) KR950700274A (es)
CN (1) CN1074681A (es)
AP (1) AP385A (es)
AT (1) ATE149493T1 (es)
AU (1) AU2773392A (es)
BG (1) BG98873A (es)
BR (1) BR9207064A (es)
CA (1) CA2117349C (es)
CZ (1) CZ395492A3 (es)
DE (1) DE69217998T2 (es)
DK (1) DK0623122T3 (es)
ES (1) ES2098547T3 (es)
FI (1) FI943473A0 (es)
GR (1) GR3022999T3 (es)
HU (1) HUT67929A (es)
IL (1) IL104421A0 (es)
IS (1) IS3968A (es)
MX (1) MX9300313A (es)
NO (1) NO942758L (es)
OA (1) OA10713A (es)
PT (1) PT101182A (es)
TW (1) TW213456B (es)
UY (1) UY23537A1 (es)
WO (1) WO1993015066A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9300312A (es) * 1992-01-23 1993-07-31 Pfizer Antagonistas benzopiranicos y relacionado de ltb.
WO1996011920A1 (en) * 1994-10-13 1996-04-25 Pfizer Inc. Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene b4 (ltb4) antagonists
MX9702734A (es) * 1994-10-13 1997-06-28 Pfizer Benzopirano y compuestos benzocondensados, su preparacion y su uso como antagonistas de leucotrieno b4 (ltb4).
EP0925292B1 (en) * 1996-09-16 2003-09-10 Pfizer Inc. Processes and intermediates for preparing substituted chromanol derivatives
US6416733B1 (en) 1996-10-07 2002-07-09 Bristol-Myers Squibb Pharma Company Radiopharmaceuticals for imaging infection and inflammation
EP0836850A3 (en) * 1996-10-17 2000-11-29 Pfizer Inc. Method of preventing allograft rejection
EP0963755A3 (en) * 1998-04-16 2001-03-14 Pfizer Products Inc. Use of benzopyranes for preventing allograft rejection
US6770259B2 (en) 2000-11-03 2004-08-03 Bristol-Myers Squibb Pharma Company Simultaneous dual isotope imaging of cardiac perfusion and cardiac inflammation
US6541613B2 (en) * 2000-12-15 2003-04-01 Uyrex Corporation Isoflavone derivatives
US6958156B2 (en) * 2000-12-15 2005-10-25 Vyrex Corporation Isoflavone derivatives
JP2004518685A (ja) * 2001-01-30 2004-06-24 ファイザー・プロダクツ・インク クロマニル安息香酸の調製方法
JP2008506768A (ja) * 2004-07-22 2008-03-06 ファルマシア コーポレーション Ｃｏｘ−２選択的阻害剤とｌｔｂ４受容体アンタゴニストを組み合わせて用いる炎症および疼痛を治療するための組成物
ATE537151T1 (de) * 2006-10-31 2011-12-15 Pfizer Prod Inc Pyrazolinverbindungen als mineralocorticoidrezeptorantagonisten
CN104710438B (zh) * 2013-12-11 2019-11-29 中国科学院上海药物研究所 促进iPS细胞产生的螺环类化合物及其制备方法和用途
WO2016076006A1 (ja) * 2014-11-11 2016-05-19 学校法人順天堂 加齢黄斑変性症予防又は治療剤
US10029995B2 (en) 2015-09-03 2018-07-24 Forma Therapeutics, Inc. [6,6] fused bicyclic HDAC8 inhibitors
EP3383869B1 (en) 2015-11-30 2023-06-28 Merck Sharp & Dohme LLC Aryl sulfonamides as blt1 antagonists
US10370368B2 (en) 2015-11-30 2019-08-06 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as BLT1 antagonists
WO2017095724A1 (en) 2015-11-30 2017-06-08 Merck Sharp & Dohme Corp. Aryl sulfonamides as blt1 antagonists
EP3383388B1 (en) 2015-11-30 2021-04-14 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as blt1 antagonists
CN109289091B (zh) * 2018-10-09 2021-04-13 温州医科大学附属第一医院 一种用于装载骨髓间充质干细胞的复合支架及其制备方法
CN111647003B (zh) * 2020-06-08 2022-06-21 中国科学院昆明植物研究所 三环氧六氢色酮a及其药物组合物和其应用
CN111671745A (zh) * 2020-07-29 2020-09-18 北京大学 化合物在治疗溃疡性结肠炎药物制备中的应用

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Publication number Priority date Publication date Assignee Title
US4565882A (en) * 1984-01-06 1986-01-21 G. D. Searle & Co. Substituted dihydrobenzopyran-2-carboxylates
CA1320490C (en) * 1987-01-12 1993-07-20 Darrel M. Gapinski Anti-inflammatory agents
US4889871A (en) * 1987-05-29 1989-12-26 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives
US5059609A (en) * 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
WO1990015801A1 (en) * 1989-06-22 1990-12-27 Pfizer Inc. Substituted sulfonamides and related compounds in the treatment of asthma, arthritis and related diseases

Also Published As

Publication number Publication date
HU9402163D0 (en) 1994-09-28
NO942758D0 (no) 1994-07-22
DK0623122T3 (da) 1997-04-21
NO942758L (no) 1994-07-22
CA2117349A1 (en) 1993-08-05
JP2813464B2 (ja) 1998-10-22
FI943473A (fi) 1994-07-22
EP0623122A1 (en) 1994-11-09
DE69217998T2 (de) 1997-06-12
CZ395492A3 (en) 1994-03-16
EP0623122B1 (en) 1997-03-05
AP385A (en) 1995-05-15
DE69217998D1 (de) 1997-04-10
KR950700274A (ko) 1995-01-16
IS3968A (is) 1993-07-24
OA10713A (en) 2002-12-04
HUT67929A (en) 1995-05-29
ATE149493T1 (de) 1997-03-15
GR3022999T3 (en) 1997-07-30
IL104421A0 (en) 1993-05-13
BR9207064A (pt) 1995-12-19
US5550152A (en) 1996-08-27
TW213456B (es) 1993-09-21
BG98873A (en) 1995-03-31
FI943473A0 (fi) 1994-07-22
CA2117349C (en) 2000-02-29
CN1074681A (zh) 1993-07-28
AP9200441A0 (en) 1993-01-31
ES2098547T3 (es) 1997-05-01
WO1993015066A1 (en) 1993-08-05
MX9300313A (es) 1994-06-30
PT101182A (pt) 1994-03-31
AU2773392A (en) 1993-09-01
JPH07503464A (ja) 1995-04-13

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