FR2374334A1 - Nouveaux nucleosides utiles comme medicaments et procede pour leur preparation - Google Patents

Nouveaux nucleosides utiles comme medicaments et procede pour leur preparation

Info

Publication number
FR2374334A1
FR2374334A1 FR7738041A FR7738041A FR2374334A1 FR 2374334 A1 FR2374334 A1 FR 2374334A1 FR 7738041 A FR7738041 A FR 7738041A FR 7738041 A FR7738041 A FR 7738041A FR 2374334 A1 FR2374334 A1 FR 2374334A1
Authority
FR
France
Prior art keywords
preparation
medicinal products
useful
nucleosides useful
new nucleosides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7738041A
Other languages
English (en)
Other versions
FR2374334B1 (fr
Inventor
Alan Frederick Cook
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of FR2374334A1 publication Critical patent/FR2374334A1/fr
Application granted granted Critical
Publication of FR2374334B1 publication Critical patent/FR2374334B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

La présente invention concerne des composés chimiques nouveaux. Il s'agit d'un pyrimidine nucléoside choisi parmi la 5'-désoxy-5-fluorocytidine, la 5'-désoxy-5-fluoro-undine et les sels d'addition d'acide pharmaceutiquement acceptables de ces composés, préparé par un procéde ou par un équivalent chimiquement évident Ces produits sont utiles comme médicaments.
FR7738041A 1976-12-20 1977-12-16 Nouveaux nucleosides utiles comme medicaments et procede pour leur preparation Granted FR2374334A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/752,510 US4071680A (en) 1976-12-20 1976-12-20 5'-Deoxy-5-fluoropyrimidine nucleosides

Publications (2)

Publication Number Publication Date
FR2374334A1 true FR2374334A1 (fr) 1978-07-13
FR2374334B1 FR2374334B1 (fr) 1981-11-27

Family

ID=25026612

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7738041A Granted FR2374334A1 (fr) 1976-12-20 1977-12-16 Nouveaux nucleosides utiles comme medicaments et procede pour leur preparation

Country Status (30)

Country Link
US (1) US4071680A (fr)
JP (2) JPS5834479B2 (fr)
AR (2) AR220692A1 (fr)
AT (1) AT355733B (fr)
AU (1) AU515446B2 (fr)
BE (1) BE861984A (fr)
CA (1) CA1085390A (fr)
DE (1) DE2756653C2 (fr)
DK (2) DK147858C (fr)
ES (2) ES465217A1 (fr)
FI (1) FI63946C (fr)
FR (1) FR2374334A1 (fr)
GB (1) GB1589688A (fr)
GR (1) GR70039B (fr)
HK (1) HK78284A (fr)
HU (1) HU177104B (fr)
IE (1) IE46107B1 (fr)
IL (2) IL53589A (fr)
IT (1) IT1089318B (fr)
LU (1) LU78717A1 (fr)
MC (1) MC1174A1 (fr)
MY (1) MY8500246A (fr)
NL (1) NL178878C (fr)
NO (1) NO145307C (fr)
NZ (1) NZ185965A (fr)
PH (1) PH12784A (fr)
PT (1) PT67429B (fr)
SE (1) SE440361B (fr)
YU (2) YU40688B (fr)
ZA (1) ZA777238B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU724533A1 (ru) * 1977-08-02 1980-03-30 Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвийской Сср 1-(5-Фторурацилил-1) - - глюкофурануронова кислота или ее ацилзамещенный лактон,обладающие антибластическим действием
FR2428638A1 (fr) * 1978-06-15 1980-01-11 Aec Chim Organ Biolog Nouveau derive de la xylidine-3,4, sa preparation et son utilisation
CA1135258A (fr) 1979-06-15 1982-11-09 Richard D'souza Procede d'obtention de 5'-desoxy-5- fluorouridine
US5455339A (en) * 1986-05-01 1995-10-03 University Of Georgia Research Foundation, Inc. Method for the preparation of 2',3'-dideoxy and 2',3'-dideoxydide-hydro nucleosides
US5084445A (en) * 1986-05-01 1992-01-28 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxy-5-methylcytidine
US4841039A (en) * 1986-05-01 1989-06-20 Emory University 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents
US4916122A (en) * 1987-01-28 1990-04-10 University Of Georgia Research Foundation, Inc. 3'-Azido-2',3'-dideoxyuridine anti-retroviral composition
US5077279A (en) * 1986-05-01 1991-12-31 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxy-5-methylcytidine anti-viral composition
US5190926A (en) * 1987-01-28 1993-03-02 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxypyrimidines and related compounds as antiviral agents
CA1327358C (fr) * 1987-11-17 1994-03-01 Morio Fujiu Derives fluorocytidine
US5384396A (en) * 1988-02-23 1995-01-24 The University Of Georgia Research Foundation, Inc. Process for the deoxygenation of nucleosides
US5077280A (en) * 1988-04-12 1991-12-31 Brown University Research Foundation Treatment of viral infections
US4987224A (en) * 1988-08-02 1991-01-22 University Of Georgia Research Foundation, Inc. Method of preparation of 2',3'-dideoxynucleosides
US5141943A (en) * 1990-04-12 1992-08-25 Brown University Research Foundation 5-benzyl barbiturate derivatives
US5278167A (en) * 1992-05-13 1994-01-11 Brown University Research Foundation 6-pyridyl substituted pyrimidine derivatives
US6593467B2 (en) 1997-05-23 2003-07-15 Clariant Finance (Bvi) Limited Process for the preparation of a deoxyuridine derivative
IT1291983B1 (it) * 1997-05-23 1999-01-25 Pro Bio Sint Srl Prodcedimento per la preparazione di un derivato della desossiuridina
NZ330360A (en) * 1997-06-02 1999-03-29 Hoffmann La Roche 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents
CN1931869B (zh) * 2005-09-14 2011-05-11 上海瑞广生化科技开发有限公司 5’-脱氧-5-氟胞苷类衍生物，它的制备方法及其用途
CN105343029B (zh) * 2015-12-08 2018-10-12 上海朝晖药业有限公司 一种去氧氟尿苷胶囊及其制备方法
SG11202100411TA (en) * 2018-08-03 2021-02-25 Cellix Bio Private Ltd Compositions and methods for the treatment of cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2359108A1 (de) * 1972-11-28 1974-05-30 Kohjin Co Verfahren zur herstellung von 5fluorcytidin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3687931A (en) * 1970-03-19 1972-08-29 Syntex Corp Halogenated purine and pyrimidine nucleosides and process therefor
US3928319A (en) * 1971-06-16 1975-12-23 Syntex Inc 4 -Fluoro nucleosides, novel intermediates and methods of preparing same
JPS5726278B2 (fr) * 1973-03-13 1982-06-03
US3910885A (en) * 1974-03-12 1975-10-07 Syntex Inc 4-Alkoxy nucleosides and intermediates therefore

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2359108A1 (de) * 1972-11-28 1974-05-30 Kohjin Co Verfahren zur herstellung von 5fluorcytidin

Also Published As

Publication number Publication date
SE7714462L (sv) 1978-06-21
DK148745B (da) 1985-09-16
ZA777238B (en) 1978-09-27
BE861984A (fr) 1978-06-19
NL7714069A (nl) 1978-06-22
AR225410A1 (es) 1982-03-31
YU204984A (en) 1985-08-31
NZ185965A (en) 1979-03-28
DE2756653A1 (de) 1978-06-22
JPS5395982A (en) 1978-08-22
AT355733B (de) 1980-03-25
PH12784A (en) 1979-08-17
YU40688B (en) 1986-04-30
AU3149177A (en) 1979-06-21
PT67429A (en) 1978-01-01
JPS5747000A (en) 1982-03-17
ES465217A1 (es) 1978-12-01
NO145307B (no) 1981-11-16
FI63946B (fi) 1983-05-31
DK147858B (da) 1984-12-24
IL53589A (en) 1981-05-20
DK566777A (da) 1978-06-21
GB1589688A (en) 1981-05-20
CA1085390A (fr) 1980-09-09
IL53589A0 (en) 1978-03-10
SE440361B (sv) 1985-07-29
NL178878C (nl) 1986-06-02
ATA909577A (de) 1979-08-15
FI63946C (fi) 1983-09-12
AU515446B2 (en) 1981-04-02
FR2374334B1 (fr) 1981-11-27
GR70039B (fr) 1982-07-26
PT67429B (en) 1979-12-19
DE2756653C2 (de) 1982-06-24
HU177104B (en) 1981-07-28
AR220692A1 (es) 1980-11-28
DK148745C (da) 1986-03-17
MY8500246A (en) 1985-12-31
IT1089318B (it) 1985-06-18
IL61311A0 (en) 1980-12-31
FI773804A (fi) 1978-06-21
YU302277A (en) 1983-01-21
YU44478B (en) 1990-08-31
HK78284A (en) 1984-10-26
IE46107B1 (en) 1983-02-23
US4071680A (en) 1978-01-31
JPS5936999B2 (ja) 1984-09-06
DK531781A (da) 1981-11-30
NO774375L (no) 1978-06-21
ES471584A1 (es) 1979-01-16
DK147858C (da) 1985-06-10
NO145307C (no) 1982-02-24
JPS5834479B2 (ja) 1983-07-27
LU78717A1 (fr) 1979-02-02
MC1174A1 (fr) 1978-09-25
IE46107L (en) 1978-06-20

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