FI773804A - Nya nukleosider och foerfarande foer deras framstaellning - Google Patents

Nya nukleosider och foerfarande foer deras framstaellning

Info

Publication number
FI773804A
FI773804A FI773804A FI773804A FI773804A FI 773804 A FI773804 A FI 773804A FI 773804 A FI773804 A FI 773804A FI 773804 A FI773804 A FI 773804A FI 773804 A FI773804 A FI 773804A
Authority
FI
Finland
Prior art keywords
nucleosider
nya
foerfarande foer
och foerfarande
deras framstaellning
Prior art date
Application number
FI773804A
Other languages
English (en)
Other versions
FI63946B (fi
FI63946C (fi
Inventor
Alan Frederick Cook
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI773804A publication Critical patent/FI773804A/fi
Publication of FI63946B publication Critical patent/FI63946B/fi
Application granted granted Critical
Publication of FI63946C publication Critical patent/FI63946C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI773804A 1976-12-20 1977-12-15 Foerfarande foer framstaellning av terapeutiskt anvaendbara 5'deoxi-5-fluorcytidin och 5'-deoxi-5-fluoruridin FI63946C (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75251076 1976-12-20
US05/752,510 US4071680A (en) 1976-12-20 1976-12-20 5'-Deoxy-5-fluoropyrimidine nucleosides

Publications (3)

Publication Number Publication Date
FI773804A true FI773804A (fi) 1978-06-21
FI63946B FI63946B (fi) 1983-05-31
FI63946C FI63946C (fi) 1983-09-12

Family

ID=25026612

Family Applications (1)

Application Number Title Priority Date Filing Date
FI773804A FI63946C (fi) 1976-12-20 1977-12-15 Foerfarande foer framstaellning av terapeutiskt anvaendbara 5'deoxi-5-fluorcytidin och 5'-deoxi-5-fluoruridin

Country Status (30)

Country Link
US (1) US4071680A (fi)
JP (2) JPS5834479B2 (fi)
AR (2) AR220692A1 (fi)
AT (1) AT355733B (fi)
AU (1) AU515446B2 (fi)
BE (1) BE861984A (fi)
CA (1) CA1085390A (fi)
DE (1) DE2756653C2 (fi)
DK (2) DK147858C (fi)
ES (2) ES465217A1 (fi)
FI (1) FI63946C (fi)
FR (1) FR2374334A1 (fi)
GB (1) GB1589688A (fi)
GR (1) GR70039B (fi)
HK (1) HK78284A (fi)
HU (1) HU177104B (fi)
IE (1) IE46107B1 (fi)
IL (2) IL53589A (fi)
IT (1) IT1089318B (fi)
LU (1) LU78717A1 (fi)
MC (1) MC1174A1 (fi)
MY (1) MY8500246A (fi)
NL (1) NL178878C (fi)
NO (1) NO145307C (fi)
NZ (1) NZ185965A (fi)
PH (1) PH12784A (fi)
PT (1) PT67429B (fi)
SE (1) SE440361B (fi)
YU (2) YU40688B (fi)
ZA (1) ZA777238B (fi)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU724533A1 (ru) * 1977-08-02 1980-03-30 Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвийской Сср 1-(5-Фторурацилил-1) - - глюкофурануронова кислота или ее ацилзамещенный лактон,обладающие антибластическим действием
FR2428638A1 (fr) * 1978-06-15 1980-01-11 Aec Chim Organ Biolog Nouveau derive de la xylidine-3,4, sa preparation et son utilisation
CA1135258A (en) * 1979-06-15 1982-11-09 Richard D'souza Process for the preparation of 5'deoxy-5-fluorouridine
US4841039A (en) * 1986-05-01 1989-06-20 Emory University 2',3'-dideoxy-5-substituted uridines and related compounds as antiviral agents
US5084445A (en) * 1986-05-01 1992-01-28 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxy-5-methylcytidine
US5077279A (en) * 1986-05-01 1991-12-31 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxy-5-methylcytidine anti-viral composition
US4916122A (en) * 1987-01-28 1990-04-10 University Of Georgia Research Foundation, Inc. 3'-Azido-2',3'-dideoxyuridine anti-retroviral composition
US5455339A (en) * 1986-05-01 1995-10-03 University Of Georgia Research Foundation, Inc. Method for the preparation of 2',3'-dideoxy and 2',3'-dideoxydide-hydro nucleosides
US5190926A (en) * 1987-01-28 1993-03-02 University Of Georgia Research Foundation, Inc. 3'-azido-2',3'-dideoxypyrimidines and related compounds as antiviral agents
CA1327358C (en) * 1987-11-17 1994-03-01 Morio Fujiu Fluoro cytidine derivatives
US5384396A (en) * 1988-02-23 1995-01-24 The University Of Georgia Research Foundation, Inc. Process for the deoxygenation of nucleosides
US5077280A (en) * 1988-04-12 1991-12-31 Brown University Research Foundation Treatment of viral infections
US4987224A (en) * 1988-08-02 1991-01-22 University Of Georgia Research Foundation, Inc. Method of preparation of 2',3'-dideoxynucleosides
US5141943A (en) * 1990-04-12 1992-08-25 Brown University Research Foundation 5-benzyl barbiturate derivatives
US5278167A (en) * 1992-05-13 1994-01-11 Brown University Research Foundation 6-pyridyl substituted pyrimidine derivatives
US6593467B2 (en) 1997-05-23 2003-07-15 Clariant Finance (Bvi) Limited Process for the preparation of a deoxyuridine derivative
IT1291983B1 (it) * 1997-05-23 1999-01-25 Pro Bio Sint Srl Prodcedimento per la preparazione di un derivato della desossiuridina
NZ330360A (en) * 1997-06-02 1999-03-29 Hoffmann La Roche 5'-deoxy-cytidine derivatives, their manufacture and use as antitumoral agents
CN1931869B (zh) * 2005-09-14 2011-05-11 上海瑞广生化科技开发有限公司 5’-脱氧-5-氟胞苷类衍生物，它的制备方法及其用途
CN105343029B (zh) * 2015-12-08 2018-10-12 上海朝晖药业有限公司 一种去氧氟尿苷胶囊及其制备方法
CA3108362A1 (en) * 2018-08-03 2020-02-06 Cellix Bio Private Limited Compositions and methods for the treatment of cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3687931A (en) * 1970-03-19 1972-08-29 Syntex Corp Halogenated purine and pyrimidine nucleosides and process therefor
US3928319A (en) * 1971-06-16 1975-12-23 Syntex Inc 4 -Fluoro nucleosides, novel intermediates and methods of preparing same
JPS5545560B2 (fi) * 1972-11-28 1980-11-18
JPS5726278B2 (fi) * 1973-03-13 1982-06-03
US3910885A (en) * 1974-03-12 1975-10-07 Syntex Inc 4-Alkoxy nucleosides and intermediates therefore

Also Published As

Publication number Publication date
ATA909577A (de) 1979-08-15
AT355733B (de) 1980-03-25
YU40688B (en) 1986-04-30
IT1089318B (it) 1985-06-18
IE46107B1 (en) 1983-02-23
DK148745B (da) 1985-09-16
MY8500246A (en) 1985-12-31
AU3149177A (en) 1979-06-21
CA1085390A (en) 1980-09-09
NO145307B (no) 1981-11-16
SE7714462L (sv) 1978-06-21
DK566777A (da) 1978-06-21
DK531781A (da) 1981-11-30
NZ185965A (en) 1979-03-28
BE861984A (fr) 1978-06-19
YU44478B (en) 1990-08-31
JPS5395982A (en) 1978-08-22
FI63946B (fi) 1983-05-31
PH12784A (en) 1979-08-17
MC1174A1 (fr) 1978-09-25
YU204984A (en) 1985-08-31
DE2756653A1 (de) 1978-06-22
JPS5834479B2 (ja) 1983-07-27
ZA777238B (en) 1978-09-27
US4071680A (en) 1978-01-31
FR2374334B1 (fi) 1981-11-27
IE46107L (en) 1978-06-20
ES471584A1 (es) 1979-01-16
NL178878C (nl) 1986-06-02
IL53589A0 (en) 1978-03-10
FI63946C (fi) 1983-09-12
IL61311A0 (en) 1980-12-31
NO774375L (no) 1978-06-21
DK148745C (da) 1986-03-17
AR225410A1 (es) 1982-03-31
LU78717A1 (fi) 1979-02-02
PT67429B (en) 1979-12-19
FR2374334A1 (fr) 1978-07-13
GR70039B (fi) 1982-07-26
PT67429A (en) 1978-01-01
ES465217A1 (es) 1978-12-01
YU302277A (en) 1983-01-21
AU515446B2 (en) 1981-04-02
JPS5747000A (en) 1982-03-17
HK78284A (en) 1984-10-26
GB1589688A (en) 1981-05-20
NO145307C (no) 1982-02-24
HU177104B (en) 1981-07-28
DK147858C (da) 1985-06-10
DE2756653C2 (de) 1982-06-24
IL53589A (en) 1981-05-20
AR220692A1 (es) 1980-11-28
NL7714069A (nl) 1978-06-22
SE440361B (sv) 1985-07-29
DK147858B (da) 1984-12-24
JPS5936999B2 (ja) 1984-09-06

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Legal Events

Date Code Title Description
MA Patent expired
MA Patent expired

Owner name: F. HOFFMANN-LA ROCHE AG