US3911640A - Method for the packing under aseptic conditions of sterile goods into containers - Google Patents
Method for the packing under aseptic conditions of sterile goods into containers Download PDFInfo
- Publication number
- US3911640A US3911640A US380574A US38057473A US3911640A US 3911640 A US3911640 A US 3911640A US 380574 A US380574 A US 380574A US 38057473 A US38057473 A US 38057473A US 3911640 A US3911640 A US 3911640A
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- United States
- Prior art keywords
- web
- sterile
- chamber
- tunnel
- containers
- Prior art date
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- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title claims abstract description 24
- 238000012856 packing Methods 0.000 title abstract description 27
- 239000000463 material Substances 0.000 claims description 107
- 238000007789 sealing Methods 0.000 claims description 9
- 239000000945 filler Substances 0.000 claims description 5
- 238000012545 processing Methods 0.000 abstract description 15
- 238000010438 heat treatment Methods 0.000 description 22
- 239000007788 liquid Substances 0.000 description 22
- 238000002203 pretreatment Methods 0.000 description 22
- 230000001954 sterilising effect Effects 0.000 description 21
- 238000003856 thermoforming Methods 0.000 description 11
- 238000005406 washing Methods 0.000 description 11
- 239000003795 chemical substances by application Substances 0.000 description 10
- 238000004659 sterilization and disinfection Methods 0.000 description 9
- 239000004033 plastic Substances 0.000 description 8
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- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 7
- 230000000249 desinfective effect Effects 0.000 description 7
- 239000012530 fluid Substances 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- -1 chloride-polyethylene Chemical group 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 229920001328 Polyvinylidene chloride Polymers 0.000 description 3
- 239000011888 foil Substances 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 238000004806 packaging method and process Methods 0.000 description 3
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- 239000005033 polyvinylidene chloride Substances 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- 239000004698 Polyethylene Substances 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 239000005030 aluminium foil Substances 0.000 description 2
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- 229920000915 polyvinyl chloride Polymers 0.000 description 2
- 239000004800 polyvinyl chloride Substances 0.000 description 2
- 230000002035 prolonged effect Effects 0.000 description 2
- 235000012431 wafers Nutrition 0.000 description 2
- 101100508883 Bacillus subtilis (strain 168) iolI gene Proteins 0.000 description 1
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- 235000013365 dairy product Nutrition 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
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- 238000010981 drying operation Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005485 electric heating Methods 0.000 description 1
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- 238000005429 filling process Methods 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/08—Radiation
- A61L2/10—Ultraviolet radiation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
- B65B55/02—Sterilising, e.g. of complete packages
- B65B55/025—Packaging in aseptic tunnels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
- B67C7/00—Concurrent cleaning, filling, and closing of bottles; Processes or devices for at least two of these operations
- B67C7/0073—Sterilising, aseptic filling and closing
Definitions
- thermoformable web is introduced into one end of a processing tunnel within which sterile conditions are maintained. As the web passes through the tunnel it is drawn into a series of end-to-end connected open-top containers which are then filled from above with the sterile goods to be packaged. After filling, and while still within the tunnel, a closure in the form of a second web is applied to the upper ends of the containers and heat sealed into place. After the end-to-end connected formed, filled and sealed containers pass out of the opposite end of the tunnel they are then separated from one another by severing.
- the present invention relates to a method for the packing under aseptic conditions of sterile goods into cntainers, a thermoformable material web, after it has been subjected to a sterilizing medium or with simultaneous sterilization, being heated up to a temperature required for a thermoforming processing, whereupon the web or a selected part of the same is subjected to a thermoforming processing with the object of forming containers from the web, which whilst continuing to be joined to the web and being oriented so that the container openings are situated mainly in the plane of the web, are filled with the sterile goods intended for packing and are closed in that the openings of the container are covered by another web, which is sealed or in some other manner joined to the first material web at least along zones closed in themselves around the container openings with the object of enclosing the sterile goods in the containers.
- a compound material web which comprises a fibrous base layer and plastic layer and metal foil layer placed thereon.
- the web is converted to a tube which is filled with the sterile goods and which is divided under aseptic conditions to wholly filled and closed packing units.
- closed and sterile containers are punctured with a cannula, through which the sterile goods are fed to the interior of these containers.
- This system of packing is of course not rational for the packing of such consumption goods as foodstuffs.
- a web of plastic material is used, from which containers are formed by means of vacuum drawing, at least the filling and closing operations being carried out in an aseptic atmosphere.
- thermoformable material web is introduced into a tunnel and is passed through the same in such a manner that the material web, together with the walls of the tunnel, forms a chamber, in which a sterile atmosphere is maintained, the filling of the containers formed and the sealing of the filled containers are carried out with the help of a second material web in the said chamber, whereupon the filled and sealed containers are moved out of the tunnel while the combined first and second webs present a plane upper side, and that the containers are finally separated from one another by means of a cut through the said two webs.
- FIG. 1 shows in side view and partly in section a setup for the execution of the method in accordance with the invention
- FIG. 2a-FIG. 2e show in cross-section various executions of the sterile tunnel which forms part of the set-up according to FIG. 1.
- reference indication 1 indicates a tunnel and 2 a thermoformable material web which is intended to be introduced into the one end of the tunnel and to be moved out from its other end together with a second material web 3, which is applied to the first thermoformable material web in the tunnel.
- the walls of the tunnel 1 form, together with the web 2 and the joined first and second webs 2 and 3, a sterile chamber 4.
- the sterile chamber can be provided at its front end with a pre-treatment chamber 5, which may consist of an extended part of the tunnel 1, this chamber being formed similar to the sterile chamber 4, that it to say that the walls of the tunnel together with the web 2 form the chamber.
- a pre-treatment chamber 6 is arranged for the introduction of the said material web 3. This chamber is realized preferably as a superstructure on the sterile tunnel l and communicates with the same via an opening 36 in the tunnel wall.
- a forming tool 19 is arranged for the forming of container bodies 21 by means of thermoforming processing of the material web 2.
- the forming tool may consist of a forming box which comprises at least one, but preferably several forming cavities and which is adapted for example for vacuum drawing of the material web 2.
- the forming box is adapted so that it canfollow the web some distance in the direction of movement of the same during the forming operation itself, thereafter rapidly to revert to the original position for the processing of a nonprocessed part of the web.
- the forming tool may consist of a number of forming bodies which are designed for the same purpose as the said forming box, the forming bodies being arranged so that they run on an endless chain underneath the material web 2.
- the containers formed in the forming bodies can be allowed to remain in the forming cavity of the forming bodies for an appreciably longer time than what is possible otherwise for a rational forming process.
- the container bodies can cool down in the forming cavity without special cooling having to be applied and also better conditions for a pre- ,vention of a shrinkage of the material being obtained.
- the thermoformable material web 2 is given a necessary push up during the transport through the sterile chamber 4 as well as a support at the different working operations.
- a tool On the side opposite the thermoformable material web 2, that is to say in the sterile chamber 4, a tool may be arranged for a positive forming effect on the material web 2.
- a filler 22 which is adapted so that it fills the container bodies 21 with sterile goods.
- a sealing device 23 is provided in the chamber 4, which for example by means of heat and pressure and by means of compression plates 24 seals the said second web 3 to the material web 2, so that the sterile goods filled into the container bodies 21 becomes enclosed.
- an intake 18 for sterile air In the upper part of the tunnel 1 is an intake 18 for sterile air, which air is introduced into the sterile chamber 4 and is contained in the same, preferably under a certain pressure.
- thermoforming processing Before the thermoformable material web 2 is subjected to a thermoforming processing by means of the forming tools 19, 20, the material web has to be heated up to a temperature necessary for the thermoforming processing, that is to say to a suitable degree of softening.
- This heeating operation is carried out appropriately outside the sterile chamber 4, because the sterile atmosphere contained in the chamber may become mixed with medium evaporating off the web.
- the heating elements are indicated by reference numeral 12, which are arranged outside the sterile chamber 4. These heating elements may consist for example of heating spirals designed for electric heating.
- the heating operation may be carried out, as shown in the figure, in a chamber,- which in turn may consist of the said pre-treatment chamber.
- the upper part'of the pretreatment chamber 5 may be provided with an element 17 for extracting by suction the atmosphere contained in the chamber.
- the pre-treatment chamber may be provided instead or at the same time with different elements for the washing and/or sterilization of the material web 2.
- the said pre-treatment chambers 5 and 6 are intended foremost to contain elements for the cleaning of the two respective material webs 2, 3 by means of washing and/or sterilizing before they are introduced into the sterile chamber 4.
- the element 11 may be adapted so as to irradiate the webs with ultraviolet light, the element 4 for electron spraying of the webs or bath and spray devices containing hydrogen peroxide, alcohol or some other sterilizing, washing or disinfecting fluid which is kept in the bath or which is applied to the webs in the form f finely divided particles. Traces of such liquid medium can be removed from the webs by evaporation, suitable heating elements for the purpose being arranged in chambers 5, 6.
- the web can be subjected to a thermal sterilization.
- sterile atmospheres are of course being maintained for this purpose and suitable delimitations exist against the atmosphere surrounding the chambers.
- the elements 15, 15' and 15" are provided at the entrance 13, 13, 36, 36' and at the exit 37 respectively, which prevent the surrounding atmosphere from penetrating into the tunnel 1 and/or the chambers 5 and 6.
- These elements may consist of a sluice comprising a suitble sterilizing or disinfecting fluid, an air curtain consisting of a sterile air stream, a liquid curtain consisting of finely divided particles of hydrogen peroxide, alcohol or a washing or disinfecting, non-corrosive liquid, a sleeve element or any other means which prevents the surrounding atmosphere from penetrating into the tunnel and/or the chambers.
- the pre-treatment chambers 5 and 6 respectively must be separated from the sterile chamber, which can be done in the simplest form by a screen wall 14 and 35 respectively, the pressure of sterile air prevailing in the Sterile chamber 4 being made to flow out to the pretreatment chambers through the openings 13 and 36 respectively which are arranged between the screen walls and the material webs 2 and 3 respectively.
- the pre-treatment chambers can also be separated from the sterile chamber by means of a sluice, a liquid or air curtain or any other suitable arrangement.
- the washing and/or sterilization process must be carried out outside the sterile chamber 4. If liquid or gaseous washing and/or sterilization agents are used, the said processes must likewise be carried out outside the pre-treatment chambers 5, 6, since the agents, if used in the pre-treatment chambers, may be blended into the atmosphere contained in the chambers and there is an obvious danger, in spite of the presence of sluices or similar arrangements between the pre-treatment chambers and the sterile chamber, that the atmosphere mixed with washing and/or sterilization agents may penetrate into the sterile chamber 4 or that such agents may precipitate in liquid form (condensation) on the material web to accompany the same into the sterile chamber.
- vats 8 and 28 are arranged outside the pretreatment chambers 5 and 6 respectively. These vats are intended to contain a washing and/or sterilizing liquid 9 and 29 respectively for the material webs 2 and 3, consisting for example of an alcohol or a hydrogen peroxide solution. Behind the tanks are arranged elements 10 and 31 respectively for the absorption of the surplus liquid and heating elements 16 and 32 respectively in the form of for example heating spirals for the heating of the respective web so that the residues of the treatment fluids evaporate. For the removal of the surplus fluid it is also possible for example to use an air knife, such as that indicated in FIG. 1 by numeral 30, with the surplus liquid flowing or dripping back into the vat 28.
- an air knife such as that indicated in FIG. 1 by numeral 30, with the surplus liquid flowing or dripping back into the vat 28.
- a knife or shear element 38 which is intended to separate the filled and sealed containers from one another by means of a cut through the two material webs 2 and 3. Possible surplus material from the said second material web 3 may be rolled up on a roller 39.
- An endless belt 40 or another suitable transport device is arranged for taking over the separated packing containers 41.
- FIG. 2aFlG. 2e there is shown a cross-section of the sterile chamber 4 in different manners of realization.
- the figures show, that the sterile chamber consists on the one hand of the said tunnel 1, on the other hand of the thermoformable material web 2 which constitutes the bottom of the sterile chamber. Since the sterile chamber consists of two parts movable in relation to one another, a seal has to be provided between the parts which is satisfactory in respect of the aseptic conditions. According to FIG. 2a it is intended that the pressure prevailing in the sterile chamber 4 shall be allowed to seep out in the cracks 42 which have to be maintained between the longitudinal edges of the web 2 and the side walls of the tunnel 1.
- FIG. 2 b differs from FIG. 2 a only in that the bottom portions of the wall 43 have been folded-in a bit under the thermoformable material web 2 so as to form a better protection against the surrounding atmosphere.
- the longitudinal edges of the thermoformable material web 2 are allowed to run in a liquid 45 which is contained in a channel 44 running along each web edge.
- Each of the channels can be constructed as a container closed in itself which has, however, a longitudinal opening matched to the web'edges, so that the respective longitudinal edge portions of the web can project into an adjacent channel 44. With the object of achieving a seal the said opening in each channel can be provided with sleeves or the like. In the manner of realization shown in FIG.
- the longitudinal web edges of the thermoformable material web 2 likewise run in a liquid 49.
- the liquid is contained in elongated channels or containers 48 which are arranged adjoining to the web edges.
- the edge portions on the material web have been folded over in such a manner that from the horizontally guided web, edge flanges 46 largely extending vertically downwards, are obtained.
- the bottom portions of the side walls 47 of the tunnel are also allowed to dip into the same liquid, as a result of which a liquid sluice is formed between the walls of the tunnel and the longitudinal edge portions of the thermoformable material web.
- Reference numeral 50 indicates the element for the formation of a liquid or preferably air curtain as a screening agent. Different types of sleeves, or any other element, are also conceivable as screening agent in this context.
- the thermoformable material web 2 may consist of a polyvinylidene chloride-coated polyvinylchloride web, a polyvinylidene chloride-coated polystyrene web, a co-extruded web consisting of a polyethylenepolyvinylidene chloride-polyethylene combination, an acrylonitrile copolymer built up of polystyrenepolyvinylidene chloride-polyethylene.
- Other combinations may of course also be used in the building up of a thermoformable material web which can be used in this connection.
- two or more of the following materials namely polystyrene, polyvinylidene chloride, polyethylene, polyvinylchloride and also aluminium foil can be combined.
- the said second material web 3 may be built up of a multi-layer material consisting of a metal foil, a polyethylene layer, a more rigid layer consisting of fibres or polyester and a preoxylene-based coating which is heat-scalable.
- a multi-layer material consisting of a metal foil, a polyethylene layer, a more rigid layer consisting of fibres or polyester and a preoxylene-based coating which is heat-scalable.
- Other material compositions are of course conceivable.
- the sterile chamber 4 and the pre-treatment chambers 5 and 6, if such are used must be set up, which is done in that at least the thermoformable plastic material web 2 is introduced into the tunnel 1. Subsequently the sterile chamber and the pretreatment chambers 5, 6, if any, have to be sterilized and/or disinfected, which implies that the elements situated in the sterile chamber, such as the forming elements 20, the fillers 22 and so on become washed and sterilized.
- thermoformable material web 2 is passed from a roller 7 and down into a vat 8 containing a washing and/or sterilizing liquid 9 for the purpose of cleaning or washing and sterilizing the material web 2.
- the vat 8 the surplus liquid is absorbed or removed in some other manner from the web 2 by means of the element 10 designed for this purpose.
- the thermoformable material web 2 would be ready to be introduced into the sterile chamber.
- the web has to be heated to the required thermoforming processing temperature before it is introduced into the sterile chamber.
- the heating elements intended for this are arranged in the vicinity of the inlet opening 13 of the sterile chamber, so that the web is strongly heated when it is introduced into the chamber, the heating operation acting as a disinfecting sluice for the entrance of the web into the sterile chamber.
- the said special heating element 16 for the drying of the web would then probably be omitted.
- thermoformable material web 2 is introduced into the sterile tunnel 1 after cleaning and drying operations.
- the web is introduced into the sterile tunnel in a preferably horizontal plane and in a substantially even layer.
- the web is passed through or via a sluice or some other element which is arranged so as to delimit the sterile chamber against the surrounding atmosphere.
- the element delimiting against the environment may consist simply of a vertically directed curtain consisting of sterile air. The curtain will then form an extension of the end wall of the sterile tunnel 1.
- the front part of the sterile chamber 4 is realized according to FIG. 1 as a pre-treatment chamber, where the web 2 can be subjected to a sterilizing and/or disinfecting effect by means of different elements or agents.
- This pretreatment chamber 5 may also be arranged for the heating of the material web 2 to the necessary thermoforming processing temperature, the material web 2 being subjected in this same heating process to a thermal sterilization.
- the material web 2 thus passes after entrance into the sterile tunnel 1 an element 11 which may be provided for subjecting the web to electron spraying and/or ultraviolet light for the purpose of disinfecting and/or sterilizing the web before being introduced into the sterile chamber 4.
- the material web 2 before being introduced into the sterile chamber, passes the heating element 12, where the web is heated up to the temperature required for thermoforming processing. If the web is to be formed with folded over edge portions 46 in accordance with the sterile chamber design as shown in FIG. 2d, it will be appropriate to carry out this folding-over operation in connection with, or after, the said heating operation.
- the material web When the material web has a degree of softening suitable for the thermoforming processing, it is introduced into the sterile chamber itself.
- the sterile chamber 4 is delimited against the pre-treatment chamber 5 in such a manner that the atmosphere maintained in the pretreatment chamber should not be able to penetrate into the sterile chamber.
- the delimitation between the chamber may consist simply of a single screen wall 14 or the like, as shown in the figure, the material web being introduced into the sterile chamber through the inlet opening 13.
- the material web 2 thus heated to softening is subjected subsequently to the thermoforming processing by means of the forming elements 19 and/or 20 with the object of forming container bodies 21, which in a later stage are filled with the sterile goods intended for packaging by means of the fillers 22 shown. After the containers have been filled they must be sealed, which is done by applying the said second material web 3 to the thermoformable material web 2 so that it is wholly covered.
- the said second material web 3 is passed down from a roller 27 into a vat 28 which contains a cleaning, washing and/or sterilizing liquid similarly to the set-up for the treatment of the first thermoformable material web 2.
- the surplus fluid is drawn off the web by means of the air knife 30 shown or by an ab sorbing element 31.
- the web passes a heating element 32, whereby any residual traces of the treatment fluids are evaporated.
- the material web 3 is then introduced into the pre-treatment chamber 6 through its opening 36'. In the opening the web passes the element which is intended to form a sluice or a curtain, so that the atmosphere surrounding the chamber cannot penetrate into the chamber.
- the said element may be designed for the production of a vertical or horizontal sterile air curtain or air seal, which fills out the interspace between the walls of the chamber and the surface of the material web.
- the material web 3 passes further various elements 34 for the disinfection and/or sterilization of the web, whereby it is possible, as mentioned earlier, for the elements to be arranged so as to subject the web to electron spraying and/or ultraviolet light.
- the material web 3 is introduced into the sterile chamber 4 to be joined to the first thermoformable material web 2.
- the web 3 passes through an opening 36 in the wall of the sterile tunnel 1.
- This pretreatment chamber 6, similar to the other pretreatment chamber 5, is separated from the sterile chambeer 4 by means of a screen wall 35 or the like.
- the said second material web 3 is applied and sealed to, or joined in some other manner to, the first thermoformable material web, and this is done at least along zones closed in themselves around the openings on the container bodies 21 formed in the material web, so that the sterile goods filled into the containers are enclosed.
- the sealing or closures are done for example by means of heat and pressure with the tool 23 shown in the fig ure.
- the material web 3 applied is fitted so that it preferably wholly covers the thermoformable material web 2 and forms a substantially even upper side on this web.
- the container bodies 21 so sealed are then passed out of the sterile tunnel 1 Whilst they continue to be attached to one another, and form a substantially even surface towards the tunnel or the chamber.
- the combined first and second material webs 2, 3 pass a curtain 15, a sluice or some other element which screens the opening or mouth 37 of the tunnel in such a manner, that the atmosphere existing outside the sterile chamber 4 cannot penetrate through the said opening.
- the thermoformable material web 2 has been given an even upper side through the application of the second material web 3 and in this case the combined first and second material webs 2, 3 are passed substantially horizontally out of the tunnel l
- the said curtain or sluice element 15' may consist of a device for the generation of a laminar, vertically directed sterile air stream which in the form of a curtain fills the space between the end wall of the tunnel l and the upper side of the combined webs.
- the openings 13 and 36 between the sterile chamber 4 and the pre-treatment chambers 5 and 6 respectively, if any, may have special elements for the delimiting of the chambers from one another.
- Such elements may consist of a liquid seal filled with a suitable liquid, an air curtain consisting of a laminar, sterile air stream, a liquid curtain consisting of for example finely divided hydrogen peroxide or alcohol particles a sleeve element or some other means for preventing the atmosphere prevailing in the pre-treatment chambers from penetrating into the sterile chamber 4.
- the elements or agents mentioned here are specially applicable for the purpose of screening the sterile chamber 4 and the pre-treatment chambers 5, 6 in the limit zones of the same towards, or the inlet and outlet openings to, the atmosphere surrounding the chambers.
- the said pre-treatment chambers 5, 6 may of course take the most suitable shape and they may thus be quite different from the design referred to in the description and shown in the figures. Thus they need not, as is the case in the pretreatment chamber 5 shown in FIG. 1, consist of partly a tunnel, partly a material web which in fact is intended for further processing to container bodies. It would also be possible, if this were found appropriate, and as pointed out earlier, wholly to eliminate the pre-treatment chambers 5, 6.
- the heating element 12 provided outside the sterile chamber 4 for the heating of the thermoformable material web 2 constitutes an advantageous treatment so that the material web should be able to be introduced directly into the sterile chamber. It is also conceivable, however, to allow the second material web 3 to pass a heated zone before or during its introduction into the sterile chamber 4, which means that in certain cases the pretreatment chamber 6 could be discarded.
- the material or combination of materials in the first and second material webs 2, 3 applied can of course be different from the ones suggested earlier.
- the said second and closing material web 3 may consist of simply a metal foil, for example an aluminium foil, which is coated possibly with for example a thermally active, adhesion promoting agent.
- thermoformable material web 2, the said second material web 3 and/or the combined material webs 2, 3 are passed into and out of the sterile unit as limits to the surrounding atmosphere with a surface or upper side which is even, and that the web or webs are conveyed in an either substantially horizontal plane or vertical plane. Furthermore, it is essential that the said first material web 2 and/or the combined first and second material webs 2, 3 together with the sterile tunnel 1 form the said sterile chamber 4, that is to say that the material web and the combined webs 2, 3 constitute a side wall in the sterile chamber.
- a method for forming, filling and sealing containers under aseptic conditions from a first web of substantially impermeable thermoformable material of indeterminate length comprising moving the first web in the direction of its length with one surface facing a sterile chamber and cooperating therewith to constitute one outer wall thereof by forming a substantial seal therewith, forming a plurality of container elements in the first web, introducing a filler material into the container elements, applying a second web of substantially impermeable thermoformable material to the filled container elements, and sealing the second web to the first web to close and seal the filled container elements, the steps of forming the container elements, filling the container elements and applying and sealing the second web to the filled container elements being carried out while the first web constitutes the one outer wall of the sterile chamber and finally separating the filled and sealed containers after leaving the sterile chamber.
- a method as claimed in claim 1 wherein a sterile gas is passed into said sterile chamber under a pressure exceeding that of the surrounding air so as to prevent surrounding air from entering said sterile chamber.
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- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Containers And Plastic Fillers For Packaging (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE7210418A SE423517B (sv) | 1972-08-11 | 1972-08-11 | Sett att under aseptiska betingelser forpacka sterilt fyllgods i behallare |
Publications (1)
Publication Number | Publication Date |
---|---|
US3911640A true US3911640A (en) | 1975-10-14 |
Family
ID=31989640
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US380574A Expired - Lifetime US3911640A (en) | 1972-08-11 | 1973-07-19 | Method for the packing under aseptic conditions of sterile goods into containers |
Country Status (9)
Country | Link |
---|---|
US (1) | US3911640A (it) |
JP (1) | JPS5435542B2 (it) |
CA (1) | CA987579A (it) |
CH (1) | CH567963A5 (it) |
DE (1) | DE2339517C3 (it) |
FR (1) | FR2195551B1 (it) |
GB (1) | GB1400112A (it) |
IT (1) | IT995093B (it) |
SE (1) | SE423517B (it) |
Cited By (60)
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US4035981A (en) * | 1974-12-11 | 1977-07-19 | Alcan Research And Development Limited | Aseptic packaging |
US4152464A (en) * | 1977-08-22 | 1979-05-01 | The Mead Corporation | Method for the aseptic packaging of high acid food |
US4165594A (en) * | 1977-05-10 | 1979-08-28 | Societe Dite: Gatrun Anstalt | Packaging of a product in a sterile medium |
US4208852A (en) * | 1974-11-08 | 1980-06-24 | Pont-A-Mousson S.A. | Process for the aseptic packing of products and machine employing said process |
US4224779A (en) * | 1977-09-23 | 1980-09-30 | Scal Societe De Conditionnements En Aluminium | Method for fabrication of coated metal packages by thermoforming |
US4287702A (en) * | 1977-05-10 | 1981-09-08 | Gatrun Anstalt | Method and installation for packaging in a sterile medium |
US4375145A (en) * | 1979-12-20 | 1983-03-01 | Novus Corp. N.V. | Packaging, particularly aseptic packaging of aseptic products in cartons |
EP0095812A2 (en) * | 1982-06-01 | 1983-12-07 | Unilever N.V. | Process and apparatus for the aseptic packaging of products such as foodstuffs and pharmaceutical products |
EP0099605A2 (en) * | 1982-07-15 | 1984-02-01 | Shikoku Kakoki Co., Ltd. | Packaging machine |
US4503656A (en) * | 1982-11-12 | 1985-03-12 | Societe Anonyme Dite: Etude Et Realisation De Chaines Automatiques Erca | Initial sterilization of sterile chamber of asceptic packaging machine |
US4543770A (en) * | 1982-03-02 | 1985-10-01 | Kurt Walter | Apparatus for producing and charging containers in a sterile atmosphere |
US4693052A (en) * | 1986-03-06 | 1987-09-15 | Robert Bosch Gmbh | Apparatus for aseptic packaging |
US4835937A (en) * | 1987-03-30 | 1989-06-06 | L'air Liquide | Apparatus for providing inert atmosphere in airtight packages for food products |
US4944132A (en) * | 1988-03-11 | 1990-07-31 | Ab Tetra Pak | Apparatus for the sterile packaging of contents |
US4996824A (en) * | 1988-11-18 | 1991-03-05 | Erca Holding | Method and device for sterilizing a packaging installation for food and pharmaceutical products |
US5008076A (en) * | 1988-05-31 | 1991-04-16 | Roby Teknik Aktiebolag | Method and an arrangement for the pretreatment of a moving material web |
US5069017A (en) * | 1989-07-15 | 1991-12-03 | Karl Fabricius | Aseptic filling machine for food |
US5299408A (en) * | 1990-05-11 | 1994-04-05 | Wine Recorker, Inc. | Wine recorking apparatus and method |
US5377475A (en) * | 1992-06-10 | 1995-01-03 | Robert Bosch Gmbh | Device for sterilizing packaging containers |
US5477660A (en) * | 1994-11-01 | 1995-12-26 | Multivac Sepp Haggenmuller Kg | Process and apparatus for maximizing vacuum packaging machine cycle rate |
US5671591A (en) * | 1995-05-01 | 1997-09-30 | Ashland, Inc. | Integrated container moulding and filling facility |
US5759218A (en) * | 1996-10-24 | 1998-06-02 | Allergan | Point of fill air system |
FR2766121A1 (fr) * | 1997-07-18 | 1999-01-22 | Sidel Sa | Procede pour la fabrication de recipients steriles, et installation pour la mise en oeuvre |
US5910138A (en) * | 1996-05-13 | 1999-06-08 | B. Braun Medical, Inc. | Flexible medical container with selectively enlargeable compartments and method for making same |
US5928213A (en) * | 1996-05-13 | 1999-07-27 | B. Braun Medical, Inc. | Flexible multiple compartment medical container with preferentially rupturable seals |
US5944709A (en) * | 1996-05-13 | 1999-08-31 | B. Braun Medical, Inc. | Flexible, multiple-compartment drug container and method of making and using same |
US6134866A (en) * | 1998-12-29 | 2000-10-24 | Vital Signs, Inc. | Apparatus for manufacturing articles |
EP1122170A1 (de) * | 2000-01-31 | 2001-08-08 | Hassia Verpackungsmaschinen GmbH | Steriltunnel für aseptisch arbeitende Verpackungsmaschinen |
US20020070130A1 (en) * | 2000-06-12 | 2002-06-13 | John Skoufis | Peroxide preservation |
US6457299B1 (en) * | 1998-04-21 | 2002-10-01 | Fehland Engineering Gmbh | Beverage-filling device |
US20030085147A1 (en) * | 2001-11-07 | 2003-05-08 | Gabriele Joseph M. | Aseptic enclosure for medical equipment and method of making same |
US20030101684A1 (en) * | 2000-07-03 | 2003-06-05 | Paolo Scarabelli | Packaging machine for continuously producing sealed packages |
US6638476B1 (en) | 1998-06-30 | 2003-10-28 | Tetra Laval Holdings & Finance S.A. | Packaging material sterilizing unit for a pourable food product packaging machine |
US6748720B2 (en) | 1999-12-10 | 2004-06-15 | Tetra Laval Holdings & Finance S.A. | Continuous apparatus in distribution equipment |
US20050217211A1 (en) * | 2004-03-08 | 2005-10-06 | Daniel Py | Method for molding and assembling containers with stoppers and filling same |
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US20090173039A1 (en) * | 2003-08-20 | 2009-07-09 | Multivac, Inc. | Inline processing and irradiation system |
US20090317506A1 (en) * | 2006-10-26 | 2009-12-24 | Sidel Participations | Furnace and equipment for producing sterile vessels from decontaminated preforms of a thermoplastic material |
US7726352B2 (en) | 2000-02-11 | 2010-06-01 | Medical Instill Technologies, Inc. | Sealed containers and methods of making and filling same |
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US20100189831A1 (en) * | 2009-01-23 | 2010-07-29 | Proaseptic Technologies S.L.U. | Machine for horizontally manufacturing flexible sheet material packagings with outside chamber |
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FR2392879A2 (fr) * | 1976-10-06 | 1978-12-29 | Nasica Jean | Bande composite, son procede de fabrication et son application a la fabrication d'emballages steriles |
DE2754816A1 (de) * | 1976-12-15 | 1978-06-22 | Nasica Jean Roger | Verfahren und vorrichtung zum verpacken von waren in steriler umgebung |
CH619408A5 (en) * | 1976-12-15 | 1980-09-30 | Nasica Jean Roger | Method for packaging in a sterile environment and installation for implementing the method |
JPS53116701U (it) * | 1977-01-19 | 1978-09-16 | ||
JPS53116102A (en) * | 1977-03-18 | 1978-10-11 | Matsushita Electric Ind Co Ltd | Acoustic reproducer |
JPS6050646B2 (ja) * | 1977-07-12 | 1985-11-09 | 大日本印刷株式会社 | 予備シ−ルを具えた無菌包装方法と装置 |
JPS5836653Y2 (ja) * | 1978-10-26 | 1983-08-18 | シ−ケ−デイ株式会社 | 無菌包装機用ハウジング |
JPS5564028A (en) * | 1978-10-26 | 1980-05-14 | Ckd Corp | Aseptic packer |
IN153503B (it) * | 1979-01-11 | 1984-07-21 | Nat Res Dev | |
JPS6217587Y2 (it) * | 1981-04-15 | 1987-05-07 | ||
DE4031472C2 (de) * | 1990-10-05 | 2001-06-28 | Hoerauf Michael Maschf | Vorrichtung zum Sterilisieren, Füllen und Verschließen von eine Füllöffnung aufweisenden Behältern |
FR2672869A1 (fr) * | 1991-02-19 | 1992-08-21 | Erca | Machine de conditionnement comportant une zone d'air propre en surpression. |
DE19504558C2 (de) * | 1995-02-11 | 1997-05-07 | Pkl Verpackungssysteme Gmbh | Vorrichtung zum Sterilisieren bei der Abfüllung vorzugsweiser flüssiger Lebensmittel in Packungsbehälter |
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DE19507639C2 (de) * | 1995-03-04 | 1997-09-18 | Hassia Verpackung Ag | Sterilisationseinrichtung an einer FFS-Verpackungsmaschine |
DE10028009A1 (de) * | 2000-06-06 | 2001-12-20 | Bosch Gmbh Robert | Vorrichtung zum Herstellen becherartiger und mit einem Füllgut befüllter Behältnisse |
ITMI20111944A1 (it) * | 2011-10-26 | 2013-04-27 | I M A Ind Macchine Automatic He S P A | Blisteratrice migliorata, procedimento connesso di confezionamento in blister, e blister cosi' ottenuto |
NL2014837B1 (en) * | 2015-05-21 | 2017-01-31 | Nikinc Holding B V | Decontamination device and method for medical instruments. |
IT201900021762A1 (it) * | 2019-11-21 | 2021-05-21 | Davide Martelli | Impianto di confezionamento per prodotti farmaceutici, prodotti chimici, biocidi e simili |
CN113307213B (zh) * | 2021-06-04 | 2022-09-16 | 杭州娃哈哈精密机械有限公司 | 一种瓶体灌装前的在线连续灭菌装置及瓶体灭菌方法 |
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Publication number | Priority date | Publication date | Assignee | Title |
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US4208852A (en) * | 1974-11-08 | 1980-06-24 | Pont-A-Mousson S.A. | Process for the aseptic packing of products and machine employing said process |
US4035981A (en) * | 1974-12-11 | 1977-07-19 | Alcan Research And Development Limited | Aseptic packaging |
US4165594A (en) * | 1977-05-10 | 1979-08-28 | Societe Dite: Gatrun Anstalt | Packaging of a product in a sterile medium |
US4287702A (en) * | 1977-05-10 | 1981-09-08 | Gatrun Anstalt | Method and installation for packaging in a sterile medium |
US4152464A (en) * | 1977-08-22 | 1979-05-01 | The Mead Corporation | Method for the aseptic packaging of high acid food |
US4224779A (en) * | 1977-09-23 | 1980-09-30 | Scal Societe De Conditionnements En Aluminium | Method for fabrication of coated metal packages by thermoforming |
US4375145A (en) * | 1979-12-20 | 1983-03-01 | Novus Corp. N.V. | Packaging, particularly aseptic packaging of aseptic products in cartons |
US4543770A (en) * | 1982-03-02 | 1985-10-01 | Kurt Walter | Apparatus for producing and charging containers in a sterile atmosphere |
US4597242A (en) * | 1982-06-01 | 1986-07-01 | Lever Brothers Company | Process and apparatus for the aseptic packaging of products such as foodstuffs and pharmaceutical products |
EP0095812A3 (en) * | 1982-06-01 | 1984-01-11 | Unilever Nv | Process and apparatus for the aseptic packaging of products such as foodstuffs and pharmaceutical products |
EP0095812A2 (en) * | 1982-06-01 | 1983-12-07 | Unilever N.V. | Process and apparatus for the aseptic packaging of products such as foodstuffs and pharmaceutical products |
EP0099605A2 (en) * | 1982-07-15 | 1984-02-01 | Shikoku Kakoki Co., Ltd. | Packaging machine |
US4633645A (en) * | 1982-07-15 | 1987-01-06 | Shikoku Kakooki Co., Ltd. | Packaging machine |
EP0099605A3 (en) * | 1982-07-15 | 1988-05-11 | Shikoku Kakooki Co., Ltd. | Packaging machine |
US4503656A (en) * | 1982-11-12 | 1985-03-12 | Societe Anonyme Dite: Etude Et Realisation De Chaines Automatiques Erca | Initial sterilization of sterile chamber of asceptic packaging machine |
US4693052A (en) * | 1986-03-06 | 1987-09-15 | Robert Bosch Gmbh | Apparatus for aseptic packaging |
US4835937A (en) * | 1987-03-30 | 1989-06-06 | L'air Liquide | Apparatus for providing inert atmosphere in airtight packages for food products |
US4944132A (en) * | 1988-03-11 | 1990-07-31 | Ab Tetra Pak | Apparatus for the sterile packaging of contents |
US5008076A (en) * | 1988-05-31 | 1991-04-16 | Roby Teknik Aktiebolag | Method and an arrangement for the pretreatment of a moving material web |
US4996824A (en) * | 1988-11-18 | 1991-03-05 | Erca Holding | Method and device for sterilizing a packaging installation for food and pharmaceutical products |
US5069017A (en) * | 1989-07-15 | 1991-12-03 | Karl Fabricius | Aseptic filling machine for food |
US5299408A (en) * | 1990-05-11 | 1994-04-05 | Wine Recorker, Inc. | Wine recorking apparatus and method |
US5377475A (en) * | 1992-06-10 | 1995-01-03 | Robert Bosch Gmbh | Device for sterilizing packaging containers |
US5477660A (en) * | 1994-11-01 | 1995-12-26 | Multivac Sepp Haggenmuller Kg | Process and apparatus for maximizing vacuum packaging machine cycle rate |
US5671591A (en) * | 1995-05-01 | 1997-09-30 | Ashland, Inc. | Integrated container moulding and filling facility |
WO1998039214A1 (en) * | 1995-05-01 | 1998-09-11 | Ashland Inc. | Integrated container molding and filling facility |
US6203535B1 (en) | 1996-05-13 | 2001-03-20 | B. Braun Medical, Inc. | Method of making and using a flexible, multiple-compartment drug container |
US6468377B1 (en) | 1996-05-13 | 2002-10-22 | B. Braun Medical Inc. | Flexible medical container with selectively enlargeable compartments and method for making same |
US5910138A (en) * | 1996-05-13 | 1999-06-08 | B. Braun Medical, Inc. | Flexible medical container with selectively enlargeable compartments and method for making same |
US5928213A (en) * | 1996-05-13 | 1999-07-27 | B. Braun Medical, Inc. | Flexible multiple compartment medical container with preferentially rupturable seals |
US5944709A (en) * | 1996-05-13 | 1999-08-31 | B. Braun Medical, Inc. | Flexible, multiple-compartment drug container and method of making and using same |
US6996951B2 (en) | 1996-05-13 | 2006-02-14 | B. Braun Medical Inc. | Flexible multi-compartment container with peelable seals and method for making same |
US6846305B2 (en) | 1996-05-13 | 2005-01-25 | B. Braun Medical Inc. | Flexible multi-compartment container with peelable seals and method for making same |
US6165161A (en) * | 1996-05-13 | 2000-12-26 | B. Braun Medical, Inc. | Sacrificial port for filling flexible, multiple-compartment drug container |
US6198106B1 (en) | 1996-05-13 | 2001-03-06 | B. Braun Medical, Inc. | Transport and sterilization carrier for flexible, multiple compartment drug container |
US6764567B2 (en) | 1996-05-13 | 2004-07-20 | B. Braun Medical | Flexible medical container with selectively enlargeable compartments and method for making same |
US20040068960A1 (en) * | 1996-05-13 | 2004-04-15 | Smith Steven L. | Flexible multi-compartment container with peelable seals and method for making same |
US20030000632A1 (en) * | 1996-05-13 | 2003-01-02 | Sperko William A. | Flexible medical container with selectively enlargeable compartments and method for making same |
US5759218A (en) * | 1996-10-24 | 1998-06-02 | Allergan | Point of fill air system |
CN1081531C (zh) * | 1997-07-18 | 2002-03-27 | 西德尔公司 | 塑料无菌容器的制造方法及其实施设备 |
AU727807B2 (en) * | 1997-07-18 | 2000-12-21 | Sidel S.A. | Method for making sterilised plastic containers, and installation therefor |
FR2766121A1 (fr) * | 1997-07-18 | 1999-01-22 | Sidel Sa | Procede pour la fabrication de recipients steriles, et installation pour la mise en oeuvre |
WO1999003667A1 (fr) * | 1997-07-18 | 1999-01-28 | Sidel S.A. | Procede pour la fabrication de recipients steriles en matiere plastique, et installation pour la mise en oeuvre |
US6562281B1 (en) | 1997-07-18 | 2003-05-13 | Sidel | Method for making sterilized plastic containers, and installation therefor |
US6457299B1 (en) * | 1998-04-21 | 2002-10-01 | Fehland Engineering Gmbh | Beverage-filling device |
US6638476B1 (en) | 1998-06-30 | 2003-10-28 | Tetra Laval Holdings & Finance S.A. | Packaging material sterilizing unit for a pourable food product packaging machine |
US6134866A (en) * | 1998-12-29 | 2000-10-24 | Vital Signs, Inc. | Apparatus for manufacturing articles |
US6748720B2 (en) | 1999-12-10 | 2004-06-15 | Tetra Laval Holdings & Finance S.A. | Continuous apparatus in distribution equipment |
EP1122170A1 (de) * | 2000-01-31 | 2001-08-08 | Hassia Verpackungsmaschinen GmbH | Steriltunnel für aseptisch arbeitende Verpackungsmaschinen |
US7726352B2 (en) | 2000-02-11 | 2010-06-01 | Medical Instill Technologies, Inc. | Sealed containers and methods of making and filling same |
US7992597B2 (en) | 2000-02-11 | 2011-08-09 | Medical Instill Technologies, Inc. | Sealed containers and methods of filling and resealing same |
US8960242B2 (en) | 2000-02-11 | 2015-02-24 | Medinstill Development Llc | Sealed containers and methods of filling and resealing same |
US9102097B2 (en) | 2000-02-11 | 2015-08-11 | Medinstill Development Llc | Resealable member and method of resealing same |
US9637251B2 (en) | 2000-02-11 | 2017-05-02 | Medinstill Development Llc | Sealed containers and methods of filling and resealing same |
US7611011B2 (en) | 2000-06-12 | 2009-11-03 | Illinois Toolworks, Inc. | Peroxide preservation |
US20020070130A1 (en) * | 2000-06-12 | 2002-06-13 | John Skoufis | Peroxide preservation |
US20030101684A1 (en) * | 2000-07-03 | 2003-06-05 | Paolo Scarabelli | Packaging machine for continuously producing sealed packages |
US6962032B2 (en) | 2000-07-03 | 2005-11-08 | Tetra Laval Holdings & Finance S.A. | Packaging machine for continuously producing sealed packages |
US20030085147A1 (en) * | 2001-11-07 | 2003-05-08 | Gabriele Joseph M. | Aseptic enclosure for medical equipment and method of making same |
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Also Published As
Publication number | Publication date |
---|---|
CA987579A (en) | 1976-04-20 |
JPS4944882A (it) | 1974-04-27 |
SE423517B (sv) | 1982-05-10 |
FR2195551B1 (it) | 1977-05-13 |
DE2339517B2 (de) | 1978-05-24 |
DE2339517C3 (de) | 1979-01-11 |
AU5819973A (en) | 1975-01-23 |
JPS5435542B2 (it) | 1979-11-02 |
GB1400112A (en) | 1975-07-16 |
FR2195551A1 (it) | 1974-03-08 |
IT995093B (it) | 1975-11-10 |
DE2339517A1 (de) | 1974-02-21 |
CH567963A5 (it) | 1975-10-15 |
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