NO942758D0 - Benzopyraner og beslektede LTB4 antagonister - Google Patents

Benzopyraner og beslektede LTB4 antagonister

Info

Publication number
NO942758D0
NO942758D0 NO942758A NO942758A NO942758D0 NO 942758 D0 NO942758 D0 NO 942758D0 NO 942758 A NO942758 A NO 942758A NO 942758 A NO942758 A NO 942758A NO 942758 D0 NO942758 D0 NO 942758D0
Authority
NO
Norway
Prior art keywords
benzopyrans
ltb4 antagonists
related ltb4
antagonists
ltb4
Prior art date
Application number
NO942758A
Other languages
English (en)
Other versions
NO942758L (no
Inventor
Kevin Koch
Jr Lawrence S Melvin
Lawrence Alan Reiter
Sally G Ruggeri
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of NO942758L publication Critical patent/NO942758L/no
Publication of NO942758D0 publication Critical patent/NO942758D0/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/08Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/01Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/11Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton
    • C07C255/13Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46Friedel-Crafts reactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/58Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
NO942758A 1992-01-23 1994-07-22 Benzopyraner og beslektede LTB4 antagonister NO942758D0 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US82467892A 1992-01-23 1992-01-23
US89005592A 1992-05-28 1992-05-28
PCT/US1992/008555 WO1993015066A1 (en) 1992-01-23 1992-10-13 Benzopyran and related ltb4 antagonists

Publications (2)

Publication Number Publication Date
NO942758L NO942758L (no) 1994-07-22
NO942758D0 true NO942758D0 (no) 1994-07-22

Family

ID=27124835

Family Applications (1)

Application Number Title Priority Date Filing Date
NO942758A NO942758D0 (no) 1992-01-23 1994-07-22 Benzopyraner og beslektede LTB4 antagonister

Country Status (27)

Country Link
US (1) US5550152A (no)
EP (1) EP0623122B1 (no)
JP (1) JP2813464B2 (no)
KR (1) KR950700274A (no)
CN (1) CN1074681A (no)
AP (1) AP385A (no)
AT (1) ATE149493T1 (no)
AU (1) AU2773392A (no)
BG (1) BG98873A (no)
BR (1) BR9207064A (no)
CA (1) CA2117349C (no)
CZ (1) CZ395492A3 (no)
DE (1) DE69217998T2 (no)
DK (1) DK0623122T3 (no)
ES (1) ES2098547T3 (no)
FI (1) FI943473A0 (no)
GR (1) GR3022999T3 (no)
HU (1) HUT67929A (no)
IL (1) IL104421A0 (no)
IS (1) IS3968A (no)
MX (1) MX9300313A (no)
NO (1) NO942758D0 (no)
OA (1) OA10713A (no)
PT (1) PT101182A (no)
TW (1) TW213456B (no)
UY (1) UY23537A1 (no)
WO (1) WO1993015066A1 (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9300312A (es) * 1992-01-23 1993-07-31 Pfizer Antagonistas benzopiranicos y relacionado de ltb.
HUT77515A (hu) * 1994-10-13 1998-05-28 Pfizer Inc. Hidrogénezett benzopirán- és naftalinszármazékok, ezeket tartalmazó gyógyszerkészítmények és intermedierjeik
US5939452A (en) * 1994-10-13 1999-08-17 Pfizer Inc Benzopyran and benzo-fused compounds, their preparation and their use as leukotriene B4' (LTB4) antagonists
BR9711482A (pt) * 1996-09-16 1999-08-24 Pfizer Processos e intermedi rios para a prepara-Æo de derivados de cromanol substitu¡dos
US6416733B1 (en) 1996-10-07 2002-07-09 Bristol-Myers Squibb Pharma Company Radiopharmaceuticals for imaging infection and inflammation
EP0836850A3 (en) * 1996-10-17 2000-11-29 Pfizer Inc. Method of preventing allograft rejection
EP0963755A3 (en) * 1998-04-16 2001-03-14 Pfizer Products Inc. Use of benzopyranes for preventing allograft rejection
EP1347784A2 (en) 2000-11-03 2003-10-01 Bristol-Myers Squibb Pharma Company Simultaneous dual isotope imaging of cardiac perfusion and cardiac inflammation
US6541613B2 (en) * 2000-12-15 2003-04-01 Uyrex Corporation Isoflavone derivatives
US6958156B2 (en) * 2000-12-15 2005-10-25 Vyrex Corporation Isoflavone derivatives
WO2002060888A1 (en) * 2001-01-30 2002-08-08 Pfizer Products Inc. Processes for preparing chromanylbenzoic acids
RU2007101510A (ru) * 2004-07-22 2008-08-27 Фармаци Корпорейшн (US) Композиции для лечения воспаления и боли с использованием комбинации селективного ингибитора сох-2 и антагониста рецептора ltb4
JP4977760B2 (ja) * 2006-10-31 2012-07-18 ファイザー・プロダクツ・インク 鉱質コルチコイド受容体拮抗薬としてのピラゾリン化合物
CN104710438B (zh) * 2013-12-11 2019-11-29 中国科学院上海药物研究所 促进iPS细胞产生的螺环类化合物及其制备方法和用途
US10849954B2 (en) * 2014-11-11 2020-12-01 Juntendo Educational Foundation Preventive or therapeutic agent for age-related macular degeneration
AR105911A1 (es) 2015-09-03 2017-11-22 Forma Therapeutics Inc Inhibidores de hdac8 bicíclicos fusionados [6,6]
EP3383869B1 (en) 2015-11-30 2023-06-28 Merck Sharp & Dohme LLC Aryl sulfonamides as blt1 antagonists
EP3383388B1 (en) 2015-11-30 2021-04-14 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as blt1 antagonists
EP3383868B1 (en) 2015-11-30 2022-10-05 Merck Sharp & Dohme LLC Aryl sulfonamides as blt1 antagonists
US10370368B2 (en) 2015-11-30 2019-08-06 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as BLT1 antagonists
CN109289091B (zh) * 2018-10-09 2021-04-13 温州医科大学附属第一医院 一种用于装载骨髓间充质干细胞的复合支架及其制备方法
CN111647003B (zh) * 2020-06-08 2022-06-21 中国科学院昆明植物研究所 三环氧六氢色酮a及其药物组合物和其应用
CN111671745A (zh) * 2020-07-29 2020-09-18 北京大学 化合物在治疗溃疡性结肠炎药物制备中的应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4565882A (en) * 1984-01-06 1986-01-21 G. D. Searle & Co. Substituted dihydrobenzopyran-2-carboxylates
CA1320490C (en) * 1987-01-12 1993-07-20 Darrel M. Gapinski Anti-inflammatory agents
US4889871A (en) * 1987-05-29 1989-12-26 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives
US5059609A (en) * 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
WO1990015801A1 (en) * 1989-06-22 1990-12-27 Pfizer Inc. Substituted sulfonamides and related compounds in the treatment of asthma, arthritis and related diseases

Also Published As

Publication number Publication date
FI943473A (fi) 1994-07-22
TW213456B (no) 1993-09-21
PT101182A (pt) 1994-03-31
OA10713A (en) 2002-12-04
WO1993015066A1 (en) 1993-08-05
AP9200441A0 (en) 1993-01-31
CA2117349C (en) 2000-02-29
DE69217998D1 (de) 1997-04-10
UY23537A1 (es) 1993-06-28
DE69217998T2 (de) 1997-06-12
CZ395492A3 (en) 1994-03-16
EP0623122B1 (en) 1997-03-05
MX9300313A (es) 1994-06-30
ES2098547T3 (es) 1997-05-01
HU9402163D0 (en) 1994-09-28
FI943473A0 (fi) 1994-07-22
GR3022999T3 (en) 1997-07-30
ATE149493T1 (de) 1997-03-15
CN1074681A (zh) 1993-07-28
NO942758L (no) 1994-07-22
BR9207064A (pt) 1995-12-19
HUT67929A (en) 1995-05-29
AU2773392A (en) 1993-09-01
EP0623122A1 (en) 1994-11-09
IL104421A0 (en) 1993-05-13
US5550152A (en) 1996-08-27
BG98873A (en) 1995-03-31
DK0623122T3 (da) 1997-04-21
IS3968A (is) 1993-07-24
JPH07503464A (ja) 1995-04-13
JP2813464B2 (ja) 1998-10-22
CA2117349A1 (en) 1993-08-05
KR950700274A (ko) 1995-01-16
AP385A (en) 1995-05-15

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