US3682930A - 4(1-alkyl-4-piperidylidine)-4h-benzo {84,5{9 {0 cyclohepta {8 1,2{14 6{9 - Google Patents
4(1-alkyl-4-piperidylidine)-4h-benzo {84,5{9 {0 cyclohepta {8 1,2{14 6{9 Download PDFInfo
- Publication number
- US3682930A US3682930A US120738A US3682930DA US3682930A US 3682930 A US3682930 A US 3682930A US 120738 A US120738 A US 120738A US 3682930D A US3682930D A US 3682930DA US 3682930 A US3682930 A US 3682930A
- Authority
- US
- United States
- Prior art keywords
- benzo
- piperidylidene
- cyclohepta
- methyl
- base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/78—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
- C07D333/80—Seven-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH359870A CH533639A (de) | 1970-03-11 | 1970-03-11 | Verfahren zur Herstellung neuer Benzo(4,5)cyclohepta(1,2-b)-thiophen-Derivate |
CH1159370A CH531000A (de) | 1970-03-11 | 1970-07-31 | Verfahren zur Herstellung neuer Benzocycloheptathiophene |
CH1412070A CH537404A (de) | 1970-09-24 | 1970-09-24 | Verfahren zur Herstellung neuer Thiophenderivate |
CH163271 | 1971-02-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
US3682930A true US3682930A (en) | 1972-08-08 |
Family
ID=27428249
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US120738A Expired - Lifetime US3682930A (en) | 1970-03-11 | 1971-03-03 | 4(1-alkyl-4-piperidylidine)-4h-benzo {84,5{9 {0 cyclohepta {8 1,2{14 6{9 |
US00178449A Expired - Lifetime US3770728A (en) | 1970-03-11 | 1971-09-07 | Substituted 4h-benzo(4,5)cyclohepta(1,2-b)thiophen-10(9h)-ones |
US00278244A Expired - Lifetime US3749786A (en) | 1970-03-11 | 1972-08-07 | Organic compounds in treating allergic conditions |
US00278738A Expired - Lifetime US3853915A (en) | 1970-03-11 | 1972-08-08 | 9-or 10-halo-4h-benzo{8 4,5{9 cyclo-hepta{8 1,2-b{9 thiophen-4-ones |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US00178449A Expired - Lifetime US3770728A (en) | 1970-03-11 | 1971-09-07 | Substituted 4h-benzo(4,5)cyclohepta(1,2-b)thiophen-10(9h)-ones |
US00278244A Expired - Lifetime US3749786A (en) | 1970-03-11 | 1972-08-07 | Organic compounds in treating allergic conditions |
US00278738A Expired - Lifetime US3853915A (en) | 1970-03-11 | 1972-08-08 | 9-or 10-halo-4h-benzo{8 4,5{9 cyclo-hepta{8 1,2-b{9 thiophen-4-ones |
Country Status (12)
Country | Link |
---|---|
US (4) | US3682930A (fr) |
AT (2) | AT319238B (fr) |
BE (2) | BE764019A (fr) |
CA (2) | CA960673A (fr) |
CH (1) | CH531000A (fr) |
DE (2) | DE2111071C3 (fr) |
FR (2) | FR2085695B1 (fr) |
GB (4) | GB1355539A (fr) |
LU (2) | LU62757A1 (fr) |
NL (2) | NL167431C (fr) |
OA (2) | OA03692A (fr) |
SE (2) | SE368954B (fr) |
Cited By (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3862156A (en) * | 1972-01-24 | 1975-01-21 | Sandoz Ag | 4h-benzo{8 4,5{9 cyclohepta{8 1,2-6{9 thiophenes |
US4032640A (en) * | 1975-06-16 | 1977-06-28 | Sandoz Ltd. | 4H-Benzo[4,5]cyclohepta[1,2-b]thiophenes |
US4072756A (en) * | 1973-05-17 | 1978-02-07 | Sandoz Ltd. | Tricyclo piperidino ketones and soporific compositions thereof |
US4073915A (en) * | 1975-05-20 | 1978-02-14 | Sandoz Ltd. | Treating asthma |
US4128549A (en) * | 1976-02-27 | 1978-12-05 | Sandoz Ltd. | Precursors of 4-(1-alkyl-4-piperidylidene-4H-benzo[4,5]cyclohepta-[1,2-b]thiophen-10(9H)-ones |
US4223035A (en) * | 1973-10-08 | 1980-09-16 | Sandoz Ltd. | Treating prostate hypertrophy with 4-(4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-1-methylpiperidines |
US4615881A (en) * | 1980-11-29 | 1986-10-07 | Sandoz Ltd. | Pharmaceutical compositions |
GB2191696A (en) * | 1986-06-21 | 1987-12-23 | Sandoz Ltd | Ketotifen compositions |
US5089496A (en) * | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
US5393753A (en) * | 1990-10-10 | 1995-02-28 | Schering Corporation | Substituted imidazobenzazepines |
US5438062A (en) * | 1986-10-31 | 1995-08-01 | Schering Corporation | Benzo(5,6)cycloheptapyridines, compositions and methods of use |
US5891460A (en) * | 1995-06-07 | 1999-04-06 | University Of Southern California University Park Campus | Method for reducing or preventing post-surgical adhesion formation using ketotifen and analogs thereof |
WO2001039774A1 (fr) * | 1999-12-01 | 2001-06-07 | Klein Pharmaceuticals | Administration topique de ketotifene |
EP1218007A1 (fr) * | 1999-09-13 | 2002-07-03 | Bridge Pharma, Inc. | Isomeres de ketotifene optiquement actifs et metabolites therapeutiquement actifs |
US20030212078A1 (en) * | 2001-05-17 | 2003-11-13 | Klein Gerald L. | Topical administration of pharmacological compositions for non-systemic treatment of pruritus |
US20070077295A1 (en) * | 2005-06-13 | 2007-04-05 | Gilead Sciences, Inc. | Method and composition for pharmaceutical product |
US20070099902A1 (en) * | 2005-06-13 | 2007-05-03 | Bristol-Myers Squibb & Gilead Sciences, Llc | Unitary pharmaceutical dosage form |
CN100381439C (zh) * | 2005-04-05 | 2008-04-16 | 浙江华海药业股份有限公司 | 9,10-二溴-9,10-二氢-4-H苯并[4,5]环庚烯并[1,2-b]噻吩-4-酮的制备方法 |
US20090036408A1 (en) * | 2003-01-14 | 2009-02-05 | Gilead Sciences, Inc. | Compositions and methods for combination antiviral therapy |
US20100166804A1 (en) * | 2007-05-23 | 2010-07-01 | Dennis Penn | Methods |
US8377967B2 (en) | 2008-01-30 | 2013-02-19 | Nippon Zoki Pharmaceutical Co., Ltd. | Piperidine derivative |
US8557846B1 (en) | 2012-10-23 | 2013-10-15 | Bridge Pharma, Inc. | Medicinal treatment of dermal diseases in dogs |
WO2014066212A1 (fr) | 2012-10-23 | 2014-05-01 | Bridge Pharma, Inc. | Traitement médicinal des maladies dermiques chez des animaux de compagnie au moyen de norkétotifène |
WO2014070696A2 (fr) | 2012-10-30 | 2014-05-08 | Bridge Pharma, Inc. | Traitement médicinal de maladies inflammatoires dermiques chroniques par le norkétotifène |
WO2015020878A1 (fr) | 2013-08-06 | 2015-02-12 | Bridge Pharma, Inc. | Méthodes de traitement d'affections prurigineuses médiées par les récepteurs de l'histamine h-4 |
US9345697B2 (en) | 2013-08-06 | 2016-05-24 | Bridge Pharma, Inc. | Methods of treatment of non-histaminic pruritus |
US9439895B2 (en) | 2013-08-06 | 2016-09-13 | Bridge Pharma, Inc. | Methods of treating pruritic conditions mediated through non-histaminergic mechanisms in diabetic patients |
WO2016200578A1 (fr) | 2015-06-11 | 2016-12-15 | Bridge Pharma, Inc. | Procédés de traitement du prurit non histaminique chez des mammifères |
US9649303B2 (en) | 2008-05-23 | 2017-05-16 | Mastcell Pharmaceuticals, Inc. | Methods and treatment for allergies and inflammation associated with gastrointestinal diseases |
US9808419B2 (en) | 2012-10-30 | 2017-11-07 | Bridge Pharma, Inc | Medicinal treatment of dermal infectious disorders with norketotifen |
WO2020067866A1 (fr) | 2018-09-26 | 2020-04-02 | AMEZCUA AMEZCUA, Federico | Combinaison pharmaceutique synergique d'un antagoniste des récepteurs de leucotriènes et d'un agoniste inverse de l'histamine h1 |
US10959992B2 (en) | 2019-02-22 | 2021-03-30 | Bridge Pharma Inc. | Methods of treatment of asthma and COPD |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH531000A (de) * | 1970-03-11 | 1972-11-30 | Sandoz Ag | Verfahren zur Herstellung neuer Benzocycloheptathiophene |
US3960894A (en) * | 1972-01-24 | 1976-06-01 | Sandoz Ltd. | 9-Bromo-or chloro-9,10-dihydro-10-dihydro-10-alkoxy-4H-benzo[4,5]cyclo-hepta[1,2-b]thiophen-4-ones |
CA1041100A (fr) * | 1973-10-04 | 1978-10-24 | Herbert G. Johnson | Acide pyridine-diyldioxamique |
US4282233B1 (en) * | 1980-06-19 | 2000-09-05 | Schering Corp | Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines |
DZ1460A1 (fr) * | 1989-11-22 | 2004-09-13 | Sod Conseils Rech Applic | Nouveaux dérivés du sélénophèn ainsi que leur procédé de préparation. |
CA2038417A1 (fr) * | 1990-04-11 | 1991-10-12 | Yasuo Ito | Composes de piperidine, methode de preparation de ces composes, et une composition pharmaceutique qui en contient. |
WO1998056381A1 (fr) * | 1997-06-09 | 1998-12-17 | Bridge Pharma, Inc. | Composes a combinaison d'activites antihistaminique et stabilisatrice des membranes cellulaires de mastocytes, utilises a des fins ophtalmiques |
US6221897B1 (en) * | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
CN104693215B (zh) * | 2008-08-01 | 2017-09-01 | 日本脏器制药株式会社 | 氨基亚丙基衍生物 |
AU2010279164A1 (en) * | 2009-07-28 | 2012-02-02 | Nippon Zoki Pharmaceutical Co., Ltd. | Method for producing thiabenzoazulene propionic acid derivative |
BR112014010223B8 (pt) | 2011-10-28 | 2021-02-23 | Lumena Pharmaceuticals Llc | uso de uma composição compreendendo inibidores de reciclagem de ácido de bílis e forma de dosagem pediátrica |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3272826A (en) * | 1962-08-31 | 1966-09-13 | Sandoz Ltd | Substituted 4[piperidylidene(4')]-9, 10-dihydro-4h-benzo [4, 5] cyclohepta [1, 2-b] thiophene and the 4 piperidyl 4 ol compounds |
US3491103A (en) * | 1963-12-19 | 1970-01-20 | Sandoz Ag | Certain 4h-benzo(4,5)cyclohepta-(1,2-b) thiophenes |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1437412A (fr) * | 1963-12-19 | 1966-05-06 | Sandoz Sa | Nouveaux benzo-cyclohepta-thiophènes et leur préparation |
GB1084450A (en) * | 1963-12-20 | 1967-09-20 | Sandoz Ltd | Improvements in or relating to 4h-benzo[4,5]cyclohepta-[1,2-b] thiophene derivatives |
CH537897A (de) * | 1968-03-20 | 1973-06-15 | Hoffmann La Roche | Verfahren zur Herstellung von tricyclischen Verbindungen |
US3574199A (en) * | 1968-06-28 | 1971-04-06 | Searle & Co | 6-(aminoalkyl- and aminoalkylidene)-1,1a,6,10b -tetrahydro-dibenzo(a,e)cyclopropa(c)cycloheptenes |
CH531000A (de) * | 1970-03-11 | 1972-11-30 | Sandoz Ag | Verfahren zur Herstellung neuer Benzocycloheptathiophene |
US3709947A (en) * | 1971-07-26 | 1973-01-09 | Searle & Co | 6-chloropropylidene-1,1a,6,10b-tetrahydrobenzo(a,e)cyclopropa(c)cycloheptenes |
-
1970
- 1970-07-31 CH CH1159370A patent/CH531000A/de not_active IP Right Cessation
-
1971
- 1971-03-03 US US120738A patent/US3682930A/en not_active Expired - Lifetime
- 1971-03-08 FR FR7107901A patent/FR2085695B1/fr not_active Expired
- 1971-03-09 OA OA54190A patent/OA03692A/fr unknown
- 1971-03-09 DE DE2111071A patent/DE2111071C3/de not_active Expired
- 1971-03-09 LU LU62757D patent/LU62757A1/xx unknown
- 1971-03-09 BE BE764019A patent/BE764019A/fr not_active IP Right Cessation
- 1971-03-10 SE SE03074/71A patent/SE368954B/xx unknown
- 1971-03-10 NL NL7103174.A patent/NL167431C/xx not_active IP Right Cessation
- 1971-03-10 CA CA107,340A patent/CA960673A/en not_active Expired
- 1971-03-10 AT AT206471A patent/AT319238B/de not_active IP Right Cessation
- 1971-04-19 GB GB2882373A patent/GB1355539A/en not_active Expired
- 1971-04-19 GB GB2348271*A patent/GB1355537A/en not_active Expired
- 1971-06-04 GB GB1894073A patent/GB1355538A/en not_active Expired
- 1971-08-27 NL NLAANVRAGE7111808,A patent/NL171449C/xx not_active IP Right Cessation
- 1971-08-30 BE BE771964A patent/BE771964A/fr unknown
- 1971-08-31 CA CA121,762A patent/CA947767A/en not_active Expired
- 1971-09-02 LU LU63829D patent/LU63829A1/xx unknown
- 1971-09-02 AT AT766471A patent/AT321905B/de not_active IP Right Cessation
- 1971-09-03 SE SE7111154A patent/SE378820B/xx unknown
- 1971-09-03 FR FR7131866A patent/FR2107917B1/fr not_active Expired
- 1971-09-03 OA OA54351A patent/OA03786A/fr unknown
- 1971-09-06 DE DE19712144490 patent/DE2144490A1/de active Pending
- 1971-09-07 US US00178449A patent/US3770728A/en not_active Expired - Lifetime
- 1971-09-21 GB GB4392471A patent/GB1360219A/en not_active Expired
-
1972
- 1972-08-07 US US00278244A patent/US3749786A/en not_active Expired - Lifetime
- 1972-08-08 US US00278738A patent/US3853915A/en not_active Expired - Lifetime
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3272826A (en) * | 1962-08-31 | 1966-09-13 | Sandoz Ltd | Substituted 4[piperidylidene(4')]-9, 10-dihydro-4h-benzo [4, 5] cyclohepta [1, 2-b] thiophene and the 4 piperidyl 4 ol compounds |
US3491103A (en) * | 1963-12-19 | 1970-01-20 | Sandoz Ag | Certain 4h-benzo(4,5)cyclohepta-(1,2-b) thiophenes |
Cited By (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3862156A (en) * | 1972-01-24 | 1975-01-21 | Sandoz Ag | 4h-benzo{8 4,5{9 cyclohepta{8 1,2-6{9 thiophenes |
US4072756A (en) * | 1973-05-17 | 1978-02-07 | Sandoz Ltd. | Tricyclo piperidino ketones and soporific compositions thereof |
US4223035A (en) * | 1973-10-08 | 1980-09-16 | Sandoz Ltd. | Treating prostate hypertrophy with 4-(4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ylidene)-1-methylpiperidines |
US4073915A (en) * | 1975-05-20 | 1978-02-14 | Sandoz Ltd. | Treating asthma |
US4032640A (en) * | 1975-06-16 | 1977-06-28 | Sandoz Ltd. | 4H-Benzo[4,5]cyclohepta[1,2-b]thiophenes |
US4128549A (en) * | 1976-02-27 | 1978-12-05 | Sandoz Ltd. | Precursors of 4-(1-alkyl-4-piperidylidene-4H-benzo[4,5]cyclohepta-[1,2-b]thiophen-10(9H)-ones |
US4615881A (en) * | 1980-11-29 | 1986-10-07 | Sandoz Ltd. | Pharmaceutical compositions |
GB2191696A (en) * | 1986-06-21 | 1987-12-23 | Sandoz Ltd | Ketotifen compositions |
GB2191696B (en) * | 1986-06-21 | 1991-01-16 | Sandoz Ltd | Pharmaceutical compositions |
US5089496A (en) * | 1986-10-31 | 1992-02-18 | Schering Corporation | Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies |
US5438062A (en) * | 1986-10-31 | 1995-08-01 | Schering Corporation | Benzo(5,6)cycloheptapyridines, compositions and methods of use |
US5151423A (en) * | 1989-05-01 | 1992-09-29 | Schering Corporation | Heterocyclic n-oxide derivatives of substituted benzo[5,6]cycloheptapyridines, compositions and methods of use |
US5393753A (en) * | 1990-10-10 | 1995-02-28 | Schering Corporation | Substituted imidazobenzazepines |
US5891460A (en) * | 1995-06-07 | 1999-04-06 | University Of Southern California University Park Campus | Method for reducing or preventing post-surgical adhesion formation using ketotifen and analogs thereof |
US7557128B2 (en) | 1999-09-13 | 2009-07-07 | Bridge Pharma, Inc. | Optically active isomers of ketotifen and therapeutically active metabolites thereof |
US20090149502A1 (en) * | 1999-09-13 | 2009-06-11 | Aberg A K Gunnar | Optically active isomers of ketotifen and therapeutically active metabolites thereof |
EP1218007A4 (fr) * | 1999-09-13 | 2003-04-09 | Bridge Pharma Inc | Isomeres de ketotifene optiquement actifs et metabolites therapeutiquement actifs |
US7872025B2 (en) | 1999-09-13 | 2011-01-18 | Bridge Pharma, Inc. | Optically active isomers of ketotifen and therapeutically active metabolites thereof |
US7226934B1 (en) | 1999-09-13 | 2007-06-05 | Bridge Pharma, Inc. | Optically active isomers of ketotifen and therapeutically active metabolites thereof |
EP1218007A1 (fr) * | 1999-09-13 | 2002-07-03 | Bridge Pharma, Inc. | Isomeres de ketotifene optiquement actifs et metabolites therapeutiquement actifs |
US20080287498A1 (en) * | 1999-09-13 | 2008-11-20 | Aberg A K Gunnar | Optically active isomers of ketotifen and therapeutically active metabolites thereof |
WO2001039774A1 (fr) * | 1999-12-01 | 2001-06-07 | Klein Pharmaceuticals | Administration topique de ketotifene |
US20030212078A1 (en) * | 2001-05-17 | 2003-11-13 | Klein Gerald L. | Topical administration of pharmacological compositions for non-systemic treatment of pruritus |
US9457036B2 (en) | 2003-01-14 | 2016-10-04 | Gilead Sciences, Inc. | Compositions and methods for combination antiviral therapy |
US20090143314A1 (en) * | 2003-01-14 | 2009-06-04 | Gilead Sciences, Inc. | Compositions and methods for combination antiviral therapy |
US20090036408A1 (en) * | 2003-01-14 | 2009-02-05 | Gilead Sciences, Inc. | Compositions and methods for combination antiviral therapy |
US8716264B2 (en) | 2003-01-14 | 2014-05-06 | Gilead Sciences, Inc. | Compositions and methods for combination antiviral therapy |
US8592397B2 (en) | 2003-01-14 | 2013-11-26 | Gilead Sciences, Inc. | Compositions and methods for combination antiviral therapy |
US9744181B2 (en) | 2003-01-14 | 2017-08-29 | Gilead Sciences, Inc. | Compositions and methods for combination antiviral therapy |
CN100381439C (zh) * | 2005-04-05 | 2008-04-16 | 浙江华海药业股份有限公司 | 9,10-二溴-9,10-二氢-4-H苯并[4,5]环庚烯并[1,2-b]噻吩-4-酮的制备方法 |
US8598185B2 (en) | 2005-06-13 | 2013-12-03 | Bristol-Myers Squibb & Gilead Sciences, Inc. | Unitary pharmaceutical dosage form |
US9018192B2 (en) | 2005-06-13 | 2015-04-28 | Bristol-Myers Squibb & Gilead Sciences, Inc. | Unitary pharmaceutical dosage form |
US20070099902A1 (en) * | 2005-06-13 | 2007-05-03 | Bristol-Myers Squibb & Gilead Sciences, Llc | Unitary pharmaceutical dosage form |
US9545414B2 (en) | 2005-06-13 | 2017-01-17 | Bristol-Myers Squibb & Gilead Sciences, Llc | Unitary pharmaceutical dosage form |
US8871271B2 (en) | 2005-06-13 | 2014-10-28 | Gilead Sciences, Inc. | Method and composition for pharmaceutical product |
US20070077295A1 (en) * | 2005-06-13 | 2007-04-05 | Gilead Sciences, Inc. | Method and composition for pharmaceutical product |
US20100166804A1 (en) * | 2007-05-23 | 2010-07-01 | Dennis Penn | Methods |
US8377967B2 (en) | 2008-01-30 | 2013-02-19 | Nippon Zoki Pharmaceutical Co., Ltd. | Piperidine derivative |
US9649303B2 (en) | 2008-05-23 | 2017-05-16 | Mastcell Pharmaceuticals, Inc. | Methods and treatment for allergies and inflammation associated with gastrointestinal diseases |
WO2014066212A1 (fr) | 2012-10-23 | 2014-05-01 | Bridge Pharma, Inc. | Traitement médicinal des maladies dermiques chez des animaux de compagnie au moyen de norkétotifène |
US8778971B2 (en) | 2012-10-23 | 2014-07-15 | Bridge Pharma, Inc. | Medicinal treatment of dermal diseases in companion animals |
US8557846B1 (en) | 2012-10-23 | 2013-10-15 | Bridge Pharma, Inc. | Medicinal treatment of dermal diseases in dogs |
US9808419B2 (en) | 2012-10-30 | 2017-11-07 | Bridge Pharma, Inc | Medicinal treatment of dermal infectious disorders with norketotifen |
WO2014070696A2 (fr) | 2012-10-30 | 2014-05-08 | Bridge Pharma, Inc. | Traitement médicinal de maladies inflammatoires dermiques chroniques par le norkétotifène |
US9439895B2 (en) | 2013-08-06 | 2016-09-13 | Bridge Pharma, Inc. | Methods of treating pruritic conditions mediated through non-histaminergic mechanisms in diabetic patients |
WO2015020878A1 (fr) | 2013-08-06 | 2015-02-12 | Bridge Pharma, Inc. | Méthodes de traitement d'affections prurigineuses médiées par les récepteurs de l'histamine h-4 |
US9345697B2 (en) | 2013-08-06 | 2016-05-24 | Bridge Pharma, Inc. | Methods of treatment of non-histaminic pruritus |
US9333199B2 (en) | 2013-08-06 | 2016-05-10 | Bridge Pharma, Inc. | Methods of treatment of histamine H-4 receptor-related pruritus associated with nerve disorders |
US9138431B2 (en) | 2013-08-06 | 2015-09-22 | Bridge Pharma, Inc. | Methods of treatment of histamine H-4 receptor-related pruritus |
WO2016200578A1 (fr) | 2015-06-11 | 2016-12-15 | Bridge Pharma, Inc. | Procédés de traitement du prurit non histaminique chez des mammifères |
WO2020067866A1 (fr) | 2018-09-26 | 2020-04-02 | AMEZCUA AMEZCUA, Federico | Combinaison pharmaceutique synergique d'un antagoniste des récepteurs de leucotriènes et d'un agoniste inverse de l'histamine h1 |
US10959992B2 (en) | 2019-02-22 | 2021-03-30 | Bridge Pharma Inc. | Methods of treatment of asthma and COPD |
US11197851B2 (en) | 2019-02-22 | 2021-12-14 | Bridge Pharma Inc. | Methods of treatment of asthma and COPD |
Also Published As
Publication number | Publication date |
---|---|
US3770728A (en) | 1973-11-06 |
US3749786A (en) | 1973-07-31 |
OA03692A (fr) | 1971-12-24 |
DE2111071C3 (de) | 1979-07-12 |
OA03786A (fr) | 1971-12-24 |
NL167431C (nl) | 1981-12-16 |
BE764019A (fr) | 1971-09-09 |
CA960673A (en) | 1975-01-07 |
FR2107917A1 (fr) | 1972-05-12 |
CA947767A (en) | 1974-05-21 |
SE378820B (fr) | 1975-09-15 |
NL7103174A (fr) | 1971-09-14 |
US3853915A (en) | 1974-12-10 |
AT319238B (de) | 1974-12-10 |
GB1355537A (en) | 1974-06-05 |
CH531000A (de) | 1972-11-30 |
FR2107917B1 (fr) | 1975-04-18 |
FR2085695B1 (fr) | 1974-11-15 |
SE368954B (fr) | 1974-07-29 |
DE2111071B2 (de) | 1978-11-09 |
GB1355539A (en) | 1974-06-05 |
NL171449C (nl) | 1983-04-05 |
NL7111808A (fr) | 1972-03-28 |
LU62757A1 (fr) | 1971-10-13 |
GB1355538A (en) | 1974-06-05 |
FR2085695A1 (fr) | 1971-12-31 |
LU63829A1 (fr) | 1972-06-27 |
DE2111071A1 (de) | 1971-09-23 |
GB1360219A (en) | 1974-07-17 |
BE771964A (fr) | 1972-02-29 |
DE2144490A1 (de) | 1972-03-30 |
AT321905B (de) | 1975-04-25 |
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