US20190054182A1 - Trispecific and/or trivalent binding proteins for prevention or treatment of hiv infection - Google Patents

Trispecific and/or trivalent binding proteins for prevention or treatment of hiv infection Download PDF

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Publication number
US20190054182A1
US20190054182A1 US15/770,471 US201615770471A US2019054182A1 US 20190054182 A1 US20190054182 A1 US 20190054182A1 US 201615770471 A US201615770471 A US 201615770471A US 2019054182 A1 US2019054182 A1 US 2019054182A1
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US
United States
Prior art keywords
amino acid
seq
acid sequence
sequence
cdr
Prior art date
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Abandoned
Application number
US15/770,471
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English (en)
Inventor
Zhi-Yong Yang
Gary J. Nabel
Ling Xu
Ronnie Wei
Huawei Qiu
Jochen Beninga
Jochen Kruip
Ercole Rao
Wulf Dirk LEUSCHNER
Christian Beil
Christian Lange
Mark Connors
John R. Mascola
Richard A. Koup
Jinghe Huang
Nicole A. DORIA-ROSE
Tongqing Zhou
Peter D. Kwong
Young Do Kwon
Amarendra PEGU
Mangaiarkarasi ASOKAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
US Department of Health and Human Services
Original Assignee
Sanofi SA
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA, US Department of Health and Human Services filed Critical Sanofi SA
Priority to US15/770,471 priority Critical patent/US20190054182A1/en
Assigned to SANOFI reassignment SANOFI ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: YANG, ZHI-YONG, NABEL, GARY J.
Assigned to THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES reassignment THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: CONNORS, MARK, KWONG, PETER D., ZHOU, TONGQING, MASCOLA, JOHN R., KOUP, RICHARD A., HUANG, Jinghe, KWON, YOUNG DO, DORIA-ROSE, NICOLE A., PEGU, Amarendra
Assigned to THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES reassignment THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: ASOKAN, Mangaiarkarasi
Assigned to SANOFI reassignment SANOFI ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: KRUIP, JOCHEN, XU, LING, QIU, HUAWEI, BEIL, CHRISTIAN, BENINGA, JOCHEN, LANGE, CHRISTIAN, LEUSCHNER, Wulf Dirk, RAO, ERCOLE, WEI, Ronnie
Publication of US20190054182A1 publication Critical patent/US20190054182A1/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6881—Cluster-antibody conjugates, i.e. the modifying agent consists of a plurality of antibodies covalently linked to each other or of different antigen-binding fragments covalently linked to each other
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
US15/770,471 2015-10-25 2016-10-24 Trispecific and/or trivalent binding proteins for prevention or treatment of hiv infection Abandoned US20190054182A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US15/770,471 US20190054182A1 (en) 2015-10-25 2016-10-24 Trispecific and/or trivalent binding proteins for prevention or treatment of hiv infection

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562246113P 2015-10-25 2015-10-25
EPEP16305211.1 2016-02-24
EP16305211 2016-02-24
US201662322029P 2016-04-13 2016-04-13
US201662331169P 2016-05-03 2016-05-03
PCT/US2016/058540 WO2017074878A1 (en) 2015-10-25 2016-10-24 Trispecific and/or trivalent binding proteins for prevention or treatment of hiv infection
US15/770,471 US20190054182A1 (en) 2015-10-25 2016-10-24 Trispecific and/or trivalent binding proteins for prevention or treatment of hiv infection

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2016/058540 A-371-Of-International WO2017074878A1 (en) 2015-10-25 2016-10-24 Trispecific and/or trivalent binding proteins for prevention or treatment of hiv infection

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US16/659,426 Continuation US11129905B2 (en) 2015-10-25 2019-10-21 Bivalent, bispecific binding proteins for prevention or treatment of HIV infection

Publications (1)

Publication Number Publication Date
US20190054182A1 true US20190054182A1 (en) 2019-02-21

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Application Number Title Priority Date Filing Date
US15/770,471 Abandoned US20190054182A1 (en) 2015-10-25 2016-10-24 Trispecific and/or trivalent binding proteins for prevention or treatment of hiv infection
US16/659,426 Active US11129905B2 (en) 2015-10-25 2019-10-21 Bivalent, bispecific binding proteins for prevention or treatment of HIV infection
US17/404,908 Active US11779651B2 (en) 2015-10-25 2021-08-17 Bivalent, bispecific binding proteins for prevention or treatment of HIV infection

Family Applications After (2)

Application Number Title Priority Date Filing Date
US16/659,426 Active US11129905B2 (en) 2015-10-25 2019-10-21 Bivalent, bispecific binding proteins for prevention or treatment of HIV infection
US17/404,908 Active US11779651B2 (en) 2015-10-25 2021-08-17 Bivalent, bispecific binding proteins for prevention or treatment of HIV infection

Country Status (31)

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US (3) US20190054182A1 (ja)
EP (2) EP3365366B1 (ja)
JP (3) JP7169190B2 (ja)
KR (1) KR20180063336A (ja)
CN (4) CN117069855A (ja)
AR (1) AR106466A1 (ja)
AU (2) AU2016347058B2 (ja)
BR (1) BR112018008011A2 (ja)
CA (1) CA3002664A1 (ja)
CL (1) CL2018001065A1 (ja)
CO (1) CO2018005337A2 (ja)
CR (1) CR20180288A (ja)
DO (1) DOP2018000102A (ja)
EA (1) EA201891028A1 (ja)
ES (1) ES2894304T3 (ja)
HK (1) HK1253385A1 (ja)
HR (1) HRP20211528T1 (ja)
HU (1) HUE056608T2 (ja)
IL (2) IL301140A (ja)
MA (1) MA42641A1 (ja)
MX (2) MX2018005048A (ja)
MY (1) MY192278A (ja)
PE (1) PE20181167A1 (ja)
PH (1) PH12018500873A1 (ja)
PL (1) PL3365366T3 (ja)
RS (1) RS62437B1 (ja)
SG (1) SG11201803324VA (ja)
SI (1) SI3365366T1 (ja)
TW (2) TWI750139B (ja)
UY (1) UY36965A (ja)
WO (1) WO2017074878A1 (ja)

Cited By (8)

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US10882922B2 (en) 2016-04-13 2021-01-05 Sanofi Trispecific and/or trivalent binding proteins
US11129905B2 (en) 2015-10-25 2021-09-28 Sanofi Bivalent, bispecific binding proteins for prevention or treatment of HIV infection
US11186649B2 (en) 2017-10-10 2021-11-30 Sanofi Anti-CD38 antibodies and methods of use
WO2021203103A3 (en) * 2020-04-03 2021-12-16 Somasekar Seshagiri Ace2 receptor polymorphisms and varying susceptibility to sars-cov-2, methods for diagnosis and treatment
US11236152B2 (en) * 2015-11-03 2022-02-01 The United States of America, as represented by the Sectetary, Department of Health and Human Services Neutralizing antibodies to HIV-1 GP41 and their use
US11530268B2 (en) 2018-10-09 2022-12-20 Sanofi Trispecific anti-CD38, anti-CD28, and anti-CD3 binding proteins and methods of use for treating viral infection
US11613576B2 (en) 2019-04-09 2023-03-28 Sanofi Trispecific binding proteins, methods, and uses thereof
US11932704B2 (en) 2016-04-13 2024-03-19 Sanofi Trispecific and/or trivalent binding proteins

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Cited By (11)

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